Bahler Lab

Search term: YDR373W

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name FRQ1

SGD link S000002781

Alternative ID YDR373W

Description N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily

Synonyms YDR373W

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG0044 -CDHYPE

KOGs classification KOGs description

CELLULAR PROCESSES AND SIGNALING Ca2+ sensor (EF-Hand superfamily)

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000139 Golgi membrane C
IDA
Sce S000002781

GO:0005622 intracellular C
IDA
Hsa HPCAL4

GO:0005634 nucleus C
IDA
Spo SPAC18B11.04

GO:0005737 cytoplasm C
IDA
Spo SPAC18B11.04

GO:0005829 cytosol C
IDA
Spo SPAC18B11.04

GO:0005886 plasma membrane C
IDA
Spo SPAC18B11.04

GO:0008021 synaptic vesicle C
NAS
Dme Frq2

GO:0043025 neuronal cell body C
IDA
Cel WBGene00003563

GO:0003714 transcription corepressor activity F
TAS
Hsa KCNIP3

GO:0005509 calcium ion binding F
IDA
Spo SPAC18B11.04
ISS
Sce S000002781

GO:0008047 enzyme activator activity F
IDA
Sce S000002781

GO:0008048 calcium sensitive guanylate cyclase activator
activity F
TAS
Hsa RCVRN

GO:0000003 reproduction P
IMP
Cel WBGene00003564

GO:0006357 regulation of transcription from RNA polymerase II
promoter P
TAS
Hsa KCNIP3

GO:0006874 cellular calcium ion homeostasis P
TAS
Spo SPAC18B11.04

GO:0007165 signal transduction P
TAS
Hsa RCVRN
KCNIP3

GO:0007268 synaptic transmission P
IMP
Dme Frq2

GO:0007269 neurotransmitter secretion P
NAS
Dme Frq2

GO:0007417 central nervous system development P
TAS
Hsa HPCAL4

GO:0007528 neuromuscular junction development P
IMP
Dme Frq2

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00021116

GO:0009966 regulation of signal transduction P
IMP
Sce S000002781
IPI
Sce S000002781

GO:0016192 vesicle-mediated transport P
NAS
Dme Frq2

GO:0019933 cAMP-mediated signaling P
TAS
Spo SPAC18B11.04

GO:0031137 regulation of conjugation with cellular
fusion P
IMP
Spo SPAC18B11.04

GO:0046928 regulation of neurotransmitter
secretion P
IGI
Dme Frq2

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

101571

Species Gene ID NCBI link UniProt link

Schizosaccharomyces pombe (Spo) ncs1
(SPAC18B11.04) GI:19113791 Q09711

Saccharomyces cerevisiae (Sce) FRQ1
(S000002781) GI:6320581 Q06389

Kluyveromyces lactis (Kla) KLLA0E02398g GI:50308111

Eremothecium gossypii (Ego) AGOS_ACL163W GI:45185525

Magnaporthe grisea (Mgr) MGG_01550 GI:39951815

Neurospora crassa (Ncr) NCU04379.1 GI:32406238

GO terms for Homologene results:

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_1169

Species OrthoMCL
sequence Model organism
protein page UniProt link

Anopheles gambiae (Aga) aga2679 ENSANGP00000015900

Ashbya gossypii (Ago) ago886 ACL163W

Arabidopsis thaliana (Ath) ath19473 At4g16350.1

Caenorhabditis elegans (Cel) cel3994 C44C1.3
(CE24845;
WBGene00003563)

Candida glabrata (Cgl) cgl121 CAGL0A02948g

Cryptococcus neoformans (Cne) cne4302 177.m03057

Dictyostelium discoideum (Ddi) ddi12101 DDB0231007

Debaryomyces hansenii (Dha) dha3873 DEHA0E14289g

Drosophila melanogaster (Dme) dme18450 CG5744-PB
(FBgn0030897)

Drosophila melanogaster (Dme) dme18452 CG5907-PA

Drosophila melanogaster (Dme) dme18453 CG5907-PB

Drosophila melanogaster (Dme) dme18454 CG5907-PC

Drosophila melanogaster (Dme) dme10319 CG7641-PA
(FBgn0013303)

Danio rerio (Dre) dre10452 ENSDARP00000012565
(zgc:73126) Q6PC34

Danio rerio (Dre) dre30640 ENSDARP00000028736

Danio rerio (Dre) dre12606 ENSDARP00000038816
(zgc:63695) Q7SXX4

Danio rerio (Dre) dre22871 ENSDARP00000039612

Danio rerio (Dre) dre16489 ENSDARP00000044612

Danio rerio (Dre) dre22870 ENSDARP00000049459

Encephalitozoon cuniculi (Ecu) ecu796 19074158

Takifugu rubripes (Fru) fru19479 SINFRUP00000145542

Takifugu rubripes (Fru) fru9346 SINFRUP00000147829

Takifugu rubripes (Fru) fru2035 SINFRUP00000166988

Gallus gallus (Gga) gga8008 ENSGALP00000006397

Gallus gallus (Gga) gga26424 ENSGALP00000021767
(NCALD) P62758

Gallus gallus (Gga) gga15967 ENSGALP00000026475
(HPCAL1) P42324

Homo sapiens (Hsa) hsa30596 ENSP00000220931
(NCALD) P61601

Homo sapiens (Hsa) hsa32063 ENSP00000223979

Homo sapiens (Hsa) hsa30595 ENSP00000310587
(NCALD) P61601

Homo sapiens (Hsa) hsa17462 ENSP00000310749
(HPCAL1) P37235

Kluyveromyces lactis (Kla) kla3055 KLLA0E02398g

Mus musculus (Mmu) mmu14391 ENSMUSP00000000199
(MGI:109166) Q8BNY6

Mus musculus (Mmu) mmu8904 ENSMUSP00000054594

Neurospora crassa (Ncr) ncr4252 NCU04379.2

Oryza sativa (Osa) osa11082 2763.m00156

Oryza sativa (Osa) osa30827 4367.m00140

Rattus norvegicus (Rno) rno24921 ENSRNOP00000007374
(RGD:708375) P62749

Rattus norvegicus (Rno) rno18382 ENSRNOP00000011648
(RGD:68417) P62168

Saccharomyces cerevisiae (Sce) sce1436 YDR373W
(S000002781)

Schizosaccharomyces pombe (Spo) spo4047 SPAC18B11.04 Q09711

Yarrowia lipolytica (Yli) yli4487 YALI0E15180g

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000139 Golgi membrane C
IDA
Sce S000002781

GO:0005634 nucleus C
IDA
Spo SPAC18B11.04

GO:0005737 cytoplasm C
IDA
Spo SPAC18B11.04

GO:0005829 cytosol C
IDA
Spo SPAC18B11.04
ISO
Mmu MGI:109166

GO:0005886 plasma membrane C
IDA
Spo SPAC18B11.04

GO:0030424 axon C
IDA
Mmu MGI:109166

GO:0030425 dendrite C
IDA
Mmu MGI:109166

GO:0031045 dense core granule C
ISO
Mmu MGI:109166

GO:0043025 neuronal cell body C
IDA
Cel WBGene00003563

GO:0045202 synapse C
NAS
Dme FBgn0030897

GO:0005509 calcium ion binding F
IDA
Dme FBgn0013303
FBgn0030897
Spo SPAC18B11.04
ISS
Ath At4g16350
Dme FBgn0013303
Sce S000002781
NAS
Dme FBgn0013303
FBgn0030897
TAS
Mmu MGI:109166

GO:0008047 enzyme activator activity F
IDA
Sce S000002781

GO:0008048 calcium sensitive guanylate cyclase activator
activity F
IDA
Dme FBgn0030897
ISS
Dme FBgn0030897
NAS
Dme FBgn0030897

GO:0006874 cellular calcium ion homeostasis P
TAS
Spo SPAC18B11.04

GO:0007268 synaptic transmission P
IMP
Dme FBgn0030897
NAS
Dme FBgn0030897

GO:0007269 neurotransmitter secretion P
IMP
Dme FBgn0030897

GO:0007528 neuromuscular junction development P
IMP
Dme FBgn0030897

GO:0009966 regulation of signal transduction P
IMP
Sce S000002781
IPI
Sce S000002781

GO:0010975 regulation of neuron projection
development P
ISO
Mmu MGI:109166

GO:0019722 calcium-mediated signaling P
ISS
Ath At4g16350

GO:0019933 cAMP-mediated signaling P
TAS
Spo SPAC18B11.04

GO:0031137 regulation of conjugation with cellular
fusion P
IMP
Spo SPAC18B11.04

GO:0042326 negative regulation of phosphorylation P
NAS
Dme FBgn0013303

GO:0045921 positive regulation of exocytosis P
ISO
Mmu MGI:109166

GO:0046928 regulation of neurotransmitter
secretion P
ISS
Dme FBgn0030897

GO:0048015 phosphoinositide-mediated signaling P
ISO
Mmu MGI:109166

GO:0050806 positive regulation of synaptic
transmission P
TAS
Mmu MGI:109166

GO:0051927 negative regulation of calcium ion transport via
voltage-gated calcium channel activity P
ISO
Mmu MGI:109166

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPAC18B11.04
(Q09711) YDR373W
(S000002781)

GO terms for curated homolog results:

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0044	-CDHYPE

KOGs classification	KOGs description
CELLULAR PROCESSES AND SIGNALING	Ca2+ sensor (EF-Hand superfamily)

Species	KOG link	NCBI link	UniProt link
Caenorhabditis elegans (Cel)	CE08235	GI:17550494
Caenorhabditis elegans (Cel)	CE09340 (WBGene00003564)	GI:17508451	P36609
Caenorhabditis elegans (Cel)	CE15731	GI:17558924
Caenorhabditis elegans (Cel)	CE18623 (WBGene00008998)	GI:17567221	A6PVB9
Caenorhabditis elegans (Cel)	CE19523	GI:17568669
Caenorhabditis elegans (Cel)	CE24845 (WBGene00003563)	GI:17569087	P36608
Caenorhabditis elegans (Cel)	CE29365 (WBGene00021116)	GI:17536811	O16638
Drosophila melanogaster (Dme)	7290875	GI:7290875
Drosophila melanogaster (Dme)	7292618	GI:7292618	Q9VZ14
Drosophila melanogaster (Dme)	7293433 (Frq2)	GI:17933604	Q9VWX8
Drosophila melanogaster (Dme)	7293713	GI:17737671
Drosophila melanogaster (Dme)	7293714	GI:7293714	Q9VW66
Drosophila melanogaster (Dme)	7301392	GI:7301392
Homo sapiens (Hsa)	Hs7305199 (KCNIP3)	GI:7305199	Q9Y2W7
Homo sapiens (Hsa)	Hs7657247	GI:7657247	Q9NZI2
Homo sapiens (Hsa)	HsM7657249	GI:7657249
Homo sapiens (Hsa)	Hs7705419 (HPCAL4)	GI:7705419	Q9UM19
Homo sapiens (Hsa)	Hs17738308	GI:9790115
Homo sapiens (Hsa)	Hs21361559	GI:6755983
Homo sapiens (Hsa)	Hs21361460	GI:14091326	Q9H0N4
Homo sapiens (Hsa)	Hs22049589	GI:22049589
Homo sapiens (Hsa)	Hs20555208	GI:20555208
Homo sapiens (Hsa)	Hs13375787 (EFCAB1)	GI:13375787	Q9HAE3
Homo sapiens (Hsa)	Hs13376828	GI:13376828
Homo sapiens (Hsa)	Hs14042974	GI:14042974
Homo sapiens (Hsa)	Hs15887358	GI:15887358
Homo sapiens (Hsa)	Hs19913441 (HPCAL1)	GI:19913441	O75544
Homo sapiens (Hsa)	Hs19913446	GI:6754240
Homo sapiens (Hsa)	Hs4504207	GI:4504207
Homo sapiens (Hsa)	Hs4506459 (RCVRN)	GI:4506459	P35243
Homo sapiens (Hsa)	HsM4507905	GI:4507905
Homo sapiens (Hsa)	Hs4885367	GI:4885367
Saccharomyces cerevisiae (Sce)	YDR373w (S000002781)	GI:6320581	Q06389
Schizosaccharomyces pombe (Spo)	SPAC18B11.04	GI:19113791	Q09711
Encephalitozoon cuniculi (Ecu)	ECU04g0810	GI:19074158	Q8SS44
Caenorhabditis elegans (Cel)	CE08235	GI:17550494
Caenorhabditis elegans (Cel)	CE09340 (WBGene00003564)	GI:17508451	P36609
Caenorhabditis elegans (Cel)	CE15731	GI:17558924
Caenorhabditis elegans (Cel)	CE18623 (WBGene00008998)	GI:17567221	A6PVB9
Caenorhabditis elegans (Cel)	CE19523	GI:17568669
Caenorhabditis elegans (Cel)	CE24845 (WBGene00003563)	GI:17569087	P36608
Caenorhabditis elegans (Cel)	CE29365 (WBGene00021116)	GI:17536811	O16638
Drosophila melanogaster (Dme)	7290875	GI:7290875
Drosophila melanogaster (Dme)	7292618	GI:7292618	Q9VZ14
Drosophila melanogaster (Dme)	7293433 (Frq2)	GI:17933604	Q9VWX8
Drosophila melanogaster (Dme)	7293713	GI:17737671
Drosophila melanogaster (Dme)	7293714	GI:7293714	Q9VW66
Drosophila melanogaster (Dme)	7301392	GI:7301392
