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Search term: YDR390C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name UBA2
SGD link S000002798
Alternative ID YDR390C
Description Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
Synonyms YDR390C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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Search for GO info:  

GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2013 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING SMT3/SUMO-activating complex, catalytic component UBA2

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g21470 GI:15226562
Caenorhabditis elegans (Cel) CE25130 GI:17509465
Caenorhabditis elegans (Cel) CE25131 GI:17509467
Drosophila melanogaster (Dme) 7295159_1 GI:7295159
Homo sapiens (Hsa) Hs22043534 GI:22043534
Homo sapiens (Hsa) Hs4885649
(UBA2)
GI:4885649 Q9UBT2
Saccharomyces cerevisiae (Sce) YDR390c
(S000002798)
GI:6320598 P52488
Schizosaccharomyces pombe (Spo) SPBC16H5.03c GI:19112737 O42939
Encephalitozoon cuniculi (Ecu) ECU02g1340 GI:19074053 Q8SW98


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002798
SpoSPBC16H5.03c
ISS
SpoSPBC16H5.03c
GO:0005829 cytosol C
IDA
AthAt2g21470
GO:0031510 SUMO activating enzyme complex C
IPI
SceS000002798
TAS
SpoSPBC16H5.03c
GO:0005515 protein binding F
IPI
HsaUBA2
GO:0008047 enzyme activator activity F
TAS
HsaUBA2
GO:0019948 SUMO activating enzyme activity F
IDA
AthAt2g21470
HsaUBA2
SceS000002798
IMP
SceS000002798
IPI
SceS000002798
ISS
AthAt2g21470
SpoSPBC16H5.03c
GO:0046982 protein heterodimerization activity F
IPI
HsaUBA2
GO:0009793 embryo development ending in seed
dormancy
P
IMP
AthAt2g21470
GO:0016925 protein sumoylation P
IDA
AthAt2g21470
HsaUBA2
SceS000002798
IGI
SpoSPBC16H5.03c
IMP
SceS000002798
ISS
AthAt2g21470

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4018

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) UBA2 GI:4885649 Q9UBT2
Pan troglodytes (Ptr) UBA2 GI:114676625
Canis familiaris (Cfa) UBA2 GI:73947972
Mus musculus (Mmu) Uba2
(MGI:1858313)
GI:7709986 Q9Z1F9
Rattus norvegicus (Rno) Uba2 GI:109458570
Gallus gallus (Gga) SAE2 GI:71895547
Drosophila melanogaster (Dme) Uba2
(FBgn0029113)
GI:24660640
Anopheles gambiae (Aga) AgaP_AGAP008637 GI:158293387
Caenorhabditis elegans (Cel) uba-2
(CE40719;
WBGene00006700)
GI:193203301
Schizosaccharomyces pombe (Spo) fub2
(SPBC16H5.03c)
GI:19112737 O42939
Saccharomyces cerevisiae (Sce) UBA2
(S000002798)
GI:6320598 P52488
Kluyveromyces lactis (Kla) KLLA0E03036g GI:50308169
Eremothecium gossypii (Ego) AGOS_AFR138W GI:45198656
Magnaporthe grisea (Mgr) MGG_06733 GI:39977697
Neurospora crassa (Ncr) NCU03526.1 GI:32404342
Arabidopsis thaliana (Ath) SAE2 GI:30681414
Oryza sativa (Osa) Os07g0586500 GI:115473063
Plasmodium falciparum (Pfa) PFL1790w GI:124806587


