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Search term: YDR440W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name DOT1
SGD link S000002848
Alternative ID YDR440W
Description Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response
Synonyms YDR440W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3924 -CDHY--

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGINFORMATION STORAGE AND PROCESSING Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1)

Species KOG link NCBI link UniProt link
Homo sapiens (Hsa) Hs22053032 GI:22053032
Caenorhabditis elegans (Cel) CE03100 GI:17551304
Caenorhabditis elegans (Cel) CE03422 GI:17568143
Caenorhabditis elegans (Cel) CE03424
(WBGene00010120)		 GI:17568207 Q20856
Caenorhabditis elegans (Cel) CE06555
(WBGene00012302)		 GI:17570285 Q23200
Caenorhabditis elegans (Cel) CE07588
(WBGene00022512)		 GI:17570581
Caenorhabditis elegans (Cel) CE29107 GI:17509937
Drosophila melanogaster (Dme) 7298917 GI:7298917
Saccharomyces cerevisiae (Sce) YDR440w
(S000002848)		 GI:6320648 Q04089


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002848
GO:0031151 histone methyltransferase activity (H3-K79
specific)		 F
IDA
SceS000002848
IMP
SceS000002848
GO:0031493 nucleosomal histone binding F
IDA
SceS000002848
GO:0000077 DNA damage checkpoint P
IGI
SceS000002848
IMP
SceS000002848
GO:0000725 recombinational repair P
IGI
SceS000002848
IMP
SceS000002848
GO:0006289 nucleotide-excision repair P
IGI
SceS000002848
IMP
SceS000002848
GO:0006301 postreplication repair P
IGI
SceS000002848
GO:0006348 chromatin silencing at telomere P
IMP
SceS000002848
GO:0034729 histone H3-K79 methylation P
IDA
SceS000002848
IMP
SceS000002848
GO:0051598 meiotic recombination checkpoint P
IGI
SceS000002848

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
35744

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) DOT1
(S000002848)		 GI:6320648 Q04089
Kluyveromyces lactis (Kla) KLLA0B01287g GI:50303293
Eremothecium gossypii (Ego) AGOS_AER326C GI:45190928


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002848
GO:0031151 histone methyltransferase activity (H3-K79
specific)		 F
IDA
SceS000002848
IMP
SceS000002848
GO:0031493 nucleosomal histone binding F
IDA
SceS000002848
GO:0000077 DNA damage checkpoint P
IGI
SceS000002848
IMP
SceS000002848
GO:0000725 recombinational repair P
IGI
SceS000002848
IMP
SceS000002848
GO:0006289 nucleotide-excision repair P
IGI
SceS000002848
IMP
SceS000002848
GO:0006301 postreplication repair P
IGI
SceS000002848
GO:0006348 chromatin silencing at telomere P
IMP
SceS000002848
GO:0034729 histone H3-K79 methylation P
IDA
SceS000002848
IMP
SceS000002848
GO:0051598 meiotic recombination checkpoint P
IGI
SceS000002848

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3243

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5604 ENSANGP00000013539
Ashbya gossypii (Ago) ago2827 AER326C
Caenorhabditis elegans (Cel) cel10281 F54F7.7
(CE35555;
WBGene00010067)
Caenorhabditis elegans (Cel) cel17125 W06D11.4
(CE06555;
WBGene00012302)
Caenorhabditis elegans (Cel) cel18588 Y39G10AR.18a
(CE38003;
WBGene00021474)
Caenorhabditis elegans (Cel) cel18589 Y39G10AR.18b
(CE36735)
Caenorhabditis elegans (Cel) cel21444 ZC53.6
(CE07588;
WBGene00022512)
Candida glabrata (Cgl) cgl3454 CAGL0J10516g
Cryptococcus neoformans (Cne) cne3625 176.m02359
Debaryomyces hansenii (Dha) dha2403 DEHA0D02387g
Drosophila melanogaster (Dme) dme11225 CG10272-PA
Drosophila melanogaster (Dme) dme11226 CG10272-PB
Drosophila melanogaster (Dme) dme11228 CG10272-PC
Drosophila melanogaster (Dme) dme11227 CG10272-PD
Danio rerio (Dre) dre21079 ENSDARP00000012356
Takifugu rubripes (Fru) fru16024 SINFRUP00000142261
Gallus gallus (Gga) gga14023 ENSGALP00000001234
Homo sapiens (Hsa) hsa15264 ENSP00000221482
(DOT1L)		 Q8TEK3-1
Homo sapiens (Hsa) hsa15265 ENSP00000346170
Kluyveromyces lactis (Kla) kla586 KLLA0B01287g
Mus musculus (Mmu) mmu2534 ENSMUSP00000041160
Neurospora crassa (Ncr) ncr6091 NCU06266.2
Rattus norvegicus (Rno) rno26236 ENSRNOP00000041997
(RGD:1306644)
Rattus norvegicus (Rno) rno26235 ENSRNOP00000043691
(RGD:1306644)
Saccharomyces cerevisiae (Sce) sce1506 YDR440W
(S000002848)
Yarrowia lipolytica (Yli) yli4797 YALI0E22715g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002848
GO:0031151 histone methyltransferase activity (H3-K79
specific)		 F
IDA
SceS000002848
IMP
SceS000002848
GO:0031493 nucleosomal histone binding F
IDA
SceS000002848
GO:0000077 DNA damage checkpoint P
IGI
SceS000002848
IMP
SceS000002848
GO:0000725 recombinational repair P
IGI
SceS000002848
IMP
SceS000002848
GO:0006289 nucleotide-excision repair P
IGI
SceS000002848
IMP
SceS000002848
GO:0006301 postreplication repair P
IGI
SceS000002848
GO:0006348 chromatin silencing at telomere P
IMP
SceS000002848
GO:0034729 histone H3-K79 methylation P
IDA
SceS000002848
IMP
SceS000002848
GO:0051598 meiotic recombination checkpoint P
IGI
SceS000002848

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GO info in one table:

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