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Search term: YDR432W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name NPL3
SGD link S000002840
Alternative ID YDR432W
Description RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
Synonyms YDR432W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0106 ACDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g46610 GI:15226019
Arabidopsis thaliana (Ath) At3g61860 GI:11346383
Arabidopsis thaliana (Ath) At4g25500 GI:15235112
Arabidopsis thaliana (Ath) At5g52040 GI:15242264
Caenorhabditis elegans (Cel) CE00998_1 GI:17534019 Q20402
Caenorhabditis elegans (Cel) CE02067 GI:17536571
Caenorhabditis elegans (Cel) CE03762
(WBGene00004699)		 GI:17535713 Q23120
Caenorhabditis elegans (Cel) CE03763
(WBGene00004698)		 GI:17535711 Q23121
Caenorhabditis elegans (Cel) CE07952A GI:17505496 O01475
Caenorhabditis elegans (Cel) CE07952B GI:17505496 O01475
Caenorhabditis elegans (Cel) CE16984_2 GI:17533199
Caenorhabditis elegans (Cel) CE16985 GI:17533201
Caenorhabditis elegans (Cel) CE22180
(WBGene00021663)		 GI:17510109 Q9N3P9
Caenorhabditis elegans (Cel) CE28093 GI:17536567
Caenorhabditis elegans (Cel) CE28094 GI:17536573 Q10021
Caenorhabditis elegans (Cel) CE28352 GI:17536569
Drosophila melanogaster (Dme) 7299789 GI:7299789 A4V2U2
Drosophila melanogaster (Dme) 7299790 GI:7299790
Homo sapiens (Hsa) Hs20127499
(SFRS6)		 GI:20127499 Q13247
Homo sapiens (Hsa) Hs21361282 GI:16160456
Homo sapiens (Hsa) Hs5902078 GI:5902078
Homo sapiens (Hsa) HsM5032089 GI:5032089
Saccharomyces cerevisiae (Sce) YDR432w
(S000002840)		 GI:6320640 Q01560
Schizosaccharomyces pombe (Spo) SPAC16.02c GI:19115482 P78814
Arabidopsis thaliana (Ath) At2g46610 GI:15226019
Arabidopsis thaliana (Ath) At3g61860 GI:11346383
Arabidopsis thaliana (Ath) At4g25500 GI:15235112
Arabidopsis thaliana (Ath) At5g52040 GI:15242264
Caenorhabditis elegans (Cel) CE00998_1 GI:17534019 Q20402
Caenorhabditis elegans (Cel) CE02067 GI:17536571
Caenorhabditis elegans (Cel) CE03762
(WBGene00004699)		 GI:17535713 Q23120
Caenorhabditis elegans (Cel) CE03763
(WBGene00004698)		 GI:17535711 Q23121
Caenorhabditis elegans (Cel) CE07952A GI:17505496 O01475
Caenorhabditis elegans (Cel) CE07952B GI:17505496 O01475
Caenorhabditis elegans (Cel) CE16984_2 GI:17533199
Caenorhabditis elegans (Cel) CE16985 GI:17533201
Caenorhabditis elegans (Cel) CE22180
(WBGene00021663)		 GI:17510109 Q9N3P9
Caenorhabditis elegans (Cel) CE28093 GI:17536567
Caenorhabditis elegans (Cel) CE28094 GI:17536573 Q10021
Caenorhabditis elegans (Cel) CE28352 GI:17536569
Drosophila melanogaster (Dme) 7299789 GI:7299789 A4V2U2
Drosophila melanogaster (Dme) 7299790 GI:7299790
Homo sapiens (Hsa) Hs20127499
(SFRS6)		 GI:20127499 Q13247
Homo sapiens (Hsa) Hs21361282 GI:16160456
Homo sapiens (Hsa) Hs5902078 GI:5902078
Homo sapiens (Hsa) HsM5032089 GI:5032089
Saccharomyces cerevisiae (Sce) YDR432w
(S000002840)		 GI:6320640 Q01560
Schizosaccharomyces pombe (Spo) SPAC16.02c GI:19115482 P78814
Arabidopsis thaliana (Ath) At2g46610 GI:15226019
Arabidopsis thaliana (Ath) At3g61860 GI:11346383
Arabidopsis thaliana (Ath) At4g25500 GI:15235112
Arabidopsis thaliana (Ath) At5g52040 GI:15242264
Caenorhabditis elegans (Cel) CE00998_1 GI:17534019 Q20402
Caenorhabditis elegans (Cel) CE02067 GI:17536571
Caenorhabditis elegans (Cel) CE03762
(WBGene00004699)		 GI:17535713 Q23120
Caenorhabditis elegans (Cel) CE03763
(WBGene00004698)		 GI:17535711 Q23121
Caenorhabditis elegans (Cel) CE07952A GI:17505496 O01475
Caenorhabditis elegans (Cel) CE07952B GI:17505496 O01475
Caenorhabditis elegans (Cel) CE16984_2 GI:17533199
Caenorhabditis elegans (Cel) CE16985 GI:17533201
Caenorhabditis elegans (Cel) CE22180
(WBGene00021663)		 GI:17510109 Q9N3P9
Caenorhabditis elegans (Cel) CE28093 GI:17536567
Caenorhabditis elegans (Cel) CE28094 GI:17536573 Q10021
Caenorhabditis elegans (Cel) CE28352 GI:17536569
Drosophila melanogaster (Dme) 7299789 GI:7299789 A4V2U2
Drosophila melanogaster (Dme) 7299790 GI:7299790
Homo sapiens (Hsa) Hs20127499
(SFRS6)		 GI:20127499 Q13247
Homo sapiens (Hsa) Hs21361282 GI:16160456
Homo sapiens (Hsa) Hs5902078 GI:5902078
Homo sapiens (Hsa) HsM5032089 GI:5032089
Saccharomyces cerevisiae (Sce) YDR432w
(S000002840)		 GI:6320640 Q01560
Schizosaccharomyces pombe (Spo) SPAC16.02c GI:19115482 P78814


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt2g46610
GO:0005634 nucleus C
IDA
CelWBGene00004699
WBGene00004698
SceS000002840
SpoSPAC16.02c
IMP
SceS000002840
GO:0005681 spliceosomal complex C
ISS
AthAt5g52040
At4g25500
TAS
AthAt3g61860
GO:0005737 cytoplasm C
IMP
SceS000002840
GO:0005938 cell cortex C
IDA
CelWBGene00009701
GO:0016607 nuclear speck C
IDA
AthAt4g25500
At3g61860
GO:0003723 RNA binding F
ISS
AthAt4g25500
At3g61860
At2g46610
At5g52040
SpoSPAC16.02c
GO:0003729 mRNA binding F
IDA
SceS000002840
ISS
SpoSPAC16.02c
GO:0005515 protein binding F
IPI
HsaSFRS6
GO:0008143 poly(A) RNA binding F
IDA
SceS000002840
ISS
SpoSPAC16.02c
GO:0016944 RNA polymerase II transcription elongation factor
activity		 F
IDA
SceS000002840
IMP
SceS000002840
GO:0046982 protein heterodimerization activity F
IPI
SpoSPAC16.02c
GO:0000003 reproduction P
IMP
CelWBGene00004698
WBGene00009701
GO:0000398 nuclear mRNA splicing, via spliceosome P
IDA
AthAt3g61860
IGI
SceS000002840
IMP
SceS000002840
ISS
AthAt4g25500
At5g52040
GO:0001703 gastrulation with mouth forming
first		 P
IMP
CelWBGene00004698
WBGene00004699
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00004699
GO:0002119 nematode larval development P
IMP
CelWBGene00004698
WBGene00004699
GO:0006376 mRNA splice site selection P
TAS
HsaSFRS6
GO:0006406 mRNA export from nucleus P
IGI
SceS000002840
ISS
SpoSPAC16.02c
GO:0006414 translational elongation P
RCA
SceS000002840
GO:0006415 translational termination P
IGI
SceS000002840
IMP
SceS000002840
GO:0007124 pseudohyphal growth P
IMP
SceS000002840
GO:0007283 spermatogenesis P
IMP
CelWBGene00004699
WBGene00004698
GO:0007369 gastrulation P
IMP
CelWBGene00004698
WBGene00004699
GO:0008150 biological_process P
ND
AthAt2g46610
GO:0008380 RNA splicing P
EXP
HsaSFRS6
NAS
AthAt4g25500
At5g52040
At3g61860
GO:0008406 gonad development P
IMP
CelWBGene00004698
GO:0009790 embryo development P
IMP
CelWBGene00004699
WBGene00004698
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004699
WBGene00004698
WBGene00009701
GO:0010171 body morphogenesis P
IMP
CelWBGene00004699
GO:0031554 regulation of transcription termination P
IMP
SceS000002840
GO:0032786 positive regulation of RNA elongation P
IDA
SceS000002840
IMP
SceS000002840
GO:0040007 growth P
IMP
CelWBGene00004699
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004699
WBGene00004698
GO:0040011 locomotion P
IMP
CelWBGene00004698
GO:0040026 positive regulation of vulval development P
IMP
CelWBGene00004698
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00004699
GO:0048477 oogenesis P
IMP
CelWBGene00009701

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
113627

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) srp2
(SPAC16.02c)		 GI:19115482 P78814
Saccharomyces cerevisiae (Sce) NPL3
(S000002840)		 GI:6320640 Q01560
Kluyveromyces lactis (Kla) KLLA0B00979g GI:50303265
Eremothecium gossypii (Ego) AGOS_ADR183C GI:45188056
Magnaporthe grisea (Mgr) MGG_11457 GI:145610673
Neurospora crassa (Ncr) NCU07069.1 GI:32413751


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002840
SpoSPAC16.02c
IMP
SceS000002840
GO:0005737 cytoplasm C
IMP
SceS000002840
GO:0003723 RNA binding F
ISS
SpoSPAC16.02c
GO:0003729 mRNA binding F
IDA
SceS000002840
ISS
SpoSPAC16.02c
GO:0008143 poly(A) RNA binding F
IDA
SceS000002840
ISS
SpoSPAC16.02c
GO:0016944 RNA polymerase II transcription elongation factor
activity		 F
IDA
SceS000002840
IMP
SceS000002840
GO:0046982 protein heterodimerization activity F
IPI
SpoSPAC16.02c
GO:0000398 nuclear mRNA splicing, via spliceosome P
IGI
SceS000002840
IMP
SceS000002840
GO:0006406 mRNA export from nucleus P
IGI
SceS000002840
ISS
SpoSPAC16.02c
GO:0006414 translational elongation P
RCA
SceS000002840
GO:0006415 translational termination P
IGI
SceS000002840
IMP
SceS000002840
GO:0007124 pseudohyphal growth P
IMP
SceS000002840
GO:0031554 regulation of transcription termination P
IMP
SceS000002840
GO:0032786 positive regulation of RNA elongation P
IDA
SceS000002840
IMP
SceS000002840

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3990

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3755 ENSANGP00000022179
Ashbya gossypii (Ago) ago1924 ADR183C
Arabidopsis thaliana (Ath) ath27898 At5g58470.1
Arabidopsis thaliana (Ath) ath27899 At5g58470.2
Candida glabrata (Cgl) cgl2269 CAGL0H04763g
Dictyostelium discoideum (Ddi) ddi4973 DDB0218473
Danio rerio (Dre) dre17529 ENSDARP00000039975
Danio rerio (Dre) dre17527 ENSDARP00000041703
Takifugu rubripes (Fru) fru22605 SINFRUP00000132101
Takifugu rubripes (Fru) fru22606 SINFRUP00000167920
Takifugu rubripes (Fru) fru22607 SINFRUP00000175416
Gallus gallus (Gga) gga8776 ENSGALP00000003198
Gallus gallus (Gga) gga8777 ENSGALP00000003199
(TAF15)
Homo sapiens (Hsa) hsa13479 ENSP00000309558
(TAF15)		 Q92804-1
Kluyveromyces lactis (Kla) kla572 KLLA0B00979g
Mus musculus (Mmu) mmu4431 ENSMUSP00000021018
(MGI:1917689)		 Q3TLE4
Oryza sativa (Osa) osa12435 2841.m00155
Oryza sativa (Osa) osa39516 4992.m00114
Oryza sativa (Osa) osa39525 4992.m00119
Oryza sativa (Osa) osa39526 4992.m00120
Rattus norvegicus (Rno) rno5749 ENSRNOP00000014438
(RGD:1309595)
Saccharomyces cerevisiae (Sce) sce1498 YDR432W
(S000002840)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1917689
GO:0005634 nucleus C
IDA
SceS000002840
IMP
SceS000002840
GO:0005737 cytoplasm C
IMP
SceS000002840
GO:0009507 chloroplast C
IDA
AthAt5g58470
GO:0003674 molecular_function F
ND
MmuMGI:1917689
GO:0003729 mRNA binding F
IDA
SceS000002840
GO:0005488 binding F
ISS
AthAt5g58470
GO:0008143 poly(A) RNA binding F
IDA
SceS000002840
GO:0016944 RNA polymerase II transcription elongation factor
activity		 F
IDA
SceS000002840
IMP
SceS000002840
GO:0000398 nuclear mRNA splicing, via spliceosome P
IGI
SceS000002840
IMP
SceS000002840
GO:0006406 mRNA export from nucleus P
IGI
SceS000002840
GO:0006414 translational elongation P
RCA
SceS000002840
GO:0006415 translational termination P
IGI
SceS000002840
IMP
SceS000002840
GO:0007124 pseudohyphal growth P
IMP
SceS000002840
GO:0008150 biological_process P
ND
AthAt5g58470
MmuMGI:1917689
GO:0031554 regulation of transcription termination P
IMP
SceS000002840
GO:0032786 positive regulation of RNA elongation P
IDA
SceS000002840
IMP
SceS000002840

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC16.02c
(P78814)		 YDR432W
(S000002840)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002840
SpoSPAC16.02c
IMP
SceS000002840
GO:0005737 cytoplasm C
IMP
SceS000002840
GO:0003723 RNA binding F
ISS
SpoSPAC16.02c
GO:0003729 mRNA binding F
IDA
SceS000002840
ISS
SpoSPAC16.02c
GO:0008143 poly(A) RNA binding F
IDA
SceS000002840
ISS
SpoSPAC16.02c
GO:0016944 RNA polymerase II transcription elongation factor
activity		 F
IDA
SceS000002840
IMP
SceS000002840
GO:0046982 protein heterodimerization activity F
IPI
SpoSPAC16.02c
GO:0000398 nuclear mRNA splicing, via spliceosome P
IGI
SceS000002840
IMP
SceS000002840
GO:0006406 mRNA export from nucleus P
IGI
SceS000002840
ISS
SpoSPAC16.02c
GO:0006414 translational elongation P
RCA
SceS000002840
GO:0006415 translational termination P
IGI
SceS000002840
IMP
SceS000002840
GO:0007124 pseudohyphal growth P
IMP
SceS000002840
GO:0031554 regulation of transcription termination P
IMP
SceS000002840
GO:0032786 positive regulation of RNA elongation P
IDA
SceS000002840
IMP
SceS000002840

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