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
PfaPFL1790w
GO:0005634 nucleus C
IDA
DmeFBgn0029113
SceS000002798
SpoSPBC16H5.03c
ISS
SpoSPBC16H5.03c
GO:0005737 cytoplasm C
IDA
DmeFBgn0029113
GO:0005829 cytosol C
IDA
AthSAE2
GO:0031510 SUMO activating enzyme complex C
IPI
SceS000002798
ISS
DmeFBgn0029113
TAS
SpoSPBC16H5.03c
GO:0004839 ubiquitin activating enzyme activity F
NAS
DmeFBgn0029113
GO:0005515 protein binding F
IPI
DmeFBgn0029113
HsaUBA2
GO:0008047 enzyme activator activity F
TAS
HsaUBA2
GO:0008134 transcription factor binding F
IPI
MmuMGI:1858313
GO:0008641 small protein activating enzyme
activity
F
IPI
DmeFBgn0029113
ISS
DmeFBgn0029113
NAS
DmeFBgn0029113
GO:0019948 SUMO activating enzyme activity F
IDA
AthSAE2
CelWBGene00006700
HsaUBA2
SceS000002798
IMP
SceS000002798
IPI
SceS000002798
ISS
AthSAE2
DmeFBgn0029113
SpoSPBC16H5.03c
NAS
DmeFBgn0029113
GO:0046982 protein heterodimerization activity F
IPI
HsaUBA2
GO:0000003 reproduction P
IMP
CelWBGene00006700
GO:0002119 nematode larval development P
IGI
CelWBGene00006700
IMP
CelWBGene00006700
GO:0009792 embryo development ending in birth or egg
hatching
P
IGI
CelWBGene00006700
IMP
CelWBGene00006700
GO:0009793 embryo development ending in seed
dormancy
P
IMP
AthSAE2
GO:0009952 anterior/posterior pattern formation P
IGI
CelWBGene00006700
GO:0016925 protein sumoylation P
IDA
AthSAE2
CelWBGene00006700
HsaUBA2
SceS000002798
IGI
SpoSPBC16H5.03c
IMP
SceS000002798
ISS
AthSAE2
DmeFBgn0029113
GO:0018991 oviposition P
IMP
CelWBGene00006700
GO:0019950 SMT3-dependent protein catabolic
process
P
NAS
DmeFBgn0029113
GO:0040007 growth P
IMP
CelWBGene00006700
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00006700
GO:0040011 locomotion P
IMP
CelWBGene00006700
GO:0040026 positive regulation of vulval development P
IMP
CelWBGene00006700
GO:0040027 negative regulation of vulval development P
IMP
CelWBGene00006700
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00006700
GO:0040039 inductive cell migration P
IMP
CelWBGene00006700
GO:0051092 positive regulation of NF-kappaB transcription
factor activity
P
IDA
DmeFBgn0029113

