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Search term: YER136W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GDI1
SGD link S000000938
Alternative ID YER136W
Description GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
Synonyms YER136W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1439 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING RAB proteins geranylgeranyltransferase component A (RAB escort protein)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g44100 GI:15224814
Arabidopsis thaliana (Ath) At3g59920 GI:15232210
Arabidopsis thaliana (Ath) At5g09550 GI:15242440
Caenorhabditis elegans (Cel) CE14944
(WBGene00001558)		 GI:17540906
Drosophila melanogaster (Dme) 7297522 GI:18467646
Homo sapiens (Hsa) Hs4503971
(GDI1)		 GI:4503971 P31150
Homo sapiens (Hsa) Hs17448269 GI:17448269
Homo sapiens (Hsa) Hs18547831 GI:18547831
Homo sapiens (Hsa) Hs6598323
(GDI2)		 GI:6598323 P50395
Saccharomyces cerevisiae (Sce) YER136w
(S000000938)		 GI:6320983 P39958
Saccharomyces cerevisiae (Sce) YOR370c
(S000005897)		 GI:6324946 P32864
Schizosaccharomyces pombe (Spo) SPAC22H10.12c GI:19114661 Q10305
Schizosaccharomyces pombe (Spo) SPBC15C4.03 GI:19112715 O60112
Encephalitozoon cuniculi (Ecu) ECU02g1410 GI:19074060 Q8SSD5
Encephalitozoon cuniculi (Ecu) ECU11g0350 GI:19074835 Q8SQY9


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g09550
At2g44100
At3g59920
GO:0005624 membrane fraction C
IDA
SceS000000938
GO:0005625 soluble fraction C
IDA
SceS000000938
GO:0005634 nucleus C
IDA
SpoSPBC15C4.03
GO:0005737 cytoplasm C
IDA
HsaGDI1
SceS000005897
SpoSPAC22H10.12c
TAS
HsaGDI2
GO:0005829 cytosol C
IDA
SpoSPAC22H10.12c
SPBC15C4.03
GO:0005968 Rab-protein geranylgeranyltransferase
complex		 C
IDA
SceS000005897
GO:0009986 cell surface C
IDA
HsaGDI2
GO:0016020 membrane C
IDA
SceS000005897
GO:0032153 cell division site C
IDA
SpoSPAC22H10.12c
GO:0004663 Rab geranylgeranyltransferase activity F
IDA
SceS000005897
IMP
SceS000005897
GO:0005092 GDP-dissociation inhibitor activity F
ISS
SpoSPBC15C4.03
TAS
HsaGDI1
GO:0005093 Rab GDP-dissociation inhibitor
activity		 F
IDA
SceS000000938
IGI
AthAt2g44100
ISS
AthAt5g09550
At3g59920
SpoSPAC22H10.12c
GO:0005515 protein binding F
IPI
HsaGDI1
GDI2
GO:0017137 Rab GTPase binding F
IMP
SceS000005897
GO:0000003 reproduction P
IMP
CelWBGene00001558
GO:0006612 protein targeting to membrane P
IMP
SceS000005897
GO:0006886 intracellular protein transport P
IC
SpoSPAC22H10.12c
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SceS000005897
GO:0007165 signal transduction P
TAS
HsaGDI1
GDI2
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC22H10.12c
ISS
SpoSPBC15C4.03
GO:0008219 cell death P
IMP
CelWBGene00001558
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00001558
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00001558
GO:0015031 protein transport P
ISS
AthAt3g59920
At2g44100
At5g09550
GO:0016192 vesicle-mediated transport P
IMP
SceS000000938
ISS
SpoSPAC22H10.12c
GO:0018348 protein amino acid geranylgeranylation P
IMP
SceS000005897
GO:0032858 activation of Rab GTPase activity P
IMP
SceS000005897
GO:0033554 cellular response to stress P
IEP
SpoSPAC22H10.12c
GO:0048227 plasma membrane to endosome transport P
IGI
AthAt2g44100

