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Search term: YFL008W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SMC1
SGD link S000001886
Alternative ID YFL008W
Description Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
Synonyms YFL008W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0018 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Structural maintenance of chromosome protein 1 (sister chromatid cohesion complex Cohesin, subunit SMC1)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g54670 GI:15232561
Caenorhabditis elegans (Cel) CE05411 GI:17551002
Caenorhabditis elegans (Cel) CE05412
(WBGene00008086)		 GI:17551004 Q18617
Caenorhabditis elegans (Cel) CE05417
(WBGene00008090)		 GI:17551014 Q18618
Caenorhabditis elegans (Cel) CE29497 GI:17506951
Drosophila melanogaster (Dme) 7301097 GI:7301097
Homo sapiens (Hsa) Hs14764231 GI:14764231
Homo sapiens (Hsa) Hs18594408 GI:18594408
Homo sapiens (Hsa) Hs5453642 GI:5453642
Saccharomyces cerevisiae (Sce) YFL008w
(S000001886)		 GI:14318514 P32908
Schizosaccharomyces pombe (Spo) SPBC29A10.04 GI:19112841 O94383
Encephalitozoon cuniculi (Ecu) ECU04g0930 GI:19074170 Q8SS38
Arabidopsis thaliana (Ath) At3g54670 GI:15232561
Caenorhabditis elegans (Cel) CE05411 GI:17551002
Caenorhabditis elegans (Cel) CE05412
(WBGene00008086)		 GI:17551004 Q18617
Caenorhabditis elegans (Cel) CE05417
(WBGene00008090)		 GI:17551014 Q18618
Caenorhabditis elegans (Cel) CE29497 GI:17506951
Drosophila melanogaster (Dme) 7301097 GI:7301097
Homo sapiens (Hsa) Hs14764231 GI:14764231
Homo sapiens (Hsa) Hs18594408 GI:18594408
Homo sapiens (Hsa) Hs5453642 GI:5453642
Saccharomyces cerevisiae (Sce) YFL008w
(S000001886)		 GI:14318514 P32908
Schizosaccharomyces pombe (Spo) SPBC29A10.04 GI:19112841 O94383
Encephalitozoon cuniculi (Ecu) ECU04g0930 GI:19074170 Q8SS38
Arabidopsis thaliana (Ath) At3g54670 GI:15232561
Caenorhabditis elegans (Cel) CE05411 GI:17551002
Caenorhabditis elegans (Cel) CE05412
(WBGene00008086)		 GI:17551004 Q18617
Caenorhabditis elegans (Cel) CE05417
(WBGene00008090)		 GI:17551014 Q18618
Caenorhabditis elegans (Cel) CE29497 GI:17506951
Drosophila melanogaster (Dme) 7301097 GI:7301097
Homo sapiens (Hsa) Hs14764231 GI:14764231
Homo sapiens (Hsa) Hs18594408 GI:18594408
Homo sapiens (Hsa) Hs5453642 GI:5453642
Saccharomyces cerevisiae (Sce) YFL008w
(S000001886)		 GI:14318514 P32908
Schizosaccharomyces pombe (Spo) SPBC29A10.04 GI:19112841 O94383
Encephalitozoon cuniculi (Ecu) ECU04g0930 GI:19074170 Q8SS38


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SpoSPBC29A10.04
ISS
AthAt3g54670
GO:0008278 cohesin complex C
ISS
AthAt3g54670
GO:0009507 chloroplast C
IDA
AthAt3g54670
GO:0030892 mitotic cohesin complex C
TAS
SpoSPBC29A10.04
GO:0034990 nuclear mitotic cohesin complex C
IDA
SceS000001886
GO:0000217 DNA secondary structure binding F
IDA
SceS000001886
GO:0003680 AT DNA binding F
IDA
SceS000001886
GO:0003690 double-stranded DNA binding F
IDA
SceS000001886
GO:0005215 transporter activity F
ISS
AthAt3g54670
GO:0005515 protein binding F
IPI
SpoSPBC29A10.04
GO:0005524 ATP binding F
ISS
AthAt3g54670
GO:0016887 ATPase activity F
ISS
SceS000001886
GO:0046982 protein heterodimerization activity F
IPI
SpoSPBC29A10.04
GO:0000070 mitotic sister chromatid segregation P
IMP
SceS000001886
GO:0006302 double-strand break repair P
IMP
SceS000001886
GO:0007059 chromosome segregation P
ISS
AthAt3g54670
GO:0007062 sister chromatid cohesion P
IMP
AthAt3g54670
GO:0007064 mitotic sister chromatid cohesion P
IGI
SceS000001886
IMP
SpoSPBC29A10.04
GO:0007076 mitotic chromosome condensation P
RCA
SceS000001886
GO:0030261 chromosome condensation P
RCA
SceS000001886

