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Search term: YGL012W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ERG4
SGD link S000002980
Alternative ID YGL012W
Description C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
Synonyms YGL012W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1435 ACDHYP-

KOGs classification KOGs description
METABOLISMCELLULAR PROCESSES AND SIGNALING Sterol reductase/lamin B receptor

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g50430 GI:15222967
Arabidopsis thaliana (Ath) At3g52940 GI:11358585
Caenorhabditis elegans (Cel) CE19655_2 GI:17557324
Drosophila melanogaster (Dme) 7291331 GI:7291331
Homo sapiens (Hsa) Hs4504961 GI:4504961
Homo sapiens (Hsa) Hs4503321 GI:4503321
Homo sapiens (Hsa) Hs4507547 GI:4507547
Homo sapiens (Hsa) Hs20537133 GI:20537133
Saccharomyces cerevisiae (Sce) YGL012w
(S000002980)		 GI:6321426 P25340
Saccharomyces cerevisiae (Sce) YNL280c
(S000005224)		 GI:6324049 P32462
Schizosaccharomyces pombe (Spo) SPAC20G4.07c GI:19115654 P36209
Schizosaccharomyces pombe (Spo) SPBC16G5.18 GI:19113559 Q09195


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000002980
S000005224
SpoSPBC16G5.18
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPAC20G4.07c
SPBC16G5.18
GO:0005886 plasma membrane C
IDA
AthAt1g50430
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
AthAt1g50430
GO:0000246 delta24(24-1) sterol reductase
activity		 F
IDA
SceS000002980
ISS
SpoSPAC20G4.07c
GO:0009918 sterol delta7 reductase activity F
IMP
AthAt1g50430
GO:0050613 delta14-sterol reductase activity F
IDA
SceS000005224
IGI
AthAt3g52940
IMP
AthAt3g52940
SceS000005224
ISS
SpoSPBC16G5.18
GO:0006066 alcohol metabolic process P
RCA
SceS000005224
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000005224
S000002980
SpoSPAC20G4.07c
ISS
SpoSPBC16G5.18
GO:0006970 response to osmotic stress P
IMP
SpoSPAC20G4.07c
GO:0009793 embryo development ending in seed
dormancy		 P
IMP
AthAt3g52940
GO:0016126 sterol biosynthetic process P
TAS
AthAt3g52940
At1g50430
GO:0016132 brassinosteroid biosynthetic process P
IMP
AthAt1g50430
GO:0030437 ascospore formation P
IMP
SpoSPAC20G4.07c
GO:0042493 response to drug P
IMP
SpoSPAC20G4.07c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000005224
GO:0043157 response to cation stress P
IMP
SpoSPAC20G4.07c
GO:0044255 cellular lipid metabolic process P
RCA
SceS000005224
GO:0071210 protein insertion into membrane
raft		 P
IMP
SpoSPAC20G4.07c
GO:0090002 establishment of protein localization in plasma
membrane		 P
IMP
SpoSPAC20G4.07c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5946

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) erg4 GI:19115654
Saccharomyces cerevisiae (Sce) ERG4
(S000002980)		 GI:6321426 P25340
Kluyveromyces lactis (Kla) KLLA0A05071g GI:50302575
Magnaporthe grisea (Mgr) MGG_02465 GI:39968745
Neurospora crassa (Ncr) NCU01333.1 GI:32412692


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000002980
GO:0000246 delta24(24-1) sterol reductase
activity		 F
IDA
SceS000002980
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000002980

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_11593

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago4224 AGL087C
Candida glabrata (Cgl) cgl16 CAGL0A00429g
Cryptococcus neoformans (Cne) cne5529 179.m00382
Debaryomyces hansenii (Dha) dha394 DEHA0A08888g
Kluyveromyces lactis (Kla) kla220 KLLA0A05071g
Neurospora crassa (Ncr) ncr1292 NCU01333.2
Saccharomyces cerevisiae (Sce) sce2103 YGL012W
(S000002980)
Schizosaccharomyces pombe (Spo) spo2452 SPAC20G4.07c P36209
Yarrowia lipolytica (Yli) yli3509 YALI0D19206g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000002980
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPAC20G4.07c
GO:0000246 delta24(24-1) sterol reductase
activity		 F
IDA
SceS000002980
ISS
SpoSPAC20G4.07c
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000002980
SpoSPAC20G4.07c
GO:0006970 response to osmotic stress P
IMP
SpoSPAC20G4.07c
GO:0030437 ascospore formation P
IMP
SpoSPAC20G4.07c
GO:0042493 response to drug P
IMP
SpoSPAC20G4.07c
GO:0043157 response to cation stress P
IMP
SpoSPAC20G4.07c
GO:0071210 protein insertion into membrane
raft		 P
IMP
SpoSPAC20G4.07c
GO:0090002 establishment of protein localization in plasma
membrane		 P
IMP
SpoSPAC20G4.07c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC20G4.07c
(P36209)		 YGL012W
(S000002980)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000002980
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPAC20G4.07c
GO:0000246 delta24(24-1) sterol reductase
activity		 F
IDA
SceS000002980
ISS
SpoSPAC20G4.07c
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000002980
SpoSPAC20G4.07c
GO:0006970 response to osmotic stress P
IMP
SpoSPAC20G4.07c
GO:0030437 ascospore formation P
IMP
SpoSPAC20G4.07c
GO:0042493 response to drug P
IMP
SpoSPAC20G4.07c
GO:0043157 response to cation stress P
IMP
SpoSPAC20G4.07c
GO:0071210 protein insertion into membrane
raft		 P
IMP
SpoSPAC20G4.07c
GO:0090002 establishment of protein localization in plasma
membrane		 P
IMP
SpoSPAC20G4.07c

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s.khadayate@ucl.ac.uk