YOGY Home YOGY Help

Search term: YDR490C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PKH1
SGD link S000002898
Alternative ID YDR490C
Description Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
Synonyms YDR490C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0592 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING 3-phosphoinositide-dependent protein kinase (PDK1)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g10540 GI:15228328
Arabidopsis thaliana (Ath) At5g04510 GI:11357147
Caenorhabditis elegans (Cel) CE20142
(WBGene00021022)		 GI:17555466 Q9UA62
Caenorhabditis elegans (Cel) CE28739
(WBGene00003965)		 GI:17568523
Caenorhabditis elegans (Cel) CE28740 GI:17568521
Drosophila melanogaster (Dme) 7291910 GI:18203559
Homo sapiens (Hsa) Hs4505695
(PDPK1)		 GI:4505695 Q9UPJ8
Saccharomyces cerevisiae (Sce) YDR466w
(S000002874)		 GI:6320674 Q03306
Saccharomyces cerevisiae (Sce) YDR490c
(S000002898)		 GI:6320698 Q03407
Saccharomyces cerevisiae (Sce) YOL100w
(S000005460)		 GI:6324472 Q12236
Schizosaccharomyces pombe (Spo) SPBC4C3.11 GI:19113086
Schizosaccharomyces pombe (Spo) SPCC576.15c GI:19075942 Q12701
Arabidopsis thaliana (Ath) At3g10540 GI:15228328
Arabidopsis thaliana (Ath) At5g04510 GI:11357147
Caenorhabditis elegans (Cel) CE20142
(WBGene00021022)		 GI:17555466 Q9UA62
Caenorhabditis elegans (Cel) CE28739
(WBGene00003965)		 GI:17568523
Caenorhabditis elegans (Cel) CE28740 GI:17568521
Drosophila melanogaster (Dme) 7291910 GI:18203559
Homo sapiens (Hsa) Hs4505695
(PDPK1)		 GI:4505695 Q9UPJ8
Saccharomyces cerevisiae (Sce) YDR466w
(S000002874)		 GI:6320674 Q03306
Saccharomyces cerevisiae (Sce) YDR490c
(S000002898)		 GI:6320698 Q03407
Saccharomyces cerevisiae (Sce) YOL100w
(S000005460)		 GI:6324472 Q12236
Schizosaccharomyces pombe (Spo) SPBC4C3.11 GI:19113086
Schizosaccharomyces pombe (Spo) SPCC576.15c GI:19075942 Q12701


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g04510
SceS000002874
GO:0005634 nucleus C
IDA
CelWBGene00003965
SceS000005460
GO:0005737 cytoplasm C
IDA
HsaPDPK1
SpoSPCC576.15c
GO:0005829 cytosol C
EXP
HsaPDPK1
IDA
SceS000002898
GO:0005886 plasma membrane C
EXP
HsaPDPK1
IDA
AthAt3g10540
HsaPDPK1
GO:0005938 cell cortex C
IDA
SceS000005460
S000002898
GO:0030424 axon C
IDA
CelWBGene00003965
GO:0043025 neuronal cell body C
IDA
CelWBGene00003965
GO:0004672 protein kinase activity F
IDA
AthAt5g04510
SceS000002898
S000005460
ISS
SceS000002874
GO:0004674 protein serine/threonine kinase
activity		 F
EXP
HsaPDPK1
IDA
HsaPDPK1
RCA
SceS000002898
S000005460
GO:0004676 3-phosphoinositide-dependent protein kinase
activity		 F
EXP
HsaPDPK1
IDA
HsaPDPK1
IGI
AthAt5g04510
ISS
SpoSPCC576.15c
GO:0005515 protein binding F
IPI
AthAt5g04510
HsaPDPK1
SpoSPCC576.15c
GO:0016301 kinase activity F
ISS
AthAt5g04510
At3g10540
GO:0035091 phosphoinositide binding F
IDA
AthAt5g04510
GO:0000003 reproduction P
IMP
CelWBGene00021022
GO:0000196 MAPKKK cascade involved in cell wall
biogenesis		 P
IGI
SceS000002898
S000002874
S000005460
IMP
SceS000002898
S000005460
GO:0002119 nematode larval development P
IMP
CelWBGene00021022
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000002898
S000005460
GO:0006469 negative regulation of protein kinase
activity		 P
IDA
HsaPDPK1
GO:0006897 endocytosis P
IMP
SceS000002898
GO:0006914 autophagy P
RCA
SceS000005460
GO:0007047 cellular cell wall organization P
IMP
SpoSPCC576.15c
GO:0007165 signal transduction P
IC
SpoSPCC576.15c
GO:0007611 learning or memory P
IMP
CelWBGene00003965
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00021022
GO:0018107 peptidyl-threonine phosphorylation P
IDA
HsaPDPK1
GO:0023034 intracellular signaling pathway P
IDA
HsaPDPK1
GO:0030036 actin cytoskeleton organization P
TAS
HsaPDPK1
GO:0030437 ascospore formation P
IMP
SpoSPCC576.15c
GO:0031137 regulation of conjugation with cellular
fusion		 P
IMP
SpoSPCC576.15c
GO:0032148 activation of protein kinase B
activity		 P
IDA
HsaPDPK1
GO:0032869 cellular response to insulin stimulus P
IMP
HsaPDPK1
GO:0040007 growth P
IMP
CelWBGene00021022
GO:0040024 dauer larval development P
IGI
CelWBGene00003965
IMP
CelWBGene00003965
GO:0045860 positive regulation of protein kinase
activity		 P
IDA
AthAt5g04510
GO:0050920 regulation of chemotaxis P
IMP
CelWBGene00003965
GO:0090004 positive regulation of establishment of protein
localization in plasma membrane		 P
IMP
HsaPDPK1

Back to the top

OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1105

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3562 ENSANGP00000011675
Ashbya gossypii (Ago) ago3527 AFR335C
Ashbya gossypii (Ago) ago3569 AFR377C
Arabidopsis thaliana (Ath) ath13151 At3g10540.1
Arabidopsis thaliana (Ath) ath22618 At5g04510.1
Arabidopsis thaliana (Ath) ath22619 At5g04510.2
Caenorhabditis elegans (Cel) cel11506 H42K12.1a
(CE28739;
WBGene00003965)
Caenorhabditis elegans (Cel) cel11507 H42K12.1b
(CE28740)
Caenorhabditis elegans (Cel) cel16995 W04B5.5
(CE20142;
WBGene00021022)
Candida glabrata (Cgl) cgl2846 CAGL0I07513g
Candida glabrata (Cgl) cgl3800 CAGL0K06479g
Cryptococcus neoformans (Cne) cne5840 179.m00716
Dictyostelium discoideum (Ddi) ddi12257 DDB0216243
Dictyostelium discoideum (Ddi) ddi12919 DDB0216246
Debaryomyces hansenii (Dha) dha6160 DEHA0G10417g
Drosophila melanogaster (Dme) dme7162 CG1210-PA
(FBgn0020386)
Drosophila melanogaster (Dme) dme7167 CG1210-PB
(FBgn0020386)
Drosophila melanogaster (Dme) dme7165 CG1210-PC
(FBgn0020386)
Drosophila melanogaster (Dme) dme7161 CG1210-PD
(FBgn0020386)
Drosophila melanogaster (Dme) dme7168 CG1210-PE
(FBgn0020386)
Drosophila melanogaster (Dme) dme7164 CG1210-PF
(FBgn0020386)
Drosophila melanogaster (Dme) dme7166 CG1210-PG
(FBgn0020386)
Drosophila melanogaster (Dme) dme7163 CG1210-PH
(FBgn0020386)
Danio rerio (Dre) dre17787 ENSDARP00000017312
Danio rerio (Dre) dre24176 ENSDARP00000019085
(zgc:77318)		 Q6NZV1
Takifugu rubripes (Fru) fru16873 SINFRUP00000146153
Gallus gallus (Gga) gga6659 ENSGALP00000010343
(PDPK1)
Homo sapiens (Hsa) hsa11513 ENSP00000344220
(PDPK1)		 O15530-1
Homo sapiens (Hsa) hsa11514 ENSP00000346895
(PDPK1)		 C9JWR9
Kluyveromyces lactis (Kla) kla1754 KLLA0C12485g
Kluyveromyces lactis (Kla) kla3105 KLLA0E03487g
Mus musculus (Mmu) mmu11063 ENSMUSP00000024933
Mus musculus (Mmu) mmu11062 ENSMUSP00000061942
(MGI:1338068)
Neurospora crassa (Ncr) ncr3462 NCU03571.2
Oryza sativa (Osa) osa27708 4217.m00170
Oryza sativa (Osa) osa30720 4365.m00151
Rattus norvegicus (Rno) rno4585 ENSRNOP00000008434
(RGD:620307)
Saccharomyces cerevisiae (Sce) sce1533 YDR466W
(S000002874)
Saccharomyces cerevisiae (Sce) sce1556 YDR490C
(S000002898)
Saccharomyces cerevisiae (Sce) sce5656 YOL100W
(S000005460)
Schizosaccharomyces pombe (Spo) spo1107 SPCC576.15c Q12701
Yarrowia lipolytica (Yli) yli968 YALI0B05566g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g04510
SceS000002874
GO:0005634 nucleus C
IDA
CelWBGene00003965
SceS000005460
GO:0005737 cytoplasm C
IDA
MmuMGI:1338068
SpoSPCC576.15c
ISS
DmeFBgn0020386
GO:0005829 cytosol C
IDA
SceS000002898
ISO
MmuMGI:1338068
GO:0005886 plasma membrane C
IDA
AthAt3g10540
ISO
MmuMGI:1338068
ISS
DmeFBgn0020386
GO:0005938 cell cortex C
IDA
SceS000005460
S000002898
GO:0016023 cytoplasmic membrane-bounded vesicle C
IDA
MmuMGI:1338068
GO:0030424 axon C
IDA
CelWBGene00003965
GO:0043025 neuronal cell body C
IDA
CelWBGene00003965
GO:0004672 protein kinase activity F
IDA
AthAt5g04510
SceS000002898
S000005460
ISS
SceS000002874
NAS
DmeFBgn0020386
GO:0004674 protein serine/threonine kinase
activity		 F
ISS
DmeFBgn0020386
NAS
DmeFBgn0020386
RCA
SceS000002898
S000005460
GO:0004676 3-phosphoinositide-dependent protein kinase
activity		 F
IDA
MmuMGI:1338068
IGI
AthAt5g04510
ISO
MmuMGI:1338068
ISS
SpoSPCC576.15c
GO:0005158 insulin receptor binding F
ISO
MmuMGI:1338068
GO:0005515 protein binding F
IPI
AthAt5g04510
SpoSPCC576.15c
GO:0016301 kinase activity F
ISS
AthAt5g04510
At3g10540
GO:0019901 protein kinase binding F
ISO
MmuMGI:1338068
GO:0035091 phosphoinositide binding F
IDA
AthAt5g04510
GO:0000003 reproduction P
IMP
CelWBGene00021022
GO:0000196 MAPKKK cascade involved in cell wall
biogenesis		 P
IGI
SceS000002898
S000002874
S000005460
IMP
SceS000002898
S000005460
GO:0001558 regulation of cell growth P
IMP
DmeFBgn0020386
GO:0002119 nematode larval development P
IMP
CelWBGene00021022
GO:0006468 protein amino acid phosphorylation P
IDA
DmeFBgn0020386
SceS000002898
S000005460
ISS
DmeFBgn0020386
NAS
DmeFBgn0020386
GO:0006897 endocytosis P
IMP
SceS000002898
GO:0006914 autophagy P
RCA
SceS000005460
GO:0006916 anti-apoptosis P
IMP
DmeFBgn0020386
GO:0006972 hyperosmotic response P
IDA
MmuMGI:1338068
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0020386
GO:0007047 cellular cell wall organization P
IMP
SpoSPCC576.15c
GO:0007165 signal transduction P
IC
SpoSPCC576.15c
TAS
MmuMGI:1338068
GO:0007166 cell surface receptor linked signaling
pathway		 P
IGI
DmeFBgn0020386
GO:0007283 spermatogenesis P
NAS
DmeFBgn0020386
TAS
DmeFBgn0020386
GO:0007548 sex differentiation P
NAS
DmeFBgn0020386
TAS
DmeFBgn0020386
GO:0007611 learning or memory P
IMP
CelWBGene00003965
GO:0008286 insulin receptor signaling pathway P
ISS
DmeFBgn0020386
NAS
DmeFBgn0020386
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00021022
GO:0016310 phosphorylation P
IDA
MmuMGI:1338068
GO:0030036 actin cytoskeleton organization P
ISS
DmeFBgn0020386
GO:0030307 positive regulation of cell growth P
NAS
DmeFBgn0020386
GO:0030437 ascospore formation P
IMP
SpoSPCC576.15c
GO:0031137 regulation of conjugation with cellular
fusion		 P
IMP
SpoSPCC576.15c
GO:0040007 growth P
IMP
CelWBGene00021022
GO:0040024 dauer larval development P
IGI
CelWBGene00003965
IMP
CelWBGene00003965
GO:0045793 positive regulation of cell size P
TAS
DmeFBgn0020386
GO:0045860 positive regulation of protein kinase
activity		 P
IDA
AthAt5g04510
GO:0046620 regulation of organ growth P
IMP
DmeFBgn0020386
GO:0048041 focal adhesion assembly P
ISO
MmuMGI:1338068
GO:0048477 oogenesis P
NAS
DmeFBgn0020386
TAS
DmeFBgn0020386
GO:0050920 regulation of chemotaxis P
IMP
CelWBGene00003965

Back to the top

Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC1778.10c
(Q9Y7J6)		 YDR490C
(S000002898)
SPCC576.15c
(Q12701)		 YDR490C
(S000002898)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBC1778.10c
GO:0005737 cytoplasm C
IDA
SpoSPCC576.15c
GO:0005816 spindle pole body C
IDA
SpoSPBC1778.10c
GO:0005829 cytosol C
IDA
SceS000002898
SpoSPBC1778.10c
GO:0005938 cell cortex C
IDA
SceS000002898
GO:0032153 cell division site C
IDA
SpoSPBC1778.10c
GO:0051286 cell tip C
IDA
SpoSPBC1778.10c
GO:0004672 protein kinase activity F
IDA
SceS000002898
GO:0004674 protein serine/threonine kinase
activity		 F
ISS
SpoSPBC1778.10c
RCA
SceS000002898
TAS
SpoSPBC1778.10c
GO:0004676 3-phosphoinositide-dependent protein kinase
activity		 F
ISS
SpoSPCC576.15c
GO:0005515 protein binding F
IPI
SpoSPCC576.15c
GO:0005524 ATP binding F
ISS
SpoSPBC1778.10c
GO:0000196 MAPKKK cascade involved in cell wall
biogenesis		 P
IGI
SceS000002898
IMP
SceS000002898
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000002898
ISS
SpoSPBC1778.10c
GO:0006897 endocytosis P
IMP
SceS000002898
GO:0007047 cellular cell wall organization P
IMP
SpoSPCC576.15c
GO:0007165 signal transduction P
IC
SpoSPCC576.15c
NAS
SpoSPBC1778.10c
GO:0030437 ascospore formation P
IMP
SpoSPCC576.15c
GO:0031137 regulation of conjugation with cellular
fusion		 P
IMP
SpoSPCC576.15c
GO:0033205 cell cycle cytokinesis P
TAS
SpoSPBC1778.10c
GO:0033554 cellular response to stress P
IEP
SpoSPBC1778.10c

Back to the top
YOGY Home YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk