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Search term: YDR410C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name STE14
SGD link S000002818
Alternative ID YDR410C
Description Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane
Synonyms YDR410C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2628 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Farnesyl cysteine-carboxyl methyltransferase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g08340 GI:10178276
Arabidopsis thaliana (Ath) At5g23320 GI:15237283
Arabidopsis thaliana (Ath) At5g59500 GI:15238431
Caenorhabditis elegans (Cel) CE09533
(WBGene00017673)		 GI:17506725 P91266
Caenorhabditis elegans (Cel) CE12288
(WBGene00019710)		 GI:17508325 P91402
Drosophila melanogaster (Dme) 7294512 GI:7294512
Homo sapiens (Hsa) Hs6912430
(ICMT)		 GI:6912430 Q9NRT1
Saccharomyces cerevisiae (Sce) YDR410c
(S000002818)		 GI:6320618 P32584
Schizosaccharomyces pombe (Spo) SPAC10F6.12c GI:19114175 P87014
Encephalitozoon cuniculi (Ecu) ECU01g1350 GI:19075148


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g59500
At5g08340
GO:0005637 nuclear inner membrane C
IMP
SceS000002818
GO:0005783 endoplasmic reticulum C
IDA
AthAt5g23320
HsaICMT
SpoSPAC10F6.12c
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000002818
ISS
SpoSPAC10F6.12c
GO:0003674 molecular_function F
ND
AthAt5g59500
GO:0003880 protein C-terminal carboxyl O-methyltransferase
activity		 F
TAS
HsaICMT
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl
O-methyltransferase activity		 F
IDA
AthAt5g23320
SceS000002818
IGI
AthAt5g23320
IMP
SceS000002818
SpoSPAC10F6.12c
ISS
AthAt5g23320
GO:0010340 carboxyl-O-methyltransferase activity F
IMP
AthAt5g23320
GO:0000749 response to pheromone involved in conjugation with
cellular fusion		 P
IC
SpoSPAC10F6.12c
GO:0006464 protein modification process P
TAS
HsaICMT
GO:0006481 C-terminal protein amino acid methylation P
IDA
AthAt5g23320
IMP
AthAt5g23320
SceS000002818
ISS
AthAt5g23320
TAS
HsaICMT
GO:0006612 protein targeting to membrane P
TAS
HsaICMT
GO:0007323 peptide pheromone maturation P
IMP
SceS000002818
GO:0008150 biological_process P
ND
AthAt5g59500
GO:0009788 negative regulation of abscisic acid mediated
signaling pathway		 P
NAS
AthAt5g23320
GO:0009908 flower development P
IMP
AthAt5g23320
GO:0034613 cellular protein localization P
IGI
SpoSPAC10F6.12c
GO:0048367 shoot development P
IMP
AthAt5g23320
GO:0071432 peptide mating pheromone maturation involved in
conjugation with cellular fusion		 P
IGI
SpoSPAC10F6.12c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5735

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ICMT GI:6912430 Q9NRT1
Pan troglodytes (Ptr) ICMT GI:114551869
Canis familiaris (Cfa) ICMT GI:57087005
Mus musculus (Mmu) Icmt
(MGI:1888594)		 GI:51317397 Q3U4N2
Rattus norvegicus (Rno) Icmt
(RGD:621618)		 GI:54020672
Gallus gallus (Gga) ICMT GI:57529416
Drosophila melanogaster (Dme) CG11268
(FBgn0036336)		 GI:21356091
Anopheles gambiae (Aga) AgaP_AGAP001310 GI:158302247
Caenorhabditis elegans (Cel) F21F3.3
(CE09533;
WBGene00017673)		 GI:17506725 P91266
Caenorhabditis elegans (Cel) M01E11.1
(CE12288;
WBGene00019710)		 GI:17508325 P91402
Schizosaccharomyces pombe (Spo) mam4
(SPAC10F6.12c)		 GI:19114175 P87014
Saccharomyces cerevisiae (Sce) STE14
(S000002818)		 GI:6320618 P32584
Kluyveromyces lactis (Kla) KLLA0A02167g GI:50302323
Eremothecium gossypii (Ego) AGOS_AAR122C GI:45184946
Magnaporthe grisea (Mgr) MGG_05331 GI:145601915
Neurospora crassa (Ncr) NCU00034.1 GI:32403014
Arabidopsis thaliana (Ath) ATSTE14B GI:18415785
Arabidopsis thaliana (Ath) ATSTE14A GI:15237283
Oryza sativa (Osa) Os04g0602900 GI:115460354


