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Search term: YER116C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SLX8
SGD link S000000918
Alternative ID YER116C
Description Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain
Synonyms YER116C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2164 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Predicted E3 ubiquitin ligase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g26730 GI:15231612
Arabidopsis thaliana (Ath) At4g33940_1 GI:7485612
Caenorhabditis elegans (Cel) CE21607
(WBGene00012606)		 GI:17537047 Q9XWM0
Drosophila melanogaster (Dme) 7292099 GI:7292099 Q9W0D8
Homo sapiens (Hsa) Hs21361954 GI:14042657 Q96K19
Homo sapiens (Hsa) Hs7662653 GI:7662653
Homo sapiens (Hsa) HsM13569926 GI:13569926
Saccharomyces cerevisiae (Sce) YER116c
(S000000918)		 GI:6320962 P40072
Saccharomyces cerevisiae (Sce) YLR427w
(S000004419)		 GI:6323459 Q06436
Schizosaccharomyces pombe (Spo) SPBP8B7.23 GI:19113322 O94271


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
IDA
SceS000000918
GO:0005634 nucleus C
IDA
SceS000000918
SpoSPBP8B7.23
GO:0005737 cytoplasm C
IDA
SceS000004419
SpoSPBP8B7.23
GO:0005829 cytosol C
IDA
SpoSPBP8B7.23
GO:0003674 molecular_function F
ND
SceS000004419
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000000918
S000000918
GO:0005515 protein binding F
ISS
AthAt3g26730
GO:0008270 zinc ion binding F
ISS
AthAt4g33940
At3g26730
GO:0000723 telomere maintenance P
IMP
SceS000000918
GO:0006366 transcription from RNA polymerase II
promoter		 P
ISS
SpoSPBP8B7.23
GO:0006974 response to DNA damage stimulus P
IGI
SceS000000918
IMP
SceS000000918
GO:0008150 biological_process P
ND
AthAt3g26730
SceS000004419
GO:0010200 response to chitin P
IEP
AthAt4g33940
GO:0016567 protein ubiquitination P
IDA
SceS000000918
NAS
SpoSPBP8B7.23
GO:0016925 protein sumoylation P
IGI
SceS000000918
IMP
SceS000000918

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3727

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago4023 AGL289C
Arabidopsis thaliana (Ath) ath12808 At3g07200.1
Arabidopsis thaliana (Ath) ath26768 At5g48655.1
Arabidopsis thaliana (Ath) ath26769 At5g48655.2
Arabidopsis thaliana (Ath) ath26770 At5g48655.3
Candida glabrata (Cgl) cgl1779 CAGL0G03553g
Debaryomyces hansenii (Dha) dha1680 DEHA0C05610g
Drosophila melanogaster (Dme) dme11133 CG10981-PA
(FBgn0037384)
Drosophila melanogaster (Dme) dme11134 CG10981-PB
(FBgn0037384)
Takifugu rubripes (Fru) fru21252 SINFRUP00000146083
Homo sapiens (Hsa) hsa23817 ENSP00000315212
(RNF4)		 P78317
Kluyveromyces lactis (Kla) kla3264 KLLA0E07007g
Mus musculus (Mmu) mmu19966 ENSMUSP00000030992
(MGI:1201691)		 Q3ULB8
Oryza sativa (Osa) osa8395 2604.m00146
Oryza sativa (Osa) osa8410 2604.m00186
Oryza sativa (Osa) osa13013 2913.m00132
Oryza sativa (Osa) osa80123 8152.m00073
Rattus norvegicus (Rno) rno10581 ENSRNOP00000019555
(RGD:3583)		 O88846
Rattus norvegicus (Rno) rno10583 ENSRNOP00000019604
Rattus norvegicus (Rno) rno10582 ENSRNOP00000042071
Saccharomyces cerevisiae (Sce) sce1853 YER116C
(S000000918)
Schizosaccharomyces pombe (Spo) spo1959 SPAC343.18 Q9UT72
Schizosaccharomyces pombe (Spo) spo1448 SPBC3D6.11c P87176
Yarrowia lipolytica (Yli) yli750 YALI0B00110g
Yarrowia lipolytica (Yli) yli3147 YALI0D10615g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
IDA
SceS000000918
GO:0005634 nucleus C
IDA
MmuMGI:1201691
SceS000000918
SpoSPAC343.18
SPBC3D6.11c
ISO
MmuMGI:1201691
GO:0005737 cytoplasm C
IDA
MmuMGI:1201691
GO:0033768 SUMO-targeted ubiquitin ligase
complex		 C
IPI
SpoSPBC3D6.11c
SPAC343.18
GO:0003677 DNA binding F
ISO
MmuMGI:1201691
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000000918
S000000918
SpoSPBC3D6.11c
ISO
MmuMGI:1201691
GO:0005515 protein binding F
IPI
MmuMGI:1201691
SpoSPAC343.18
SPBC3D6.11c
ISS
AthAt5g48655
GO:0008134 transcription factor binding F
IPI
MmuMGI:1201691
GO:0008270 zinc ion binding F
ISO
MmuMGI:1201691
ISS
AthAt5g48655
SpoSPAC343.18
SPBC3D6.11c
GO:0031491 nucleosome binding F
ISO
MmuMGI:1201691
GO:0032184 SUMO polymer binding F
ISO
MmuMGI:1201691
GO:0042156 zinc-mediated transcriptional activator
activity		 F
ISO
MmuMGI:1201691
GO:0050681 androgen receptor binding F
ISO
MmuMGI:1201691
GO:0000077 DNA damage checkpoint P
IMP
SpoSPBC3D6.11c
GO:0000723 telomere maintenance P
IMP
SceS000000918
GO:0006281 DNA repair P
IGI
SpoSPAC343.18
GO:0006310 DNA recombination P
IGI
SpoSPBC3D6.11c
GO:0006974 response to DNA damage stimulus P
IGI
SceS000000918
SpoSPAC343.18
IMP
SceS000000918
GO:0007346 regulation of mitotic cell cycle P
IGI
SpoSPAC343.18
GO:0010200 response to chitin P
IEP
AthAt5g48655
GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IDA
MmuMGI:1201691
GO:0016567 protein ubiquitination P
IDA
SceS000000918
SpoSPBC3D6.11c
ISO
MmuMGI:1201691
NAS
SpoSPAC343.18
GO:0016925 protein sumoylation P
IGI
SceS000000918
IMP
SceS000000918
GO:0033234 negative regulation of protein
sumoylation		 P
IGI
SpoSPAC343.18
IMP
SpoSPAC343.18
SPBC3D6.11c
GO:0045893 positive regulation of transcription,
DNA-dependent		 P
ISO
MmuMGI:1201691
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter		 P
ISO
MmuMGI:1201691
GO:0051865 protein autoubiquitination P
ISO
MmuMGI:1201691
GO:0070534 protein K63-linked ubiquitination P
ISO
MmuMGI:1201691
GO:0070936 protein K48-linked ubiquitination P
ISO
MmuMGI:1201691
GO:0070979 protein K11-linked ubiquitination P
ISO
MmuMGI:1201691
GO:0085020 protein K6-linked ubiquitination P
ISO
MmuMGI:1201691

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC3D6.11c
(P87176)		 YER116C
(S000000918)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
IDA
SceS000000918
GO:0005634 nucleus C
IDA
SceS000000918
SpoSPBC3D6.11c
GO:0033768 SUMO-targeted ubiquitin ligase
complex		 C
IPI
SpoSPBC3D6.11c
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000000918
S000000918
SpoSPBC3D6.11c
GO:0005515 protein binding F
IPI
SpoSPBC3D6.11c
GO:0008270 zinc ion binding F
ISS
SpoSPBC3D6.11c
GO:0000077 DNA damage checkpoint P
IMP
SpoSPBC3D6.11c
GO:0000723 telomere maintenance P
IMP
SceS000000918
GO:0006310 DNA recombination P
IGI
SpoSPBC3D6.11c
GO:0006974 response to DNA damage stimulus P
IGI
SceS000000918
IMP
SceS000000918
GO:0016567 protein ubiquitination P
IDA
SceS000000918
SpoSPBC3D6.11c
GO:0016925 protein sumoylation P
IGI
SceS000000918
IMP
SceS000000918
GO:0033234 negative regulation of protein
sumoylation		 P
IMP
SpoSPBC3D6.11c

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