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Search term: YFL045C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SEC53
SGD link S000001849
Alternative ID YFL045C
Description Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
Synonyms YFL045C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3189 ACDHYPE

KOGs classification KOGs description
METABOLISM Phosphomannomutase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g45790 GI:15225896
Caenorhabditis elegans (Cel) CE18722 GI:17540570
Drosophila melanogaster (Dme) 7294559 GI:12585299
Homo sapiens (Hsa) Hs4557839
(PMM2)		 GI:4557839 O15305
Homo sapiens (Hsa) Hs4505905 GI:4505905
Saccharomyces cerevisiae (Sce) YFL045c
(S000001849)		 GI:14318474 P07283
Schizosaccharomyces pombe (Spo) SPAC1556.07 GI:19115237 Q9UTJ2
Encephalitozoon cuniculi (Ecu) ECU05g0260 GI:19173562 Q8SVM5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC1556.07
GO:0005737 cytoplasm C
ISS
AthAt2g45790
GO:0005829 cytosol C
IDA
SceS000001849
SpoSPAC1556.07
ISS
SpoSPAC1556.07
GO:0004615 phosphomannomutase activity F
IDA
AthAt2g45790
SceS000001849
IGI
AthAt2g45790
ISS
AthAt2g45790
SpoSPAC1556.07
GO:0005515 protein binding F
IPI
AthAt2g45790
GO:0006417 regulation of translation P
RCA
SceS000001849
GO:0006486 protein amino acid glycosylation P
TAS
HsaPMM2
GO:0006886 intracellular protein transport P
IMP
SpoSPAC1556.07
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SpoSPAC1556.07
GO:0006998 nuclear envelope organization P
IMP
SpoSPAC1556.07
GO:0009298 GDP-mannose biosynthetic process P
TAS
HsaPMM2
GO:0009651 response to salt stress P
IEP
AthAt2g45790
GO:0019307 mannose biosynthetic process P
ISS
AthAt2g45790
GO:0019853 L-ascorbic acid biosynthetic process P
IMP
AthAt2g45790
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001849
GO:0045047 protein targeting to ER P
IMP
SceS000001849
ISS
SpoSPAC1556.07

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
257

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PMM2 GI:4557839 O15305
Pan troglodytes (Ptr) PMM2 GI:55643391
Canis familiaris (Cfa) PMM2 GI:73959199
Mus musculus (Mmu) Pmm2
(MGI:1859214)		 GI:8393988 Q545N8
Rattus norvegicus (Rno) Pmm2 GI:62655656
Gallus gallus (Gga) PMM2 GI:71895479
Drosophila melanogaster (Dme) CG10688
(FBgn0036300)		 GI:24663365
Anopheles gambiae (Aga) AgaP_AGAP011353 GI:58376927
Caenorhabditis elegans (Cel) F52B11.2
(CE36163;
WBGene00009925)		 GI:71989167
Schizosaccharomyces pombe (Spo) pmm1
(SPAC1556.07)		 GI:19115237 Q9UTJ2
Saccharomyces cerevisiae (Sce) SEC53
(S000001849)		 GI:14318474 P07283
Kluyveromyces lactis (Kla) KLLA0D05709g GI:50306685
Eremothecium gossypii (Ego) AGOS_ABR236W GI:45185468
Magnaporthe grisea (Mgr) MGG_01637 GI:39951989
Neurospora crassa (Ncr) NCU02829.1 GI:32419078
Arabidopsis thaliana (Ath) PMM GI:15225896
Oryza sativa (Osa) Os04g0682300 GI:115461390
Plasmodium falciparum (Pfa) PF10_0169 GI:124802381


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC1556.07
GO:0005737 cytoplasm C
ISS
AthPMM
NAS
DmeFBgn0036300
GO:0005829 cytosol C
IDA
SceS000001849
SpoSPAC1556.07
ISS
SpoSPAC1556.07
GO:0004615 phosphomannomutase activity F
IDA
AthPMM
SceS000001849
IGI
AthPMM
ISS
AthPMM
DmeFBgn0036300
SpoSPAC1556.07
NAS
DmeFBgn0036300
GO:0005515 protein binding F
IPI
AthPMM
GO:0006417 regulation of translation P
RCA
SceS000001849
GO:0006486 protein amino acid glycosylation P
TAS
HsaPMM2
GO:0006886 intracellular protein transport P
IMP
SpoSPAC1556.07
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SpoSPAC1556.07
GO:0006998 nuclear envelope organization P
IMP
SpoSPAC1556.07
GO:0009298 GDP-mannose biosynthetic process P
ISS
PfaPF10_0169
NAS
DmeFBgn0036300
TAS
HsaPMM2
GO:0009651 response to salt stress P
IEP
AthPMM
GO:0019307 mannose biosynthetic process P
ISS
AthPMM
GO:0019853 L-ascorbic acid biosynthetic process P
IMP
AthPMM
GO:0019915 lipid storage P
IMP
CelWBGene00009925
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00009925
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001849
GO:0045047 protein targeting to ER P
IMP
SceS000001849
ISS
SpoSPAC1556.07

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1201

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga8419 ENSANGP00000017981
Ashbya gossypii (Ago) ago830 ABR236W
Arabidopsis thaliana (Ath) ath11804 At2g45790.1
Caenorhabditis elegans (Cel) cel9799 F52B11.2
(CE36163;
WBGene00009925)
Candida glabrata (Cgl) cgl4072 CAGL0K12848g
Dictyostelium discoideum (Ddi) ddi12509 DDB0231660
Dictyostelium discoideum (Ddi) ddi11797 DDB0231661
Debaryomyces hansenii (Dha) dha1505 DEHA0C01639g
Drosophila melanogaster (Dme) dme9260 CG10688-PA
(FBgn0036300)
Danio rerio (Dre) dre181 ENSDARP00000009232
Encephalitozoon cuniculi (Ecu) ecu1124 19173562
Takifugu rubripes (Fru) fru15524 SINFRUP00000156638
Takifugu rubripes (Fru) fru8629 SINFRUP00000161309
Takifugu rubripes (Fru) fru15523 SINFRUP00000169796
Takifugu rubripes (Fru) fru8630 SINFRUP00000172663
Takifugu rubripes (Fru) fru8627 SINFRUP00000175734
Gallus gallus (Gga) gga6758 ENSGALP00000011838
(PMM2)
Gallus gallus (Gga) gga822 ENSGALP00000019455
Gallus gallus (Gga) gga823 ENSGALP00000019456
(PMM1)
Homo sapiens (Hsa) hsa21749 ENSP00000216259
(PMM1)		 Q92871
Homo sapiens (Hsa) hsa11634 ENSP00000268261
(PMM2)		 O15305
Kluyveromyces lactis (Kla) kla2315 KLLA0D05709g
Mus musculus (Mmu) mmu9369 ENSMUSP00000023112
(MGI:1353418)		 O35621
Mus musculus (Mmu) mmu9864 ENSMUSP00000023396
(MGI:1859214)		 Q9Z2M7
Neurospora crassa (Ncr) ncr2739 NCU02829.2
Oryza sativa (Osa) osa47192 5773.m00093
Oryza sativa (Osa) osa81366 8123.m00146
Plasmodium falciparum (Pfa) pfa390 PF10_0169
Rattus norvegicus (Rno) rno4433 ENSRNOP00000003542
(RGD:1309366)		 B5DF46
Rattus norvegicus (Rno) rno27463 ENSRNOP00000007164
(RGD:1310897)		 Q5RK25
Rattus norvegicus (Rno) rno27464 ENSRNOP00000007349
(RGD:1310897)
Saccharomyces cerevisiae (Sce) sce2000 YFL045C
(S000001849)
Schizosaccharomyces pombe (Spo) spo3869 SPAC1556.07 Q9UTJ2
Yarrowia lipolytica (Yli) yli3261 YALI0D13112g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC1556.07
GO:0005737 cytoplasm C
ISS
AthAt2g45790
NAS
DmeFBgn0036300
GO:0005829 cytosol C
IDA
SceS000001849
SpoSPAC1556.07
ISS
SpoSPAC1556.07
GO:0004615 phosphomannomutase activity F
IDA
AthAt2g45790
SceS000001849
IGI
AthAt2g45790
ISS
AthAt2g45790
DmeFBgn0036300
SpoSPAC1556.07
NAS
DmeFBgn0036300
GO:0005515 protein binding F
IPI
AthAt2g45790
GO:0006417 regulation of translation P
RCA
SceS000001849
GO:0006886 intracellular protein transport P
IMP
SpoSPAC1556.07
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SpoSPAC1556.07
GO:0006998 nuclear envelope organization P
IMP
SpoSPAC1556.07
GO:0009298 GDP-mannose biosynthetic process P
ISS
PfaPF10_0169
NAS
DmeFBgn0036300
GO:0009651 response to salt stress P
IEP
AthAt2g45790
GO:0019307 mannose biosynthetic process P
ISS
AthAt2g45790
GO:0019853 L-ascorbic acid biosynthetic process P
IMP
AthAt2g45790
GO:0019915 lipid storage P
IMP
CelWBGene00009925
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00009925
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001849
GO:0045047 protein targeting to ER P
IMP
SceS000001849
ISS
SpoSPAC1556.07

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC1556.07
(Q9UTJ2)		 YFL045C
(S000001849)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC1556.07
GO:0005829 cytosol C
IDA
SceS000001849
SpoSPAC1556.07
ISS
SpoSPAC1556.07
GO:0004615 phosphomannomutase activity F
IDA
SceS000001849
ISS
SpoSPAC1556.07
GO:0006417 regulation of translation P
RCA
SceS000001849
GO:0006886 intracellular protein transport P
IMP
SpoSPAC1556.07
GO:0006888 ER to Golgi vesicle-mediated transport P
IMP
SpoSPAC1556.07
GO:0006998 nuclear envelope organization P
IMP
SpoSPAC1556.07
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001849
GO:0045047 protein targeting to ER P
IMP
SceS000001849
ISS
SpoSPAC1556.07

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Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk