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Search term: YGL048C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RPT6
SGD link S000003016
Alternative ID YGL048C
Description One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle
Synonyms YGL048C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0728 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING 26S proteasome regulatory complex, ATPase RPT6

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g19990 GI:6652888
Arabidopsis thaliana (Ath) At5g20000 GI:15241241
Caenorhabditis elegans (Cel) CE22219
(WBGene00004506)		 GI:17554786 Q9XTT9
Caenorhabditis elegans (Cel) CE28467
(WBGene00018991)		 GI:17553708
Drosophila melanogaster (Dme) 7295522
(FBgn0020369)		 GI:19920408
Drosophila melanogaster (Dme) 7301963 GI:7301963
Homo sapiens (Hsa) Hs14771027 GI:7110703
Homo sapiens (Hsa) Hs20541927 GI:20541927
Homo sapiens (Hsa) Hs4506213 GI:4506213
Saccharomyces cerevisiae (Sce) YGL048c
(S000003016)		 GI:6321390 Q01939
Schizosaccharomyces pombe (Spo) SPBC23G7.12c GI:19112662 P41836
Encephalitozoon cuniculi (Ecu) ECU09g1840 GI:19173306
Arabidopsis thaliana (Ath) At5g19990 GI:6652888
Arabidopsis thaliana (Ath) At5g20000 GI:15241241
Caenorhabditis elegans (Cel) CE22219
(WBGene00004506)		 GI:17554786 Q9XTT9
Caenorhabditis elegans (Cel) CE28467
(WBGene00018991)		 GI:17553708
Drosophila melanogaster (Dme) 7295522
(FBgn0020369)		 GI:19920408
Drosophila melanogaster (Dme) 7301963 GI:7301963
Homo sapiens (Hsa) Hs14771027 GI:7110703
Homo sapiens (Hsa) Hs20541927 GI:20541927
Homo sapiens (Hsa) Hs4506213 GI:4506213
Saccharomyces cerevisiae (Sce) YGL048c
(S000003016)		 GI:6321390 Q01939
Schizosaccharomyces pombe (Spo) SPBC23G7.12c GI:19112662 P41836
Encephalitozoon cuniculi (Ecu) ECU09g1840 GI:19173306


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
NAS
DmeFBgn0020369
GO:0005634 nucleus C
IDA
SceS000003016
SpoSPBC23G7.12c
TAS
AthAt5g19990
At5g20000
GO:0005635 nuclear envelope C
IDA
SpoSPBC23G7.12c
GO:0005829 cytosol C
IDA
SpoSPBC23G7.12c
GO:0005838 proteasome regulatory particle C
IDA
DmeFBgn0020369
ISS
DmeFBgn0020369
NAS
DmeFBgn0020369
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0020369
GO:0005886 plasma membrane C
IDA
AthAt5g19990
GO:0008540 proteasome regulatory particle, base
subcomplex		 C
IDA
AthAt5g19990
SceS000003016
ISS
AthAt5g20000
DmeFBgn0020369
SpoSPBC23G7.12c
NAS
DmeFBgn0020369
GO:0034515 proteasome storage granule C
IDA
SceS000003016
GO:0004175 endopeptidase activity F
IDA
DmeFBgn0020369
ISS
SpoSPBC23G7.12c
NAS
DmeFBgn0020369
GO:0005524 ATP binding F
ISS
SpoSPBC23G7.12c
GO:0010843 promoter binding F
IDA
SceS000003016
GO:0016887 ATPase activity F
IGI
AthAt5g19990
ISS
AthAt5g20000
At5g19990
DmeFBgn0020369
SpoSPBC23G7.12c
NAS
DmeFBgn0020369
TAS
SceS000003016
GO:0000003 reproduction P
IMP
CelWBGene00018991
WBGene00004506
GO:0000278 mitotic cell cycle P
IC
SpoSPBC23G7.12c
GO:0002119 nematode larval development P
IMP
CelWBGene00004506
WBGene00018991
GO:0006200 ATP catabolic process P
ISS
SpoSPBC23G7.12c
GO:0006508 proteolysis P
IDA
DmeFBgn0020369
ISS
DmeFBgn0020369
RCA
SceS000003016
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000003016
ISS
AthAt5g20000
SpoSPBC23G7.12c
NAS
DmeFBgn0020369
TAS
AthAt5g19990
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0020369
GO:0007091 mitotic metaphase/anaphase transition P
IMP
CelWBGene00004506
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPBC23G7.12c
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004506
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004506
WBGene00018991
GO:0032968 positive regulation of RNA elongation from RNA
polymerase II promoter		 P
IMP
SceS000003016
GO:0040007 growth P
IMP
CelWBGene00018991
WBGene00004506
GO:0040011 locomotion P
IMP
CelWBGene00004506
WBGene00018991
GO:0040017 positive regulation of locomotion P
IMP
CelWBGene00018991
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00018991
GO:0045899 positive regulation of RNA polymerase II
transcriptional preinitiation complex
assembly		 P
IGI
SceS000003016
IMP
SceS000003016
GO:0070682 proteasome regulatory particle
assembly		 P
IMP
SceS000003016

