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Search term: YER007W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PAC2
SGD link S000000809
Alternative ID YER007W
Description Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
Synonyms YER007W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3207 -CDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Beta-tubulin folding cofactor E

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE18021
(WBGene00019503)		 GI:17541264 Q20068
Drosophila melanogaster (Dme) 7302192 GI:7302192
Homo sapiens (Hsa) Hs4507375 GI:4507375 Q15813
Saccharomyces cerevisiae (Sce) YER007w
(S000000809)		 GI:6320843 P39937
Schizosaccharomyces pombe (Spo) SPAC22H10.10 GI:19114659 Q10303


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000000809
GO:0005634 nucleus C
IDA
SpoSPAC22H10.10
GO:0005829 cytosol C
IDA
SpoSPAC22H10.10
GO:0005515 protein binding F
IPI
SpoSPAC22H10.10
GO:0008017 microtubule binding F
RCA
SceS000000809
GO:0043014 alpha-tubulin binding F
IPI
SceS000000809
SpoSPAC22H10.10
GO:0006457 protein folding P
TAS
SceS000000809
SpoSPAC22H10.10
GO:0006461 protein complex assembly P
RCA
SceS000000809
GO:0007017 microtubule-based process P
NAS
SpoSPAC22H10.10
GO:0007023 post-chaperonin tubulin folding
pathway		 P
ISS
SpoSPAC22H10.10
TAS
SceS000000809
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00019503
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019503
GO:0051129 negative regulation of cellular component
organization		 P
RCA
SceS000000809
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000000809

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68680

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) PAC2
(S000000809)		 GI:6320843 P39937
Kluyveromyces lactis (Kla) KLLA0D13596g GI:50307381
Eremothecium gossypii (Ego) AGOS_ADR009W GI:45187882


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000000809
GO:0008017 microtubule binding F
RCA
SceS000000809
GO:0043014 alpha-tubulin binding F
IPI
SceS000000809
GO:0006457 protein folding P
TAS
SceS000000809
GO:0006461 protein complex assembly P
RCA
SceS000000809
GO:0007023 post-chaperonin tubulin folding
pathway		 P
TAS
SceS000000809
GO:0051129 negative regulation of cellular component
organization		 P
RCA
SceS000000809
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000000809

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2642

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga7746 ENSANGP00000019642
Ashbya gossypii (Ago) ago1750 ADR009W
Arabidopsis thaliana (Ath) ath6433 At1g71440.1
Caenorhabditis elegans (Cel) cel12186 K07H8.1
(CE18021;
WBGene00019503)
Candida glabrata (Cgl) cgl2487 CAGL0H09702g
Cryptococcus neoformans (Cne) cne526 163.m06502
Dictyostelium discoideum (Ddi) ddi4126 DDB0190721
Debaryomyces hansenii (Dha) dha3117 DEHA0D18205g
Drosophila melanogaster (Dme) dme3429 CG7861-PA
(FBgn0033055)
Drosophila melanogaster (Dme) dme3428 CG7861-PB
(FBgn0033055)
Danio rerio (Dre) dre28397 ENSDARP00000027496
Danio rerio (Dre) dre28398 ENSDARP00000036390
Gallus gallus (Gga) gga26209 ENSGALP00000021422
Gallus gallus (Gga) gga26210 ENSGALP00000021423
Gallus gallus (Gga) gga26901 ENSGALP00000022566
(TBCE)
Homo sapiens (Hsa) hsa3265 ENSP00000264180
Kluyveromyces lactis (Kla) kla2668 KLLA0D13596g
Mus musculus (Mmu) mmu6529 ENSMUSP00000047880
(MGI:1917680)		 Q8CIV8
Neurospora crassa (Ncr) ncr8907 NCU09139.2
Oryza sativa (Osa) osa14683 2972.m00178
Oryza sativa (Osa) osa17878 3322.m00094
Rattus norvegicus (Rno) rno13442 ENSRNOP00000039282
Rattus norvegicus (Rno) rno13441 ENSRNOP00000042689
(RGD:1305533)		 Q5FVQ9
Saccharomyces cerevisiae (Sce) sce1718 YER007W
(S000000809)
Schizosaccharomyces pombe (Spo) spo726 SPAC22H10.10 Q10303
Yarrowia lipolytica (Yli) yli571 YALI0A17358g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000000809
GO:0005634 nucleus C
IDA
SpoSPAC22H10.10
GO:0005737 cytoplasm C
IDA
DmeFBgn0033055
GO:0005829 cytosol C
IDA
SpoSPAC22H10.10
GO:0009507 chloroplast C
IDA
AthAt1g71440
GO:0005515 protein binding F
IPI
SpoSPAC22H10.10
GO:0008017 microtubule binding F
RCA
SceS000000809
GO:0043014 alpha-tubulin binding F
IPI
SceS000000809
SpoSPAC22H10.10
GO:0051082 unfolded protein binding F
TAS
MmuMGI:1917680
GO:0000226 microtubule cytoskeleton organization P
IMP
MmuMGI:1917680
GO:0000910 cytokinesis P
IGI
AthAt1g71440
GO:0006457 protein folding P
TAS
MmuMGI:1917680
SceS000000809
SpoSPAC22H10.10
GO:0006461 protein complex assembly P
RCA
SceS000000809
GO:0007017 microtubule-based process P
NAS
SpoSPAC22H10.10
GO:0007021 tubulin complex assembly P
ISS
AthAt1g71440
DmeFBgn0033055
TAS
MmuMGI:1917680
GO:0007023 post-chaperonin tubulin folding
pathway		 P
ISS
SpoSPAC22H10.10
TAS
SceS000000809
GO:0007274 neuromuscular synaptic transmission P
IMP
DmeFBgn0033055
GO:0007409 axonogenesis P
IMP
MmuMGI:1917680
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00019503
GO:0008344 adult locomotory behavior P
IMP
MmuMGI:1917680
GO:0008582 regulation of synaptic growth at neuromuscular
junction		 P
IMP
DmeFBgn0033055
GO:0009791 post-embryonic development P
IMP
MmuMGI:1917680
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019503
GO:0009793 embryo development ending in seed
dormancy		 P
IMP
AthAt1g71440
GO:0014889 muscle atrophy P
IMP
MmuMGI:1917680
GO:0046785 microtubule polymerization P
IGI
DmeFBgn0033055
IMP
DmeFBgn0033055
GO:0048589 developmental growth P
IMP
MmuMGI:1917680
GO:0048936 peripheral nervous system neuron
axonogenesis		 P
IMP
MmuMGI:1917680
GO:0051129 negative regulation of cellular component
organization		 P
RCA
SceS000000809
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000000809

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC22H10.10
(Q10303)		 YER007W
(S000000809)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000000809
GO:0005634 nucleus C
IDA
SpoSPAC22H10.10
GO:0005829 cytosol C
IDA
SpoSPAC22H10.10
GO:0005515 protein binding F
IPI
SpoSPAC22H10.10
GO:0008017 microtubule binding F
RCA
SceS000000809
GO:0043014 alpha-tubulin binding F
IPI
SceS000000809
SpoSPAC22H10.10
GO:0006457 protein folding P
TAS
SceS000000809
SpoSPAC22H10.10
GO:0006461 protein complex assembly P
RCA
SceS000000809
GO:0007017 microtubule-based process P
NAS
SpoSPAC22H10.10
GO:0007023 post-chaperonin tubulin folding
pathway		 P
ISS
SpoSPAC22H10.10
TAS
SceS000000809
GO:0051129 negative regulation of cellular component
organization		 P
RCA
SceS000000809
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000000809

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