YOGY Home YOGY Help

Search term: YDR386W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MUS81
SGD link S000002794
Alternative ID YDR386W
Description Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein
Synonyms YDR386W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2379 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Endonuclease MUS81

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g30870 GI:15234920
Arabidopsis thaliana (Ath) At5g39770 GI:15242470
Caenorhabditis elegans (Cel) CE08680
(WBGene00016602)		 GI:17505985 P91153
Drosophila melanogaster (Dme) 7290106
(FBgn0040347)		 GI:18543201
Homo sapiens (Hsa) Hs13376707 GI:13376707
Saccharomyces cerevisiae (Sce) YDR386w
(S000002794)		 GI:6320594 Q04149
Schizosaccharomyces pombe (Spo) SPCC4G3.05c GI:19075333 P87231
Encephalitozoon cuniculi (Ecu) ECU02g1390 GI:19074058 Q8SW97


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000794 condensed nuclear chromosome C
IDA
AthAt4g30870
GO:0005634 nucleus C
IDA
SpoSPCC4G3.05c
IMP
SceS000002794
IPI
SceS000002794
TAS
SpoSPCC4G3.05c
GO:0005739 mitochondrion C
IDA
SpoSPCC4G3.05c
GO:0048476 Holliday junction resolvase complex C
IDA
SceS000002794
SpoSPCC4G3.05c
GO:0003676 nucleic acid binding F
ISS
AthAt5g39770
At4g30870
GO:0004519 endonuclease activity F
IDA
SceS000002794
ISS
AthAt5g39770
At4g30870
GO:0005515 protein binding F
IPI
SpoSPCC4G3.05c
GO:0008821 crossover junction endodeoxyribonuclease
activity		 F
IDA
SceS000002794
SpoSPCC4G3.05c
NAS
DmeFBgn0040347
GO:0000076 DNA replication checkpoint P
IMP
SpoSPCC4G3.05c
GO:0000709 meiotic joint molecule formation P
TAS
SpoSPCC4G3.05c
GO:0000711 meiotic DNA repair synthesis P
IMP
SpoSPCC4G3.05c
GO:0000712 resolution of meiotic recombination
intermediates		 P
IGI
SceS000002794
GO:0006265 DNA topological change P
IGI
SceS000002794
GO:0006281 DNA repair P
IGI
SceS000002794
IMP
AthAt4g30870
ISS
AthAt5g39770
At4g30870
GO:0006301 postreplication repair P
TAS
SpoSPCC4G3.05c
GO:0006312 mitotic recombination P
IMP
AthAt4g30870
GO:0006974 response to DNA damage stimulus P
IMP
SceS000002794
GO:0007131 reciprocal meiotic recombination P
IGI
SceS000002794
IMP
SpoSPCC4G3.05c
NAS
DmeFBgn0040347
GO:0019725 cellular homeostasis P
IMP
CelWBGene00016602
GO:0031297 replication fork processing P
TAS
SpoSPCC4G3.05c
GO:0031573 intra-S DNA damage checkpoint P
IDA
SpoSPCC4G3.05c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00016602
GO:0051026 chiasma assembly P
IGI
AthAt4g30870

Back to the top

HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5725

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) MUS81 GI:156151413
Pan troglodytes (Ptr) MUS81 GI:114638610
Canis familiaris (Cfa) MUS81 GI:73983047
Mus musculus (Mmu) Mus81
(MGI:1918961)		 GI:31980667 Q91ZJ0
Rattus norvegicus (Rno) Mus81
(RGD:1311957)		 GI:71043706
Drosophila melanogaster (Dme) mus81
(FBgn0040347)		 GI:18543201
Anopheles gambiae (Aga) AgaP_AGAP008836 GI:158299447
Schizosaccharomyces pombe (Spo) mus81
(SPCC4G3.05c)		 GI:19075333 P87231
Saccharomyces cerevisiae (Sce) MUS81
(S000002794)		 GI:6320594 Q04149
Kluyveromyces lactis (Kla) KLLA0E02948g GI:50308161
Eremothecium gossypii (Ego) AGOS_AFR141C GI:45198659
Magnaporthe grisea (Mgr) MGG_04585 GI:39945206
Neurospora crassa (Ncr) NCU07457.1 GI:32414527


