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Search term: YDR363W-A


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SEM1
SGD link S000007235
Alternative ID YDR363W-A
Description Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1
Synonyms YDR363W-A
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4764 ACDHYP-

KOGs classification KOGs description
POORLY CHARACTERIZED Uncharacterized conserved protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g64750 GI:18408121
Arabidopsis thaliana (Ath) At5g45010 GI:15241644
Caenorhabditis elegans (Cel) CE23377 GI:17556747
Drosophila melanogaster (Dme) 7297216 GI:7297216
Homo sapiens (Hsa) Hs5453640
(SHFM1)
GI:5453640 P60896
Saccharomyces cerevisiae (Sce) YDR363w-a
(S000007235)
GI:6320571 O94742
Schizosaccharomyces pombe (Spo) SPAC3G6.02 GI:19115880 O14140


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
IDA
HsaSHFM1
GO:0005575 cellular_component C
ND
AthAt1g64750
At5g45010
GO:0005634 nucleus C
IDA
SpoSPAC3G6.02
IPI
SceS000007235
GO:0005643 nuclear pore C
IDA
SpoSPAC3G6.02
GO:0005737 cytoplasm C
IDA
SpoSPAC3G6.02
GO:0005792 microsome C
IDA
SceS000007235
GO:0005829 cytosol C
IDA
SceS000007235
SpoSPAC3G6.02
GO:0008541 proteasome regulatory particle, lid
subcomplex
C
IDA
SceS000007235
SpoSPAC3G6.02
GO:0032039 integrator complex C
IDA
HsaSHFM1
GO:0034515 proteasome storage granule C
IDA
SceS000007235
GO:0003674 molecular_function F
ND
AthAt5g45010
At1g64750
SceS000007235
GO:0005515 protein binding F
IPI
HsaSHFM1
SpoSPAC3G6.02
GO:0008233 peptidase activity F
IDA
HsaSHFM1
GO:0006406 mRNA export from nucleus P
IGI
SceS000007235
IMP
SceS000007235
IPI
SceS000007235
GO:0006508 proteolysis P
IDA
HsaSHFM1
RCA
SceS000007235
GO:0006511 ubiquitin-dependent protein catabolic
process
P
IMP
SceS000007235
GO:0006887 exocytosis P
IGI
SceS000007235
IPI
SceS000007235
GO:0006974 response to DNA damage stimulus P
ISS
SpoSPAC3G6.02
GO:0007346 regulation of mitotic cell cycle P
IMP
SpoSPAC3G6.02
GO:0008150 biological_process P
ND
AthAt5g45010
At1g64750
GO:0016973 poly(A)+ mRNA export from nucleus P
IGI
SpoSPAC3G6.02
IMP
SpoSPAC3G6.02
GO:0030447 filamentous growth P
IMP
SceS000007235
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process
P
IDA
SceS000007235
IGI
SpoSPAC3G6.02
IMP
SceS000007235
GO:0043248 proteasome assembly P
IMP
SceS000007235
GO:0051726 regulation of cell cycle P
IMP
SceS000007235

