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Search term: YER019W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ISC1
SGD link S000000821
Alternative ID YER019W
Description Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance
Synonyms YER019W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3873 -CDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Sphingomyelinase family protein

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE16515 GI:17509303
Drosophila melanogaster (Dme) 7292334 GI:20139294
Homo sapiens (Hsa) Hs4507095 GI:4507095
Saccharomyces cerevisiae (Sce) YER019w
(S000000821)
GI:6320856 P40015
Schizosaccharomyces pombe (Spo) SPBC685.10c GI:19112936


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000000821
GO:0005783 endoplasmic reticulum C
IDA
SceS000000821
GO:0031307 integral to mitochondrial outer
membrane
C
IDA
SceS000000821
GO:0004629 phospholipase C activity F
IDA
SceS000000821
GO:0009651 response to salt stress P
IMP
SceS000000821
GO:0030149 sphingolipid catabolic process P
IDA
SceS000000821
GO:0046513 ceramide biosynthetic process P
IMP
SceS000000821

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
38905

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) ISC1
(S000000821)
GI:6320856 P40015
Kluyveromyces lactis (Kla) KLLA0C02057g GI:50304665
Eremothecium gossypii (Ego) AGOS_AFR680W GI:45199199
Magnaporthe grisea (Mgr) MGG_04474 GI:145603103
Neurospora crassa (Ncr) NCU03243.1 GI:32420471


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000000821
GO:0005783 endoplasmic reticulum C
IDA
SceS000000821
GO:0031307 integral to mitochondrial outer
membrane
C
IDA
SceS000000821
GO:0004629 phospholipase C activity F
IDA
SceS000000821
GO:0009651 response to salt stress P
IMP
SceS000000821
GO:0030149 sphingolipid catabolic process P
IDA
SceS000000821
GO:0046513 ceramide biosynthetic process P
IMP
SceS000000821

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_5779

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga10036 ENSANGP00000011578
Ashbya gossypii (Ago) ago3873 AFR680W
Caenorhabditis elegans (Cel) cel16552 T27F6.6
(CE34214;
WBGene00012105)
Candida glabrata (Cgl) cgl1228 CAGL0E06556g
Cryptococcus neoformans (Cne) cne2591 181.m08794
Debaryomyces hansenii (Dha) dha4187 DEHA0E21417g
Drosophila melanogaster (Dme) dme7742 CG12034-PA
(FBgn0035421)
Takifugu rubripes (Fru) fru10388 SINFRUP00000150555
Gallus gallus (Gga) gga16414 ENSGALP00000001406
(SMPD2)
Homo sapiens (Hsa) hsa27585 ENSP00000258052
(SMPD2)
O60906
Kluyveromyces lactis (Kla) kla1287 KLLA0C02057g
Mus musculus (Mmu) mmu2063 ENSMUSP00000019965
(MGI:1278330)
O70572
Neurospora crassa (Ncr) ncr3143 NCU03243.2
Rattus norvegicus (Rno) rno18037 ENSRNOP00000000336
(RGD:619753)
Q9ET64
Saccharomyces cerevisiae (Sce) sce1732 YER019W
(S000000821)
Schizosaccharomyces pombe (Spo) spo4080 SPBC32F12.01c O74369
Yarrowia lipolytica (Yli) yli3475 YALI0D18458g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
ISO
MmuMGI:1278330
GO:0005739 mitochondrion C
IDA
SceS000000821
ISS
SpoSPBC32F12.01c
GO:0005783 endoplasmic reticulum C
IDA
SceS000000821
SpoSPBC32F12.01c
ISS
SpoSPBC32F12.01c
GO:0005886 plasma membrane C
IDA
SpoSPBC32F12.01c
GO:0005901 caveola C
ISO
MmuMGI:1278330
GO:0031307 integral to mitochondrial outer
membrane
C
IDA
SceS000000821
GO:0004629 phospholipase C activity F
IDA
SceS000000821
ISS
SpoSPBC32F12.01c
GO:0004767 sphingomyelin phosphodiesterase
activity
F
IMP
MmuMGI:1278330
ISO
MmuMGI:1278330
ISS
DmeFBgn0035421
NAS
DmeFBgn0035421
GO:0006684 sphingomyelin metabolic process P
ISS
DmeFBgn0035421
GO:0007243 intracellular protein kinase cascade P
ISO
MmuMGI:1278330
GO:0008152 metabolic process P
IMP
MmuMGI:1278330
GO:0009612 response to mechanical stimulus P
ISO
MmuMGI:1278330
GO:0009651 response to salt stress P
IMP
SceS000000821
GO:0030149 sphingolipid catabolic process P
IDA
SceS000000821
ISS
SpoSPBC32F12.01c
GO:0046513 ceramide biosynthetic process P
IMP
SceS000000821
ISO
MmuMGI:1278330
ISS
SpoSPBC32F12.01c
GO:0051278 fungal-type cell wall polysaccharide biosynthetic
process
P
IMP
SpoSPBC32F12.01c

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPBC32F12.01c
(O74369)
YER019W
(S000000821)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000000821
ISS
SpoSPBC32F12.01c
GO:0005783 endoplasmic reticulum C
IDA
SceS000000821
SpoSPBC32F12.01c
ISS
SpoSPBC32F12.01c
GO:0005886 plasma membrane C
IDA
SpoSPBC32F12.01c
GO:0031307 integral to mitochondrial outer
membrane
C
IDA
SceS000000821
GO:0004629 phospholipase C activity F
IDA
SceS000000821
ISS
SpoSPBC32F12.01c
GO:0009651 response to salt stress P
IMP
SceS000000821
GO:0030149 sphingolipid catabolic process P
IDA
SceS000000821
ISS
SpoSPBC32F12.01c
GO:0046513 ceramide biosynthetic process P
IMP
SceS000000821
ISS
SpoSPBC32F12.01c
GO:0051278 fungal-type cell wall polysaccharide biosynthetic
process
P
IMP
SpoSPBC32F12.01c

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GO info in one table:

s.khadayate@ucl.ac.uk