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4597

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SMC1A GI:30581135
Canis familiaris (Cfa) SMC1A GI:74007448
Mus musculus (Mmu) Smc1a
(MGI:1344345)		 GI:9790237 A0JLM6
Rattus norvegicus (Rno) Smc1a GI:13928946
Drosophila melanogaster (Dme) SMC1
(FBgn0040283)		 GI:24649535
Anopheles gambiae (Aga) AgaP_AGAP002947 GI:118781930
Caenorhabditis elegans (Cel) him-1
(CE42002;
WBGene00001860)		 GI:193202684
Schizosaccharomyces pombe (Spo) psm1
(SPBC29A10.04)		 GI:19112841 O94383
Saccharomyces cerevisiae (Sce) SMC1
(S000001886)		 GI:14318514 P32908
Kluyveromyces lactis (Kla) KLLA0D07502g GI:50306843
Eremothecium gossypii (Ego) AGOS_AGL023W GI:45201073
Magnaporthe grisea (Mgr) MGG_06894 GI:145605734
Neurospora crassa (Ncr) NCU01323.1 GI:32412672
Arabidopsis thaliana (Ath) TTN8 GI:79444781
Oryza sativa (Osa) Os12g0641500 GI:115489834
Plasmodium falciparum (Pfa) PF11_0317 GI:124804391


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000776 kinetochore C
IDA
HsaSMC1A
GO:0000790 nuclear chromatin C
IDA
CelWBGene00001860
GO:0000794 condensed nuclear chromosome C
TAS
HsaSMC1A
GO:0005634 nucleus C
IC
SpoSPBC29A10.04
IDA
CelWBGene00001860
DmeFBgn0040283
HsaSMC1A
ISS
AthTTN8
GO:0005694 chromosome C
IDA
DmeFBgn0040283
GO:0005700 polytene chromosome C
IDA
DmeFBgn0040283
GO:0005737 cytoplasm C
IDA
HsaSMC1A
GO:0008278 cohesin complex C
IDA
DmeFBgn0040283
ISS
AthTTN8
CelWBGene00001860
DmeFBgn0040283
PfaPF11_0317
NAS
DmeFBgn0040283
GO:0008280 cohesin core heterodimer C
TAS
HsaSMC1A
GO:0009507 chloroplast C
IDA
AthTTN8
GO:0030892 mitotic cohesin complex C
TAS
SpoSPBC29A10.04
GO:0034990 nuclear mitotic cohesin complex C
IDA
SceS000001886
GO:0035327 transcriptionally active chromatin C
IDA
DmeFBgn0040283
GO:0000217 DNA secondary structure binding F
IDA
SceS000001886
GO:0003677 DNA binding F
IDA
CelWBGene00001860
ISS
DmeFBgn0040283
GO:0003680 AT DNA binding F
IDA
SceS000001886
ISS
PfaPF11_0317
GO:0003682 chromatin binding F
IDA
HsaSMC1A
GO:0003690 double-stranded DNA binding F
IDA
SceS000001886
ISS
PfaPF11_0317
GO:0003777 microtubule motor activity F
NAS
HsaSMC1A
GO:0005215 transporter activity F
ISS
AthTTN8
GO:0005515 protein binding F
IDA
CelWBGene00001860
IPI
HsaSMC1A
SpoSPBC29A10.04
GO:0005524 ATP binding F
ISS
AthTTN8
GO:0016887 ATPase activity F
ISS
PfaPF11_0317
SceS000001886
GO:0046982 protein heterodimerization activity F
IPI
HsaSMC1A
SpoSPBC29A10.04
GO:0000003 reproduction P
IMP
CelWBGene00001860
GO:0000070 mitotic sister chromatid segregation P
IMP
SceS000001886
ISS
PfaPF11_0317
TAS
HsaSMC1A
GO:0000075 cell cycle checkpoint P
IDA
HsaSMC1A
GO:0002119 nematode larval development P
IMP
CelWBGene00001860
GO:0006281 DNA repair P
TAS
HsaSMC1A
GO:0006302 double-strand break repair P
IMP
SceS000001886
GO:0006310 DNA recombination P
IMP
CelWBGene00001860
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00001860
GO:0007052 mitotic spindle organization P
TAS
HsaSMC1A
GO:0007059 chromosome segregation P
IMP
CelWBGene00001860
ISS
AthTTN8
GO:0007062 sister chromatid cohesion P
IMP
AthTTN8
HsaSMC1A
ISS
DmeFBgn0040283
NAS
DmeFBgn0040283
GO:0007064 mitotic sister chromatid cohesion P
IGI
SceS000001886
IMP
SpoSPBC29A10.04
ISS
CelWBGene00001860
TAS
HsaSMC1A
GO:0007076 mitotic chromosome condensation P
RCA
SceS000001886
GO:0007126 meiosis P
IPI
MmuMGI:1344345
ISO
MmuMGI:1344345
ISS
HsaSMC1A
GO:0008380 RNA splicing P
EXP
HsaSMC1A
GO:0009314 response to radiation P
IEP
HsaSMC1A
GO:0009411 response to UV P
IMP
CelWBGene00001860
GO:0009790 embryo development P
IMP
CelWBGene00001860
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00001860
GO:0010165 response to X-ray P
IMP
CelWBGene00001860
GO:0010629 negative regulation of gene expression P
IGI
DmeFBgn0040283
GO:0016319 mushroom body development P
IMP
DmeFBgn0040283
GO:0016322 neuron remodeling P
IMP
DmeFBgn0040283
GO:0030261 chromosome condensation P
RCA
SceS000001886
GO:0032876 negative regulation of DNA endoreduplication P
IMP
HsaSMC1A
GO:0040007 growth P
IMP
CelWBGene00001860
GO:0040011 locomotion P
IMP
CelWBGene00001860
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00001860
GO:0042770 DNA damage response, signal transduction P
IDA
HsaSMC1A
GO:0045132 meiotic chromosome segregation P
IMP
CelWBGene00001860
GO:0048813 dendrite morphogenesis P
IMP
DmeFBgn0040283

