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Search term: YER174C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GRX4
SGD link S000000976
Alternative ID YER174C
Description Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage
Synonyms YER174C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0911 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Glutaredoxin-related protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g38270 GI:18404699
Arabidopsis thaliana (Ath) At3g15660 GI:18400858
Arabidopsis thaliana (Ath) At3g54900 GI:15233118
Arabidopsis thaliana (Ath) At4g04950 GI:15234516
Arabidopsis thaliana (Ath) At4g32580 GI:15236855
Caenorhabditis elegans (Cel) CE10636
(WBGene00009804)		 GI:17561080 Q20519
Caenorhabditis elegans (Cel) CE10638
(WBGene00009805)		 GI:17561082 Q20518
Caenorhabditis elegans (Cel) CE22220
(WBGene00013029)		 GI:17556042 Q9XTU9
Drosophila melanogaster (Dme) 7293005_2 GI:7293005
Drosophila melanogaster (Dme) 7298047
(FBgn0032509)		 GI:19921242
Homo sapiens (Hsa) Hs5730104 GI:5730104
Saccharomyces cerevisiae (Sce) YDR098c
(S000002505)		 GI:6320303 Q03835
Saccharomyces cerevisiae (Sce) YER174c
(S000000976)		 GI:6321022 P32642
Saccharomyces cerevisiae (Sce) YPL059w
(S000005980)		 GI:6325198 Q02784
Schizosaccharomyces pombe (Spo) SPAPB2B4.02 GI:19114800 Q9HDW8
Schizosaccharomyces pombe (Spo) SPBC26H8.06 GI:19113439 O74790
Encephalitozoon cuniculi (Ecu) ECU05g1380 GI:19173678 Q8SVH1
Arabidopsis thaliana (Ath) At2g38270 GI:18404699
Arabidopsis thaliana (Ath) At3g15660 GI:18400858
Arabidopsis thaliana (Ath) At3g54900 GI:15233118
Arabidopsis thaliana (Ath) At4g04950 GI:15234516
Arabidopsis thaliana (Ath) At4g32580 GI:15236855
Caenorhabditis elegans (Cel) CE10636
(WBGene00009804)		 GI:17561080 Q20519
Caenorhabditis elegans (Cel) CE10638
(WBGene00009805)		 GI:17561082 Q20518
Caenorhabditis elegans (Cel) CE22220
(WBGene00013029)		 GI:17556042 Q9XTU9
Drosophila melanogaster (Dme) 7293005_2 GI:7293005
Drosophila melanogaster (Dme) 7298047
(FBgn0032509)		 GI:19921242
Homo sapiens (Hsa) Hs5730104 GI:5730104
Saccharomyces cerevisiae (Sce) YDR098c
(S000002505)		 GI:6320303 Q03835
Saccharomyces cerevisiae (Sce) YER174c
(S000000976)		 GI:6321022 P32642
Saccharomyces cerevisiae (Sce) YPL059w
(S000005980)		 GI:6325198 Q02784
Schizosaccharomyces pombe (Spo) SPAPB2B4.02 GI:19114800 Q9HDW8
Schizosaccharomyces pombe (Spo) SPBC26H8.06 GI:19113439 O74790
Encephalitozoon cuniculi (Ecu) ECU05g1380 GI:19173678 Q8SVH1


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g32580
GO:0005634 nucleus C
IDA
SceS000002505
SpoSPBC26H8.06
IGI
SceS000002505
S000000976
IPI
SceS000002505
S000000976
GO:0005737 cytoplasm C
IDA
SpoSPBC26H8.06
GO:0005739 mitochondrion C
IDA
AthAt3g15660
SceS000005980
SpoSPAPB2B4.02
GO:0005759 mitochondrial matrix C
IDA
SceS000005980
ISS
SpoSPAPB2B4.02
TAS
SceS000005980
GO:0005829 cytosol C
IDA
SceS000002505
SpoSPBC26H8.06
GO:0009507 chloroplast C
IDA
AthAt2g38270
At3g54900
GO:0009570 chloroplast stroma C
IDA
AthAt2g38270
GO:0008794 arsenate reductase (glutaredoxin)
activity		 F
TAS
SpoSPAPB2B4.02
SPBC26H8.06
GO:0015035 protein disulfide oxidoreductase
activity		 F
ISS
SpoSPAPB2B4.02
NAS
SpoSPBC26H8.06
GO:0015036 disulfide oxidoreductase activity F
IDA
SceS000005980
IGI
SceS000002505
S000000976
S000005980
IMP
SceS000000976
S000005980
S000002505
ISS
DmeFBgn0032509
SceS000005980
S000002505
S000000976
GO:0015038 glutathione disulfide oxidoreductase
activity		 F
IGI
AthAt3g54900
GO:0015297 antiporter activity F
IDA
AthAt3g54900
GO:0046872 metal ion binding F
IDA
AthAt3g15660
GO:0000003 reproduction P
IMP
CelWBGene00013029
GO:0006812 cation transport P
IDA
AthAt3g54900
At2g38270
GO:0006879 cellular iron ion homeostasis P
IGI
SceS000002505
S000000976
IPI
SceS000002505
S000000976
GO:0006970 response to osmotic stress P
IMP
SceS000005980
ISS
SpoSPAPB2B4.02
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013029
GO:0016226 iron-sulfur cluster assembly P
ISS
SpoSPAPB2B4.02
TAS
SceS000005980
GO:0019430 removal of superoxide radicals P
IC
SpoSPBC26H8.06
SPAPB2B4.02
GO:0019915 lipid storage P
IMP
CelWBGene00009804
WBGene00009805
GO:0034599 cellular response to oxidative
stress		 P
IGI
SceS000000976
S000002505
S000005980
SpoSPAPB2B4.02
IMP
SceS000000976
S000005980
S000002505
NAS
SpoSPBC26H8.06
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013029
GO:0040015 negative regulation of multicellular organism
growth		 P
IMP
CelWBGene00013029
GO:0043157 response to cation stress P
IEP
SpoSPAPB2B4.02
GO:0051409 response to nitrosative stress P
TAS
SpoSPAPB2B4.02
GO:0055114 oxidation reduction P
RCA
SceS000005980

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4769

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) GLRX3 GI:95113651
Pan troglodytes (Ptr) GLRX3 GI:114633373
Canis familiaris (Cfa) GLRX3 GI:73999010
Mus musculus (Mmu) Glrx3
(MGI:1353653)		 GI:31981269 Q9CQM9
Rattus norvegicus (Rno) Glrx3 GI:78187979
Gallus gallus (Gga) GLRX3 GI:50749993
Caenorhabditis elegans (Cel) D2063.3
(CE29745;
WBGene00017062)		 GI:71988153
Schizosaccharomyces pombe (Spo) grx4
(SPBC26H8.06)		 GI:19113439 O74790
Saccharomyces cerevisiae (Sce) GRX4
(S000000976)		 GI:6321022 P32642
Saccharomyces cerevisiae (Sce) GRX3
(S000002505)		 GI:6320303 Q03835
Kluyveromyces lactis (Kla) KLLA0C17842g GI:50306071
Eremothecium gossypii (Ego) AGOS_AGR111W GI:45201207
Magnaporthe grisea (Mgr) MGG_06356 GI:145608814
Neurospora crassa (Ncr) NCU09803.1 GI:32420019
Arabidopsis thaliana (Ath) AT4G04950 GI:15234516
Oryza sativa (Osa) Os10g0500700 GI:115482778


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002505
SpoSPBC26H8.06
IGI
SceS000002505
S000000976
IPI
SceS000002505
S000000976
GO:0005737 cytoplasm C
IDA
SpoSPBC26H8.06
GO:0005829 cytosol C
IDA
SceS000002505
SpoSPBC26H8.06
GO:0030018 Z disc C
IDA
MmuMGI:1353653
GO:0005080 protein kinase C binding F
ISO
MmuMGI:1353653
GO:0005515 protein binding F
IPI
HsaGLRX3
MmuMGI:1353653
GO:0008794 arsenate reductase (glutaredoxin)
activity		 F
TAS
SpoSPBC26H8.06
GO:0015035 protein disulfide oxidoreductase
activity		 F
NAS
SpoSPBC26H8.06
GO:0015036 disulfide oxidoreductase activity F
IGI
SceS000002505
S000000976
IMP
SceS000000976
S000002505
ISS
SceS000002505
S000000976
GO:0002026 regulation of the force of heart
contraction		 P
IMP
MmuMGI:1353653
ISS
HsaGLRX3
GO:0006879 cellular iron ion homeostasis P
IGI
SceS000002505
S000000976
IPI
SceS000002505
S000000976
GO:0010614 negative regulation of cardiac muscle
hypertrophy		 P
IMP
MmuMGI:1353653
ISS
HsaGLRX3
GO:0019430 removal of superoxide radicals P
IC
SpoSPBC26H8.06
GO:0034599 cellular response to oxidative
stress		 P
IGI
SceS000000976
S000002505
IMP
SceS000000976
S000002505
NAS
SpoSPBC26H8.06

