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Search term: YEL012W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name UBC8
SGD link S000000738
Alternative ID YEL012W
Description Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
Synonyms YEL012W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0416 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Ubiquitin-protein ligase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g63800 GI:18407893
Arabidopsis thaliana (Ath) At2g46030 GI:18406950
Arabidopsis thaliana (Ath) At5g41340 GI:18422085
Caenorhabditis elegans (Cel) CE25632 GI:17544274
Drosophila melanogaster (Dme) 7290876
(FBgn0029996)		 GI:18858231 Q7JW03
Drosophila melanogaster (Dme) 7299561 GI:7299561
Homo sapiens (Hsa) Hs20483368 GI:20483368
Homo sapiens (Hsa) Hs4507783
(UBE2H)		 GI:4507783 P62256
Saccharomyces cerevisiae (Sce) YEL012w
(S000000738)		 GI:6579192 P28263
Schizosaccharomyces pombe (Spo) SPBC211.07c GI:19113409 Q9P7R4
Encephalitozoon cuniculi (Ecu) ECU08g0860 GI:19173413 Q8SRC0
Arabidopsis thaliana (Ath) At1g63800 GI:18407893
Arabidopsis thaliana (Ath) At2g46030 GI:18406950
Arabidopsis thaliana (Ath) At5g41340 GI:18422085
Caenorhabditis elegans (Cel) CE25632 GI:17544274
Drosophila melanogaster (Dme) 7290876
(FBgn0029996)		 GI:18858231 Q7JW03
Drosophila melanogaster (Dme) 7299561 GI:7299561
Homo sapiens (Hsa) Hs20483368 GI:20483368
Homo sapiens (Hsa) Hs4507783
(UBE2H)		 GI:4507783 P62256
Saccharomyces cerevisiae (Sce) YEL012w
(S000000738)		 GI:6579192 P28263
Schizosaccharomyces pombe (Spo) SPBC211.07c GI:19113409 Q9P7R4
Encephalitozoon cuniculi (Ecu) ECU08g0860 GI:19173413 Q8SRC0
Arabidopsis thaliana (Ath) At1g63800 GI:18407893
Arabidopsis thaliana (Ath) At2g46030 GI:18406950
Arabidopsis thaliana (Ath) At5g41340 GI:18422085
Caenorhabditis elegans (Cel) CE25632 GI:17544274
Drosophila melanogaster (Dme) 7290876
(FBgn0029996)		 GI:18858231 Q7JW03
Drosophila melanogaster (Dme) 7299561 GI:7299561
Homo sapiens (Hsa) Hs20483368 GI:20483368
Homo sapiens (Hsa) Hs4507783
(UBE2H)		 GI:4507783 P62256
Saccharomyces cerevisiae (Sce) YEL012w
(S000000738)		 GI:6579192 P28263
Schizosaccharomyces pombe (Spo) SPBC211.07c GI:19113409 Q9P7R4
Encephalitozoon cuniculi (Ecu) ECU08g0860 GI:19173413 Q8SRC0


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt1g63800
At5g41340
At2g46030
GO:0005737 cytoplasm C
IDA
SceS000000738
ISS
SpoSPBC211.07c
GO:0004842 ubiquitin-protein ligase activity F
IDA
AthAt2g46030
At5g41340
At1g63800
HsaUBE2H
SceS000000738
ISS
AthAt2g46030
At5g41340
At1g63800
DmeFBgn0029996
SceS000000738
SpoSPBC211.07c
GO:0000209 protein polyubiquitination P
TAS
SceS000000738
GO:0006508 proteolysis P
RCA
SceS000000738
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IDA
AthAt1g63800
At5g41340
At2g46030
ISS
AthAt2g46030
TAS
AthAt5g41340
At2g46030
At1g63800
HsaUBE2H
GO:0006513 protein monoubiquitination P
TAS
SceS000000738
GO:0006914 autophagy P
RCA
SceS000000738
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000000738
GO:0016567 protein ubiquitination P
ISS
SpoSPBC211.07c
GO:0033554 cellular response to stress P
IEP
SpoSPBC211.07c
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000738
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000738
GO:0045721 negative regulation of gluconeogenesis P
IMP
SceS000000738
GO:0070936 protein K48-linked ubiquitination P
IDA
HsaUBE2H
GO:0070979 protein K11-linked ubiquitination P
IDA
HsaUBE2H

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
104082

Species Gene ID NCBI link UniProt link
Mus musculus (Mmu) Gm2058 GI:149257203
Caenorhabditis elegans (Cel) ubc-8
(CE34621;
WBGene00006705)		 GI:71999648
Schizosaccharomyces pombe (Spo) ubc8
(SPBC211.07c)		 GI:19113409 Q9P7R4
Saccharomyces cerevisiae (Sce) UBC8
(S000000738)		 GI:6579192 P28263
Kluyveromyces lactis (Kla) KLLA0A11198g GI:50303099
Eremothecium gossypii (Ego) AGOS_AEL045W GI:45190562
Neurospora crassa (Ncr) NCU10046.1 GI:32405600
Arabidopsis thaliana (Ath) UBC4 GI:18422085
Arabidopsis thaliana (Ath) UBC5 GI:22330406
Arabidopsis thaliana (Ath) UBC6 GI:18406950
Oryza sativa (Osa) Os10g0447100 GI:115482252


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthUBC5
UBC6
UBC4
GO:0005737 cytoplasm C
IDA
SceS000000738
ISS
SpoSPBC211.07c
GO:0004842 ubiquitin-protein ligase activity F
IDA
AthUBC5
UBC6
UBC4
SceS000000738
ISS
AthUBC5
UBC6
UBC4
SceS000000738
SpoSPBC211.07c
GO:0000209 protein polyubiquitination P
TAS
SceS000000738
GO:0006508 proteolysis P
RCA
SceS000000738
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IDA
AthUBC5
UBC4
UBC6
ISS
AthUBC6
TAS
AthUBC5
UBC6
UBC4
GO:0006513 protein monoubiquitination P
TAS
SceS000000738
GO:0006914 autophagy P
RCA
SceS000000738
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000000738
GO:0016567 protein ubiquitination P
ISS
SpoSPBC211.07c
GO:0033554 cellular response to stress P
IEP
SpoSPBC211.07c
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000738
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000738
GO:0045721 negative regulation of gluconeogenesis P
IMP
SceS000000738

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2291

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15783 ENSANGP00000024655
Ashbya gossypii (Ago) ago2461 AEL045W
Arabidopsis thaliana (Ath) ath5584 At1g63800.1
Arabidopsis thaliana (Ath) ath11831 At2g46030.1
Arabidopsis thaliana (Ath) ath25916 At5g41340.1
Caenorhabditis elegans (Cel) cel21068 Y94H6A.6
(CE34621;
WBGene00006705)
Candida glabrata (Cgl) cgl4805 CAGL0M03399g
Cryptococcus neoformans (Cne) cne3814 185.m02395
Dictyostelium discoideum (Ddi) ddi6009 DDB0206370
Debaryomyces hansenii (Dha) dha969 DEHA0B06512g
Drosophila melanogaster (Dme) dme16933 CG2257-PA
(FBgn0029996)
Drosophila melanogaster (Dme) dme16935 CG2257-PB
(FBgn0029996)
Drosophila melanogaster (Dme) dme16934 CG2257-PC
(FBgn0029996)
Danio rerio (Dre) dre18257 ENSDARP00000000020
(ube2h)		 Q7ZUF3
Danio rerio (Dre) dre24964 ENSDARP00000042454
Encephalitozoon cuniculi (Ecu) ecu244 19173413
Takifugu rubripes (Fru) fru2404 SINFRUP00000127968
Gallus gallus (Gga) gga6838 ENSGALP00000012940
(UBE2H)		 Q5ZLI7
Homo sapiens (Hsa) hsa29418 ENSP00000334823
Homo sapiens (Hsa) hsa29416 ENSP00000347836
(UBE2H)		 P62256
Kluyveromyces lactis (Kla) kla484 KLLA0A11198g
Mus musculus (Mmu) mmu21563 ENSMUSP00000043054
(MGI:104632)		 Q3TTE3
Neurospora crassa (Ncr) ncr9781 NCU10046.2
Oryza sativa (Osa) osa16947 3145.m00194
Plasmodium falciparum (Pfa) pfa548 PF10_0330
Rattus norvegicus (Rno) rno20967 ENSRNOP00000013235
Saccharomyces cerevisiae (Sce) sce1631 YEL012W
(S000000738)
Schizosaccharomyces pombe (Spo) spo3966 SPBC211.07c Q9P7R4
Yarrowia lipolytica (Yli) yli4363 YALI0E12081g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt1g63800
At5g41340
At2g46030
PfaPF10_0330
GO:0005737 cytoplasm C
IDA
SceS000000738
ISS
SpoSPBC211.07c
GO:0004842 ubiquitin-protein ligase activity F
IDA
AthAt2g46030
At5g41340
At1g63800
SceS000000738
ISS
AthAt2g46030
At5g41340
At1g63800
DmeFBgn0029996
SceS000000738
SpoSPBC211.07c
GO:0000209 protein polyubiquitination P
TAS
SceS000000738
GO:0006508 proteolysis P
RCA
SceS000000738
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IDA
AthAt1g63800
At5g41340
At2g46030
ISS
AthAt2g46030
PfaPF10_0330
TAS
AthAt5g41340
At2g46030
At1g63800
GO:0006513 protein monoubiquitination P
TAS
SceS000000738
GO:0006914 autophagy P
RCA
SceS000000738
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000000738
GO:0016567 protein ubiquitination P
ISS
SpoSPBC211.07c
GO:0033554 cellular response to stress P
IEP
SpoSPBC211.07c
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000738
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000738
GO:0045721 negative regulation of gluconeogenesis P
IMP
SceS000000738

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC211.07c
(Q9P7R4)		 YEL012W
(S000000738)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000000738
ISS
SpoSPBC211.07c
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000000738
ISS
SceS000000738
SpoSPBC211.07c
GO:0000209 protein polyubiquitination P
TAS
SceS000000738
GO:0006508 proteolysis P
RCA
SceS000000738
GO:0006513 protein monoubiquitination P
TAS
SceS000000738
GO:0006914 autophagy P
RCA
SceS000000738
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000000738
GO:0016567 protein ubiquitination P
ISS
SpoSPBC211.07c
GO:0033554 cellular response to stress P
IEP
SpoSPBC211.07c
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000738
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000738
GO:0045721 negative regulation of gluconeogenesis P
IMP
SceS000000738

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GO info in one table:

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