Homo sapiens (Hsa)	Hs7305199 (KCNIP3)	GI:7305199	Q9Y2W7
Homo sapiens (Hsa)	Hs7657247	GI:7657247	Q9NZI2
Homo sapiens (Hsa)	HsM7657249	GI:7657249
Homo sapiens (Hsa)	Hs7705419 (HPCAL4)	GI:7705419	Q9UM19
Homo sapiens (Hsa)	Hs17738308	GI:9790115
Homo sapiens (Hsa)	Hs21361559	GI:6755983
Homo sapiens (Hsa)	Hs21361460	GI:14091326	Q9H0N4
Homo sapiens (Hsa)	Hs22049589	GI:22049589
Homo sapiens (Hsa)	Hs20555208	GI:20555208
Homo sapiens (Hsa)	Hs13375787 (EFCAB1)	GI:13375787	Q9HAE3
Homo sapiens (Hsa)	Hs13376828	GI:13376828
Homo sapiens (Hsa)	Hs14042974	GI:14042974
Homo sapiens (Hsa)	Hs15887358	GI:15887358
Homo sapiens (Hsa)	Hs19913441 (HPCAL1)	GI:19913441	O75544
Homo sapiens (Hsa)	Hs19913446	GI:6754240
Homo sapiens (Hsa)	Hs4504207	GI:4504207
Homo sapiens (Hsa)	Hs4506459 (RCVRN)	GI:4506459	P35243
Homo sapiens (Hsa)	HsM4507905	GI:4507905
Homo sapiens (Hsa)	Hs4885367	GI:4885367
Saccharomyces cerevisiae (Sce)	YDR373w (S000002781)	GI:6320581	Q06389
Schizosaccharomyces pombe (Spo)	SPAC18B11.04	GI:19113791	Q09711
Encephalitozoon cuniculi (Ecu)	ECU04g0810	GI:19074158	Q8SS44
Caenorhabditis elegans (Cel)	CE08235	GI:17550494
Caenorhabditis elegans (Cel)	CE09340 (WBGene00003564)	GI:17508451	P36609
Caenorhabditis elegans (Cel)	CE15731	GI:17558924
Caenorhabditis elegans (Cel)	CE18623 (WBGene00008998)	GI:17567221	A6PVB9
Caenorhabditis elegans (Cel)	CE19523	GI:17568669
Caenorhabditis elegans (Cel)	CE24845 (WBGene00003563)	GI:17569087	P36608
Caenorhabditis elegans (Cel)	CE29365 (WBGene00021116)	GI:17536811	O16638
Drosophila melanogaster (Dme)	7290875	GI:7290875
Drosophila melanogaster (Dme)	7292618	GI:7292618	Q9VZ14
Drosophila melanogaster (Dme)	7293433 (Frq2)	GI:17933604	Q9VWX8
Drosophila melanogaster (Dme)	7293713	GI:17737671
Drosophila melanogaster (Dme)	7293714	GI:7293714	Q9VW66
Drosophila melanogaster (Dme)	7301392	GI:7301392
Homo sapiens (Hsa)	Hs7305199 (KCNIP3)	GI:7305199	Q9Y2W7
Homo sapiens (Hsa)	Hs7657247	GI:7657247	Q9NZI2
Homo sapiens (Hsa)	HsM7657249	GI:7657249
Homo sapiens (Hsa)	Hs7705419 (HPCAL4)	GI:7705419	Q9UM19
Homo sapiens (Hsa)	Hs17738308	GI:9790115
Homo sapiens (Hsa)	Hs21361559	GI:6755983
Homo sapiens (Hsa)	Hs21361460	GI:14091326	Q9H0N4
Homo sapiens (Hsa)	Hs22049589	GI:22049589
Homo sapiens (Hsa)	Hs20555208	GI:20555208
Homo sapiens (Hsa)	Hs13375787 (EFCAB1)	GI:13375787	Q9HAE3
Homo sapiens (Hsa)	Hs13376828	GI:13376828
Homo sapiens (Hsa)	Hs14042974	GI:14042974
Homo sapiens (Hsa)	Hs15887358	GI:15887358
Homo sapiens (Hsa)	Hs19913441 (HPCAL1)	GI:19913441	O75544
Homo sapiens (Hsa)	Hs19913446	GI:6754240
Homo sapiens (Hsa)	Hs4504207	GI:4504207
Homo sapiens (Hsa)	Hs4506459 (RCVRN)	GI:4506459	P35243
Homo sapiens (Hsa)	HsM4507905	GI:4507905
Homo sapiens (Hsa)	Hs4885367	GI:4885367
Saccharomyces cerevisiae (Sce)	YDR373w (S000002781)	GI:6320581	Q06389
Schizosaccharomyces pombe (Spo)	SPAC18B11.04	GI:19113791	Q09711
Encephalitozoon cuniculi (Ecu)	ECU04g0810	GI:19074158	Q8SS44

Species	Gene ID	NCBI link	UniProt link
Schizosaccharomyces pombe (Spo)	ncs1 (SPAC18B11.04)	GI:19113791	Q09711
Saccharomyces cerevisiae (Sce)	FRQ1 (S000002781)	GI:6320581	Q06389
Kluyveromyces lactis (Kla)	KLLA0E02398g	GI:50308111
Eremothecium gossypii (Ego)	AGOS_ACL163W	GI:45185525
Magnaporthe grisea (Mgr)	MGG_01550	GI:39951815
Neurospora crassa (Ncr)	NCU04379.1	GI:32406238

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga2679	ENSANGP00000015900
Ashbya gossypii (Ago)	ago886	ACL163W
Arabidopsis thaliana (Ath)	ath19473	At4g16350.1
Caenorhabditis elegans (Cel)	cel3994	C44C1.3 (CE24845; WBGene00003563)
Candida glabrata (Cgl)	cgl121	CAGL0A02948g
Cryptococcus neoformans (Cne)	cne4302	177.m03057
Dictyostelium discoideum (Ddi)	ddi12101	DDB0231007
Debaryomyces hansenii (Dha)	dha3873	DEHA0E14289g
Drosophila melanogaster (Dme)	dme18450	CG5744-PB (FBgn0030897)
Drosophila melanogaster (Dme)	dme18452	CG5907-PA
Drosophila melanogaster (Dme)	dme18453	CG5907-PB
Drosophila melanogaster (Dme)	dme18454	CG5907-PC
Drosophila melanogaster (Dme)	dme10319	CG7641-PA (FBgn0013303)
Danio rerio (Dre)	dre10452	ENSDARP00000012565 (zgc:73126)	Q6PC34
Danio rerio (Dre)	dre30640	ENSDARP00000028736
Danio rerio (Dre)	dre12606	ENSDARP00000038816 (zgc:63695)	Q7SXX4
Danio rerio (Dre)	dre22871	ENSDARP00000039612
Danio rerio (Dre)	dre16489	ENSDARP00000044612
Danio rerio (Dre)	dre22870	ENSDARP00000049459
Encephalitozoon cuniculi (Ecu)	ecu796	19074158
Takifugu rubripes (Fru)	fru19479	SINFRUP00000145542
Takifugu rubripes (Fru)	fru9346	SINFRUP00000147829
Takifugu rubripes (Fru)	fru2035	SINFRUP00000166988
Gallus gallus (Gga)	gga8008	ENSGALP00000006397
Gallus gallus (Gga)	gga26424	ENSGALP00000021767 (NCALD)	P62758
Gallus gallus (Gga)	gga15967	ENSGALP00000026475 (HPCAL1)	P42324
Homo sapiens (Hsa)	hsa30596	ENSP00000220931 (NCALD)	P61601
Homo sapiens (Hsa)	hsa32063	ENSP00000223979
Homo sapiens (Hsa)	hsa30595	ENSP00000310587 (NCALD)	P61601
Homo sapiens (Hsa)	hsa17462	ENSP00000310749 (HPCAL1)	P37235
Kluyveromyces lactis (Kla)	kla3055	KLLA0E02398g
Mus musculus (Mmu)	mmu14391	ENSMUSP00000000199 (MGI:109166)	Q8BNY6
Mus musculus (Mmu)	mmu8904	ENSMUSP00000054594
Neurospora crassa (Ncr)	ncr4252	NCU04379.2
Oryza sativa (Osa)	osa11082	2763.m00156
Oryza sativa (Osa)	osa30827	4367.m00140
Rattus norvegicus (Rno)	rno24921	ENSRNOP00000007374 (RGD:708375)	P62749
Rattus norvegicus (Rno)	rno18382	ENSRNOP00000011648 (RGD:68417)	P62168
Saccharomyces cerevisiae (Sce)	sce1436	YDR373W (S000002781)
Schizosaccharomyces pombe (Spo)	spo4047	SPAC18B11.04	Q09711
Yarrowia lipolytica (Yli)	yli4487	YALI0E15180g

S. pombe systematic ID	S. cerevisiae systematic ID
SPAC18B11.04 (Q09711)	YDR373W (S000002781)