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
37487

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) GDI1 GI:4503971 P31150
Pan troglodytes (Ptr) GDI1 GI:57113993
Canis familiaris (Cfa) GDI1 GI:50978936
Mus musculus (Mmu) Gdi1
(MGI:99846)		 GI:33859560 P50396
Rattus norvegicus (Rno) Gdi1
(RGD:2676)		 GI:71534276 39762
Drosophila melanogaster (Dme) Gdi
(FBgn0004868)		 GI:24583049
Anopheles gambiae (Aga) AgaP_AGAP010025 GI:31235052
Caenorhabditis elegans (Cel) gdi-1
(CE14944;
WBGene00001558)		 GI:115533046
Schizosaccharomyces pombe (Spo) gdi1
(SPAC22H10.12c)		 GI:19114661 Q10305
Saccharomyces cerevisiae (Sce) GDI1
(S000000938)		 GI:6320983 P39958
Kluyveromyces lactis (Kla) KLLA0F09185g GI:50310951
Eremothecium gossypii (Ego) AGOS_AFR183C GI:45198701
Magnaporthe grisea (Mgr) MGG_07137 GI:39971643
Neurospora crassa (Ncr) NCU05288.1 GI:32408327
Arabidopsis thaliana (Ath) ATGDI1 GI:15224814
Arabidopsis thaliana (Ath) ATGDI2 GI:15232210
Oryza sativa (Osa) Os05g0304400 GI:115463085
Oryza sativa (Osa) Os05g0418000 GI:115463933


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthATGDI2
ATGDI1
GO:0005624 membrane fraction C
IDA
SceS000000938
GO:0005625 soluble fraction C
IDA
SceS000000938
GO:0005737 cytoplasm C
IDA
HsaGDI1
SpoSPAC22H10.12c
GO:0005829 cytosol C
IDA
SpoSPAC22H10.12c
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0004868
GO:0008021 synaptic vesicle C
NAS
DmeFBgn0004868
GO:0019717 synaptosome C
ISO
MmuMGI:99846
GO:0032153 cell division site C
IDA
SpoSPAC22H10.12c
GO:0043234 protein complex C
ISO
MmuMGI:99846
GO:0005092 GDP-dissociation inhibitor activity F
IDA
DmeFBgn0004868
ISS
DmeFBgn0004868
NAS
DmeFBgn0004868
TAS
HsaGDI1
GO:0005093 Rab GDP-dissociation inhibitor
activity		 F
IDA
SceS000000938
IGI
AthATGDI1
ISO
MmuMGI:99846
ISS
AthATGDI2
SpoSPAC22H10.12c
GO:0005515 protein binding F
IPI
HsaGDI1
GO:0000003 reproduction P
IMP
CelWBGene00001558
GO:0006886 intracellular protein transport P
IC
SpoSPAC22H10.12c
GO:0007165 signal transduction P
TAS
HsaGDI1
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC22H10.12c
ISO
MmuMGI:99846
GO:0007269 neurotransmitter secretion P
NAS
DmeFBgn0004868
GO:0008219 cell death P
IMP
CelWBGene00001558
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00001558
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00001558
GO:0015031 protein transport P
ISS
AthATGDI2
ATGDI1
GO:0016192 vesicle-mediated transport P
IMP
SceS000000938
ISS
SpoSPAC22H10.12c
NAS
DmeFBgn0004868
GO:0033554 cellular response to stress P
IEP
SpoSPAC22H10.12c
GO:0048227 plasma membrane to endosome transport P
IGI
AthATGDI1
GO:0051592 response to calcium ion P
ISO
MmuMGI:99846

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1310

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga12322 ENSANGP00000011972
Ashbya gossypii (Ago) ago3375 AFR183C
Arabidopsis thaliana (Ath) ath11617 At2g44100.1
Arabidopsis thaliana (Ath) ath17414 At3g59920.1
Caenorhabditis elegans (Cel) cel20032 Y57G11C.10
Candida glabrata (Cgl) cgl3604 CAGL0K01925g
Cryptococcus neoformans (Cne) cne4111 177.m02869
Dictyostelium discoideum (Ddi) ddi749 DDB0189731
Debaryomyces hansenii (Dha) dha5575 DEHA0F26620g
Drosophila melanogaster (Dme) dme1595 CG4422-PA
(FBgn0004868)
Danio rerio (Dre) dre15583 ENSDARP00000002580
Danio rerio (Dre) dre18072 ENSDARP00000009258
(gdi2)		 Q6TNT9
Encephalitozoon cuniculi (Ecu) ecu139 19074060
Takifugu rubripes (Fru) fru14111 SINFRUP00000148906
Takifugu rubripes (Fru) fru9968 SINFRUP00000159199
Gallus gallus (Gga) gga6858 ENSGALP00000013267
(GDI2)		 O93382
Homo sapiens (Hsa) hsa3463 ENSP00000340585
Kluyveromyces lactis (Kla) kla4498 KLLA0F09185g
Mus musculus (Mmu) mmu29163 ENSMUSP00000015435
(MGI:99846)		 P50396
Mus musculus (Mmu) mmu6457 ENSMUSP00000062996
(MGI:99845)		 Q61598-1
Neurospora crassa (Ncr) ncr5133 NCU05288.2
Oryza sativa (Osa) osa3965 2077.m00125
Oryza sativa (Osa) osa4222 2219.m00112
Oryza sativa (Osa) osa27223 3978.m00189
Oryza sativa (Osa) osa39039 5085.m00079
Oryza sativa (Osa) osa60371 6413.m00135
Oryza sativa (Osa) osa61884 6490.m00163
Plasmodium falciparum (Pfa) pfa5193 PFL2060c
Rattus norvegicus (Rno) rno13578 ENSRNOP00000024952
(RGD:61802)		 P50399
Rattus norvegicus (Rno) rno13579 ENSRNOP00000027516
(RGD:61802)
Saccharomyces cerevisiae (Sce) sce1875 YER136W
(S000000938)
Schizosaccharomyces pombe (Spo) spo2804 SPAC22H10.12c Q10305
Yarrowia lipolytica (Yli) yli5267 YALI0E33649g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt2g44100
At3g59920
PfaPFL2060c
GO:0005624 membrane fraction C
IDA
SceS000000938
GO:0005625 soluble fraction C
IDA
SceS000000938
GO:0005737 cytoplasm C
IDA
SpoSPAC22H10.12c
GO:0005794 Golgi apparatus C
IPI
MmuMGI:99845
GO:0005829 cytosol C
IDA
SpoSPAC22H10.12c
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0004868
GO:0008021 synaptic vesicle C
NAS
DmeFBgn0004868
GO:0019717 synaptosome C
ISO
MmuMGI:99846
GO:0032153 cell division site C
IDA
SpoSPAC22H10.12c
GO:0043234 protein complex C
ISO
MmuMGI:99846
GO:0005092 GDP-dissociation inhibitor activity F
IDA
DmeFBgn0004868
ISS
DmeFBgn0004868
NAS
DmeFBgn0004868
GO:0005093 Rab GDP-dissociation inhibitor
activity		 F
IDA
SceS000000938
IGI
AthAt2g44100
ISO
MmuMGI:99845
MGI:99846
ISS
AthAt3g59920
SpoSPAC22H10.12c
GO:0005097 Rab GTPase activator activity F
IPI
MmuMGI:99845
ISS
PfaPFL2060c
GO:0031267 small GTPase binding F
ISO
MmuMGI:99845
GO:0006886 intracellular protein transport P
IC
SpoSPAC22H10.12c
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC22H10.12c
IPI
MmuMGI:99845
ISO
MmuMGI:99846
GO:0007269 neurotransmitter secretion P
NAS
DmeFBgn0004868
GO:0015031 protein transport P
ISS
AthAt3g59920
At2g44100
GO:0016192 vesicle-mediated transport P
IMP
SceS000000938
ISS
PfaPFL2060c
SpoSPAC22H10.12c
NAS
DmeFBgn0004868
GO:0033554 cellular response to stress P
IEP
SpoSPAC22H10.12c
GO:0048227 plasma membrane to endosome transport P
IGI
AthAt2g44100
GO:0050790 regulation of catalytic activity P
IPI
MmuMGI:99845
GO:0051592 response to calcium ion P
ISO
MmuMGI:99846

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC22H10.12c
(Q10305)		 YER136W
(S000000938)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000000938
GO:0005625 soluble fraction C
IDA
SceS000000938
GO:0005737 cytoplasm C
IDA
SpoSPAC22H10.12c
GO:0005829 cytosol C
IDA
SpoSPAC22H10.12c
GO:0032153 cell division site C
IDA
SpoSPAC22H10.12c
GO:0005093 Rab GDP-dissociation inhibitor
activity		 F
IDA
SceS000000938
ISS
SpoSPAC22H10.12c
GO:0006886 intracellular protein transport P
IC
SpoSPAC22H10.12c
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC22H10.12c
GO:0016192 vesicle-mediated transport P
IMP
SceS000000938
ISS
SpoSPAC22H10.12c
GO:0033554 cellular response to stress P
IEP
SpoSPAC22H10.12c

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