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Search term: YDR294C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name DPL1
SGD link S000002702
Alternative ID YDR294C
Description Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
Synonyms YDR294C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1383 ACDHY--

KOGs classification KOGs description
METABOLISM Glutamate decarboxylase/sphingosine phosphate lyase

Species KOG link NCBI link UniProt link
Homo sapiens (Hsa) Hs10190653 GI:10190653
Homo sapiens (Hsa) Hs20471012 GI:20471012
Arabidopsis thaliana (Ath) At5g17330 GI:15237949
Arabidopsis thaliana (Ath) At2g02010 GI:15226854
Arabidopsis thaliana (Ath) At1g65960 GI:15218874
Arabidopsis thaliana (Ath) At2g02000 GI:15226852
Arabidopsis thaliana (Ath) At3g17760 GI:15229517
Drosophila melanogaster (Dme) 7302829 GI:7302829
Saccharomyces cerevisiae (Sce) YDR294c
(S000002702)		 GI:6320500 Q05567
Caenorhabditis elegans (Cel) CE06695
(WBGene00006418)		 GI:17557272 Q17456
Caenorhabditis elegans (Cel) CE20348
(WBGene00004981)		 GI:17543922 Q9Y194
Arabidopsis thaliana (Ath) At3g17720 GI:15229510
Saccharomyces cerevisiae (Sce) YMR250w
(S000004862)		 GI:6323905 Q04792
Arabidopsis thaliana (Ath) At1g27980 GI:15217780
Caenorhabditis elegans (Cel) CE26034 GI:17544292
Arabidopsis thaliana (Ath) At2g28020 GI:15226316
Arabidopsis thaliana (Ath) At2g28230 GI:15226360
Arabidopsis thaliana (Ath) At4g09070 GI:15233681


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g17760
At2g02000
At2g28020
At2g28230
At4g09070
GO:0005634 nucleus C
IDA
AthAt2g02010
GO:0005737 cytoplasm C
IDA
SceS000004862
GO:0005783 endoplasmic reticulum C
IDA
AthAt1g27980
SceS000002702
GO:0005829 cytosol C
IDA
AthAt2g02010
GO:0016020 membrane C
IDA
AthAt1g27980
GO:0003674 molecular_function F
ND
AthAt2g28020
At2g28230
At4g09070
GO:0004351 glutamate decarboxylase activity F
IDA
AthAt5g17330
At1g65960
ISS
SceS000004862
GO:0005516 calmodulin binding F
IDA
AthAt5g17330
SceS000004862
IPI
AthAt5g17330
ISS
AthAt2g02010
At2g02000
At3g17760
TAS
AthAt1g65960
At5g17330
GO:0008117 sphinganine-1-phosphate aldolase
activity		 F
IDA
SceS000002702
GO:0016831 carboxy-lyase activity F
ISS
AthAt3g17720
At1g27980
GO:0000003 reproduction P
IMP
CelWBGene00004981
GO:0006520 cellular amino acid metabolic process P
ISS
AthAt3g17720
At1g27980
GO:0006536 glutamate metabolic process P
IDA
AthAt1g65960
GO:0006538 glutamate catabolic process P
IPI
SceS000004862
ISS
SceS000004862
GO:0006665 sphingolipid metabolic process P
IGI
SceS000002702
IMP
SceS000002702
GO:0006807 nitrogen compound metabolic process P
TAS
AthAt1g65960
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000004862
GO:0008150 biological_process P
ND
AthAt2g28020
At2g28230
At4g09070
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004981
GO:0009267 cellular response to starvation P
IMP
SceS000002702
GO:0019722 calcium-mediated signaling P
IMP
SceS000002702
GO:0030149 sphingolipid catabolic process P
IMP
AthAt1g27980
GO:0034599 cellular response to oxidative
stress		 P
IMP
SceS000004862
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004981
GO:0046686 response to cadmium ion P
IEP
AthAt5g17330

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
2897

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SGPL1 GI:31982936
Pan troglodytes (Ptr) SGPL1 GI:114631008
Canis familiaris (Cfa) SGPL1 GI:73953418
Mus musculus (Mmu) Sgpl1
(MGI:1261415)		 GI:31543694 Q3UDJ2
Rattus norvegicus (Rno) Sgpl1
(RGD:628599)		 GI:27465561
Gallus gallus (Gga) SGPL1 GI:56118982
Drosophila melanogaster (Dme) Sply
(FBgn0010591)		 GI:21355963
Anopheles gambiae (Aga) AgaP_AGAP001724 GI:158301707
Caenorhabditis elegans (Cel) tag-38
(CE06695;
WBGene00006418)		 GI:17557272 Q17456
Saccharomyces cerevisiae (Sce) DPL1
(S000002702)		 GI:6320500 Q05567
Kluyveromyces lactis (Kla) KLLA0C10505g GI:50305417
Magnaporthe grisea (Mgr) MGG_07162 GI:39971693
Neurospora crassa (Ncr) NCU06761.1 GI:32413134
Arabidopsis thaliana (Ath) DPL1 GI:15217780
Oryza sativa (Osa) Os01g0100900 GI:115433964


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
AthDPL1
HsaSGPL1
SceS000002702
GO:0016020 membrane C
IDA
AthDPL1
GO:0030176 integral to endoplasmic reticulum
membrane		 C
NAS
DmeFBgn0010591
HsaSGPL1
GO:0008117 sphinganine-1-phosphate aldolase
activity		 F
IDA
DmeFBgn0010591
SceS000002702
NAS
DmeFBgn0010591
HsaSGPL1
GO:0016831 carboxy-lyase activity F
ISS
AthDPL1
GO:0001553 luteinization P
IMP
MmuMGI:1261415
GO:0001570 vasculogenesis P
IMP
MmuMGI:1261415
GO:0001822 kidney development P
IMP
MmuMGI:1261415
GO:0006520 cellular amino acid metabolic process P
ISS
AthDPL1
GO:0006665 sphingolipid metabolic process P
IGI
SceS000002702
IMP
SceS000002702
GO:0006672 ceramide metabolic process P
IDA
HsaSGPL1
GO:0006807 nitrogen compound metabolic process P
IMP
MmuMGI:1261415
GO:0006915 apoptosis P
IDA
HsaSGPL1
GO:0007283 spermatogenesis P
IMP
MmuMGI:1261415
GO:0008209 androgen metabolic process P
IMP
MmuMGI:1261415
GO:0008210 estrogen metabolic process P
IMP
MmuMGI:1261415
GO:0008585 female gonad development P
IMP
MmuMGI:1261415
GO:0009267 cellular response to starvation P
IMP
SceS000002702
GO:0009791 post-embryonic development P
IMP
MmuMGI:1261415
GO:0010761 fibroblast migration P
IMP
MmuMGI:1261415
GO:0019722 calcium-mediated signaling P
IMP
SceS000002702
GO:0030097 hemopoiesis P
IMP
MmuMGI:1261415
GO:0030149 sphingolipid catabolic process P
IMP
AthDPL1
DmeFBgn0010591
NAS
DmeFBgn0010591
HsaSGPL1
GO:0033327 Leydig cell differentiation P
IMP
MmuMGI:1261415
GO:0040014 regulation of multicellular organism
growth		 P
IMP
MmuMGI:1261415
GO:0048008 platelet-derived growth factor receptor signaling
pathway		 P
IMP
MmuMGI:1261415
GO:0048705 skeletal system morphogenesis P
IMP
MmuMGI:1261415
GO:0060021 palate development P
IMP
MmuMGI:1261415
GO:0060325 face morphogenesis P
IMP
MmuMGI:1261415

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2937

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3838 ENSANGP00000012191
Arabidopsis thaliana (Ath) ath2929 At1g27980.1
Caenorhabditis elegans (Cel) cel189 B0222.4
(CE06695;
WBGene00006418)
Caenorhabditis elegans (Cel) cel20340 Y66H1B.4
(CE20348;
WBGene00004981)
Candida glabrata (Cgl) cgl2122 CAGL0H01309g
Dictyostelium discoideum (Ddi) ddi12251 DDB0214888
Debaryomyces hansenii (Dha) dha3089 DEHA0D17589g
Drosophila melanogaster (Dme) dme5591 CG8946-PA
(FBgn0010591)
Drosophila melanogaster (Dme) dme5592 CG8946-PB
(FBgn0010591)
Danio rerio (Dre) dre4122 ENSDARP00000009784
Takifugu rubripes (Fru) fru32993 SINFRUP00000131149
Gallus gallus (Gga) gga20397 ENSGALP00000007235
(SGPL1)		 Q5ZMK8
Homo sapiens (Hsa) hsa4061 ENSP00000299297
(SGPL1)		 C9JMR8
Kluyveromyces lactis (Kla) kla1667 KLLA0C10505g
Mus musculus (Mmu) mmu2210 ENSMUSP00000020297
Neurospora crassa (Ncr) ncr6575 NCU06761.2
Oryza sativa (Osa) osa12071 2813.m00144
Oryza sativa (Osa) osa13684 2870.m00174
Rattus norvegicus (Rno) rno17879 ENSRNOP00000000686
(RGD:628599)
Saccharomyces cerevisiae (Sce) sce1347 YDR294C
(S000002702)
Yarrowia lipolytica (Yli) yli5023 YALI0E28237g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
AthAt1g27980
SceS000002702
GO:0016020 membrane C
IDA
AthAt1g27980
GO:0030176 integral to endoplasmic reticulum
membrane		 C
NAS
DmeFBgn0010591
GO:0008117 sphinganine-1-phosphate aldolase
activity		 F
IDA
DmeFBgn0010591
SceS000002702
NAS
DmeFBgn0010591
GO:0016831 carboxy-lyase activity F
ISS
AthAt1g27980
GO:0000003 reproduction P
IMP
CelWBGene00004981
GO:0006520 cellular amino acid metabolic process P
ISS
AthAt1g27980
GO:0006665 sphingolipid metabolic process P
IGI
SceS000002702
IMP
SceS000002702
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004981
GO:0009267 cellular response to starvation P
IMP
SceS000002702
GO:0019722 calcium-mediated signaling P
IMP
SceS000002702
GO:0030149 sphingolipid catabolic process P
IMP
AthAt1g27980
DmeFBgn0010591
NAS
DmeFBgn0010591
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004981

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