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Search term: YFR052W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RPN12
SGD link S000001948
Alternative ID YFR052W
Description Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
Synonyms YFR052W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3151 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING 26S proteasome regulatory complex, subunit RPN12/PSMD8

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g64520 GI:15217661
Arabidopsis thaliana (Ath) At5g42040 GI:15238267
Caenorhabditis elegans (Cel) CE06608
(WBGene00004468)		 GI:17535705 Q23449
Drosophila melanogaster (Dme) 7294091 GI:6434966
Drosophila melanogaster (Dme) 7294333 GI:7294333
Homo sapiens (Hsa) Hs4506233 GI:4506233
Saccharomyces cerevisiae (Sce) YFR052w
(S000001948)		 GI:14318577 P32496
Schizosaccharomyces pombe (Spo) SPBC16G5.01 GI:19113542 P50524


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
IDA
AthAt1g64520
GO:0005634 nucleus C
IDA
SpoSPBC16G5.01
TAS
AthAt1g64520
GO:0005829 cytosol C
IDA
SpoSPBC16G5.01
GO:0005838 proteasome regulatory particle C
ISS
AthAt5g42040
CelWBGene00004468
GO:0008541 proteasome regulatory particle, lid
subcomplex		 C
IDA
SceS000001948
ISS
AthAt1g64520
SpoSPBC16G5.01
GO:0009941 chloroplast envelope C
IDA
AthAt1g64520
GO:0034515 proteasome storage granule C
IDA
SceS000001948
GO:0003674 molecular_function F
ND
SceS000001948
SpoSPBC16G5.01
GO:0005515 protein binding F
IPI
CelWBGene00004468
GO:0008233 peptidase activity F
ISS
AthAt1g64520
At5g42040
GO:0006461 protein complex assembly P
RCA
SceS000001948
GO:0006508 proteolysis P
ISS
AthAt5g42040
RCA
SceS000001948
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000001948
ISS
SpoSPBC16G5.01
TAS
AthAt1g64520
GO:0007346 regulation of mitotic cell cycle P
IC
SpoSPBC16G5.01
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004468
GO:0009408 response to heat P
IMP
AthAt1g64520
GO:0009647 skotomorphogenesis P
IMP
AthAt1g64520
GO:0009733 response to auxin stimulus P
IMP
AthAt1g64520
GO:0009735 response to cytokinin stimulus P
IEP
AthAt1g64520
IMP
AthAt1g64520
GO:0009908 flower development P
IMP
AthAt1g64520
GO:0030163 protein catabolic process P
TAS
AthAt1g64520
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000001948
GO:0031540 regulation of anthocyanin biosynthetic
process		 P
IMP
AthAt1g64520
GO:0042176 regulation of protein catabolic
process		 P
RCA
SceS000001948
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
AthAt1g64520
GO:0043248 proteasome assembly P
IMP
AthAt1g64520
GO:0048366 leaf development P
IMP
AthAt1g64520
GO:0048528 post-embryonic root development P
IMP
AthAt1g64520
GO:0048825 cotyledon development P
IMP
AthAt1g64520
GO:0051788 response to misfolded protein P
IMP
AthAt1g64520

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
37686

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PSMD8 GI:156631005
Canis familiaris (Cfa) PSMD8 GI:57036591
Mus musculus (Mmu) Psmd8
(MGI:1888669)		 GI:27229063 Q3TG45
Rattus norvegicus (Rno) Psmd8
(RGD:1309842)		 GI:34855658
Drosophila melanogaster (Dme) Rpn12
(FBgn0028693)		 GI:21357229
Anopheles gambiae (Aga) AgaP_AGAP002606 GI:158290761
Caenorhabditis elegans (Cel) rpn-12
(CE06608;
WBGene00004468)		 GI:17535705 Q23449
Schizosaccharomyces pombe (Spo) mts3 GI:63054811
Saccharomyces cerevisiae (Sce) RPN12
(S000001948)		 GI:14318577 P32496
Kluyveromyces lactis (Kla) KLLA0D11374g GI:50307179
Eremothecium gossypii (Ego) AGOS_AFR278W GI:45198796
Magnaporthe grisea (Mgr) MGG_03512 GI:39942864
Neurospora crassa (Ncr) NCU10067.1 GI:32406124
Arabidopsis thaliana (Ath) RPN12a GI:15217661
Oryza sativa (Osa) Os07g0435100 GI:115471803
Plasmodium falciparum (Pfa) MAL3P4.9 GI:124504907


