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Search term: YFR004W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RPN11
SGD link S000001900
Alternative ID YFR004W
Description Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes
Synonyms YFR004W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1555 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING 26S proteasome regulatory complex, subunit RPN11

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g80210 GI:15220090
Arabidopsis thaliana (Ath) At3g06820 GI:15231308
Arabidopsis thaliana (Ath) At5g23540 GI:15237785
Caenorhabditis elegans (Cel) CE00707
(WBGene00018135)		 GI:17553290 P41883
Caenorhabditis elegans (Cel) CE19527
(WBGene00004467)		 GI:17535703 O76577
Drosophila melanogaster (Dme) 7296942 GI:18467228
Drosophila melanogaster (Dme) 7297828_1
(FBgn0032348)		 GI:19921138
Homo sapiens (Hsa) Hs5031981
(PSMD14)		 GI:5031981 Q96DE8
Homo sapiens (Hsa) Hs16158201_2 GI:16158201
Homo sapiens (Hsa) Hs13236583
(BRCC3)		 GI:13236583 B4DQN7
Homo sapiens (Hsa) Hs14249610 GI:14249610
Saccharomyces cerevisiae (Sce) YFR004w
(S000001900)		 GI:14318526 P43588
Schizosaccharomyces pombe (Spo) SPAC31G5.13 GI:19114926 P41878
Encephalitozoon cuniculi (Ecu) ECU11g0570 GI:19074857 Q8SQY3


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
IDA
HsaBRCC3
GO:0000152 nuclear ubiquitin ligase complex C
IDA
HsaBRCC3
GO:0000502 proteasome complex C
IPI
SpoSPAC31G5.13
TAS
HsaPSMD14
GO:0005634 nucleus C
IDA
HsaBRCC3
SceS000001900
SpoSPAC31G5.13
TAS
AthAt5g23540
SpoSPAC31G5.13
GO:0005737 cytoplasm C
IDA
SpoSPAC31G5.13
GO:0005739 mitochondrion C
IDA
SceS000001900
GO:0005829 cytosol C
IDA
SceS000001900
SpoSPAC31G5.13
GO:0005838 proteasome regulatory particle C
ISS
CelWBGene00004467
GO:0008541 proteasome regulatory particle, lid
subcomplex		 C
IDA
SceS000001900
ISS
AthAt5g23540
SpoSPAC31G5.13
GO:0034515 proteasome storage granule C
IDA
SceS000001900
GO:0070531 BRCA1-A complex C
IDA
HsaBRCC3
GO:0070552 BRISC complex C
IDA
HsaBRCC3
GO:0003674 molecular_function F
ND
AthAt3g06820
At1g80210
GO:0004221 ubiquitin thiolesterase activity F
IMP
HsaBRCC3
TAS
HsaPSMD14
GO:0004843 ubiquitin-specific protease activity F
IMP
HsaBRCC3
SceS000001900
ISS
SpoSPAC31G5.13
GO:0005515 protein binding F
IPI
CelWBGene00004467
HsaBRCC3
PSMD14
GO:0008237 metallopeptidase activity F
IMP
HsaBRCC3
ISS
SceS000001900
TAS
HsaPSMD14
GO:0030234 enzyme regulator activity F
IDA
HsaBRCC3
GO:0031593 polyubiquitin binding F
IDA
HsaBRCC3
GO:0061133 endopeptidase activator activity F
IMP
HsaPSMD14
GO:0070628 proteasome binding F
IDA
HsaPSMD14
GO:0000003 reproduction P
IMP
CelWBGene00018135
GO:0000266 mitochondrial fission P
IMP
SceS000001900
ISS
SpoSPAC31G5.13
GO:0002119 nematode larval development P
IMP
CelWBGene00004467
GO:0006302 double-strand break repair P
IMP
HsaBRCC3
GO:0006508 proteolysis P
RCA
SceS000001900
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
ISS
AthAt3g06820
TAS
AthAt5g23540
HsaPSMD14
GO:0006974 response to DNA damage stimulus P
IEP
HsaBRCC3
GO:0007346 regulation of mitotic cell cycle P
IC
SpoSPAC31G5.13
GO:0008150 biological_process P
ND
AthAt1g80210
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004467
GO:0009651 response to salt stress P
IEP
AthAt5g23540
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004467
GO:0010165 response to X-ray P
IDA
HsaBRCC3
GO:0010212 response to ionizing radiation P
IMP
HsaBRCC3
GO:0016559 peroxisome fission P
IMP
SceS000001900
GO:0016579 protein deubiquitination P
IC
SpoSPAC31G5.13
IGI
SceS000001900
IMP
SceS000001900
GO:0030163 protein catabolic process P
TAS
AthAt5g23540
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMD14
GO:0031572 G2/M transition DNA damage checkpoint P
IMP
HsaBRCC3
GO:0040007 growth P
IMP
CelWBGene00004467
GO:0040011 locomotion P
IMP
CelWBGene00004467
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IC
SpoSPAC31G5.13
IMP
SceS000001900
GO:0045739 positive regulation of DNA repair P
IMP
HsaBRCC3
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMD14
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMD14
GO:0061136 regulation of proteasomal protein catabolic
process		 P
IMP
HsaPSMD14
GO:0070536 protein K63-linked deubiquitination P
IDA
HsaBRCC3
TAS
HsaPSMD14
GO:0070537 histone H2A K63-linked deubiquitination P
IDA
HsaBRCC3
IMP
HsaBRCC3

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4240

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PSMD14 GI:5031981 Q96DE8
Pan troglodytes (Ptr) PSMD14 GI:114581427
Canis familiaris (Cfa) PSMD14 GI:74004396
Mus musculus (Mmu) Psmd14
(MGI:1913284)		 GI:10946952 O35593
Rattus norvegicus (Rno) Psmd14 GI:109468228
Gallus gallus (Gga) PSMD14 GI:71895191
Drosophila melanogaster (Dme) Rpn11
(FBgn0028694)		 GI:19920728
Anopheles gambiae (Aga) AgaP_AGAP008617 GI:58386372
Caenorhabditis elegans (Cel) rpn-11
(CE19527;
WBGene00004467)		 GI:17535703 O76577
Schizosaccharomyces pombe (Spo) bfr2 GI:19114926
Saccharomyces cerevisiae (Sce) RPN11
(S000001900)		 GI:14318526 P43588
Kluyveromyces lactis (Kla) KLLA0E14190g GI:50309165
Eremothecium gossypii (Ego) AGOS_AGR006W GI:45201101
Magnaporthe grisea (Mgr) MGG_05858 GI:145603737
Neurospora crassa (Ncr) NCU00823.1 GI:32409045
Arabidopsis thaliana (Ath) AT5G23540 GI:15237785
Oryza sativa (Osa) Os05g0371200 GI:115463511
Oryza sativa (Osa) Os01g0267200 GI:115435850
Plasmodium falciparum (Pfa) MAL13P1.343 GI:124514070