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
ISO
MmuMGI:1888594
GO:0005637 nuclear inner membrane C
IMP
SceS000002818
GO:0005783 endoplasmic reticulum C
IDA
AthATSTE14B
ATSTE14A
HsaICMT
SpoSPAC10F6.12c
ISO
MmuMGI:1888594
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000002818
ISS
SpoSPAC10F6.12c
GO:0003880 protein C-terminal carboxyl O-methyltransferase
activity		 F
TAS
HsaICMT
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl
O-methyltransferase activity		 F
IDA
AthATSTE14A
ATSTE14B
SceS000002818
IGI
AthATSTE14A
ATSTE14B
IMP
MmuMGI:1888594
SceS000002818
SpoSPAC10F6.12c
ISO
MmuMGI:1888594
ISS
AthATSTE14A
ATSTE14B
DmeFBgn0036336
GO:0008140 cAMP response element binding protein
binding		 F
IMP
MmuMGI:1888594
GO:0010340 carboxyl-O-methyltransferase activity F
IMP
AthATSTE14A
GO:0000749 response to pheromone involved in conjugation with
cellular fusion		 P
IC
SpoSPAC10F6.12c
GO:0001701 in utero embryonic development P
IMP
MmuMGI:1888594
GO:0001889 liver development P
IMP
MmuMGI:1888594
GO:0006464 protein modification process P
TAS
HsaICMT
GO:0006479 protein amino acid methylation P
IMP
MmuMGI:1888594
GO:0006481 C-terminal protein amino acid methylation P
IDA
AthATSTE14A
IMP
AthATSTE14A
MmuMGI:1888594
SceS000002818
ISO
MmuMGI:1888594
ISS
AthATSTE14A
ATSTE14B
TAS
HsaICMT
GO:0006612 protein targeting to membrane P
TAS
HsaICMT
GO:0007323 peptide pheromone maturation P
IMP
SceS000002818
GO:0008104 protein localization P
IMP
MmuMGI:1888594
GO:0008284 positive regulation of cell proliferation P
IMP
MmuMGI:1888594
GO:0009788 negative regulation of abscisic acid mediated
signaling pathway		 P
NAS
AthATSTE14A
ATSTE14B
GO:0009908 flower development P
IMP
AthATSTE14A
ATSTE14B
GO:0034613 cellular protein localization P
IGI
SpoSPAC10F6.12c
GO:0035264 multicellular organism growth P
IMP
MmuMGI:1888594
GO:0045941 positive regulation of transcription P
IMP
MmuMGI:1888594
GO:0046498 S-adenosylhomocysteine metabolic
process		 P
ISO
MmuMGI:1888594
GO:0046499 S-adenosylmethioninamine metabolic
process		 P
ISO
MmuMGI:1888594
GO:0046578 regulation of Ras protein signal
transduction		 P
IGI
MmuMGI:1888594
GO:0048367 shoot development P
IMP
AthATSTE14A
ATSTE14B
GO:0071432 peptide mating pheromone maturation involved in
conjugation with cellular fusion		 P
IGI
SpoSPAC10F6.12c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1830