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
IDA
AthRPN12a
GO:0005575 cellular_component C
ND
MmuMGI:1888669
GO:0005634 nucleus C
IDA
HsaPSMD8
TAS
AthRPN12a
GO:0005737 cytoplasm C
IDA
HsaPSMD8
GO:0005838 proteasome regulatory particle C
IDA
DmeFBgn0028693
ISS
CelWBGene00004468
DmeFBgn0028693
GO:0008541 proteasome regulatory particle, lid
subcomplex		 C
IDA
SceS000001948
ISS
AthRPN12a
DmeFBgn0028693
NAS
DmeFBgn0028693
GO:0009941 chloroplast envelope C
IDA
AthRPN12a
GO:0034515 proteasome storage granule C
IDA
SceS000001948
GO:0003674 molecular_function F
ND
MmuMGI:1888669
SceS000001948
GO:0004175 endopeptidase activity F
IDA
DmeFBgn0028693
GO:0005515 protein binding F
IPI
CelWBGene00004468
HsaPSMD8
GO:0008233 peptidase activity F
ISS
AthRPN12a
GO:0000022 mitotic spindle elongation P
IMP
DmeFBgn0028693
GO:0006461 protein complex assembly P
RCA
SceS000001948
GO:0006508 proteolysis P
IDA
DmeFBgn0028693
ISS
DmeFBgn0028693
RCA
SceS000001948
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000001948
TAS
AthRPN12a
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0028693
GO:0008150 biological_process P
ND
MmuMGI:1888669
GO:0008283 cell proliferation P
IMP
DmeFBgn0028693
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004468
GO:0009408 response to heat P
IMP
AthRPN12a
GO:0009647 skotomorphogenesis P
IMP
AthRPN12a
GO:0009733 response to auxin stimulus P
IMP
AthRPN12a
GO:0009735 response to cytokinin stimulus P
IEP
AthRPN12a
IMP
AthRPN12a
GO:0009908 flower development P
IMP
AthRPN12a
GO:0009987 cellular process P
IMP
DmeFBgn0028693
GO:0030163 protein catabolic process P
TAS
AthRPN12a
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000001948
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMD8
GO:0031540 regulation of anthocyanin biosynthetic
process		 P
IMP
AthRPN12a
GO:0042176 regulation of protein catabolic
process		 P
RCA
SceS000001948
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
AthRPN12a
GO:0043248 proteasome assembly P
IMP
AthRPN12a
GO:0048366 leaf development P
IMP
AthRPN12a
GO:0048528 post-embryonic root development P
IMP
AthRPN12a
GO:0048825 cotyledon development P
IMP
AthRPN12a
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMD8
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMD8
GO:0051788 response to misfolded protein P
IMP
AthRPN12a

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2129

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4810 ENSANGP00000010608
Ashbya gossypii (Ago) ago3470 AFR278W
Arabidopsis thaliana (Ath) ath5666 At1g64520.1
Caenorhabditis elegans (Cel) cel21746 ZK20.5
(CE06608;
WBGene00004468)
Candida glabrata (Cgl) cgl204 CAGL0A04807g
Cryptococcus neoformans (Cne) cne4775 186.m03648
Dictyostelium discoideum (Ddi) ddi12039 DDB0185109
Dictyostelium discoideum (Ddi) ddi3750 DDB0217402
Debaryomyces hansenii (Dha) dha1106 DEHA0B09922g
Drosophila melanogaster (Dme) dme9547 CG11552-PA
(FBgn0036465)
Drosophila melanogaster (Dme) dme9837 CG4157-PA
(FBgn0028693)
Danio rerio (Dre) dre9579 ENSDARP00000025160
(zgc:86762)		 Q6IQH4
Takifugu rubripes (Fru) fru8043 SINFRUP00000156674
Homo sapiens (Hsa) hsa16314 ENSP00000215071
(PSMD8)		 B4DX18
Kluyveromyces lactis (Kla) kla2567 KLLA0D11374g
Mus musculus (Mmu) mmu23548 ENSMUSP00000051657
(MGI:1888669)		 Q3TG45
Neurospora crassa (Ncr) ncr9800 NCU10067.2
Oryza sativa (Osa) osa3946 2075.m00138
Oryza sativa (Osa) osa34848 4718.m00143
Plasmodium falciparum (Pfa) pfa2774 PFC0520w
Rattus norvegicus (Rno) rno1444 ENSRNOP00000027937
(RGD:1309842)		 Q3B8P5
Saccharomyces cerevisiae (Sce) sce2084 YFR052W
(S000001948)
Schizosaccharomyces pombe (Spo) spo4529 SPBC16G5.01 P50524
Yarrowia lipolytica (Yli) yli621 YALI0A18612g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
IDA
AthAt1g64520
GO:0005575 cellular_component C
ND
MmuMGI:1888669
GO:0005634 nucleus C
IDA
SpoSPBC16G5.01
TAS
AthAt1g64520
GO:0005829 cytosol C
IDA
SpoSPBC16G5.01
GO:0005838 proteasome regulatory particle C
IDA
DmeFBgn0028693
ISS
CelWBGene00004468
DmeFBgn0028693
FBgn0036465
GO:0008541 proteasome regulatory particle, lid
subcomplex		 C
IDA
SceS000001948
ISS
AthAt1g64520
DmeFBgn0028693
SpoSPBC16G5.01
NAS
DmeFBgn0028693
GO:0009941 chloroplast envelope C
IDA
AthAt1g64520
GO:0034515 proteasome storage granule C
IDA
SceS000001948
GO:0003674 molecular_function F
ND
MmuMGI:1888669
SceS000001948
SpoSPBC16G5.01
GO:0004175 endopeptidase activity F
IDA
DmeFBgn0028693
GO:0005515 protein binding F
IPI
CelWBGene00004468
GO:0008233 peptidase activity F
ISS
AthAt1g64520
GO:0000022 mitotic spindle elongation P
IMP
DmeFBgn0028693
GO:0006461 protein complex assembly P
RCA
SceS000001948
GO:0006508 proteolysis P
IDA
DmeFBgn0028693
ISS
DmeFBgn0028693
FBgn0036465
RCA
SceS000001948
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000001948
ISS
PfaPFC0520w
SpoSPBC16G5.01
TAS
AthAt1g64520
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0028693
GO:0007346 regulation of mitotic cell cycle P
IC
SpoSPBC16G5.01
GO:0008150 biological_process P
ND
MmuMGI:1888669
GO:0008283 cell proliferation P
IMP
DmeFBgn0028693
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004468
GO:0009408 response to heat P
IMP
AthAt1g64520
GO:0009647 skotomorphogenesis P
IMP
AthAt1g64520
GO:0009733 response to auxin stimulus P
IMP
AthAt1g64520
GO:0009735 response to cytokinin stimulus P
IEP
AthAt1g64520
IMP
AthAt1g64520
GO:0009908 flower development P
IMP
AthAt1g64520
GO:0009987 cellular process P
IMP
DmeFBgn0028693
GO:0030163 protein catabolic process P
TAS
AthAt1g64520
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000001948
GO:0031540 regulation of anthocyanin biosynthetic
process		 P
IMP
AthAt1g64520
GO:0042176 regulation of protein catabolic
process		 P
RCA
SceS000001948
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
AthAt1g64520
GO:0043248 proteasome assembly P
IMP
AthAt1g64520
GO:0048366 leaf development P
IMP
AthAt1g64520
GO:0048528 post-embryonic root development P
IMP
AthAt1g64520
GO:0048825 cotyledon development P
IMP
AthAt1g64520
GO:0051788 response to misfolded protein P
IMP
AthAt1g64520

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC16G5.01
(P50524)		 YFR052W
(S000001948)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBC16G5.01
GO:0005829 cytosol C
IDA
SpoSPBC16G5.01
GO:0008541 proteasome regulatory particle, lid
subcomplex		 C
IDA
SceS000001948
ISS
SpoSPBC16G5.01
GO:0034515 proteasome storage granule C
IDA
SceS000001948
GO:0003674 molecular_function F
ND
SceS000001948
SpoSPBC16G5.01
GO:0006461 protein complex assembly P
RCA
SceS000001948
GO:0006508 proteolysis P
RCA
SceS000001948
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000001948
ISS
SpoSPBC16G5.01
GO:0007346 regulation of mitotic cell cycle P
IC
SpoSPBC16G5.01
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000001948
GO:0042176 regulation of protein catabolic
process		 P
RCA
SceS000001948

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