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3764

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga6347 ENSANGP00000017966
Ashbya gossypii (Ago) ago2755 AER253W
Arabidopsis thaliana (Ath) ath5690 At1g64750.1
Arabidopsis thaliana (Ath) ath5691 At1g64750.2
Arabidopsis thaliana (Ath) ath26340 At5g45010.1
Caenorhabditis elegans (Cel) cel17792 Y119D3B.15
(CE34396;
WBGene00022492)
Candida glabrata (Cgl) cgl111 CAGL0A02728g
Cryptococcus neoformans (Cne) cne2756 183.m01696
Dictyostelium discoideum (Ddi) ddi12987 DDB0231348
Debaryomyces hansenii (Dha) dha6318 DEHA0G13871g
Drosophila melanogaster (Dme) dme1198 CG13779-PA
(FBgn0040954)
Danio rerio (Dre) dre26126 ENSDARP00000030382
(shfm1)
Q7ZU84
Takifugu rubripes (Fru) fru17979 SINFRUP00000152929
Gallus gallus (Gga) gga9747 ENSGALP00000015826
(SHFM1)
Q5ZJW7
Homo sapiens (Hsa) hsa28999 ENSP00000248566
(SHFM1)
P60896
Kluyveromyces lactis (Kla) kla3910 KLLA0E21318g
Mus musculus (Mmu) mmu21418 ENSMUSP00000040741
(MGI:109238)
P60897
Neurospora crassa (Ncr) ncr7709 NCU07913.2
Oryza sativa (Osa) osa9086 2728.m00155
Oryza sativa (Osa) osa12718 2889.m00187
Rattus norvegicus (Rno) rno20815 ENSRNOP00000013841
(RGD:1590628)
Saccharomyces cerevisiae (Sce) sce1423 YDR363W-A
(S000007235)
Schizosaccharomyces pombe (Spo) spo4006 SPAC3G6.02 O14140
Yarrowia lipolytica (Yli) yli2621 YALI0C22528g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
ISS
DmeFBgn0040954
GO:0005575 cellular_component C
ND
AthAt1g64750
At5g45010
GO:0005634 nucleus C
IDA
CelWBGene00022492
SpoSPAC3G6.02
IPI
SceS000007235
GO:0005643 nuclear pore C
IDA
SpoSPAC3G6.02
GO:0005737 cytoplasm C
IDA
CelWBGene00022492
SpoSPAC3G6.02
GO:0005792 microsome C
IDA
SceS000007235
GO:0005829 cytosol C
IDA
SceS000007235
SpoSPAC3G6.02
GO:0008541 proteasome regulatory particle, lid
subcomplex
C
IDA
SceS000007235
SpoSPAC3G6.02
GO:0034515 proteasome storage granule C
IDA
SceS000007235
GO:0003674 molecular_function F
ND
AthAt5g45010
At1g64750
CelWBGene00022492
SceS000007235
GO:0005515 protein binding F
IPI
MmuMGI:109238
SpoSPAC3G6.02
GO:0008233 peptidase activity F
ISS
DmeFBgn0040954
GO:0000003 reproduction P
IMP
CelWBGene00022492
GO:0000724 double-strand break repair via homologous
recombination
P
IMP
MmuMGI:109238
GO:0002119 nematode larval development P
IMP
CelWBGene00022492
GO:0006406 mRNA export from nucleus P
IGI
SceS000007235
IMP
SceS000007235
IPI
SceS000007235
GO:0006508 proteolysis P
ISS
DmeFBgn0040954
RCA
SceS000007235
GO:0006511 ubiquitin-dependent protein catabolic
process
P
IMP
SceS000007235
GO:0006887 exocytosis P
IGI
SceS000007235
IPI
SceS000007235
GO:0006974 response to DNA damage stimulus P
ISS
SpoSPAC3G6.02
GO:0007346 regulation of mitotic cell cycle P
IMP
SpoSPAC3G6.02
GO:0008150 biological_process P
ND
AthAt5g45010
At1g64750
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00022492
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00022492
GO:0016973 poly(A)+ mRNA export from nucleus P
IGI
SpoSPAC3G6.02
IMP
SpoSPAC3G6.02
GO:0030447 filamentous growth P
IMP
SceS000007235
GO:0031398 positive regulation of protein
ubiquitination
P
IGI
CelWBGene00022492
GO:0040007 growth P
IMP
CelWBGene00022492
GO:0040018 positive regulation of multicellular organism
growth
P
IMP
CelWBGene00022492
GO:0040025 vulval development P
IMP
CelWBGene00022492
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00022492
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process
P
IDA
SceS000007235
IGI
SpoSPAC3G6.02
IMP
SceS000007235
GO:0043248 proteasome assembly P
IMP
SceS000007235
GO:0045927 positive regulation of growth P
IGI
CelWBGene00022492
GO:0048477 oogenesis P
IMP
CelWBGene00022492
GO:0050892 intestinal absorption P
IMP
CelWBGene00022492
GO:0051726 regulation of cell cycle P
IMP
SceS000007235
GO:0060429 epithelium development P
IMP
CelWBGene00022492

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPAC3G6.02
(O14140)
YDR363W-A
(S000007235)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC3G6.02
IPI
SceS000007235
GO:0005643 nuclear pore C
IDA
SpoSPAC3G6.02
GO:0005737 cytoplasm C
IDA
SpoSPAC3G6.02
GO:0005792 microsome C
IDA
SceS000007235
GO:0005829 cytosol C
IDA
SceS000007235
SpoSPAC3G6.02
GO:0008541 proteasome regulatory particle, lid
subcomplex
C
IDA
SceS000007235
SpoSPAC3G6.02
GO:0034515 proteasome storage granule C
IDA
SceS000007235
GO:0003674 molecular_function F
ND
SceS000007235
GO:0005515 protein binding F
IPI
SpoSPAC3G6.02
GO:0006406 mRNA export from nucleus P
IGI
SceS000007235
IMP
SceS000007235
IPI
SceS000007235
GO:0006508 proteolysis P
RCA
SceS000007235
GO:0006511 ubiquitin-dependent protein catabolic
process
P
IMP
SceS000007235
GO:0006887 exocytosis P
IGI
SceS000007235
IPI
SceS000007235
GO:0006974 response to DNA damage stimulus P
ISS
SpoSPAC3G6.02
GO:0007346 regulation of mitotic cell cycle P
IMP
SpoSPAC3G6.02
GO:0016973 poly(A)+ mRNA export from nucleus P
IGI
SpoSPAC3G6.02
IMP
SpoSPAC3G6.02
GO:0030447 filamentous growth P
IMP
SceS000007235
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process
P
IDA
SceS000007235
IGI
SpoSPAC3G6.02
IMP
SceS000007235
GO:0043248 proteasome assembly P
IMP
SceS000007235
GO:0051726 regulation of cell cycle P
IMP
SceS000007235

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GO info in one table:

s.khadayate@ucl.ac.uk