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1280

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5194 ENSANGP00000011008
Ashbya gossypii (Ago) ago4288 AGL023W
Arabidopsis thaliana (Ath) ath16834 At3g54670.1
Caenorhabditis elegans (Cel) cel7544 F28B3.7
Candida glabrata (Cgl) cgl1321 CAGL0F02079g
Cryptococcus neoformans (Cne) cne4812 186.m03686
Dictyostelium discoideum (Ddi) ddi13515 DDB0219931
Debaryomyces hansenii (Dha) dha5333 DEHA0F21296g
Drosophila melanogaster (Dme) dme14140 CG6057-PA
(FBgn0040283)
Danio rerio (Dre) dre15523 ENSDARP00000003454
Danio rerio (Dre) dre15082 ENSDARP00000014444
(LOC559893)
Danio rerio (Dre) dre15526 ENSDARP00000016460
Danio rerio (Dre) dre15525 ENSDARP00000023539
Danio rerio (Dre) dre15522 ENSDARP00000049209
Danio rerio (Dre) dre15524 ENSDARP00000050425
Encephalitozoon cuniculi (Ecu) ecu808 19074170
Takifugu rubripes (Fru) fru4323 SINFRUP00000136665
Takifugu rubripes (Fru) fru18446 SINFRUP00000161948
Gallus gallus (Gga) gga1470 ENSGALP00000022963
(SMC1B)
Gallus gallus (Gga) gga1471 ENSGALP00000022964
(SMC1B)
Gallus gallus (Gga) gga1472 ENSGALP00000022965
Homo sapiens (Hsa) hsa21862 ENSP00000315979
Homo sapiens (Hsa) hsa32835 ENSP00000323421
(SMC1A)		 Q14683
Homo sapiens (Hsa) hsa21861 ENSP00000350036
(SMC1B)		 Q8NDV3-3
Kluyveromyces lactis (Kla) kla2396 KLLA0D07502g
Mus musculus (Mmu) mmu9446 ENSMUSP00000023068
(MGI:2154049)		 Q920F6
Mus musculus (Mmu) mmu29735 ENSMUSP00000044645
(MGI:1344345)		 A0JLM6
Neurospora crassa (Ncr) ncr1282 NCU01323.2
Plasmodium falciparum (Pfa) pfa768 PF11_0317
Rattus norvegicus (Rno) rno31198 ENSRNOP00000004364
(RGD:61991)		 Q9Z1M9
Rattus norvegicus (Rno) rno27536 ENSRNOP00000043834
(RGD:1308791)
Saccharomyces cerevisiae (Sce) sce1955 YFL008W
(S000001886)
Schizosaccharomyces pombe (Spo) spo4679 SPBC29A10.04 O94383
Yarrowia lipolytica (Yli) yli4505 YALI0E15620g