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
ISS
MmuMGI:1913284
TAS
HsaPSMD14
GO:0005634 nucleus C
IDA
SceS000001900
TAS
AthAt5g23540
GO:0005739 mitochondrion C
IDA
SceS000001900
GO:0005829 cytosol C
IDA
SceS000001900
GO:0005838 proteasome regulatory particle C
IDA
DmeFBgn0028694
ISS
CelWBGene00004467
DmeFBgn0028694
PfaMAL13P1.343
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0028694
GO:0008541 proteasome regulatory particle, lid
subcomplex		 C
IDA
SceS000001900
ISS
AthAt5g23540
DmeFBgn0028694
NAS
DmeFBgn0028694
GO:0034515 proteasome storage granule C
IDA
SceS000001900
GO:0004175 endopeptidase activity F
IDA
DmeFBgn0028694
ISS
MmuMGI:1913284
GO:0004221 ubiquitin thiolesterase activity F
TAS
HsaPSMD14
GO:0004843 ubiquitin-specific protease activity F
IMP
SceS000001900
GO:0005515 protein binding F
IPI
CelWBGene00004467
HsaPSMD14
GO:0008237 metallopeptidase activity F
ISS
SceS000001900
TAS
HsaPSMD14
GO:0061133 endopeptidase activator activity F
IMP
HsaPSMD14
GO:0070628 proteasome binding F
IDA
HsaPSMD14
GO:0000266 mitochondrial fission P
IMP
SceS000001900
GO:0002119 nematode larval development P
IMP
CelWBGene00004467
GO:0006508 proteolysis P
IDA
DmeFBgn0028694
IMP
DmeFBgn0028694
ISS
DmeFBgn0028694
RCA
SceS000001900
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
ISS
PfaMAL13P1.343
TAS
AthAt5g23540
HsaPSMD14
GO:0008152 metabolic process P
ISS
MmuMGI:1913284
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004467
GO:0009651 response to salt stress P
IEP
AthAt5g23540
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004467
GO:0009987 cellular process P
IMP
DmeFBgn0028694
GO:0016559 peroxisome fission P
IMP
SceS000001900
GO:0016579 protein deubiquitination P
IGI
SceS000001900
IMP
SceS000001900
GO:0030163 protein catabolic process P
TAS
AthAt5g23540
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMD14
GO:0040007 growth P
IMP
CelWBGene00004467
GO:0040011 locomotion P
IMP
CelWBGene00004467
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000001900
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMD14
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMD14
GO:0061136 regulation of proteasomal protein catabolic
process		 P
IMP
HsaPSMD14
GO:0070536 protein K63-linked deubiquitination P
TAS
HsaPSMD14

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2186

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga10635 ENSANGP00000013055
Ashbya gossypii (Ago) ago4316 AGR006W
Arabidopsis thaliana (Ath) ath24604 At5g23540.1
Caenorhabditis elegans (Cel) cel12132 K07D4.3
(CE19527;
WBGene00004467)
Candida glabrata (Cgl) cgl4477 CAGL0L09152g
Cryptococcus neoformans (Cne) cne2000 181.m07981
Dictyostelium discoideum (Ddi) ddi12040 DDB0191298
Debaryomyces hansenii (Dha) dha5577 DEHA0F26664g
Drosophila melanogaster (Dme) dme837 CG18174-PA
(FBgn0028694)
Danio rerio (Dre) dre2394 ENSDARP00000023783
Encephalitozoon cuniculi (Ecu) ecu945 19074857
Takifugu rubripes (Fru) fru22353 SINFRUP00000139901
Gallus gallus (Gga) gga21664 ENSGALP00000018120
(PSMD14)
Homo sapiens (Hsa) hsa18766 ENSP00000263639
(PSMD14)		 Q96DE8
Kluyveromyces lactis (Kla) kla3587 KLLA0E14190g
Mus musculus (Mmu) mmu14665 ENSMUSP00000028278
(MGI:1913284)		 O35593
Neurospora crassa (Ncr) ncr801 NCU00823.2
Oryza sativa (Osa) osa9989 2716.m00127
Oryza sativa (Osa) osa18190 3333.m00171
Oryza sativa (Osa) osa20587 3443.m00091
Plasmodium falciparum (Pfa) pfa4114 MAL13P1.343
Rattus norvegicus (Rno) rno18674 ENSRNOP00000006605
(RGD:1594532)		 Q4V8E2
Saccharomyces cerevisiae (Sce) sce2027 YFR004W
(S000001900)
Schizosaccharomyces pombe (Spo) spo4261 SPAC31G5.13 P41878
Yarrowia lipolytica (Yli) yli6447 YALI0F26411g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
IPI
SpoSPAC31G5.13
ISS
MmuMGI:1913284
GO:0005634 nucleus C
IDA
SceS000001900
SpoSPAC31G5.13
TAS
AthAt5g23540
SpoSPAC31G5.13
GO:0005737 cytoplasm C
IDA
SpoSPAC31G5.13
GO:0005739 mitochondrion C
IDA
SceS000001900
GO:0005829 cytosol C
IDA
SceS000001900
SpoSPAC31G5.13
GO:0005838 proteasome regulatory particle C
IDA
DmeFBgn0028694
ISS
CelWBGene00004467
DmeFBgn0028694
PfaMAL13P1.343
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0028694
GO:0008541 proteasome regulatory particle, lid
subcomplex		 C
IDA
SceS000001900
ISS
AthAt5g23540
DmeFBgn0028694
SpoSPAC31G5.13
NAS
DmeFBgn0028694
GO:0034515 proteasome storage granule C
IDA
SceS000001900
GO:0004175 endopeptidase activity F
IDA
DmeFBgn0028694
ISS
MmuMGI:1913284
GO:0004843 ubiquitin-specific protease activity F
IMP
SceS000001900
ISS
SpoSPAC31G5.13
GO:0005515 protein binding F
IPI
CelWBGene00004467
GO:0008237 metallopeptidase activity F
ISS
SceS000001900
GO:0000266 mitochondrial fission P
IMP
SceS000001900
ISS
SpoSPAC31G5.13
GO:0002119 nematode larval development P
IMP
CelWBGene00004467
GO:0006508 proteolysis P
IDA
DmeFBgn0028694
IMP
DmeFBgn0028694
ISS
DmeFBgn0028694
RCA
SceS000001900
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
ISS
PfaMAL13P1.343
TAS
AthAt5g23540
GO:0007346 regulation of mitotic cell cycle P
IC
SpoSPAC31G5.13
GO:0008152 metabolic process P
ISS
MmuMGI:1913284
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004467
GO:0009651 response to salt stress P
IEP
AthAt5g23540
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004467
GO:0009987 cellular process P
IMP
DmeFBgn0028694
GO:0016559 peroxisome fission P
IMP
SceS000001900
GO:0016579 protein deubiquitination P
IC
SpoSPAC31G5.13
IGI
SceS000001900
IMP
SceS000001900
GO:0030163 protein catabolic process P
TAS
AthAt5g23540
GO:0040007 growth P
IMP
CelWBGene00004467
GO:0040011 locomotion P
IMP
CelWBGene00004467
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IC
SpoSPAC31G5.13
IMP
SceS000001900

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC31G5.13
(P41878)		 YFR004W
(S000001900)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
IPI
SpoSPAC31G5.13
GO:0005634 nucleus C
IDA
SceS000001900
SpoSPAC31G5.13
TAS
SpoSPAC31G5.13
GO:0005737 cytoplasm C
IDA
SpoSPAC31G5.13
GO:0005739 mitochondrion C
IDA
SceS000001900
GO:0005829 cytosol C
IDA
SceS000001900
SpoSPAC31G5.13
GO:0008541 proteasome regulatory particle, lid
subcomplex		 C
IDA
SceS000001900
ISS
SpoSPAC31G5.13
GO:0034515 proteasome storage granule C
IDA
SceS000001900
GO:0004843 ubiquitin-specific protease activity F
IMP
SceS000001900
ISS
SpoSPAC31G5.13
GO:0008237 metallopeptidase activity F
ISS
SceS000001900
GO:0000266 mitochondrial fission P
IMP
SceS000001900
ISS
SpoSPAC31G5.13
GO:0006508 proteolysis P
RCA
SceS000001900
GO:0007346 regulation of mitotic cell cycle P
IC
SpoSPAC31G5.13
GO:0016559 peroxisome fission P
IMP
SceS000001900
GO:0016579 protein deubiquitination P
IC
SpoSPAC31G5.13
IGI
SceS000001900
IMP
SceS000001900
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IC
SpoSPAC31G5.13
IMP
SceS000001900

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GO info in one table:

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