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Search term: YER125W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RSP5
SGD link S000000927
Alternative ID YER125W
Description E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes, including MVB sorting, heat shock response, transcription, and endocytosis; the human homolog is invovled in Liddle syndrome
Synonyms YER125W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0940 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Ubiquitin protein ligase RSP5/NEDD4

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g12570 GI:15235410
Caenorhabditis elegans (Cel) CE01588
(WBGene00009738)		 GI:17553480
Caenorhabditis elegans (Cel) CE03201 GI:17551664
Caenorhabditis elegans (Cel) CE25540 GI:17510413
Caenorhabditis elegans (Cel) CE27342 GI:17510679
Drosophila melanogaster (Dme) 7291074 GI:7291074
Drosophila melanogaster (Dme) 7291075 GI:7291075
Drosophila melanogaster (Dme) 7291734 GI:7291734
Drosophila melanogaster (Dme) 7293969 GI:7293969
Drosophila melanogaster (Dme) 7296014
(FBgn0003557)		 GI:17136524 B7YZY9
Drosophila melanogaster (Dme) 7299916 GI:7299916
Drosophila melanogaster (Dme) 7302746 GI:7302746
Homo sapiens (Hsa) Hs12232397
(SMURF2)		 GI:12232397 Q96DE7
Homo sapiens (Hsa) Hs13346498
(WWTR1)		 GI:13346498 Q9GZV5
Homo sapiens (Hsa) Hs13654239
(WWP1)		 GI:13654239 Q9H0M0
Homo sapiens (Hsa) Hs14043024_1
(BAG3)		 GI:14043024 O95817
Homo sapiens (Hsa) Hs14730213 GI:14730213
Homo sapiens (Hsa) Hs17486626 GI:17486626
Homo sapiens (Hsa) Hs18562439_2 GI:18562439
Homo sapiens (Hsa) Hs18860880 GI:18860880
Homo sapiens (Hsa) Hs18860882 GI:18860882
Homo sapiens (Hsa) Hs18860884 GI:18860884 Q12953
Homo sapiens (Hsa) Hs18860886 GI:18860886
Homo sapiens (Hsa) Hs18860888 GI:18860888 Q12953
Homo sapiens (Hsa) Hs19923493_1
(PLEKHA5)		 GI:19923493 Q9HAU0
Homo sapiens (Hsa) Hs20473078 GI:20473078
Homo sapiens (Hsa) Hs20539203 GI:20539203
Homo sapiens (Hsa) Hs20550102 GI:20550102
Homo sapiens (Hsa) Hs21361472 GI:15824269 Q9H2W4
Homo sapiens (Hsa) Hs21361973 GI:15079474 Q96J02
Homo sapiens (Hsa) Hs22061327 GI:22061327
Homo sapiens (Hsa) Hs22062809 GI:22062809
Homo sapiens (Hsa) Hs22065850 GI:22065850
Homo sapiens (Hsa) Hs22067492 GI:15489060 O00308
Homo sapiens (Hsa) Hs5174751 GI:5174751 P46937
Homo sapiens (Hsa) Hs5360212_1 GI:5360212
Homo sapiens (Hsa) Hs5902156 GI:5902156
Homo sapiens (Hsa) HsM14010859 GI:14010859
Homo sapiens (Hsa) HsM14719404 GI:14719404
Saccharomyces cerevisiae (Sce) YER125w
(S000000927)		 GI:6320972 P39940
Schizosaccharomyces pombe (Spo) SPAC11G7.02 GI:19115308 Q92462
Schizosaccharomyces pombe (Spo) SPAC1805.15c GI:19114838 Q9UTG2
Schizosaccharomyces pombe (Spo) SPBC16E9.11c GI:19112585 O14326
Arabidopsis thaliana (Ath) At4g12570 GI:15235410
Caenorhabditis elegans (Cel) CE01588
(WBGene00009738)		 GI:17553480
Caenorhabditis elegans (Cel) CE03201 GI:17551664
Caenorhabditis elegans (Cel) CE25540 GI:17510413
Caenorhabditis elegans (Cel) CE27342 GI:17510679
Drosophila melanogaster (Dme) 7291074 GI:7291074
Drosophila melanogaster (Dme) 7291075 GI:7291075
Drosophila melanogaster (Dme) 7291734 GI:7291734
Drosophila melanogaster (Dme) 7293969 GI:7293969
Drosophila melanogaster (Dme) 7296014
(FBgn0003557)		 GI:17136524 B7YZY9
Drosophila melanogaster (Dme) 7299916 GI:7299916
Drosophila melanogaster (Dme) 7302746 GI:7302746
Homo sapiens (Hsa) Hs12232397
(SMURF2)		 GI:12232397 Q96DE7
Homo sapiens (Hsa) Hs13346498
(WWTR1)		 GI:13346498 Q9GZV5
Homo sapiens (Hsa) Hs13654239
(WWP1)		 GI:13654239 Q9H0M0
Homo sapiens (Hsa) Hs14043024_1
(BAG3)		 GI:14043024 O95817
Homo sapiens (Hsa) Hs14730213 GI:14730213
Homo sapiens (Hsa) Hs17486626 GI:17486626
Homo sapiens (Hsa) Hs18562439_2 GI:18562439
Homo sapiens (Hsa) Hs18860880 GI:18860880
Homo sapiens (Hsa) Hs18860882 GI:18860882
Homo sapiens (Hsa) Hs18860884 GI:18860884 Q12953
Homo sapiens (Hsa) Hs18860886 GI:18860886
Homo sapiens (Hsa) Hs18860888 GI:18860888 Q12953
Homo sapiens (Hsa) Hs19923493_1
(PLEKHA5)		 GI:19923493 Q9HAU0
Homo sapiens (Hsa) Hs20473078 GI:20473078
Homo sapiens (Hsa) Hs20539203 GI:20539203
Homo sapiens (Hsa) Hs20550102 GI:20550102
Homo sapiens (Hsa) Hs21361472 GI:15824269 Q9H2W4
Homo sapiens (Hsa) Hs21361973 GI:15079474 Q96J02
Homo sapiens (Hsa) Hs22061327 GI:22061327
Homo sapiens (Hsa) Hs22062809 GI:22062809
Homo sapiens (Hsa) Hs22065850 GI:22065850
Homo sapiens (Hsa) Hs22067492 GI:15489060 O00308
Homo sapiens (Hsa) Hs5174751 GI:5174751 P46937
Homo sapiens (Hsa) Hs5360212_1 GI:5360212
Homo sapiens (Hsa) Hs5902156 GI:5902156
Homo sapiens (Hsa) HsM14010859 GI:14010859
Homo sapiens (Hsa) HsM14719404 GI:14719404
Saccharomyces cerevisiae (Sce) YER125w
(S000000927)		 GI:6320972 P39940
Schizosaccharomyces pombe (Spo) SPAC11G7.02 GI:19115308 Q92462
Schizosaccharomyces pombe (Spo) SPAC1805.15c GI:19114838 Q9UTG2
Schizosaccharomyces pombe (Spo) SPBC16E9.11c GI:19112585 O14326


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
IDA
HsaSMURF2
IPI
SceS000000927
NAS
HsaWWP1
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000000927
GO:0005575 cellular_component C
ND
HsaPLEKHA5
SpoSPBC16E9.11c
GO:0005634 nucleus C
IDA
HsaWWTR1
SceS000000927
SpoSPAC1805.15c
NAS
HsaWWTR1
SMURF2
GO:0005737 cytoplasm C
IDA
AthAt4g12570
HsaWWTR1
SceS000000927
SpoSPAC11G7.02
SPAC1805.15c
GO:0005739 mitochondrion C
IDA
SceS000000927
GO:0005794 Golgi apparatus C
IDA
SceS000000927
SpoSPAC11G7.02
GO:0005829 cytosol C
IDA
HsaBAG3
SpoSPAC1805.15c
GO:0005934 cellular bud tip C
IDA
SceS000000927
GO:0010008 endosome membrane C
IDA
SceS000000927
GO:0031234 extrinsic to internal side of plasma
membrane		 C
IDA
SceS000000927
GO:0051285 cell cortex of cell tip C
IDA
SpoSPAC1805.15c
GO:0003713 transcription coactivator activity F
IDA
HsaWWTR1
NAS
HsaWWTR1
GO:0004842 ubiquitin-protein ligase activity F
IDA
AthAt4g12570
HsaSMURF2
SceS000000927
IGI
SpoSPAC1805.15c
IMP
SceS000000927
SpoSPAC11G7.02
ISS
AthAt4g12570
DmeFBgn0003557
SpoSPBC16E9.11c
NAS
DmeFBgn0003557
TAS
HsaWWP1
GO:0005112 Notch binding F
IPI
DmeFBgn0003557
GO:0005515 protein binding F
IPI
HsaPLEKHA5
WWTR1
SMURF2
WWP1
GO:0005543 phospholipid binding F
ISS
SpoSPAC11G7.02
SPBC16E9.11c
GO:0005545 phosphatidylinositol binding F
NAS
HsaPLEKHA5
GO:0035091 phosphoinositide binding F
IDA
SceS000000927
GO:0042802 identical protein binding F
IPI
HsaSMURF2
GO:0043130 ubiquitin binding F
IDA
SceS000000927
GO:0046332 SMAD binding F
IPI
HsaSMURF2
GO:0000055 ribosomal large subunit export from
nucleus		 P
IMP
SceS000000927
GO:0000209 protein polyubiquitination P
IDA
SceS000000927
IMP
SceS000000927
GO:0006333 chromatin assembly or disassembly P
IMP
SceS000000927
GO:0006355 regulation of transcription, DNA-dependent P
NAS
HsaWWTR1
GO:0006364 rRNA processing P
IMP
SceS000000927
GO:0006409 tRNA export from nucleus P
IMP
SceS000000927
GO:0006457 protein folding P
NAS
HsaBAG3
GO:0006464 protein modification process P
ISS
AthAt4g12570
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IC
SpoSPBC16E9.11c
IDA
HsaSMURF2
IGI
SpoSPAC11G7.02
GO:0006513 protein monoubiquitination P
IDA
SceS000000927
IGI
SceS000000927
IMP
SceS000000927
GO:0006808 regulation of nitrogen utilization P
IGI
SceS000000927
GO:0006916 anti-apoptosis P
NAS
HsaBAG3
GO:0007005 mitochondrion organization P
IGI
SceS000000927
IMP
SceS000000927
GO:0007165 signal transduction P
NAS
HsaWWP1
GO:0007219 Notch signaling pathway P
IGI
DmeFBgn0003557
GO:0007417 central nervous system development P
NAS
HsaWWP1
GO:0008033 tRNA processing P
IMP
SceS000000927
GO:0008150 biological_process P
ND
HsaPLEKHA5
GO:0008284 positive regulation of cell proliferation P
IDA
HsaWWTR1
GO:0008586 imaginal disc-derived wing vein
morphogenesis		 P
IGI
DmeFBgn0003557
IMP
DmeFBgn0003557
GO:0008587 imaginal disc-derived wing margin
morphogenesis		 P
IGI
DmeFBgn0003557
GO:0010150 leaf senescence P
IMP
AthAt4g12570
GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IMP
SceS000000927
GO:0010718 positive regulation of epithelial to mesenchymal
transition		 P
IDA
HsaWWTR1
GO:0010793 regulation of mRNA export from
nucleus		 P
IPI
SceS000000927
GO:0010794 regulation of dolichol biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0010795 regulation of ubiquinone biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0010796 regulation of multivesicular body
size		 P
IMP
SceS000000927
GO:0016348 imaginal disc-derived leg joint
morphogenesis		 P
IGI
DmeFBgn0003557
GO:0016481 negative regulation of transcription P
ISS
HsaWWP1
NAS
HsaSMURF2
GO:0016567 protein ubiquitination P
IC
SpoSPAC11G7.02
NAS
SpoSPAC1805.15c
SPBC16E9.11c
TAS
HsaWWP1
GO:0017015 regulation of transforming growth factor beta
receptor signaling pathway		 P
NAS
HsaSMURF2
GO:0017145 stem cell division P
IDA
HsaWWTR1
GO:0019220 regulation of phosphate metabolic
process		 P
IGI
SceS000000927
GO:0019915 lipid storage P
IDA
DmeFBgn0003557
GO:0030509 BMP signaling pathway P
EXP
HsaSMURF2
GO:0030579 ubiquitin-dependent SMAD protein catabolic
process		 P
IDA
HsaSMURF2
GO:0031623 receptor internalization P
IMP
DmeFBgn0003557
GO:0032443 regulation of ergosterol biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0032511 late endosome to vacuole transport via
multivesicular body sorting pathway		 P
IMP
SceS000000927
IPI
SceS000000927
GO:0032880 regulation of protein localization P
IMP
DmeFBgn0003557
SceS000000927
IPI
SceS000000927
GO:0032956 regulation of actin cytoskeleton
organization		 P
IGI
SceS000000927
GO:0034517 ribophagy P
IGI
SceS000000927
GO:0034644 cellular response to UV P
IMP
SceS000000927
GO:0034762 regulation of transmembrane transport P
IMP
SpoSPAC11G7.02
GO:0035329 hippo signaling cascade P
IDA
HsaWWTR1
GO:0042493 response to drug P
IMP
SceS000000927
IPI
SceS000000927
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000927
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IPI
SceS000000927
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SceS000000927
GO:0045723 positive regulation of fatty acid biosynthetic
process		 P
IMP
SceS000000927
GO:0045746 negative regulation of Notch signaling
pathway		 P
IMP
DmeFBgn0003557
GO:0045807 positive regulation of endocytosis P
IMP
SceS000000927
GO:0046718 entry of virus into host cell P
TAS
HsaWWP1
GO:0048260 positive regulation of receptor-mediated
endocytosis		 P
IMP
SceS000000927
GO:0051453 regulation of intracellular pH P
IGI
SpoSPAC11G7.02
GO:0051726 regulation of cell cycle P
IGI
SpoSPAC11G7.02
GO:0060360 negative regulation of leucine import in response
to ammonium ion		 P
IMP
SpoSPAC11G7.02
GO:0060390 regulation of SMAD protein nuclear
translocation		 P
IDA
HsaWWTR1
GO:0070086 ubiquitin-dependent endocytosis P
IMP
SceS000000927

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
86986

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) NEDD4L GI:222352086
Pan troglodytes (Ptr) NEDD4L GI:114673301
Canis familiaris (Cfa) NEDD4L GI:73945946
Mus musculus (Mmu) Nedd4l
(MGI:1933754)		 GI:14010861 Q3TQK9
Rattus norvegicus (Rno) Nedd4l
(RGD:735047)		 GI:109506712
Gallus gallus (Gga) NEDD4L GI:118103503
Anopheles gambiae (Aga) AgaP_AGAP003133 GI:158291295
Schizosaccharomyces pombe (Spo) pub1
(SPAC11G7.02)		 GI:19115308 Q92462
Saccharomyces cerevisiae (Sce) RSP5
(S000000927)		 GI:6320972 P39940
Kluyveromyces lactis (Kla) KLLA0E13607g GI:50309113
Eremothecium gossypii (Ego) AGOS_ADL055C GI:45187818
Magnaporthe grisea (Mgr) MGG_07255 GI:145612617
Neurospora crassa (Ncr) NCU03947.1 GI:32405306


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
IPI
SceS000000927
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000000927
GO:0005622 intracellular C
IC
HsaNEDD4L
GO:0005634 nucleus C
IDA
SceS000000927
GO:0005737 cytoplasm C
IDA
SceS000000927
SpoSPAC11G7.02
GO:0005739 mitochondrion C
IDA
SceS000000927
GO:0005794 Golgi apparatus C
IDA
SceS000000927
SpoSPAC11G7.02
GO:0005934 cellular bud tip C
IDA
SceS000000927
GO:0010008 endosome membrane C
IDA
SceS000000927
GO:0031234 extrinsic to internal side of plasma
membrane		 C
IDA
SceS000000927
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000000927
IMP
SceS000000927
SpoSPAC11G7.02
NAS
HsaNEDD4L
GO:0005515 protein binding F
IPI
HsaNEDD4L
MmuMGI:1933754
GO:0005543 phospholipid binding F
ISS
SpoSPAC11G7.02
GO:0017080 sodium channel regulator activity F
IDA
HsaNEDD4L
GO:0019871 sodium channel inhibitor activity F
IDA
MmuMGI:1933754
GO:0035091 phosphoinositide binding F
IDA
SceS000000927
GO:0043130 ubiquitin binding F
IDA
SceS000000927
GO:0000055 ribosomal large subunit export from
nucleus		 P
IMP
SceS000000927
GO:0000209 protein polyubiquitination P
IDA
SceS000000927
IMP
SceS000000927
GO:0006333 chromatin assembly or disassembly P
IMP
SceS000000927
GO:0006364 rRNA processing P
IMP
SceS000000927
GO:0006409 tRNA export from nucleus P
IMP
SceS000000927
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IGI
SpoSPAC11G7.02
GO:0006513 protein monoubiquitination P
IDA
SceS000000927
IGI
SceS000000927
IMP
SceS000000927
GO:0006808 regulation of nitrogen utilization P
IGI
SceS000000927
GO:0006814 sodium ion transport P
NAS
HsaNEDD4L
GO:0006883 cellular sodium ion homeostasis P
NAS
HsaNEDD4L
GO:0007005 mitochondrion organization P
IGI
SceS000000927
IMP
SceS000000927
GO:0007588 excretion P
NAS
HsaNEDD4L
GO:0008033 tRNA processing P
IMP
SceS000000927
GO:0010038 response to metal ion P
IDA
HsaNEDD4L
GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IMP
SceS000000927
GO:0010766 negative regulation of sodium ion
transport		 P
IDA
MmuMGI:1933754
ISO
MmuMGI:1933754
GO:0010793 regulation of mRNA export from
nucleus		 P
IPI
SceS000000927
GO:0010794 regulation of dolichol biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0010795 regulation of ubiquinone biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0010796 regulation of multivesicular body
size		 P
IMP
SceS000000927
GO:0016567 protein ubiquitination P
IC
SpoSPAC11G7.02
NAS
HsaNEDD4L
GO:0019220 regulation of phosphate metabolic
process		 P
IGI
SceS000000927
GO:0030104 water homeostasis P
NAS
HsaNEDD4L
GO:0032443 regulation of ergosterol biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0032511 late endosome to vacuole transport via
multivesicular body sorting pathway		 P
IMP
SceS000000927
IPI
SceS000000927
GO:0032880 regulation of protein localization P
IMP
SceS000000927
IPI
SceS000000927
GO:0032956 regulation of actin cytoskeleton
organization		 P
IGI
SceS000000927
GO:0034517 ribophagy P
IGI
SceS000000927
GO:0034644 cellular response to UV P
IMP
SceS000000927
GO:0034762 regulation of transmembrane transport P
IMP
SpoSPAC11G7.02
GO:0042176 regulation of protein catabolic
process		 P
NAS
HsaNEDD4L
GO:0042493 response to drug P
IMP
SceS000000927
IPI
SceS000000927
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000927
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IPI
SceS000000927
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SceS000000927
GO:0045723 positive regulation of fatty acid biosynthetic
process		 P
IMP
SceS000000927
GO:0045807 positive regulation of endocytosis P
IMP
SceS000000927
NAS
HsaNEDD4L
GO:0048260 positive regulation of receptor-mediated
endocytosis		 P
IMP
SceS000000927
GO:0051453 regulation of intracellular pH P
IGI
SpoSPAC11G7.02
GO:0051726 regulation of cell cycle P
IGI
SpoSPAC11G7.02
GO:0060360 negative regulation of leucine import in response
to ammonium ion		 P
IMP
SpoSPAC11G7.02
GO:0070086 ubiquitin-dependent endocytosis P
IMP
SceS000000927

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_708

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15459 ENSANGP00000021314
Anopheles gambiae (Aga) aga15460 ENSANGP00000025653
Ashbya gossypii (Ago) ago1686 ADL055C
Caenorhabditis elegans (Cel) cel21037 Y92H12A.2
(CE33003;
WBGene00022358)
Candida glabrata (Cgl) cgl3618 CAGL0K02255g
Debaryomyces hansenii (Dha) dha2496 DEHA0D04422g
Drosophila melanogaster (Dme) dme9997 CG7555-PA
(FBgn0036736)
Drosophila melanogaster (Dme) dme9999 CG7555-PB
(FBgn0036736)
Drosophila melanogaster (Dme) dme9998 CG7555-PC
(FBgn0036736)
Drosophila melanogaster (Dme) dme10000 CG7555-PD
(FBgn0036736)
Danio rerio (Dre) dre2120 ENSDARP00000003170
Danio rerio (Dre) dre4696 ENSDARP00000019771
Takifugu rubripes (Fru) fru5987 SINFRUP00000149842
Takifugu rubripes (Fru) fru5989 SINFRUP00000149845
Takifugu rubripes (Fru) fru18915 SINFRUP00000160481
Takifugu rubripes (Fru) fru18909 SINFRUP00000167385
Takifugu rubripes (Fru) fru18912 SINFRUP00000167791
Takifugu rubripes (Fru) fru5990 SINFRUP00000169258
Takifugu rubripes (Fru) fru18913 SINFRUP00000170098
Takifugu rubripes (Fru) fru5992 SINFRUP00000170149
Takifugu rubripes (Fru) fru5988 SINFRUP00000170335
Takifugu rubripes (Fru) fru18910 SINFRUP00000171651
Takifugu rubripes (Fru) fru18908 SINFRUP00000172465
Takifugu rubripes (Fru) fru5991 SINFRUP00000172952
Takifugu rubripes (Fru) fru5994 SINFRUP00000175090
Takifugu rubripes (Fru) fru18914 SINFRUP00000175251
Takifugu rubripes (Fru) fru18911 SINFRUP00000176261
Gallus gallus (Gga) gga24104 ENSGALP00000004594
Gallus gallus (Gga) gga24102 ENSGALP00000004595
Gallus gallus (Gga) gga24103 ENSGALP00000004596
(NEDD4L)		 Q8QGJ2
Gallus gallus (Gga) gga3831 ENSGALP00000006923
Gallus gallus (Gga) gga3832 ENSGALP00000006924
Gallus gallus (Gga) gga3830 ENSGALP00000006925
(NEDD4)
Gallus gallus (Gga) gga3829 ENSGALP00000006926
Homo sapiens (Hsa) hsa10685 ENSP00000164316
(NEDD4)
Homo sapiens (Hsa) hsa15005 ENSP00000256830
(NEDD4L)		 Q96PU5-3
Homo sapiens (Hsa) hsa15008 ENSP00000256832
(NEDD4L)		 Q96PU5-8
Homo sapiens (Hsa) hsa10684 ENSP00000345530
(NEDD4)		 P46934-3
Homo sapiens (Hsa) hsa15006 ENSP00000348847
(NEDD4L)		 Q96PU5-2
Homo sapiens (Hsa) hsa15007 ENSP00000350569
(NEDD4L)		 Q96PU5-7
Kluyveromyces lactis (Kla) kla3561 KLLA0E13607g
Mus musculus (Mmu) mmu12834 ENSMUSP00000025485
(MGI:1933754)		 Q8CFI0-3
Mus musculus (Mmu) mmu27913 ENSMUSP00000034740
(MGI:97297)		 P46935
Mus musculus (Mmu) mmu12835 ENSMUSP00000079280
(MGI:1933754)		 Q8CFI0-2
Neurospora crassa (Ncr) ncr3834 NCU03947.2
Rattus norvegicus (Rno) rno28906 ENSRNOP00000009747
(RGD:3157)
Rattus norvegicus (Rno) rno14291 ENSRNOP00000023770
Rattus norvegicus (Rno) rno14290 ENSRNOP00000023890
(RGD:735047)
Rattus norvegicus (Rno) rno14292 ENSRNOP00000023921
Saccharomyces cerevisiae (Sce) sce1863 YER125W
(S000000927)
Schizosaccharomyces pombe (Spo) spo4459 SPAC11G7.02 Q92462
Schizosaccharomyces pombe (Spo) spo966 SPBC16E9.11c O14326
Yarrowia lipolytica (Yli) yli4608 YALI0E18117g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
IPI
MmuMGI:97297
SceS000000927
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000000927
GO:0005575 cellular_component C
ND
SpoSPBC16E9.11c
GO:0005624 membrane fraction C
IDA
MmuMGI:97297
GO:0005634 nucleus C
IDA
SceS000000927
GO:0005737 cytoplasm C
IDA
MmuMGI:97297
SceS000000927
SpoSPAC11G7.02
GO:0005739 mitochondrion C
IDA
SceS000000927
GO:0005794 Golgi apparatus C
IDA
SceS000000927
SpoSPAC11G7.02
GO:0005829 cytosol C
IDA
MmuMGI:97297
GO:0005902 microvillus C
ISO
MmuMGI:97297
GO:0005934 cellular bud tip C
IDA
SceS000000927
GO:0010008 endosome membrane C
IDA
SceS000000927
GO:0031234 extrinsic to internal side of plasma
membrane		 C
IDA
SceS000000927
GO:0045121 membrane raft C
ISO
MmuMGI:97297
GO:0004842 ubiquitin-protein ligase activity F
IDA
MmuMGI:97297
SceS000000927
IMP
SceS000000927
SpoSPAC11G7.02
ISS
SpoSPBC16E9.11c
GO:0005515 protein binding F
IPI
MmuMGI:1933754
MGI:97297
GO:0005543 phospholipid binding F
ISS
SpoSPAC11G7.02
SPBC16E9.11c
GO:0008022 protein C-terminus binding F
ISO
MmuMGI:97297
GO:0017080 sodium channel regulator activity F
ISO
MmuMGI:97297
GO:0019871 sodium channel inhibitor activity F
IDA
MmuMGI:1933754
MGI:97297
GO:0035091 phosphoinositide binding F
IDA
SceS000000927
GO:0043130 ubiquitin binding F
IDA
SceS000000927
GO:0050815 phosphoserine binding F
IDA
MmuMGI:97297
GO:0050816 phosphothreonine binding F
IDA
MmuMGI:97297
GO:0070064 proline-rich region binding F
IPI
MmuMGI:97297
GO:0000055 ribosomal large subunit export from
nucleus		 P
IMP
SceS000000927
GO:0000209 protein polyubiquitination P
IDA
SceS000000927
IMP
SceS000000927
GO:0006333 chromatin assembly or disassembly P
IMP
SceS000000927
GO:0006364 rRNA processing P
IMP
SceS000000927
GO:0006409 tRNA export from nucleus P
IMP
SceS000000927
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IC
SpoSPBC16E9.11c
IGI
SpoSPAC11G7.02
GO:0006513 protein monoubiquitination P
IDA
SceS000000927
IGI
SceS000000927
IMP
SceS000000927
GO:0006808 regulation of nitrogen utilization P
IGI
SceS000000927
GO:0007005 mitochondrion organization P
IGI
SceS000000927
IMP
SceS000000927
GO:0008033 tRNA processing P
IMP
SceS000000927
GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IMP
SceS000000927
GO:0010766 negative regulation of sodium ion
transport		 P
IDA
MmuMGI:1933754
MGI:97297
ISO
MmuMGI:1933754
GO:0010793 regulation of mRNA export from
nucleus		 P
IPI
SceS000000927
GO:0010794 regulation of dolichol biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0010795 regulation of ubiquinone biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0010796 regulation of multivesicular body
size		 P
IMP
SceS000000927
GO:0016567 protein ubiquitination P
IC
SpoSPAC11G7.02
IDA
MmuMGI:97297
NAS
SpoSPBC16E9.11c
GO:0019220 regulation of phosphate metabolic
process		 P
IGI
SceS000000927
GO:0030948 negative regulation of vascular endothelial growth
factor receptor signaling pathway		 P
IDA
MmuMGI:97297
GO:0032443 regulation of ergosterol biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0032511 late endosome to vacuole transport via
multivesicular body sorting pathway		 P
IMP
SceS000000927
IPI
SceS000000927
GO:0032880 regulation of protein localization P
IMP
SceS000000927
IPI
SceS000000927
GO:0032956 regulation of actin cytoskeleton
organization		 P
IGI
SceS000000927
GO:0034517 ribophagy P
IGI
SceS000000927
GO:0034644 cellular response to UV P
IMP
SceS000000927
GO:0034762 regulation of transmembrane transport P
IMP
SpoSPAC11G7.02
GO:0042493 response to drug P
IMP
SceS000000927
IPI
SceS000000927
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000927
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IPI
SceS000000927
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SceS000000927
GO:0045723 positive regulation of fatty acid biosynthetic
process		 P
IMP
SceS000000927
GO:0045732 positive regulation of protein catabolic
process		 P
IDA
MmuMGI:97297
ISO
MmuMGI:97297
GO:0045807 positive regulation of endocytosis P
IMP
SceS000000927
GO:0048260 positive regulation of receptor-mediated
endocytosis		 P
IMP
SceS000000927
GO:0051453 regulation of intracellular pH P
IGI
SpoSPAC11G7.02
GO:0051726 regulation of cell cycle P
IGI
SpoSPAC11G7.02
GO:0060360 negative regulation of leucine import in response
to ammonium ion		 P
IMP
SpoSPAC11G7.02
GO:0070086 ubiquitin-dependent endocytosis P
IMP
SceS000000927

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC16E9.11c
(O14326)		 YER125W
(S000000927)
SPAC1805.15c
(Q9UTG2)		 YER125W
(S000000927)
SPAC11G7.02
(Q92462)		 YER125W
(S000000927)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
IPI
SceS000000927
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000000927
GO:0005575 cellular_component C
ND
SpoSPBC16E9.11c
GO:0005634 nucleus C
IDA
SceS000000927
SpoSPAC1805.15c
GO:0005737 cytoplasm C
IDA
SceS000000927
SpoSPAC11G7.02
SPAC1805.15c
GO:0005739 mitochondrion C
IDA
SceS000000927
GO:0005794 Golgi apparatus C
IDA
SceS000000927
SpoSPAC11G7.02
GO:0005829 cytosol C
IDA
SpoSPAC1805.15c
GO:0005934 cellular bud tip C
IDA
SceS000000927
GO:0010008 endosome membrane C
IDA
SceS000000927
GO:0031234 extrinsic to internal side of plasma
membrane		 C
IDA
SceS000000927
GO:0051285 cell cortex of cell tip C
IDA
SpoSPAC1805.15c
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000000927
IGI
SpoSPAC1805.15c
IMP
SceS000000927
SpoSPAC11G7.02
ISS
SpoSPBC16E9.11c
GO:0005543 phospholipid binding F
ISS
SpoSPAC11G7.02
SPBC16E9.11c
GO:0035091 phosphoinositide binding F
IDA
SceS000000927
GO:0043130 ubiquitin binding F
IDA
SceS000000927
GO:0000055 ribosomal large subunit export from
nucleus		 P
IMP
SceS000000927
GO:0000209 protein polyubiquitination P
IDA
SceS000000927
IMP
SceS000000927
GO:0006333 chromatin assembly or disassembly P
IMP
SceS000000927
GO:0006364 rRNA processing P
IMP
SceS000000927
GO:0006409 tRNA export from nucleus P
IMP
SceS000000927
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IC
SpoSPBC16E9.11c
IGI
SpoSPAC11G7.02
GO:0006513 protein monoubiquitination P
IDA
SceS000000927
IGI
SceS000000927
IMP
SceS000000927
GO:0006808 regulation of nitrogen utilization P
IGI
SceS000000927
GO:0007005 mitochondrion organization P
IGI
SceS000000927
IMP
SceS000000927
GO:0008033 tRNA processing P
IMP
SceS000000927
GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IMP
SceS000000927
GO:0010793 regulation of mRNA export from
nucleus		 P
IPI
SceS000000927
GO:0010794 regulation of dolichol biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0010795 regulation of ubiquinone biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0010796 regulation of multivesicular body
size		 P
IMP
SceS000000927
GO:0016567 protein ubiquitination P
IC
SpoSPAC11G7.02
NAS
SpoSPAC1805.15c
SPBC16E9.11c
GO:0019220 regulation of phosphate metabolic
process		 P
IGI
SceS000000927
GO:0032443 regulation of ergosterol biosynthetic
process		 P
IGI
SceS000000927
IMP
SceS000000927
GO:0032511 late endosome to vacuole transport via
multivesicular body sorting pathway		 P
IMP
SceS000000927
IPI
SceS000000927
GO:0032880 regulation of protein localization P
IMP
SceS000000927
IPI
SceS000000927
GO:0032956 regulation of actin cytoskeleton
organization		 P
IGI
SceS000000927
GO:0034517 ribophagy P
IGI
SceS000000927
GO:0034644 cellular response to UV P
IMP
SceS000000927
GO:0034762 regulation of transmembrane transport P
IMP
SpoSPAC11G7.02
GO:0042493 response to drug P
IMP
SceS000000927
IPI
SceS000000927
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000000927
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IPI
SceS000000927
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SceS000000927
GO:0045723 positive regulation of fatty acid biosynthetic
process		 P
IMP
SceS000000927
GO:0045807 positive regulation of endocytosis P
IMP
SceS000000927
GO:0048260 positive regulation of receptor-mediated
endocytosis		 P
IMP
SceS000000927
GO:0051453 regulation of intracellular pH P
IGI
SpoSPAC11G7.02
GO:0051726 regulation of cell cycle P
IGI
SpoSPAC11G7.02
GO:0060360 negative regulation of leucine import in response
to ammonium ion		 P
IMP
SpoSPAC11G7.02
GO:0070086 ubiquitin-dependent endocytosis P
IMP
SceS000000927

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