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Search term: YER125W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RSP5
SGD link S000000927
Alternative ID YER125W
Description E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes, including MVB sorting, heat shock response, transcription, and endocytosis; the human homolog is invovled in Liddle syndrome
Synonyms YER125W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0940 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Ubiquitin protein ligase RSP5/NEDD4

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g12570 GI:15235410
Caenorhabditis elegans (Cel) CE01588
(WBGene00009738)		 GI:17553480
Caenorhabditis elegans (Cel) CE03201 GI:17551664
Caenorhabditis elegans (Cel) CE25540 GI:17510413
Caenorhabditis elegans (Cel) CE27342 GI:17510679
Drosophila melanogaster (Dme) 7291074 GI:7291074
Drosophila melanogaster (Dme) 7291075 GI:7291075
Drosophila melanogaster (Dme) 7291734 GI:7291734
Drosophila melanogaster (Dme) 7293969 GI:7293969
Drosophila melanogaster (Dme) 7296014
(FBgn0003557)		 GI:17136524 B7YZY9
Drosophila melanogaster (Dme) 7299916 GI:7299916
Drosophila melanogaster (Dme) 7302746 GI:7302746
Homo sapiens (Hsa) Hs12232397
(SMURF2)		 GI:12232397 Q96DE7
Homo sapiens (Hsa) Hs13346498
(WWTR1)		 GI:13346498 Q9GZV5
Homo sapiens (Hsa) Hs13654239
(WWP1)		 GI:13654239 Q9H0M0
Homo sapiens (Hsa) Hs14043024_1
(BAG3)		 GI:14043024 O95817
Homo sapiens (Hsa) Hs14730213 GI:14730213
Homo sapiens (Hsa) Hs17486626 GI:17486626
Homo sapiens (Hsa) Hs18562439_2 GI:18562439
Homo sapiens (Hsa) Hs18860880 GI:18860880
Homo sapiens (Hsa) Hs18860882 GI:18860882
Homo sapiens (Hsa) Hs18860884 GI:18860884 Q12953
Homo sapiens (Hsa) Hs18860886 GI:18860886
Homo sapiens (Hsa) Hs18860888 GI:18860888 Q12953
Homo sapiens (Hsa) Hs19923493_1
(PLEKHA5)		 GI:19923493 Q9HAU0
Homo sapiens (Hsa) Hs20473078 GI:20473078
Homo sapiens (Hsa) Hs20539203 GI:20539203
Homo sapiens (Hsa) Hs20550102 GI:20550102
Homo sapiens (Hsa) Hs21361472 GI:15824269 Q9H2W4
Homo sapiens (Hsa) Hs21361973 GI:15079474 Q96J02
Homo sapiens (Hsa) Hs22061327 GI:22061327
Homo sapiens (Hsa) Hs22062809 GI:22062809
Homo sapiens (Hsa) Hs22065850 GI:22065850
Homo sapiens (Hsa) Hs22067492 GI:15489060 O00308
Homo sapiens (Hsa) Hs5174751 GI:5174751 P46937
Homo sapiens (Hsa) Hs5360212_1 GI:5360212
Homo sapiens (Hsa) Hs5902156 GI:5902156
Homo sapiens (Hsa) HsM14010859 GI:14010859
Homo sapiens (Hsa) HsM14719404 GI:14719404
Saccharomyces cerevisiae (Sce) YER125w
(S000000927)		 GI:6320972 P39940
Schizosaccharomyces pombe (Spo) SPAC11G7.02 GI:19115308 Q92462
Schizosaccharomyces pombe (Spo) SPAC1805.15c GI:19114838 Q9UTG2
Schizosaccharomyces pombe (Spo) SPBC16E9.11c GI:19112585 O14326
Arabidopsis thaliana (Ath) At4g12570 GI:15235410
Caenorhabditis elegans (Cel) CE01588
(WBGene00009738)		 GI:17553480
Caenorhabditis elegans (Cel) CE03201 GI:17551664
Caenorhabditis elegans (Cel) CE25540 GI:17510413
Caenorhabditis elegans (Cel) CE27342 GI:17510679
Drosophila melanogaster (Dme) 7291074 GI:7291074
Drosophila melanogaster (Dme) 7291075 GI:7291075
Drosophila melanogaster (Dme) 7291734 GI:7291734
Drosophila melanogaster (Dme) 7293969 GI:7293969
Drosophila melanogaster (Dme) 7296014
(FBgn0003557)		 GI:17136524 B7YZY9
Drosophila melanogaster (Dme) 7299916 GI:7299916
Drosophila melanogaster (Dme) 7302746 GI:7302746
Homo sapiens (Hsa) Hs12232397
(SMURF2)		 GI:12232397 Q96DE7
Homo sapiens (Hsa) Hs13346498
(WWTR1)		 GI:13346498 Q9GZV5
Homo sapiens (Hsa) Hs13654239
(WWP1)		 GI:13654239 Q9H0M0
Homo sapiens (Hsa) Hs14043024_1
(BAG3)		 GI:14043024 O95817
Homo sapiens (Hsa) Hs14730213 GI:14730213
Homo sapiens (Hsa) Hs17486626 GI:17486626
Homo sapiens (Hsa) Hs18562439_2 GI:18562439
Homo sapiens (Hsa) Hs18860880 GI:18860880
Homo sapiens (Hsa) Hs18860882 GI:18860882
Homo sapiens (Hsa) Hs18860884 GI:18860884 Q12953
Homo sapiens (Hsa) Hs18860886 GI:18860886
Homo sapiens (Hsa) Hs18860888 GI:18860888 Q12953
Homo sapiens (Hsa) Hs19923493_1
(PLEKHA5)		 GI:19923493 Q9HAU0
Homo sapiens (Hsa) Hs20473078 GI:20473078
Homo sapiens (Hsa) Hs20539203 GI:20539203
Homo sapiens (Hsa) Hs20550102 GI:20550102
Homo sapiens (Hsa) Hs21361472 GI:15824269 Q9H2W4
Homo sapiens (Hsa) Hs21361973 GI:15079474 Q96J02
Homo sapiens (Hsa) Hs22061327 GI:22061327
Homo sapiens (Hsa) Hs22062809 GI:22062809
Homo sapiens (Hsa) Hs22065850 GI:22065850
Homo sapiens (Hsa) Hs22067492 GI:15489060 O00308
Homo sapiens (Hsa) Hs5174751 GI:5174751 P46937
Homo sapiens (Hsa) Hs5360212_1 GI:5360212
Homo sapiens (Hsa) Hs5902156 GI:5902156
Homo sapiens (Hsa) HsM14010859 GI:14010859
Homo sapiens (Hsa) HsM14719404 GI:14719404
Saccharomyces cerevisiae (Sce) YER125w
(S000000927)		 GI:6320972 P39940
Schizosaccharomyces pombe (Spo) SPAC11G7.02 GI:19115308 Q92462
Schizosaccharomyces pombe (Spo) SPAC1805.15c GI:19114838 Q9UTG2
Schizosaccharomyces pombe (Spo) SPBC16E9.11c GI:19112585 O14326


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
IDA
HsaSMURF2
IPI
SceS000000927
NAS
HsaWWP1
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000000927
GO:0005575 cellular_component C
ND
HsaPLEKHA5
SpoSPBC16E9.11c
GO:0005634 nucleus C
IDA
HsaWWTR1
SceS000000927
SpoSPAC1805.15c
NAS
HsaWWTR1
SMURF2
GO:0005737 cytoplasm C
IDA
AthAt4g12570
HsaWWTR1
SceS000000927
SpoSPAC11G7.02
SPAC1805.15c
GO:0005739 mitochondrion C
IDA
SceS000000927
GO:0005794 Golgi apparatus C
IDA
SceS000000927
SpoSPAC11G7.02
GO:0005829 cytosol C
IDA
HsaBAG3
SpoSPAC1805.15c
GO:0005934 cellular bud tip C
IDA
SceS000000927
GO:0010008 endosome membrane C
IDA
SceS000000927
GO:0031234 extrinsic to internal side of plasma
membrane		 C
IDA
SceS000000927
GO:0051285 cell cortex of cell tip C
IDA
SpoSPAC1805.15c
GO:0003713 transcription coactivator activity F
IDA
HsaWWTR1
NAS
HsaWWTR1
GO:0004842 ubiquitin-protein ligase activity F
IDA
AthAt4g12570
HsaSMURF2
SceS000000927
IGI
SpoSPAC1805.15c
IMP
SceS000000927
SpoSPAC11G7.02
ISS
AthAt4g12570
DmeFBgn0003557
SpoSPBC16E9.11c
NAS
DmeFBgn0003557
TAS
HsaWWP1
GO:0005112 Notch binding F
IPI
DmeFBgn0003557
GO:0005515 protein binding F
IPI
HsaPLEKHA5
WWTR1
SMURF2
WWP1
GO:0005543 phospholipid binding F
ISS
SpoSPAC11G7.02
SPBC16E9.11c
GO:0005545 phosphatidylinositol binding F
NAS
HsaPLEKHA5
GO:0035091 phosphoinositide binding F
IDA
SceS000000927
GO:0042802 identical protein binding F
IPI
HsaSMURF2
GO:0043130 ubiquitin binding F
IDA
SceS000000927
GO:0046332 SMAD binding F
IPI
HsaSMURF2
GO:0000055 ribosomal large subunit export from
nucleus		 P
IMP
SceS000000927
GO:0000209 protein polyubiquitination P
IDA
SceS000000927
IMP
SceS000000927
GO:0006333 chromatin assembly or disassembly P
IMP
SceS000000927
GO:0006355 regulation of transcription, DNA-dependent P
NAS
HsaWWTR1
GO:0006364 rRNA processing P
IMP
SceS000000927
GO:0006409 tRNA export from nucleus P
IMP
SceS000000927
GO:0006457 protein folding P
NAS
HsaBAG3
GO:0006464 protein modification process P
ISS
AthAt4g12570
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IC
SpoSPBC16E9.11c
IDA
HsaSMURF2
IGI
SpoSPAC11G7.02
GO:0006513 protein monoubiquitination P
IDA
SceS000000927
IGI
SceS000000927
IMP
SceS000000927
GO:0006808 regulation of nitrogen utilization P
IGI
SceS000000927
GO:0006916 anti-apoptosis P
NAS
HsaBAG3
GO:0007005 mitochondrion organization P
IGI
SceS000000927
IMP
SceS000000927
GO:0007165 signal transduction P
NAS
HsaWWP1
GO:0007219 Notch signaling pathway P
IGI
DmeFBgn0003557
GO:0007417 central nervous system development P
NAS
HsaWWP1
GO:0008033 tRNA processing P
IMP
SceS000000927
GO:0008150 biological_process P
ND
HsaPLEKHA5
GO:0008284 positive regulation of cell proliferation P
IDA
HsaWWTR1
GO:0008586 imaginal disc-derived wing vein
morphogenesis		 P
IGI
DmeFBgn0003557
IMP
DmeFBgn0003557
GO:0008587 imaginal disc-derived wing margin
morphogenesis		 P
IGI
Dme