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1967

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga10657 ENSANGP00000013083
Ashbya gossypii (Ago) ago3330 AFR138W
Arabidopsis thaliana (Ath) ath9041 At2g21470.1
Arabidopsis thaliana (Ath) ath9042 At2g21470.2
Caenorhabditis elegans (Cel) cel16771 W02A11.4
(CE40719;
WBGene00006700)
Candida glabrata (Cgl) cgl4724 CAGL0M01606g
Cryptococcus neoformans (Cne) cne1329 180.m00276
Dictyostelium discoideum (Ddi) ddi8661 DDB0187190
Debaryomyces hansenii (Dha) dha6419 DEHA0G16148g
Drosophila melanogaster (Dme) dme8492 CG7528-PA
(FBgn0029113)
Danio rerio (Dre) dre16777 ENSDARP00000030093
Danio rerio (Dre) dre16776 ENSDARP00000040920
Encephalitozoon cuniculi (Ecu) ecu132 19074053
Takifugu rubripes (Fru) fru3227 SINFRUP00000159164
Takifugu rubripes (Fru) fru21822 SINFRUP00000162370
Gallus gallus (Gga) gga4698 ENSGALP00000008002
(SAE2)
Gallus gallus (Gga) gga4699 ENSGALP00000008003
(SAE2)
Q5ZKH7
Homo sapiens (Hsa) hsa16143 ENSP00000246548
(UBA2)
Q9UBT2
Kluyveromyces lactis (Kla) kla3084 KLLA0E03036g
Mus musculus (Mmu) mmu23691 ENSMUSP00000068072
(MGI:1858313)
A2BH29
Neurospora crassa (Ncr) ncr3417 NCU03526.2
Oryza sativa (Osa) osa53383 6130.m00072
Plasmodium falciparum (Pfa) pfa5141 PFL1790w
Rattus norvegicus (Rno) rno1581 ENSRNOP00000028672
(RGD:1312023)
B1WC32
Saccharomyces cerevisiae (Sce) sce1455 YDR390C
(S000002798)
Schizosaccharomyces pombe (Spo) spo1547 SPBC16H5.03c O42939
Yarrowia lipolytica (Yli) yli2961 YALI0D06259g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
PfaPFL1790w
GO:0005634 nucleus C
IDA
DmeFBgn0029113
SceS000002798
SpoSPBC16H5.03c
ISS
SpoSPBC16H5.03c
GO:0005737 cytoplasm C
IDA
DmeFBgn0029113
GO:0005829 cytosol C
IDA
AthAt2g21470
GO:0031510 SUMO activating enzyme complex C
IPI
SceS000002798
ISS
DmeFBgn0029113
TAS
SpoSPBC16H5.03c
GO:0004839 ubiquitin activating enzyme activity F
NAS
DmeFBgn0029113
GO:0005515 protein binding F
IPI
DmeFBgn0029113
GO:0008134 transcription factor binding F
IPI
MmuMGI:1858313
GO:0008641 small protein activating enzyme
activity
F
IPI
DmeFBgn0029113
ISS
DmeFBgn0029113
NAS
DmeFBgn0029113
GO:0019948 SUMO activating enzyme activity F
IDA
AthAt2g21470
CelWBGene00006700
SceS000002798
IMP
SceS000002798
IPI
SceS000002798
ISS
AthAt2g21470
DmeFBgn0029113
SpoSPBC16H5.03c
NAS
DmeFBgn0029113
GO:0000003 reproduction P
IMP
CelWBGene00006700
GO:0002119 nematode larval development P
IGI
CelWBGene00006700
IMP
CelWBGene00006700
GO:0009792 embryo development ending in birth or egg
hatching
P
IGI
CelWBGene00006700
IMP
CelWBGene00006700
GO:0009793 embryo development ending in seed
dormancy
P
IMP
AthAt2g21470
GO:0009952 anterior/posterior pattern formation P
IGI
CelWBGene00006700
GO:0016925 protein sumoylation P
IDA
AthAt2g21470
CelWBGene00006700
SceS000002798
IGI
SpoSPBC16H5.03c
IMP
SceS000002798
ISS
AthAt2g21470
DmeFBgn0029113
GO:0018991 oviposition P
IMP
CelWBGene00006700
GO:0019950 SMT3-dependent protein catabolic
process
P
NAS
DmeFBgn0029113
GO:0040007 growth P
IMP
CelWBGene00006700
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00006700
GO:0040011 locomotion P
IMP
CelWBGene00006700
GO:0040026 positive regulation of vulval development P
IMP
CelWBGene00006700
GO:0040027 negative regulation of vulval development P
IMP
CelWBGene00006700
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00006700
GO:0040039 inductive cell migration P
IMP
CelWBGene00006700
GO:0051092 positive regulation of NF-kappaB transcription
factor activity
P
IDA
DmeFBgn0029113

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPBC16H5.03c
(O42939)
YDR390C
(S000002798)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002798
SpoSPBC16H5.03c
ISS
SpoSPBC16H5.03c
GO:0031510 SUMO activating enzyme complex C
IPI
SceS000002798
TAS
SpoSPBC16H5.03c
GO:0019948 SUMO activating enzyme activity F
IDA
SceS000002798
IMP
SceS000002798
IPI
SceS000002798
ISS
SpoSPBC16H5.03c
GO:0016925 protein sumoylation P
IDA
SceS000002798
IGI
SpoSPBC16H5.03c
IMP
SceS000002798

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Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk