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Search term: YDR335W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MSN5
SGD link S000002743
Alternative ID YDR335W
Description Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
Synonyms YDR335W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2020 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING Nuclear transport receptor CRM1/MSN5 (importin beta superfamily)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g03110 GI:6714425
Arabidopsis thaliana (Ath) At3g05040 GI:15229879
Arabidopsis thaliana (Ath) At5g17020 GI:15237894
Caenorhabditis elegans (Cel) CE23467
(WBGene00002078)		 GI:17566910
Drosophila melanogaster (Dme) 7290037 GI:17864544
Drosophila melanogaster (Dme) 7293623 GI:7293623
Homo sapiens (Hsa) Hs18583463 GI:18583463
Homo sapiens (Hsa) Hs20562336 GI:20562336
Homo sapiens (Hsa) Hs22060276 GI:20555117
Homo sapiens (Hsa) Hs4507943
(XPO1)		 GI:4507943 O14980
Saccharomyces cerevisiae (Sce) YDR335w
(S000002743)		 GI:6320542 P52918
Saccharomyces cerevisiae (Sce) YGR218w
(S000003450)		 GI:6321657 P30822
Schizosaccharomyces pombe (Spo) SPAC1805.17 GI:19114840 P14068
Schizosaccharomyces pombe (Spo) SPAC328.01c GI:19115115 O14116
Schizosaccharomyces pombe (Spo) SPAC3A11.01c GI:19115114
Encephalitozoon cuniculi (Ecu) ECU11g0240 GI:19074824 Q8SU86


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000776 kinetochore C
IDA
HsaXPO1
SceS000003450
GO:0005634 nucleus C
IDA
SceS000002743
S000003450
SpoSPAC1805.17
SPAC328.01c
ISS
AthAt3g03110
At5g17020
SpoSPAC328.01c
TAS
AthAt5g17020
GO:0005635 nuclear envelope C
IDA
SpoSPAC1805.17
SPAC328.01c
NAS
AthAt3g05040
RCA
SceS000002743
TAS
HsaXPO1
GO:0005642 annulate lamellae C
IDA
HsaXPO1
GO:0005643 nuclear pore C
ISS
AthAt5g17020
At3g03110
SpoSPAC1805.17
NAS
SpoSPAC328.01c
RCA
SceS000002743
GO:0005654 nucleoplasm C
EXP
HsaXPO1
GO:0005737 cytoplasm C
ISS
AthAt5g17020
At3g03110
GO:0005816 spindle pole body C
IDA
SceS000003450
GO:0005829 cytosol C
EXP
HsaXPO1
IDA
SpoSPAC1805.17
SPAC328.01c
GO:0016021 integral to membrane C
RCA
SceS000002743
GO:0030529 ribonucleoprotein complex C
IDA
HsaXPO1
GO:0031224 intrinsic to membrane C
RCA
SceS000002743
GO:0046930 pore complex C
RCA
SceS000002743
GO:0004872 receptor activity F
ISS
AthAt5g17020
GO:0005487 nucleocytoplasmic transporter activity F
NAS
AthAt3g05040
GO:0005515 protein binding F
IPI
AthAt5g17020
HsaXPO1
SceS000002743
GO:0005525 GTP binding F
NAS
SpoSPAC1805.17
SPAC328.01c
GO:0008262 importin-alpha export receptor
activity		 F
IDA
SceS000002743
ISS
SceS000002743
GO:0008565 protein transporter activity F
IDA
SceS000003450
IMP
SceS000003450
ISS
AthAt3g03110
At5g17020
SpoSPAC1805.17
NAS
SpoSPAC328.01c
GO:0000055 ribosomal large subunit export from
nucleus		 P
IMP
SceS000003450
ISS
SpoSPAC1805.17
GO:0000059 protein import into nucleus, docking P
ISS
AthAt3g03110
At5g17020
GO:0002119 nematode larval development P
IMP
CelWBGene00002078
GO:0006403 RNA localization P
RCA
SceS000002743
GO:0006406 mRNA export from nucleus P
IMP
SceS000003450
GO:0006407 rRNA export from nucleus P
RCA
SceS000002743
GO:0006408 snRNA export from nucleus P
RCA
SceS000002743
GO:0006409 tRNA export from nucleus P
RCA
SceS000002743
GO:0006606 protein import into nucleus P
RCA
SceS000003450
S000002743
GO:0006607 NLS-bearing substrate import into
nucleus		 P
RCA
SceS000002743
GO:0006608 snRNP protein import into nucleus P
RCA
SceS000002743
GO:0006609 mRNA-binding (hnRNP) protein import into
nucleus		 P
RCA
SceS000002743
GO:0006610 ribosomal protein import into nucleus P
RCA
SceS000002743
GO:0006611 protein export from nucleus P
IDA
SceS000002743
IGI
SpoSPAC1805.17
IMP
SceS000003450
ISS
AthAt5g17020
SpoSPAC328.01c
GO:0006999 nuclear pore organization P
RCA
SceS000002743
GO:0009415 response to water P
RCA
SceS000002743
GO:0009553 embryo sac development P
IGI
AthAt5g17020
At3g03110
GO:0009555 pollen development P
IGI
AthAt5g17020
At3g03110
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00002078
GO:0009846 pollen germination P
IGI
AthAt5g17020
At3g03110
GO:0009860 pollen tube growth P
IGI
AthAt5g17020
At3g03110
GO:0009910 negative regulation of flower development P
IMP
AthAt3g05040
GO:0009944 polarity specification of adaxial/abaxial
axis		 P
IMP
AthAt3g05040
GO:0009965 leaf morphogenesis P
IMP
AthAt3g05040
GO:0010171 body morphogenesis P
IMP
CelWBGene00002078
GO:0015931 nucleobase, nucleoside, nucleotide and nucleic
acid transport		 P
RCA
SceS000002743
GO:0017038 protein import P
RCA
SceS000002743
GO:0033365 protein localization in organelle P
RCA
SceS000002743
GO:0034501 protein localization to kinetochore P
IGI
SceS000003450
GO:0034504 protein localization in nucleus P
RCA
SceS000003450
S000002743
GO:0034599 cellular response to oxidative
stress		 P
IMP
SpoSPAC1805.17
GO:0035281 pre-microRNA export from nucleus P
TAS
AthAt3g05040
GO:0040007 growth P
IMP
CelWBGene00002078
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00002078
GO:0040011 locomotion P
IMP
CelWBGene00002078
GO:0045184 establishment of protein localization P
RCA
SceS000002743
GO:0048364 root development P
IMP
AthAt3g05040
GO:0048367 shoot development P
IMP
AthAt3g05040
GO:0051029 rRNA transport P
RCA
SceS000002743
GO:0051030 snRNA transport P
RCA
SceS000002743
GO:0051031 tRNA transport P
RCA
SceS000002743
GO:0051168 nuclear export P
IMP
SpoSPAC1805.17
GO:0051170 nuclear import P
RCA
SceS000003450
S000002743
GO:0051301 cell division P
IMP
CelWBGene00002078
GO:0071313 cellular response to caffeine P
IMP
SpoSPAC1805.17
GO:0071528 tRNA re-export from nucleus P
IGI
SceS000002743

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
38780

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) SPAC328.01c GI:63054601 O14116
Saccharomyces cerevisiae (Sce) MSN5
(S000002743)		 GI:6320542 P52918
Kluyveromyces lactis (Kla) KLLA0F21648g GI:50312029
Eremothecium gossypii (Ego) AGOS_AEL094C GI:45190513
Magnaporthe grisea (Mgr) MGG_09560 GI:145602668
Neurospora crassa (Ncr) NCU02387.1 GI:32421439


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002743
SpoSPAC328.01c
ISS
SpoSPAC328.01c
GO:0005635 nuclear envelope C
IDA
SpoSPAC328.01c
RCA
SceS000002743
GO:0005643 nuclear pore C
NAS
SpoSPAC328.01c
RCA
SceS000002743
GO:0005829 cytosol C
IDA
SpoSPAC328.01c
GO:0016021 integral to membrane C
RCA
SceS000002743
GO:0031224 intrinsic to membrane C
RCA
SceS000002743
GO:0046930 pore complex C
RCA
SceS000002743
GO:0005515 protein binding F
IPI
SceS000002743
GO:0005525 GTP binding F
NAS
SpoSPAC328.01c
GO:0008262 importin-alpha export receptor
activity		 F
IDA
SceS000002743
ISS
SceS000002743
GO:0008565 protein transporter activity F
NAS
SpoSPAC328.01c
GO:0006403 RNA localization P
RCA
SceS000002743
GO:0006407 rRNA export from nucleus P
RCA
SceS000002743
GO:0006408 snRNA export from nucleus P
RCA
SceS000002743
GO:0006409 tRNA export from nucleus P
RCA
SceS000002743
GO:0006606 protein import into nucleus P
RCA
SceS000002743
GO:0006607 NLS-bearing substrate import into
nucleus		 P
RCA
SceS000002743
GO:0006608 snRNP protein import into nucleus P
RCA
SceS000002743
GO:0006609 mRNA-binding (hnRNP) protein import into
nucleus		 P
RCA
SceS000002743
GO:0006610 ribosomal protein import into nucleus P
RCA
SceS000002743
GO:0006611 protein export from nucleus P
IDA
SceS000002743
ISS
SpoSPAC328.01c
GO:0006999 nuclear pore organization P
RCA
SceS000002743
GO:0009415 response to water P
RCA
SceS000002743
GO:0015931 nucleobase, nucleoside, nucleotide and nucleic
acid transport		 P
RCA
SceS000002743
GO:0017038 protein import P
RCA
SceS000002743
GO:0033365 protein localization in organelle P
RCA
SceS000002743
GO:0034504 protein localization in nucleus P
RCA
SceS000002743
GO:0045184 establishment of protein localization P
RCA
SceS000002743
GO:0051029 rRNA transport P
RCA
SceS000002743
GO:0051030 snRNA transport P
RCA
SceS000002743
GO:0051031 tRNA transport P
RCA
SceS000002743
GO:0051170 nuclear import P
RCA
SceS000002743
GO:0071528 tRNA re-export from nucleus P
IGI
SceS000002743

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_4766

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga9033 ENSANGP00000021239
Ashbya gossypii (Ago) ago2412 AEL094C
Arabidopsis thaliana (Ath) ath12552 At3g05040.1
Candida glabrata (Cgl) cgl4704 CAGL0M01144g
Dictyostelium discoideum (Ddi) ddi9837 DDB0185980
Debaryomyces hansenii (Dha) dha6541 DEHA0G18821g
Drosophila melanogaster (Dme) dme18677 CG12234-PA
(FBgn0031051)
Danio rerio (Dre) dre3839 ENSDARP00000006131
Takifugu rubripes (Fru) fru14279 SINFRUP00000148087
Gallus gallus (Gga) gga14842 ENSGALP00000016816
(XPO5)
Gallus gallus (Gga) gga14844 ENSGALP00000016818
Homo sapiens (Hsa) hsa27200 ENSP00000265351
(XPO5)		 Q9HAV4-1
Kluyveromyces lactis (Kla) kla5046 KLLA0F21648g
Mus musculus (Mmu) mmu11785 ENSMUSP00000012445
Neurospora crassa (Ncr) ncr2320 NCU02387.2
Rattus norvegicus (Rno) rno29681 ENSRNOP00000025921
(RGD:1311522)
Saccharomyces cerevisiae (Sce) sce1393 YDR335W
(S000002743)
Schizosaccharomyces pombe (Spo) spo4025 SPAC328.01c O14116
Yarrowia lipolytica (Yli) yli2889 YALI0D04444g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002743
SpoSPAC328.01c
ISS
SpoSPAC328.01c
GO:0005635 nuclear envelope C
IDA
SpoSPAC328.01c
NAS
AthAt3g05040
RCA
SceS000002743
GO:0005643 nuclear pore C
NAS
SpoSPAC328.01c
RCA
SceS000002743
GO:0005829 cytosol C
IDA
SpoSPAC328.01c
GO:0016021 integral to membrane C
RCA
SceS000002743
GO:0031224 intrinsic to membrane C
RCA
SceS000002743
GO:0046930 pore complex C
RCA
SceS000002743
GO:0005487 nucleocytoplasmic transporter activity F
NAS
AthAt3g05040
GO:0005515 protein binding F
IPI
SceS000002743
GO:0005525 GTP binding F
NAS
SpoSPAC328.01c
GO:0008262 importin-alpha export receptor
activity		 F
IDA
SceS000002743
ISS
SceS000002743
GO:0008536 Ran GTPase binding F
NAS
DmeFBgn0031051
GO:0008565 protein transporter activity F
NAS
SpoSPAC328.01c
GO:0006403 RNA localization P
RCA
SceS000002743
GO:0006407 rRNA export from nucleus P
RCA
SceS000002743
GO:0006408 snRNA export from nucleus P
RCA
SceS000002743
GO:0006409 tRNA export from nucleus P
RCA
SceS000002743
GO:0006606 protein import into nucleus P
RCA
SceS000002743
GO:0006607 NLS-bearing substrate import into
nucleus		 P
RCA
SceS000002743
GO:0006608 snRNP protein import into nucleus P
RCA
SceS000002743
GO:0006609 mRNA-binding (hnRNP) protein import into
nucleus		 P
RCA
SceS000002743
GO:0006610 ribosomal protein import into nucleus P
RCA
SceS000002743
GO:0006611 protein export from nucleus P
IDA
SceS000002743
ISS
SpoSPAC328.01c
GO:0006999 nuclear pore organization P
RCA
SceS000002743
GO:0009415 response to water P
RCA
SceS000002743
GO:0009910 negative regulation of flower development P
IMP
AthAt3g05040
GO:0009944 polarity specification of adaxial/abaxial
axis		 P
IMP
AthAt3g05040
GO:0009965 leaf morphogenesis P
IMP
AthAt3g05040
GO:0015931 nucleobase, nucleoside, nucleotide and nucleic
acid transport		 P
RCA
SceS000002743
GO:0017038 protein import P
RCA
SceS000002743
GO:0033365 protein localization in organelle P
RCA
SceS000002743
GO:0034504 protein localization in nucleus P
RCA
SceS000002743
GO:0035281 pre-microRNA export from nucleus P
TAS
AthAt3g05040
GO:0045184 establishment of protein localization P
RCA
SceS000002743
GO:0048364 root development P
IMP
AthAt3g05040
GO:0048367 shoot development P
IMP
AthAt3g05040
GO:0051029 rRNA transport P
RCA
SceS000002743
GO:0051030 snRNA transport P
RCA
SceS000002743
GO:0051031 tRNA transport P
RCA
SceS000002743
GO:0051170 nuclear import P
RCA
SceS000002743
GO:0071528 tRNA re-export from nucleus P
IGI
SceS000002743

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC328.01c
(O14116)		 YDR335W
(S000002743)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002743
SpoSPAC328.01c
ISS
SpoSPAC328.01c
GO:0005635 nuclear envelope C
IDA
SpoSPAC328.01c
RCA
SceS000002743
GO:0005643 nuclear pore C
NAS
SpoSPAC328.01c
RCA
SceS000002743
GO:0005829 cytosol C
IDA
SpoSPAC328.01c
GO:0016021 integral to membrane C
RCA
SceS000002743
GO:0031224 intrinsic to membrane C
RCA
SceS000002743
GO:0046930 pore complex C
RCA
SceS000002743
GO:0005515 protein binding F
IPI
SceS000002743
GO:0005525 GTP binding F
NAS
SpoSPAC328.01c
GO:0008262 importin-alpha export receptor
activity		 F
IDA
SceS000002743
ISS
SceS000002743
GO:0008565 protein transporter activity F
NAS
SpoSPAC328.01c
GO:0006403 RNA localization P
RCA
SceS000002743
GO:0006407 rRNA export from nucleus P
RCA
SceS000002743
GO:0006408 snRNA export from nucleus P
RCA
SceS000002743
GO:0006409 tRNA export from nucleus P
RCA
SceS000002743
GO:0006606 protein import into nucleus P
RCA
SceS000002743
GO:0006607 NLS-bearing substrate import into
nucleus		 P
RCA
SceS000002743
GO:0006608 snRNP protein import into nucleus P
RCA
SceS000002743
GO:0006609 mRNA-binding (hnRNP) protein import into
nucleus		 P
RCA
SceS000002743
GO:0006610 ribosomal protein import into nucleus P
RCA
SceS000002743
GO:0006611 protein export from nucleus P
IDA
SceS000002743
ISS
SpoSPAC328.01c
GO:0006999 nuclear pore organization P
RCA
SceS000002743
GO:0009415 response to water P
RCA
SceS000002743
GO:0015931 nucleobase, nucleoside, nucleotide and nucleic
acid transport		 P
RCA
SceS000002743
GO:0017038 protein import P
RCA
SceS000002743
GO:0033365 protein localization in organelle P
RCA
SceS000002743
GO:0034504 protein localization in nucleus P
RCA
SceS000002743
GO:0045184 establishment of protein localization P
RCA
SceS000002743
GO:0051029 rRNA transport P
RCA
SceS000002743
GO:0051030 snRNA transport P
RCA
SceS000002743
GO:0051031 tRNA transport P
RCA
SceS000002743
GO:0051170 nuclear import P
RCA
SceS000002743
GO:0071528 tRNA re-export from nucleus P
IGI
SceS000002743

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GO info in one table:

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