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3385 ENSANGP00000009786
Ashbya gossypii (Ago) ago309 AAR122C
Arabidopsis thaliana (Ath) ath23051 At5g08335.1
Arabidopsis thaliana (Ath) ath24577 At5g23320.1
Caenorhabditis elegans (Cel) cel6931 F21F3.3
(CE09533;
WBGene00017673)
Caenorhabditis elegans (Cel) cel12766 M01E11.1
(CE12288;
WBGene00019710)
Candida glabrata (Cgl) cgl1350 CAGL0F02805g
Cryptococcus neoformans (Cne) cne5251 179.m00100
Dictyostelium discoideum (Ddi) ddi11802 DDB0185114
Dictyostelium discoideum (Ddi) ddi3758 DDB0217410
Debaryomyces hansenii (Dha) dha5967 DEHA0G06017g
Debaryomyces hansenii (Dha) dha5968 DEHA0G06028g
Drosophila melanogaster (Dme) dme9327 CG11268-PA
(FBgn0036336)
Danio rerio (Dre) dre15428 ENSDARP00000022692
Takifugu rubripes (Fru) fru8332 SINFRUP00000128295
Gallus gallus (Gga) gga12319 ENSGALP00000000932
(ICMT)		 Q5ZMU7
Homo sapiens (Hsa) hsa155 ENSP00000313340
Homo sapiens (Hsa) hsa157 ENSP00000343552
(ICMT)		 O60725
Homo sapiens (Hsa) hsa156 ENSP00000354894
(ICMT)		 Q7Z750
Kluyveromyces lactis (Kla) kla93 KLLA0A02167g
Mus musculus (Mmu) mmu19510 ENSMUSP00000043390
(MGI:1888594)		 Q9EQK7
Neurospora crassa (Ncr) ncr33 NCU00034.2
Oryza sativa (Osa) osa43992 5499.m00170
Plasmodium falciparum (Pfa) pfa5139 PFL1780w
Rattus norvegicus (Rno) rno24504 ENSRNOP00000014625
(RGD:621618)		 Q9WVM4
Saccharomyces cerevisiae (Sce) sce1476 YDR410C
(S000002818)
Schizosaccharomyces pombe (Spo) spo2522 SPAC10F6.12c P87014
Yarrowia lipolytica (Yli) yli4807 YALI0E22913g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
ISO
MmuMGI:1888594
GO:0005637 nuclear inner membrane C
IMP
SceS000002818
GO:0005783 endoplasmic reticulum C
IDA
AthAt5g23320
At5g08335
SpoSPAC10F6.12c
ISO
MmuMGI:1888594
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000002818
ISS
SpoSPAC10F6.12c
GO:0020011 apicoplast C
RCA
PfaPFL1780w
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl
O-methyltransferase activity		 F
IDA
AthAt5g23320
At5g08335
SceS000002818
IGI
AthAt5g23320
At5g08335
IMP
MmuMGI:1888594
SceS000002818
SpoSPAC10F6.12c
ISO
MmuMGI:1888594
ISS
AthAt5g23320
At5g08335
DmeFBgn0036336
GO:0008140 cAMP response element binding protein
binding		 F
IMP
MmuMGI:1888594
GO:0010340 carboxyl-O-methyltransferase activity F
IMP
AthAt5g23320
GO:0000749 response to pheromone involved in conjugation with
cellular fusion		 P
IC
SpoSPAC10F6.12c
GO:0001701 in utero embryonic development P
IMP
MmuMGI:1888594
GO:0001889 liver development P
IMP
MmuMGI:1888594
GO:0006479 protein amino acid methylation P
IMP
MmuMGI:1888594
GO:0006481 C-terminal protein amino acid methylation P
IDA
AthAt5g23320
IMP
AthAt5g23320
MmuMGI:1888594
SceS000002818
ISO
MmuMGI:1888594
ISS
AthAt5g23320
At5g08335
GO:0007323 peptide pheromone maturation P
IMP
SceS000002818
GO:0008104 protein localization P
IMP
MmuMGI:1888594
GO:0008284 positive regulation of cell proliferation P
IMP
MmuMGI:1888594
GO:0009788 negative regulation of abscisic acid mediated
signaling pathway		 P
NAS
AthAt5g23320
At5g08335
GO:0009908 flower development P
IMP
AthAt5g23320
At5g08335
GO:0016458 gene silencing P
ISS
PfaPFL1780w
GO:0034613 cellular protein localization P
IGI
SpoSPAC10F6.12c
GO:0035264 multicellular organism growth P
IMP
MmuMGI:1888594
GO:0045941 positive regulation of transcription P
IMP
MmuMGI:1888594
GO:0046498 S-adenosylhomocysteine metabolic
process		 P
ISO
MmuMGI:1888594
GO:0046499 S-adenosylmethioninamine metabolic
process		 P
ISO
MmuMGI:1888594
GO:0046578 regulation of Ras protein signal
transduction		 P
IGI
MmuMGI:1888594
GO:0048367 shoot development P
IMP
AthAt5g23320
At5g08335
GO:0071432 peptide mating pheromone maturation involved in
conjugation with cellular fusion		 P
IGI
SpoSPAC10F6.12c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC10F6.12c
(P87014)		 YDR410C
(S000002818)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005637 nuclear inner membrane C
IMP
SceS000002818
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC10F6.12c
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000002818
ISS
SpoSPAC10F6.12c
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl
O-methyltransferase activity		 F
IDA
SceS000002818
IMP
SceS000002818
SpoSPAC10F6.12c
GO:0000749 response to pheromone involved in conjugation with
cellular fusion		 P
IC
SpoSPAC10F6.12c
GO:0006481 C-terminal protein amino acid methylation P
IMP
SceS000002818
GO:0007323 peptide pheromone maturation P
IMP
SceS000002818
GO:0034613 cellular protein localization P
IGI
SpoSPAC10F6.12c
GO:0071432 peptide mating pheromone maturation involved in
conjugation with cellular fusion		 P
IGI
SpoSPAC10F6.12c

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