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1276

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5826 ENSANGP00000015021
Ashbya gossypii (Ago) ago4422 AGR111W
Arabidopsis thaliana (Ath) ath18379 At4g04950.1
Caenorhabditis elegans (Cel) cel5117 D2063.3a
(CE29745;
WBGene00017062)
Caenorhabditis elegans (Cel) cel5118 D2063.3b
(CE36922)
Candida glabrata (Cgl) cgl1978 CAGL0G08151g
Candida glabrata (Cgl) cgl4597 CAGL0L11990g
Cryptococcus neoformans (Cne) cne5627 179.m00489
Cryptococcus neoformans (Cne) cne5628 179.m00490
Dictyostelium discoideum (Ddi) ddi1576 DDB0167363
Debaryomyces hansenii (Dha) dha3978 DEHA0E16654g
Drosophila melanogaster (Dme) dme2262 CG6523-PA
(FBgn0032509)
Danio rerio (Dre) dre3782 ENSDARP00000023393
Danio rerio (Dre) dre13651 ENSDARP00000040389
Danio rerio (Dre) dre13652 ENSDARP00000050207
Encephalitozoon cuniculi (Ecu) ecu1240 19173678
Takifugu rubripes (Fru) fru29812 SINFRUP00000145294
Gallus gallus (Gga) gga21014 ENSGALP00000017016
(GLRX3)
Gallus gallus (Gga) gga21015 ENSGALP00000017017
Homo sapiens (Hsa) hsa4800 ENSP00000225000
Homo sapiens (Hsa) hsa26377 ENSP00000330836
(GLRX3)		 O76003
Kluyveromyces lactis (Kla) kla1996 KLLA0C17842g
Mus musculus (Mmu) mmu25295 ENSMUSP00000033384
Mus musculus (Mmu) mmu25296 ENSMUSP00000066621
(MGI:1353653)		 Q9CQM9
Neurospora crassa (Ncr) ncr9547 NCU09803.2
Oryza sativa (Osa) osa40371 5186.m00200
Oryza sativa (Osa) osa40408 5186.m00218
Plasmodium falciparum (Pfa) pfa3033 PFF0340c
Rattus norvegicus (Rno) rno3170 ENSRNOP00000022406
(RGD:69414)		 Q9JLZ1-1
Saccharomyces cerevisiae (Sce) sce1133 YDR098C
(S000002505)
Saccharomyces cerevisiae (Sce) sce1924 YER174C
(S000000976)
Schizosaccharomyces pombe (Spo) spo749 SPBC26H8.06 O74790
Yarrowia lipolytica (Yli) yli1291 YALI0B13398g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002505
SpoSPBC26H8.06
IGI
SceS000002505
S000000976
IPI
SceS000002505
S000000976
GO:0005737 cytoplasm C
IDA
SpoSPBC26H8.06
GO:0005829 cytosol C
IDA
SceS000002505
SpoSPBC26H8.06
GO:0030018 Z disc C
IDA
MmuMGI:1353653
GO:0005080 protein kinase C binding F
ISO
MmuMGI:1353653
GO:0005515 protein binding F
IPI
MmuMGI:1353653
GO:0008794 arsenate reductase (glutaredoxin)
activity		 F
TAS
SpoSPBC26H8.06
GO:0015035 protein disulfide oxidoreductase
activity		 F
NAS
SpoSPBC26H8.06
GO:0015036 disulfide oxidoreductase activity F
IGI
SceS000002505
S000000976
IMP
SceS000000976
S000002505
ISS
DmeFBgn0032509
SceS000002505
S000000976
GO:0002026 regulation of the force of heart
contraction		 P
IMP
MmuMGI:1353653
GO:0006879 cellular iron ion homeostasis P
IGI
SceS000002505
S000000976
IPI
SceS000002505
S000000976
GO:0010614 negative regulation of cardiac muscle
hypertrophy		 P
IMP
MmuMGI:1353653
GO:0019430 removal of superoxide radicals P
IC
SpoSPBC26H8.06
GO:0034599 cellular response to oxidative
stress		 P
IGI
SceS000000976
S000002505
IMP
SceS000000976
S000002505
NAS
SpoSPBC26H8.06

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC26H8.06
(O74790)		 YER174C
(S000000976)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBC26H8.06
IGI
SceS000000976
IPI
SceS000000976
GO:0005737 cytoplasm C
IDA
SpoSPBC26H8.06
GO:0005829 cytosol C
IDA
SpoSPBC26H8.06
GO:0008794 arsenate reductase (glutaredoxin)
activity		 F
TAS
SpoSPBC26H8.06
GO:0015035 protein disulfide oxidoreductase
activity		 F
NAS
SpoSPBC26H8.06
GO:0015036 disulfide oxidoreductase activity F
IGI
SceS000000976
IMP
SceS000000976
ISS
SceS000000976
GO:0006879 cellular iron ion homeostasis P
IGI
SceS000000976
IPI
SceS000000976
GO:0019430 removal of superoxide radicals P
IC
SpoSPBC26H8.06
GO:0034599 cellular response to oxidative
stress		 P
IGI
SceS000000976
IMP
SceS000000976
NAS
SpoSPBC26H8.06

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