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Search term: YGL040C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HEM2
SGD link S000003008
Alternative ID YGL040C
Description Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
Synonyms YGL040C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2794 A-DHYP-

KOGs classification KOGs description
METABOLISM Delta-aminolevulinic acid dehydratase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g44318 GI:15219389
Arabidopsis thaliana (Ath) At1g69740 GI:15222443
Drosophila melanogaster (Dme) 7294597 GI:7294597
Homo sapiens (Hsa) Hs4557297 GI:4557297
Saccharomyces cerevisiae (Sce) YGL040c
(S000003008)		 GI:6321398 P05373
Schizosaccharomyces pombe (Spo) SPAC1805.06c GI:19114829 P78974


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000003008
SpoSPAC1805.06c
ISS
SpoSPAC1805.06c
GO:0005737 cytoplasm C
IDA
SceS000003008
ISS
SpoSPAC1805.06c
GO:0005829 cytosol C
IDA
SpoSPAC1805.06c
GO:0009507 chloroplast C
IDA
AthAt1g69740
GO:0009570 chloroplast stroma C
IDA
AthAt1g69740
GO:0004655 porphobilinogen synthase activity F
IDA
SceS000003008
IMP
SceS000003008
ISS
AthAt1g69740
At1g44318
SpoSPAC1805.06c
GO:0008270 zinc ion binding F
ISS
SpoSPAC1805.06c
GO:0032791 lead ion binding F
ISS
SpoSPAC1805.06c
GO:0006779 porphyrin biosynthetic process P
TAS
AthAt1g69740
At1g44318
GO:0006783 heme biosynthetic process P
IMP
SceS000003008
ISS
SpoSPAC1805.06c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
16

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ALAD GI:189083849
Pan troglodytes (Ptr) ALAD GI:114626250
Canis familiaris (Cfa) ALAD GI:73971984
Mus musculus (Mmu) Alad
(MGI:96853)		 GI:34328485 O89061
Rattus norvegicus (Rno) Alad
(RGD:2083)		 GI:6978483 41259
Drosophila melanogaster (Dme) Pbgs
(FBgn0036271)		 GI:21358291
Anopheles gambiae (Aga) AgaP_AGAP010935 GI:158287863
Schizosaccharomyces pombe (Spo) hem2
(SPAC1805.06c)		 GI:19114829 P78974
Saccharomyces cerevisiae (Sce) HEM2
(S000003008)		 GI:6321398 P05373
Kluyveromyces lactis (Kla) KLLA0F09273g GI:50310959
Eremothecium gossypii (Ego) AGOS_AGR015C GI:45201110
Magnaporthe grisea (Mgr) MGG_10655 GI:39970093
Neurospora crassa (Ncr) NCU01013.1 GI:32412051
Arabidopsis thaliana (Ath) HEMB1 GI:15222443
Oryza sativa (Osa) Os06g0704600 GI:115469822
Plasmodium falciparum (Pfa) PF14_0381 GI:124809361


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005615 extracellular space C
ISO
MmuMGI:96853
GO:0005634 nucleus C
IDA
SceS000003008
SpoSPAC1805.06c
ISS
SpoSPAC1805.06c
GO:0005737 cytoplasm C
IDA
SceS000003008
ISS
SpoSPAC1805.06c
GO:0005829 cytosol C
EXP
HsaALAD
IDA
SpoSPAC1805.06c
ISO
MmuMGI:96853
GO:0009507 chloroplast C
IDA
AthHEMB1
GO:0009570 chloroplast stroma C
IDA
AthHEMB1
GO:0020011 apicoplast C
IDA
PfaPF14_0381
GO:0003824 catalytic activity F
TAS
HsaALAD
GO:0004655 porphobilinogen synthase activity F
IDA
DmeFBgn0036271
HsaALAD
MmuMGI:96853
SceS000003008
IMP
SceS000003008
ISS
AthHEMB1
DmeFBgn0036271
SpoSPAC1805.06c
GO:0008270 zinc ion binding F
IDA
HsaALAD
ISS
SpoSPAC1805.06c
GO:0032791 lead ion binding F
IDA
HsaALAD
ISS
SpoSPAC1805.06c
GO:0042802 identical protein binding F
IPI
HsaALAD
MmuMGI:96853
GO:0006779 porphyrin biosynthetic process P
TAS
AthHEMB1
GO:0006783 heme biosynthetic process P
IDA
HsaALAD
MmuMGI:96853
IMP
SceS000003008
ISO
MmuMGI:96853
ISS
SpoSPAC1805.06c
GO:0007584 response to nutrient P
ISO
MmuMGI:96853
GO:0010033 response to organic substance P
ISO
MmuMGI:96853
GO:0010038 response to metal ion P
ISO
MmuMGI:96853
GO:0010043 response to zinc ion P
ISO
MmuMGI:96853
GO:0042221 response to chemical stimulus P
ISO
MmuMGI:96853
GO:0042493 response to drug P
ISO
MmuMGI:96853
GO:0045471 response to ethanol P
ISO
MmuMGI:96853
GO:0046685 response to arsenic P
ISO
MmuMGI:96853
GO:0046686 response to cadmium ion P
ISO
MmuMGI:96853
GO:0051260 protein homooligomerization P
IPI
HsaALAD

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1481

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga7951 ENSANGP00000012449
Ashbya gossypii (Ago) ago4325 AGR015C
Arabidopsis thaliana (Ath) ath6244 At1g69740.1
Candida glabrata (Cgl) cgl918 CAGL0D06138g
Cryptococcus neoformans (Cne) cne2119 181.m08111
Dictyostelium discoideum (Ddi) ddi11377 DDB0231415
Debaryomyces hansenii (Dha) dha4218 DEHA0E22176g
Drosophila melanogaster (Dme) dme9223 CG10335-PA
(FBgn0036271)
Danio rerio (Dre) dre1943 ENSDARP00000005850
Escherichia coli (Eco) eco360 49176016
Takifugu rubripes (Fru) fru30839 SINFRUP00000154331
Gallus gallus (Gga) gga8200 ENSGALP00000014392
Homo sapiens (Hsa) hsa31755 ENSP00000277315
(ALAD)		 B7ZBK6
Kluyveromyces lactis (Kla) kla4502 KLLA0F09273g
Mus musculus (Mmu) mmu18261 ENSMUSP00000030090
(MGI:96853)		 P10518
Neurospora crassa (Ncr) ncr978 NCU01013.2
Oryza sativa (Osa) osa3418 1972.m00165
Oryza sativa (Osa) osa3444 1972.m00221
Plasmodium falciparum (Pfa) pfa1832 PF14_0381
Rattus norvegicus (Rno) rno23271 ENSRNOP00000020625
(RGD:2083)		 P06214
Saccharomyces cerevisiae (Sce) sce2132 YGL040C
(S000003008)
Schizosaccharomyces pombe (Spo) spo2873 SPAC1805.06c P78974
Yarrowia lipolytica (Yli) yli6217 YALI0F20790g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005615 extracellular space C
ISO
MmuMGI:96853
GO:0005634 nucleus C
IDA
SceS000003008
SpoSPAC1805.06c
ISS
SpoSPAC1805.06c
GO:0005737 cytoplasm C
IDA
SceS000003008
ISS
SpoSPAC1805.06c
GO:0005829 cytosol C
IDA
SpoSPAC1805.06c
ISO
MmuMGI:96853
GO:0009507 chloroplast C
IDA
AthAt1g69740
GO:0009570 chloroplast stroma C
IDA
AthAt1g69740
GO:0020011 apicoplast C
IDA
PfaPF14_0381
GO:0004655 porphobilinogen synthase activity F
IDA
DmeFBgn0036271
MmuMGI:96853
SceS000003008
IMP
SceS000003008
ISS
AthAt1g69740
DmeFBgn0036271
SpoSPAC1805.06c
GO:0008270 zinc ion binding F
ISS
SpoSPAC1805.06c
GO:0032791 lead ion binding F
ISS
SpoSPAC1805.06c
GO:0042802 identical protein binding F
IPI
MmuMGI:96853
GO:0006779 porphyrin biosynthetic process P
TAS
AthAt1g69740
GO:0006783 heme biosynthetic process P
IDA
MmuMGI:96853
IMP
SceS000003008
ISO
MmuMGI:96853
ISS
SpoSPAC1805.06c
GO:0007584 response to nutrient P
ISO
MmuMGI:96853
GO:0010033 response to organic substance P
ISO
MmuMGI:96853
GO:0010038 response to metal ion P
ISO
MmuMGI:96853
GO:0010043 response to zinc ion P
ISO
MmuMGI:96853
GO:0042221 response to chemical stimulus P
ISO
MmuMGI:96853
GO:0042493 response to drug P
ISO
MmuMGI:96853
GO:0045471 response to ethanol P
ISO
MmuMGI:96853
GO:0046685 response to arsenic P
ISO
MmuMGI:96853
GO:0046686 response to cadmium ion P
ISO
MmuMGI:96853

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC1805.06c
(P78974)		 YGL040C
(S000003008)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000003008
SpoSPAC1805.06c
ISS
SpoSPAC1805.06c
GO:0005737 cytoplasm C
IDA
SceS000003008
ISS
SpoSPAC1805.06c
GO:0005829 cytosol C
IDA
SpoSPAC1805.06c
GO:0004655 porphobilinogen synthase activity F
IDA
SceS000003008
IMP
SceS000003008
ISS
SpoSPAC1805.06c
GO:0008270 zinc ion binding F
ISS
SpoSPAC1805.06c
GO:0032791 lead ion binding F
ISS
SpoSPAC1805.06c
GO:0006783 heme biosynthetic process P
IMP
SceS000003008
ISS
SpoSPAC1805.06c

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Search for gene by ID or name:

Query species:

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Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk