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Search term: YEL062W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name NPR2
SGD link S000000788
Alternative ID YEL062W
Description Component, with Npr3p, of an evolutionarily conserved complex that mediates downregulation of TOR Complex 1 activity in response to amino acid limitation; transcription is induced in response to proline and urea
Synonyms YEL062W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3789 -CDHYP-

KOGs classification KOGs description
METABOLISM Nitrogen permease regulator NLRG/NPR2

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE28406_2 GI:17540508
Drosophila melanogaster (Dme) 7293296
(FBgn0030800)		 GI:18859975
Homo sapiens (Hsa) Hs5729949 GI:5729949
Saccharomyces cerevisiae (Sce) YEL062w
(S000000788)		 GI:6320773
Schizosaccharomyces pombe (Spo) SPAC23H3.03c GI:19114705 O42857


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000000788
GO:0005634 nucleus C
IDA
SpoSPAC23H3.03c
GO:0005829 cytosol C
IDA
SpoSPAC23H3.03c
GO:0003674 molecular_function F
ND
SceS000000788
SpoSPAC23H3.03c
GO:0016247 channel regulator activity F
ISS
DmeFBgn0030800
GO:0006995 cellular response to nitrogen starvation P
IMP
SceS000000788
GO:0015824 proline transport P
IMP
SceS000000788
ISS
DmeFBgn0030800
GO:0015840 urea transport P
IMP
SceS000000788
ISS
DmeFBgn0030800
GO:0032006 regulation of TOR signaling cascade P
IMP
SceS000000788
ISS
SpoSPAC23H3.03c
GO:0034198 cellular response to amino acid
starvation		 P
IMP
SceS000000788
ISS
SpoSPAC23H3.03c
GO:0042493 response to drug P
IMP
SceS000000788
GO:0048813 dendrite morphogenesis P
IMP
DmeFBgn0030800
GO:0070881 regulation of proline transport P
ISS
SpoSPAC23H3.03c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
117783

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) SPAC23H3.03c GI:19114705 O42857
Saccharomyces cerevisiae (Sce) NPR2
(S000000788)		 GI:37362640
Kluyveromyces lactis (Kla) KLLA0D01067g GI:50306291
Eremothecium gossypii (Ego) AGOS_ACR009W GI:45185696
Magnaporthe grisea (Mgr) MGG_00664 GI:39974379
Neurospora crassa (Ncr) NCU03029.1 GI:32419545


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000000788
GO:0005634 nucleus C
IDA
SpoSPAC23H3.03c
GO:0005829 cytosol C
IDA
SpoSPAC23H3.03c
GO:0003674 molecular_function F
ND
SceS000000788
SpoSPAC23H3.03c
GO:0006995 cellular response to nitrogen starvation P
IMP
SceS000000788
GO:0015824 proline transport P
IMP
SceS000000788
GO:0015840 urea transport P
IMP
SceS000000788
GO:0032006 regulation of TOR signaling cascade P
IMP
SceS000000788
ISS
SpoSPAC23H3.03c
GO:0034198 cellular response to amino acid
starvation		 P
IMP
SceS000000788
ISS
SpoSPAC23H3.03c
GO:0042493 response to drug P
IMP
SceS000000788
GO:0070881 regulation of proline transport P
ISS
SpoSPAC23H3.03c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3817

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15055 ENSANGP00000020043
Ashbya gossypii (Ago) ago1057 ACR009W
Caenorhabditis elegans (Cel) cel9753 F49E8.1
(CE33650;
WBGene00018635)
Candida glabrata (Cgl) cgl4655 CAGL0L13288g
Cryptococcus neoformans (Cne) cne5500 179.m00353
Dictyostelium discoideum (Ddi) ddi4255 DDB0202838
Debaryomyces hansenii (Dha) dha3528 DEHA0E06523g
Drosophila melanogaster (Dme) dme18271 CG9104-PA
(FBgn0030800)
Danio rerio (Dre) dre31448 ENSDARP00000012385
Takifugu rubripes (Fru) fru30178 SINFRUP00000171602
Gallus gallus (Gga) gga4964 ENSGALP00000003325
Homo sapiens (Hsa) hsa22544 ENSP00000232501
(TUSC4)		 Q8WTW4-1
Kluyveromyces lactis (Kla) kla2117 KLLA0D01067g
Mus musculus (Mmu) mmu28245 ENSMUSP00000010201
(MGI:1914482)		 Q9WUE4
Neurospora crassa (Ncr) ncr2934 NCU03029.2
Rattus norvegicus (Rno) rno29245 ENSRNOP00000035524
Saccharomyces cerevisiae (Sce) sce1691 YEL062W
(S000000788)
Schizosaccharomyces pombe (Spo) spo1581 SPAC23H3.03c O42857
Yarrowia lipolytica (Yli) yli5453 YALI0F02783g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1914482
SceS000000788
GO:0005634 nucleus C
IDA
SpoSPAC23H3.03c
GO:0005829 cytosol C
IDA
SpoSPAC23H3.03c
GO:0003674 molecular_function F
ND
MmuMGI:1914482
SceS000000788
SpoSPAC23H3.03c
GO:0016247 channel regulator activity F
ISS
DmeFBgn0030800
GO:0006995 cellular response to nitrogen starvation P
IMP
SceS000000788
GO:0008150 biological_process P
ND
MmuMGI:1914482
GO:0015824 proline transport P
IMP
SceS000000788
ISS
DmeFBgn0030800
GO:0015840 urea transport P
IMP
SceS000000788
ISS
DmeFBgn0030800
GO:0032006 regulation of TOR signaling cascade P
IMP
SceS000000788
ISS
SpoSPAC23H3.03c
GO:0034198 cellular response to amino acid
starvation		 P
IMP
SceS000000788
ISS
SpoSPAC23H3.03c
GO:0042493 response to drug P
IMP
SceS000000788
GO:0048813 dendrite morphogenesis P
IMP
DmeFBgn0030800
GO:0070881 regulation of proline transport P
ISS
SpoSPAC23H3.03c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC23H3.03c
(O42857)		 YEL062W
(S000000788)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000000788
GO:0005634 nucleus C
IDA
SpoSPAC23H3.03c
GO:0005829 cytosol C
IDA
SpoSPAC23H3.03c
GO:0003674 molecular_function F
ND
SceS000000788
SpoSPAC23H3.03c
GO:0006995 cellular response to nitrogen starvation P
IMP
SceS000000788
GO:0015824 proline transport P
IMP
SceS000000788
GO:0015840 urea transport P
IMP
SceS000000788
GO:0032006 regulation of TOR signaling cascade P
IMP
SceS000000788
ISS
SpoSPAC23H3.03c
GO:0034198 cellular response to amino acid
starvation		 P
IMP
SceS000000788
ISS
SpoSPAC23H3.03c
GO:0042493 response to drug P
IMP
SceS000000788
GO:0070881 regulation of proline transport P
ISS
SpoSPAC23H3.03c

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s.khadayate@ucl.ac.uk