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPCC4G3.05c
IMP
SceS000002794
IPI
SceS000002794
ISO
MmuMGI:1918961
TAS
SpoSPCC4G3.05c
GO:0005739 mitochondrion C
IDA
SpoSPCC4G3.05c
GO:0048476 Holliday junction resolvase complex C
IDA
SceS000002794
SpoSPCC4G3.05c
GO:0004519 endonuclease activity F
IDA
SceS000002794
GO:0005515 protein binding F
IPI
HsaMUS81
SpoSPCC4G3.05c
GO:0008821 crossover junction endodeoxyribonuclease
activity		 F
IDA
SceS000002794
SpoSPCC4G3.05c
NAS
DmeFBgn0040347
GO:0048257 3'-flap endonuclease activity F
IMP
HsaMUS81
GO:0000076 DNA replication checkpoint P
IMP
SpoSPCC4G3.05c
GO:0000709 meiotic joint molecule formation P
TAS
SpoSPCC4G3.05c
GO:0000711 meiotic DNA repair synthesis P
IMP
SpoSPCC4G3.05c
GO:0000712 resolution of meiotic recombination
intermediates		 P
IGI
SceS000002794
GO:0006265 DNA topological change P
IGI
SceS000002794
GO:0006281 DNA repair P
IGI
SceS000002794
IMP
HsaMUS81
ISO
MmuMGI:1918961
GO:0006301 postreplication repair P
TAS
SpoSPCC4G3.05c
GO:0006974 response to DNA damage stimulus P
IMP
SceS000002794
GO:0007131 reciprocal meiotic recombination P
IGI
SceS000002794
IMP
SpoSPCC4G3.05c
NAS
DmeFBgn0040347
GO:0031297 replication fork processing P
TAS
SpoSPCC4G3.05c
GO:0031573 intra-S DNA damage checkpoint P
IDA
SpoSPCC4G3.05c

Back to the top

OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2313

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga10890 ENSANGP00000016665
Ashbya gossypii (Ago) ago3333 AFR141C
Arabidopsis thaliana (Ath) ath21148 At4g30870.1
Arabidopsis thaliana (Ath) ath25746 At5g39770.1
Caenorhabditis elegans (Cel) cel3925 C43E11.2a
(CE08680;
WBGene00016602)
Candida glabrata (Cgl) cgl136 CAGL0A03256g
Cryptococcus neoformans (Cne) cne4941 186.m03851
Dictyostelium discoideum (Ddi) ddi8350 DDB0185879
Dictyostelium discoideum (Ddi) ddi1693 DDB0203879
Debaryomyces hansenii (Dha) dha5959 DEHA0G05852g
Drosophila melanogaster (Dme) dme15985 CG3026-PA
(FBgn0040347)
Danio rerio (Dre) dre21121 ENSDARP00000027223
Encephalitozoon cuniculi (Ecu) ecu137 19074058
Takifugu rubripes (Fru) fru21934 SINFRUP00000158181
Takifugu rubripes (Fru) fru21936 SINFRUP00000175376
Takifugu rubripes (Fru) fru21935 SINFRUP00000176272
Homo sapiens (Hsa) hsa5991 ENSP00000307853
(MUS81)		 Q96NY9
Kluyveromyces lactis (Kla) kla3080 KLLA0E02948g
Mus musculus (Mmu) mmu13145 ENSMUSP00000025841
(MGI:1918961)		 Q91ZJ0
Neurospora crassa (Ncr) ncr7259 NCU07457.2
Oryza sativa (Osa) osa51673 5982.m00148
Plasmodium falciparum (Pfa) pfa1150 PF14_0470
Rattus norvegicus (Rno) rno3509 ENSRNOP00000028015
(RGD:1311957)		 Q4KM32
Saccharomyces cerevisiae (Sce) sce1451 YDR386W
(S000002794)
Schizosaccharomyces pombe (Spo) spo4441 SPCC4G3.05c P87231
Yarrowia lipolytica (Yli) yli2321 YALI0C14960g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000794 condensed nuclear chromosome C
IDA
AthAt4g30870
GO:0005634 nucleus C
IDA
SpoSPCC4G3.05c
IMP
SceS000002794
IPI
SceS000002794
ISO
MmuMGI:1918961
TAS
SpoSPCC4G3.05c
GO:0005739 mitochondrion C
IDA
SpoSPCC4G3.05c
GO:0020011 apicoplast C
RCA
PfaPF14_0470
GO:0048476 Holliday junction resolvase complex C
IDA
SceS000002794
SpoSPCC4G3.05c
GO:0003676 nucleic acid binding F
ISS
AthAt5g39770
At4g30870
GO:0004519 endonuclease activity F
IDA
SceS000002794
ISS
AthAt5g39770
At4g30870
GO:0005515 protein binding F
IPI
SpoSPCC4G3.05c
GO:0008821 crossover junction endodeoxyribonuclease
activity		 F
IDA
SceS000002794
SpoSPCC4G3.05c
NAS
DmeFBgn0040347
GO:0000076 DNA replication checkpoint P
IMP
SpoSPCC4G3.05c
GO:0000709 meiotic joint molecule formation P
TAS
SpoSPCC4G3.05c
GO:0000711 meiotic DNA repair synthesis P
IMP
SpoSPCC4G3.05c
GO:0000712 resolution of meiotic recombination
intermediates		 P
IGI
SceS000002794
GO:0006265 DNA topological change P
IGI
SceS000002794
GO:0006281 DNA repair P
IGI
SceS000002794
IMP
AthAt4g30870
ISO
MmuMGI:1918961
ISS
AthAt5g39770
At4g30870
GO:0006301 postreplication repair P
TAS
SpoSPCC4G3.05c
GO:0006312 mitotic recombination P
IMP
AthAt4g30870
GO:0006974 response to DNA damage stimulus P
IMP
SceS000002794
GO:0007131 reciprocal meiotic recombination P
IGI
SceS000002794
IMP
SpoSPCC4G3.05c
NAS
DmeFBgn0040347
GO:0019725 cellular homeostasis P
IMP
CelWBGene00016602
GO:0031297 replication fork processing P
TAS
SpoSPCC4G3.05c
GO:0031573 intra-S DNA damage checkpoint P
IDA
SpoSPCC4G3.05c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00016602
GO:0051026 chiasma assembly P
IGI
AthAt4g30870

Back to the top

Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC4G3.05c
(P87231)		 YDR386W
(S000002794)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPCC4G3.05c
IMP
SceS000002794
IPI
SceS000002794
TAS
SpoSPCC4G3.05c
GO:0005739 mitochondrion C
IDA
SpoSPCC4G3.05c
GO:0048476 Holliday junction resolvase complex C
IDA
SceS000002794
SpoSPCC4G3.05c
GO:0004519 endonuclease activity F
IDA
SceS000002794
GO:0005515 protein binding F
IPI
SpoSPCC4G3.05c
GO:0008821 crossover junction endodeoxyribonuclease
activity		 F
IDA
SceS000002794
SpoSPCC4G3.05c
GO:0000076 DNA replication checkpoint P
IMP
SpoSPCC4G3.05c
GO:0000709 meiotic joint molecule formation P
TAS
SpoSPCC4G3.05c
GO:0000711 meiotic DNA repair synthesis P
IMP
SpoSPCC4G3.05c
GO:0000712 resolution of meiotic recombination
intermediates		 P
IGI
SceS000002794
GO:0006265 DNA topological change P
IGI
SceS000002794
GO:0006281 DNA repair P
IGI
SceS000002794
GO:0006301 postreplication repair P
TAS
SpoSPCC4G3.05c
GO:0006974 response to DNA damage stimulus P
IMP
SceS000002794
GO:0007131 reciprocal meiotic recombination P
IGI
SceS000002794
IMP
SpoSPCC4G3.05c
GO:0031297 replication fork processing P
TAS
SpoSPCC4G3.05c
GO:0031573 intra-S DNA damage checkpoint P
IDA
SpoSPCC4G3.05c

Back to the top
YOGY Home YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk