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Search term: YFL018C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LPD1
SGD link S000001876
Alternative ID YFL018C
Description Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
Synonyms YFL018C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1335 ACDHYP-

KOGs classification KOGs description
METABOLISM Dihydrolipoamide dehydrogenase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g48030 GI:15221044
Arabidopsis thaliana (Ath) At3g16950 GI:15228916
Arabidopsis thaliana (Ath) At3g17240 GI:18401436
Caenorhabditis elegans (Cel) CE16262 GI:17541490
Drosophila melanogaster (Dme) 7293932 GI:7293932
Homo sapiens (Hsa) Hs4557525 GI:4557525
Saccharomyces cerevisiae (Sce) YFL018c
(S000001876)		 GI:14318501 P09624
Saccharomyces cerevisiae (Sce) YPL017c
(S000005938)		 GI:6325240 Q02733
Schizosaccharomyces pombe (Spo) SPAC1002.09c GI:19114408 O00087


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005730 nucleolus C
IDA
AthAt3g16950
GO:0005737 cytoplasm C
IDA
SceS000005938
GO:0005739 mitochondrion C
IDA
AthAt3g17240
At1g48030
SceS000001876
SpoSPAC1002.09c
GO:0005747 mitochondrial respiratory chain complex
I		 C
IDA
AthAt3g17240
At1g48030
GO:0005759 mitochondrial matrix C
ISS
AthAt1g48030
At3g17240
GO:0005874 microtubule C
IDA
SceS000005938
GO:0005960 glycine cleavage complex C
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0005967 mitochondrial pyruvate dehydrogenase
complex		 C
ISS
SpoSPAC1002.09c
GO:0009353 mitochondrial oxoglutarate dehydrogenase
complex		 C
IC
SpoSPAC1002.09c
IDA
SceS000001876
GO:0009507 chloroplast C
IDA
AthAt3g16950
At3g17240
GO:0009570 chloroplast stroma C
IDA
AthAt3g16950
GO:0009941 chloroplast envelope C
IDA
AthAt3g16950
GO:0042645 mitochondrial nucleoid C
IDA
SceS000001876
ISS
SpoSPAC1002.09c
GO:0048046 apoplast C
IDA
AthAt1g48030
GO:0004148 dihydrolipoyl dehydrogenase activity F
IDA
SceS000001876
IMP
AthAt3g17240
ISS
AthAt3g16950
At3g17240
At1g48030
SpoSPAC1002.09c
GO:0004375 glycine dehydrogenase (decarboxylating)
activity		 F
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring)
activity		 F
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0004738 pyruvate dehydrogenase activity F
IMP
SceS000001876
GO:0004739 pyruvate dehydrogenase (acetyl-transferring)
activity		 F
ISS
SpoSPAC1002.09c
GO:0005507 copper ion binding F
IDA
AthAt3g17240
At1g48030
GO:0005524 ATP binding F
IDA
AthAt1g48030
At3g17240
GO:0008017 microtubule binding F
IDA
SceS000005938
GO:0008270 zinc ion binding F
IDA
AthAt3g17240
At1g48030
GO:0008757 S-adenosylmethionine-dependent methyltransferase
activity		 F
ISS
SceS000005938
GO:0015036 disulfide oxidoreductase activity F
ISS
SpoSPAC1002.09c
GO:0016651 oxidoreductase activity, acting on NADH or
NADPH		 F
RCA
SceS000005938
GO:0050897 cobalt ion binding F
IDA
AthAt3g17240
At1g48030
GO:0006082 organic acid metabolic process P
RCA
SceS000001876
GO:0006086 acetyl-CoA biosynthetic process from
pyruvate		 P
ISS
SpoSPAC1002.09c
TAS
AthAt3g16950
GO:0006090 pyruvate metabolic process P
IMP
SceS000001876
GO:0006103 2-oxoglutarate metabolic process P
IC
SpoSPAC1002.09c
IMP
SceS000001876
GO:0006312 mitotic recombination P
IMP
SceS000005938
GO:0006546 glycine catabolic process P
IMP
SceS000001876
GO:0006550 isoleucine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006552 leucine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006564 L-serine biosynthetic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006574 valine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0007020 microtubule nucleation P
IDA
SceS000005938
GO:0009416 response to light stimulus P
IEP
AthAt1g48030
GO:0019464 glycine decarboxylation via glycine cleavage
system		 P
ISS
SpoSPAC1002.09c
GO:0034453 microtubule anchoring P
IMP
SceS000005938
GO:0042743 hydrogen peroxide metabolic process P
IGI
SceS000001876
IMP
SceS000001876
GO:0045144 meiotic sister chromatid segregation P
IMP
SceS000005938
GO:0045931 positive regulation of mitotic cell
cycle		 P
IMP
SceS000005938
GO:0046686 response to cadmium ion P
IEP
AthAt1g48030
At3g17240
GO:0051315 attachment of spindle microtubules to kinetochore
involved in mitotic sister chromatid
segregation		 P
IMP
SceS000005938
GO:0055114 oxidation reduction P
RCA
SceS000001876

