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Search term: YER123W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name YCK3
SGD link S000000925
Alternative ID YER123W
Description Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway
Synonyms YER123W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1165 -CDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Casein kinase (serine/threonine/tyrosine protein kinase)

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE29604
(WBGene00013709)		 GI:17510861 Q8WQ99
Drosophila melanogaster (Dme) 7300125 GI:17864624
Homo sapiens (Hsa) Hs11545751 GI:11545751
Homo sapiens (Hsa) Hs21314778 GI:18088090 P78368
Homo sapiens (Hsa) Hs4758080 GI:4758080
Homo sapiens (Hsa) HsM5579454 GI:5579454
Saccharomyces cerevisiae (Sce) YER123w
(S000000925)		 GI:7276233 P39962
Saccharomyces cerevisiae (Sce) YHR135c
(S000001177)		 GI:6321927 P23291
Saccharomyces cerevisiae (Sce) YNL154c
(S000005098)		 GI:6324175 P23292
Schizosaccharomyces pombe (Spo) SPAC1805.05 GI:19114828 O74135
Schizosaccharomyces pombe (Spo) SPBC1347.06c GI:19113490 P40233
Schizosaccharomyces pombe (Spo) SPBP35G2.05c GI:19112172 P40234
Caenorhabditis elegans (Cel) CE29604
(WBGene00013709)		 GI:17510861 Q8WQ99
Drosophila melanogaster (Dme) 7300125 GI:17864624
Homo sapiens (Hsa) Hs11545751 GI:11545751
Homo sapiens (Hsa) Hs21314778 GI:18088090 P78368
Homo sapiens (Hsa) Hs4758080 GI:4758080
Homo sapiens (Hsa) HsM5579454 GI:5579454
Saccharomyces cerevisiae (Sce) YER123w
(S000000925)		 GI:7276233 P39962
Saccharomyces cerevisiae (Sce) YHR135c
(S000001177)		 GI:6321927 P23291
Saccharomyces cerevisiae (Sce) YNL154c
(S000005098)		 GI:6324175 P23292
Schizosaccharomyces pombe (Spo) SPAC1805.05 GI:19114828 O74135
Schizosaccharomyces pombe (Spo) SPBC1347.06c GI:19113490 P40233
Schizosaccharomyces pombe (Spo) SPBP35G2.05c GI:19112172 P40234


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000000925
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000000925
SpoSPBP35G2.05c
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000005098
S000001177
GO:0005575 cellular_component C
ND
SpoSPAC1805.05
SPBC1347.06c
GO:0005634 nucleus C
IDA
SceS000000925
GO:0005737 cytoplasm C
IDA
SpoSPBP35G2.05c
GO:0005739 mitochondrion C
IDA
SceS000001177
GO:0005783 endoplasmic reticulum C
IDA
SceS000001177
GO:0005886 plasma membrane C
IDA
SceS000000925
S000005098
S000001177
GO:0005935 cellular bud neck C
IDA
SceS000005098
GO:0005937 mating projection C
IDA
SceS000005098
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SceS000005098
S000001177
ISS
SceS000000925
SpoSPAC1805.05
SPBC1347.06c
TAS
SpoSPBC1347.06c
SPAC1805.05
SPBP35G2.05c
GO:0005524 ATP binding F
ISS
SpoSPBC1347.06c
SPAC1805.05
SPBP35G2.05c
GO:0000003 reproduction P
IMP
CelWBGene00013709
GO:0000902 cell morphogenesis P
IGI
SceS000001177
S000005098
GO:0000910 cytokinesis P
IGI
SceS000005098
S000001177
GO:0002119 nematode larval development P
IMP
CelWBGene00013709
GO:0006468 protein amino acid phosphorylation P
IMP
SceS000001177
S000005098
ISS
SceS000001177
S000005098
S000000925
SpoSPAC1805.05
SPBC1347.06c
TAS
SpoSPBP35G2.05c
GO:0006897 endocytosis P
IGI
SceS000001177
S000005098
GO:0007165 signal transduction P
NAS
SpoSPAC1805.05
SPBC1347.06c
SPBP35G2.05c
GO:0008360 regulation of cell shape P
IMP
SpoSPBP35G2.05c
GO:0009749 response to glucose stimulus P
IMP
SceS000005098
S000001177
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013709
GO:0010171 body morphogenesis P
IMP
CelWBGene00013709
GO:0016192 vesicle-mediated transport P
IMP
SceS000000925
GO:0018991 oviposition P
IMP
CelWBGene00013709
GO:0030100 regulation of endocytosis P
ISS
SpoSPAC1805.05
SPBC1347.06c
SPBP35G2.05c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013709
GO:0040011 locomotion P
IMP
CelWBGene00013709
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00013709
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00013709
GO:0090215 regulation of 1-phosphatidylinositol-4-phosphate
5-kinase activity		 P
IMP
SpoSPBC1347.06c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
74665

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) YCK3
(S000000925)		 GI:7276233 P39962
Kluyveromyces lactis (Kla) KLLA0E13563g GI:50309109
Eremothecium gossypii (Ego) AGOS_ADL053C GI:45187820


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000000925
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000000925
GO:0005634 nucleus C
IDA
SceS000000925
GO:0005886 plasma membrane C
IDA
SceS000000925
GO:0004674 protein serine/threonine kinase
activity		 F
ISS
SceS000000925
GO:0006468 protein amino acid phosphorylation P
ISS
SceS000000925
GO:0016192 vesicle-mediated transport P
IMP
SceS000000925

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_31679

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago1688 ADL053C
Candida glabrata (Cgl) cgl3620 CAGL0K02299g
Kluyveromyces lactis (Kla) kla3559 KLLA0E13563g
Saccharomyces cerevisiae (Sce) sce1861 YER123W
(S000000925)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000000925
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000000925
GO:0005634 nucleus C
IDA
SceS000000925
GO:0005886 plasma membrane C
IDA
SceS000000925
GO:0004674 protein serine/threonine kinase
activity		 F
ISS
SceS000000925
GO:0006468 protein amino acid phosphorylation P
ISS
SceS000000925
GO:0016192 vesicle-mediated transport P
IMP
SceS000000925

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC1805.05
(O74135)		 YER123W
(S000000925)
SPBP35G2.05c
(P40234)		 YER123W
(S000000925)
SPBC1347.06c
(P40233)		 YER123W
(S000000925)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000000925
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000000925
SpoSPBP35G2.05c
GO:0005575 cellular_component C
ND
SpoSPAC1805.05
SPBC1347.06c
GO:0005634 nucleus C
IDA
SceS000000925
GO:0005737 cytoplasm C
IDA
SpoSPBP35G2.05c
GO:0005886 plasma membrane C
IDA
SceS000000925
GO:0004674 protein serine/threonine kinase
activity		 F
ISS
SceS000000925
SpoSPAC1805.05
SPBC1347.06c
TAS
SpoSPBC1347.06c
SPAC1805.05
SPBP35G2.05c
GO:0005524 ATP binding F
ISS
SpoSPBC1347.06c
SPAC1805.05
SPBP35G2.05c
GO:0006468 protein amino acid phosphorylation P
ISS
SceS000000925
SpoSPAC1805.05
SPBC1347.06c
TAS
SpoSPBP35G2.05c
GO:0007165 signal transduction P
NAS
SpoSPAC1805.05
SPBC1347.06c
SPBP35G2.05c
GO:0008360 regulation of cell shape P
IMP
SpoSPBP35G2.05c
GO:0016192 vesicle-mediated transport P
IMP
SceS000000925
GO:0030100 regulation of endocytosis P
ISS
SpoSPAC1805.05
SPBC1347.06c
SPBP35G2.05c
GO:0090215 regulation of 1-phosphatidylinositol-4-phosphate
5-kinase activity		 P
IMP
SpoSPBC1347.06c

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s.khadayate@ucl.ac.uk