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
84

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) DLD GI:91199540
Pan troglodytes (Ptr) DLD GI:114615450
Canis familiaris (Cfa) DLD GI:73981638
Mus musculus (Mmu) Dld
(MGI:107450)		 GI:31982856 O08749
Rattus norvegicus (Rno) Dld
(RGD:735073)		 GI:40786469
Gallus gallus (Gga) DLD GI:71897021
Drosophila melanogaster (Dme) CG7430
(FBgn0036762)		 GI:21358499
Anopheles gambiae (Aga) AgaP_AGAP011629 GI:158301129
Caenorhabditis elegans (Cel) LLC1.3
(CE31971;
WBGene00010794)		 GI:32565766
Schizosaccharomyces pombe (Spo) dld1
(SPAC1002.09c)		 GI:19114408 O00087
Saccharomyces cerevisiae (Sce) LPD1
(S000001876)		 GI:14318501 P09624
Kluyveromyces lactis (Kla) KLLA0D11154g GI:50307161
Eremothecium gossypii (Ego) AGOS_AFR512W GI:45199030
Magnaporthe grisea (Mgr) MGG_13528 GI:145616104
Neurospora crassa (Ncr) NCU02407.1 GI:32421479
Arabidopsis thaliana (Ath) mtLPD2 GI:30684419
Arabidopsis thaliana (Ath) mtLPD1 GI:15221044
Oryza sativa (Osa) Os01g0328700 GI:115436320
Plasmodium falciparum (Pfa) PFL1550w GI:124806416


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
AthmtLPD1
mtLPD2
MmuMGI:107450
SceS000001876
SpoSPAC1002.09c
ISO
MmuMGI:107450
GO:0005747 mitochondrial respiratory chain complex
I		 C
IDA
AthmtLPD1
mtLPD2
GO:0005759 mitochondrial matrix C
ISS
AthmtLPD1
mtLPD2
PfaPFL1550w
GO:0005811 lipid particle C
IDA
DmeFBgn0036762
GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase
complex		 C
ISS
DmeFBgn0036762
GO:0005960 glycine cleavage complex C
IMP
SceS000001876
ISS
DmeFBgn0036762
SpoSPAC1002.09c
GO:0005967 mitochondrial pyruvate dehydrogenase
complex		 C
ISS
SpoSPAC1002.09c
GO:0009353 mitochondrial oxoglutarate dehydrogenase
complex		 C
IC
SpoSPAC1002.09c
IDA
SceS000001876
GO:0009507 chloroplast C
IDA
AthmtLPD2
GO:0019861 flagellum C
IDA
MmuMGI:107450
GO:0042645 mitochondrial nucleoid C
IDA
SceS000001876
ISS
SpoSPAC1002.09c
GO:0043159 acrosomal matrix C
IDA
MmuMGI:107450
GO:0045252 oxoglutarate dehydrogenase complex C
ISO
MmuMGI:107450
GO:0045254 pyruvate dehydrogenase complex C
ISO
MmuMGI:107450
GO:0048046 apoplast C
IDA
AthmtLPD1
GO:0004148 dihydrolipoyl dehydrogenase activity F
IDA
SceS000001876
IMP
AthmtLPD2
MmuMGI:107450
ISO
MmuMGI:107450
ISS
AthmtLPD1
mtLPD2
DmeFBgn0036762
SpoSPAC1002.09c
GO:0004375 glycine dehydrogenase (decarboxylating)
activity		 F
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring)
activity		 F
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0004738 pyruvate dehydrogenase activity F
IMP
SceS000001876
GO:0004739 pyruvate dehydrogenase (acetyl-transferring)
activity		 F
ISS
SpoSPAC1002.09c
GO:0005507 copper ion binding F
IDA
AthmtLPD1
mtLPD2
GO:0005524 ATP binding F
IDA
AthmtLPD1
mtLPD2
GO:0008270 zinc ion binding F
IDA
AthmtLPD2
mtLPD1
GO:0015036 disulfide oxidoreductase activity F
ISS
SpoSPAC1002.09c
GO:0043544 lipoamide binding F
ISO
MmuMGI:107450
GO:0050660 FAD binding F
ISO
MmuMGI:107450
GO:0050897 cobalt ion binding F
IDA
AthmtLPD1
mtLPD2
GO:0051287 NAD or NADH binding F
ISO
MmuMGI:107450
GO:0002119 nematode larval development P
IMP
CelWBGene00010794
GO:0006082 organic acid metabolic process P
RCA
SceS000001876
GO:0006086 acetyl-CoA biosynthetic process from
pyruvate		 P
ISO
MmuMGI:107450
ISS
SpoSPAC1002.09c
GO:0006090 pyruvate metabolic process P
IMP
SceS000001876
GO:0006099 tricarboxylic acid cycle P
ISS
DmeFBgn0036762
GO:0006103 2-oxoglutarate metabolic process P
IC
SpoSPAC1002.09c
IMP
SceS000001876
ISO
MmuMGI:107450
GO:0006120 mitochondrial electron transport, NADH to
ubiquinone		 P
IMP
MmuMGI:107450
GO:0006508 proteolysis P
IDA
MmuMGI:107450
GO:0006546 glycine catabolic process P
IMP
SceS000001876
ISS
DmeFBgn0036762
GO:0006550 isoleucine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006552 leucine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006564 L-serine biosynthetic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006574 valine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006748 lipoamide metabolic process P
ISS
DmeFBgn0036762
GO:0007369 gastrulation P
IMP
MmuMGI:107450
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00010794
GO:0009106 lipoate metabolic process P
ISO
MmuMGI:107450
GO:0009416 response to light stimulus P
IEP
AthmtLPD1
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010794
GO:0010510 regulation of acetyl-CoA biosynthetic process from
pyruvate		 P
EXP
HsaDLD
GO:0019464 glycine decarboxylation via glycine cleavage
system		 P
ISS
SpoSPAC1002.09c
GO:0040007 growth P
IMP
CelWBGene00010794
GO:0040011 locomotion P
IMP
CelWBGene00010794
GO:0042391 regulation of membrane potential P
IMP
MmuMGI:107450
GO:0042743 hydrogen peroxide metabolic process P
IGI
SceS000001876
IMP
SceS000001876
GO:0046686 response to cadmium ion P
IEP
AthmtLPD1
mtLPD2
GO:0048240 sperm capacitation P
IDA
MmuMGI:107450
GO:0051068 dihydrolipoamide metabolic process P
ISO
MmuMGI:107450
GO:0055114 oxidation reduction P
RCA
SceS000001876

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_683

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga8748 ENSANGP00000019195
Ashbya gossypii (Ago) ago3704 AFR512W
Arabidopsis thaliana (Ath) ath4062 At1g48030.1
Arabidopsis thaliana (Ath) ath4063 At1g48030.2
Arabidopsis thaliana (Ath) ath13975 At3g17240.1
Arabidopsis thaliana (Ath) ath13977 At3g17240.3
Caenorhabditis elegans (Cel) cel12721 LLC1.3
(CE31971;
WBGene00010794)
Candida glabrata (Cgl) cgl1315 CAGL0F01947g
Cryptococcus neoformans (Cne) cne467 163.m06352
Dictyostelium discoideum (Ddi) ddi13429 DDB0216232
Debaryomyces hansenii (Dha) dha1497 DEHA0C01463g
Drosophila melanogaster (Dme) dme10044 CG7430-PA
(FBgn0036762)
Danio rerio (Dre) dre16932 ENSDARP00000017217
(dldh)		 Q6TNU6
Escherichia coli (Eco) eco117 16128109
Takifugu rubripes (Fru) fru21137 SINFRUP00000173099
Gallus gallus (Gga) gga102 ENSGALP00000012869
(DLD)		 Q5ZM32
Homo sapiens (Hsa) hsa29268 ENSP00000205402
(DLD)		 P09622
Kluyveromyces lactis (Kla) kla2558 KLLA0D11154g
Mus musculus (Mmu) mmu5590 ENSMUSP00000002980
(MGI:107450)		 Q3TIE8
Neurospora crassa (Ncr) ncr2340 NCU02407.2
Oryza sativa (Osa) osa10308 2726.m00149
Oryza sativa (Osa) osa11209 2766.m00171
Oryza sativa (Osa) osa17636 3313.m00119
Oryza sativa (Osa) osa32866 4495.m00163
Oryza sativa (Osa) osa61731 6485.m00178
Plasmodium falciparum (Pfa) pfa5093 PFL1550w
Rattus norvegicus (Rno) rno24978 ENSRNOP00000008980
(RGD:735073)		 Q6P6R2
Saccharomyces cerevisiae (Sce) sce1970 YFL018C
(S000001876)
Schizosaccharomyces pombe (Spo) spo4821 SPAC1002.09c O00087
Yarrowia lipolytica (Yli) yli3574 YALI0D20768g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
AthAt3g17240
At1g48030
MmuMGI:107450
SceS000001876
SpoSPAC1002.09c
ISO
MmuMGI:107450
GO:0005747 mitochondrial respiratory chain complex
I		 C
IDA
AthAt3g17240
At1g48030
GO:0005759 mitochondrial matrix C
ISS
AthAt1g48030
At3g17240
PfaPFL1550w
GO:0005811 lipid particle C
IDA
DmeFBgn0036762
GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase
complex		 C
ISS
DmeFBgn0036762
GO:0005960 glycine cleavage complex C
IMP
SceS000001876
ISS
DmeFBgn0036762
SpoSPAC1002.09c
GO:0005967 mitochondrial pyruvate dehydrogenase
complex		 C
ISS
SpoSPAC1002.09c
GO:0009353 mitochondrial oxoglutarate dehydrogenase
complex		 C
IC
SpoSPAC1002.09c
IDA
SceS000001876
GO:0009507 chloroplast C
IDA
AthAt3g17240
GO:0019861 flagellum C
IDA
MmuMGI:107450
GO:0042645 mitochondrial nucleoid C
IDA
SceS000001876
ISS
SpoSPAC1002.09c
GO:0043159 acrosomal matrix C
IDA
MmuMGI:107450
GO:0045252 oxoglutarate dehydrogenase complex C
ISO
MmuMGI:107450
GO:0045254 pyruvate dehydrogenase complex C
ISO
MmuMGI:107450
GO:0048046 apoplast C
IDA
AthAt1g48030
GO:0004148 dihydrolipoyl dehydrogenase activity F
IDA
SceS000001876
IMP
AthAt3g17240
MmuMGI:107450
ISO
MmuMGI:107450
ISS
AthAt3g17240
At1g48030
DmeFBgn0036762
SpoSPAC1002.09c
GO:0004375 glycine dehydrogenase (decarboxylating)
activity		 F
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring)
activity		 F
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0004738 pyruvate dehydrogenase activity F
IMP
SceS000001876
GO:0004739 pyruvate dehydrogenase (acetyl-transferring)
activity		 F
ISS
SpoSPAC1002.09c
GO:0005507 copper ion binding F
IDA
AthAt3g17240
At1g48030
GO:0005524 ATP binding F
IDA
AthAt1g48030
At3g17240
GO:0008270 zinc ion binding F
IDA
AthAt3g17240
At1g48030
GO:0015036 disulfide oxidoreductase activity F
ISS
SpoSPAC1002.09c
GO:0043544 lipoamide binding F
ISO
MmuMGI:107450
GO:0050660 FAD binding F
ISO
MmuMGI:107450
GO:0050897 cobalt ion binding F
IDA
AthAt3g17240
At1g48030
GO:0051287 NAD or NADH binding F
ISO
MmuMGI:107450
GO:0002119 nematode larval development P
IMP
CelWBGene00010794
GO:0006082 organic acid metabolic process P
RCA
SceS000001876
GO:0006086 acetyl-CoA biosynthetic process from
pyruvate		 P
ISO
MmuMGI:107450
ISS
SpoSPAC1002.09c
GO:0006090 pyruvate metabolic process P
IMP
SceS000001876
GO:0006099 tricarboxylic acid cycle P
ISS
DmeFBgn0036762
GO:0006103 2-oxoglutarate metabolic process P
IC
SpoSPAC1002.09c
IMP
SceS000001876
ISO
MmuMGI:107450
GO:0006120 mitochondrial electron transport, NADH to
ubiquinone		 P
IMP
MmuMGI:107450
GO:0006508 proteolysis P
IDA
MmuMGI:107450
GO:0006546 glycine catabolic process P
IMP
SceS000001876
ISS
DmeFBgn0036762
GO:0006550 isoleucine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006552 leucine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006564 L-serine biosynthetic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006574 valine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006748 lipoamide metabolic process P
ISS
DmeFBgn0036762
GO:0007369 gastrulation P
IMP
MmuMGI:107450
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00010794
GO:0009106 lipoate metabolic process P
ISO
MmuMGI:107450
GO:0009416 response to light stimulus P
IEP
AthAt1g48030
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010794
GO:0019464 glycine decarboxylation via glycine cleavage
system		 P
ISS
SpoSPAC1002.09c
GO:0040007 growth P
IMP
CelWBGene00010794
GO:0040011 locomotion P
IMP
CelWBGene00010794
GO:0042391 regulation of membrane potential P
IMP
MmuMGI:107450
GO:0042743 hydrogen peroxide metabolic process P
IGI
SceS000001876
IMP
SceS000001876
GO:0046686 response to cadmium ion P
IEP
AthAt1g48030
At3g17240
GO:0048240 sperm capacitation P
IDA
MmuMGI:107450
GO:0051068 dihydrolipoamide metabolic process P
ISO
MmuMGI:107450
GO:0055114 oxidation reduction P
RCA
SceS000001876

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC1002.09c
(O00087)		 YFL018C
(S000001876)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000001876
SpoSPAC1002.09c
GO:0005960 glycine cleavage complex C
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0005967 mitochondrial pyruvate dehydrogenase
complex		 C
ISS
SpoSPAC1002.09c
GO:0009353 mitochondrial oxoglutarate dehydrogenase
complex		 C
IC
SpoSPAC1002.09c
IDA
SceS000001876
GO:0042645 mitochondrial nucleoid C
IDA
SceS000001876
ISS
SpoSPAC1002.09c
GO:0004148 dihydrolipoyl dehydrogenase activity F
IDA
SceS000001876
ISS
SpoSPAC1002.09c
GO:0004375 glycine dehydrogenase (decarboxylating)
activity		 F
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring)
activity		 F
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0004738 pyruvate dehydrogenase activity F
IMP
SceS000001876
GO:0004739 pyruvate dehydrogenase (acetyl-transferring)
activity		 F
ISS
SpoSPAC1002.09c
GO:0015036 disulfide oxidoreductase activity F
ISS
SpoSPAC1002.09c
GO:0006082 organic acid metabolic process P
RCA
SceS000001876
GO:0006086 acetyl-CoA biosynthetic process from
pyruvate		 P
ISS
SpoSPAC1002.09c
GO:0006090 pyruvate metabolic process P
IMP
SceS000001876
GO:0006103 2-oxoglutarate metabolic process P
IC
SpoSPAC1002.09c
IMP
SceS000001876
GO:0006546 glycine catabolic process P
IMP
SceS000001876
GO:0006550 isoleucine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006552 leucine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006564 L-serine biosynthetic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0006574 valine catabolic process P
IMP
SceS000001876
ISS
SpoSPAC1002.09c
GO:0019464 glycine decarboxylation via glycine cleavage
system		 P
ISS
SpoSPAC1002.09c
GO:0042743 hydrogen peroxide metabolic process P
IGI
SceS000001876
IMP
SceS000001876
GO:0055114 oxidation reduction P
RCA
SceS000001876

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