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
2098

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PSMC5 GI:24497435
Pan troglodytes (Ptr) PSMC5 GI:114669864
Canis familiaris (Cfa) PSMC5 GI:73965193
Mus musculus (Mmu) Psmc5
(MGI:105047)		 GI:7110703 P62196
Rattus norvegicus (Rno) Psmc5
(RGD:708376)		 GI:13592141
Gallus gallus (Gga) PSMC5 GI:118102836
Drosophila melanogaster (Dme) Pros45
(FBgn0020369)		 GI:19920408
Anopheles gambiae (Aga) AgaP_AGAP007243 GI:58376339
Caenorhabditis elegans (Cel) rpt-6
(CE22219;
WBGene00004506)		 GI:17554786 Q9XTT9
Caenorhabditis elegans (Cel) F56F11.4
(CE28467;
WBGene00018991)		 GI:25144281
Schizosaccharomyces pombe (Spo) let1 GI:19112662
Saccharomyces cerevisiae (Sce) RPT6
(S000003016)		 GI:6321390 Q01939
Kluyveromyces lactis (Kla) KLLA0A04752g GI:50302545
Eremothecium gossypii (Ego) AGOS_AGL043C GI:45201053
Magnaporthe grisea (Mgr) MGG_01380 GI:39951475
Neurospora crassa (Ncr) NCU05363.1 GI:32409475
Oryza sativa (Osa) Os06g0600100 GI:115468800


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
IDA
HsaPSMC5
NAS
DmeFBgn0020369
GO:0005634 nucleus C
IDA
HsaPSMC5
SceS000003016
GO:0005675 holo TFIIH complex C
ISA
MmuMGI:105047
GO:0005737 cytoplasm C
IDA
HsaPSMC5
GO:0005838 proteasome regulatory particle C
IDA
DmeFBgn0020369
ISS
DmeFBgn0020369
NAS
DmeFBgn0020369
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0020369
GO:0008540 proteasome regulatory particle, base
subcomplex		 C
IDA
SceS000003016
ISS
DmeFBgn0020369
NAS
DmeFBgn0020369
GO:0034515 proteasome storage granule C
IDA
SceS000003016
GO:0003712 transcription cofactor activity F
TAS
HsaPSMC5
GO:0004175 endopeptidase activity F
IDA
DmeFBgn0020369
NAS
DmeFBgn0020369
GO:0005515 protein binding F
IPI
HsaPSMC5
MmuMGI:105047
GO:0008134 transcription factor binding F
IPI
HsaPSMC5
ISA
MmuMGI:105047
GO:0010843 promoter binding F
IDA
SceS000003016
GO:0016887 ATPase activity F
ISS
DmeFBgn0020369
NAS
DmeFBgn0020369
TAS
HsaPSMC5
SceS000003016
GO:0031531 thyrotropin-releasing hormone receptor
binding		 F
IPI
HsaPSMC5
GO:0000003 reproduction P
IMP
CelWBGene00018991
WBGene00004506
GO:0002119 nematode larval development P
IMP
CelWBGene00004506
WBGene00018991
GO:0006366 transcription from RNA polymerase II
promoter		 P
TAS
HsaPSMC5
GO:0006508 proteolysis P
IDA
DmeFBgn0020369
ISS
DmeFBgn0020369
RCA
SceS000003016
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000003016
NAS
DmeFBgn0020369
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0020369
GO:0007091 mitotic metaphase/anaphase transition P
IMP
CelWBGene00004506
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004506
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004506
WBGene00018991
GO:0016481 negative regulation of transcription P
IDA
MmuMGI:105047
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMC5
GO:0032968 positive regulation of RNA elongation from RNA
polymerase II promoter		 P
IMP
SceS000003016
GO:0040007 growth P
IMP
CelWBGene00018991
WBGene00004506
GO:0040011 locomotion P
IMP
CelWBGene00004506
WBGene00018991
GO:0040017 positive regulation of locomotion P
IMP
CelWBGene00018991
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00018991
GO:0043069 negative regulation of programmed cell
death		 P
NAS
HsaPSMC5
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
HsaPSMC5
GO:0043193 positive regulation of gene-specific
transcription		 P
NAS
HsaPSMC5
GO:0045899 positive regulation of RNA polymerase II
transcriptional preinitiation complex
assembly		 P
IGI
SceS000003016
IMP
SceS000003016
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMC5
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMC5
GO:0070682 proteasome regulatory particle
assembly		 P
IMP
SceS000003016

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2409

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga2674 ENSANGP00000016050
Ashbya gossypii (Ago) ago4268 AGL043C
Arabidopsis thaliana (Ath) ath24276 At5g19990.1
Arabidopsis thaliana (Ath) ath24277 At5g20000.1
Caenorhabditis elegans (Cel) cel19342 Y49E10.1
(CE22219;
WBGene00004506)
Candida glabrata (Cgl) cgl924 CAGL0D06292g
Cryptococcus neoformans (Cne) cne3861 185.m02447
Dictyostelium discoideum (Ddi) ddi13406 DDB0216230
Debaryomyces hansenii (Dha) dha1904 DEHA0C10670g
Drosophila melanogaster (Dme) dme18877 CG1489-PA
(FBgn0020369)
Danio rerio (Dre) dre29526 ENSDARP00000020207
(zgc:92464)		 Q6AZC1
Encephalitozoon cuniculi (Ecu) ecu1457 19173306
Takifugu rubripes (Fru) fru30912 SINFRUP00000145048
Gallus gallus (Gga) gga13687 ENSGALP00000000468
(PSMC5)
Homo sapiens (Hsa) hsa14157 ENSP00000310572
(PSMC5)		 P62195
Kluyveromyces lactis (Kla) kla205 KLLA0A04752g
Mus musculus (Mmu) mmu5006 ENSMUSP00000021049
(MGI:105047)		 P62196
Neurospora crassa (Ncr) ncr5208 NCU05363.2
Oryza sativa (Osa) osa62884 6515.m00134
Plasmodium falciparum (Pfa) pfa5250 PFL2345c
Rattus norvegicus (Rno) rno6305 ENSRNOP00000013997
(RGD:708376)		 P62198
Saccharomyces cerevisiae (Sce) sce2141 YGL048C
(S000003016)
Schizosaccharomyces pombe (Spo) spo4575 SPBC23G7.12c P41836
Yarrowia lipolytica (Yli) yli3418 YALI0D17204g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
ISS
PfaPFL2345c
NAS
DmeFBgn0020369
GO:0005634 nucleus C
IDA
SceS000003016
SpoSPBC23G7.12c
TAS
AthAt5g19990
At5g20000
GO:0005635 nuclear envelope C
IDA
SpoSPBC23G7.12c
GO:0005675 holo TFIIH complex C
ISA
MmuMGI:105047
GO:0005829 cytosol C
IDA
SpoSPBC23G7.12c
GO:0005838 proteasome regulatory particle C
IDA
DmeFBgn0020369
ISS
DmeFBgn0020369
NAS
DmeFBgn0020369
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0020369
GO:0005886 plasma membrane C
IDA
AthAt5g19990
GO:0008540 proteasome regulatory particle, base
subcomplex		 C
IDA
AthAt5g19990
SceS000003016
ISS
AthAt5g20000
DmeFBgn0020369
SpoSPBC23G7.12c
NAS
DmeFBgn0020369
GO:0034515 proteasome storage granule C
IDA
SceS000003016
GO:0003712 transcription cofactor activity F
ISS
PfaPFL2345c
GO:0004175 endopeptidase activity F
IDA
DmeFBgn0020369
ISS
SpoSPBC23G7.12c
NAS
DmeFBgn0020369
GO:0005515 protein binding F
IPI
MmuMGI:105047
GO:0005524 ATP binding F
ISS
SpoSPBC23G7.12c
GO:0008134 transcription factor binding F
ISA
MmuMGI:105047
GO:0010843 promoter binding F
IDA
SceS000003016
GO:0016887 ATPase activity F
IGI
AthAt5g19990
ISS
AthAt5g20000
At5g19990
DmeFBgn0020369
PfaPFL2345c
SpoSPBC23G7.12c
NAS
DmeFBgn0020369
TAS
SceS000003016
GO:0000003 reproduction P
IMP
CelWBGene00004506
GO:0000278 mitotic cell cycle P
IC
SpoSPBC23G7.12c
GO:0002119 nematode larval development P
IMP
CelWBGene00004506
GO:0006200 ATP catabolic process P
ISS
SpoSPBC23G7.12c
GO:0006508 proteolysis P
IDA
DmeFBgn0020369
ISS
DmeFBgn0020369
RCA
SceS000003016
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000003016
ISS
AthAt5g20000
PfaPFL2345c
SpoSPBC23G7.12c
NAS
DmeFBgn0020369
TAS
AthAt5g19990
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0020369
GO:0007091 mitotic metaphase/anaphase transition P
IMP
CelWBGene00004506
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPBC23G7.12c
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004506
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004506
GO:0016481 negative regulation of transcription P
IDA
MmuMGI:105047
GO:0032968 positive regulation of RNA elongation from RNA
polymerase II promoter		 P
IMP
SceS000003016
GO:0040007 growth P
IMP
CelWBGene00004506
GO:0040011 locomotion P
IMP
CelWBGene00004506
GO:0045899 positive regulation of RNA polymerase II
transcriptional preinitiation complex
assembly		 P
IGI
SceS000003016
IMP
SceS000003016
GO:0070682 proteasome regulatory particle
assembly		 P
IMP
SceS000003016

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC23G7.12c
(P41836)		 YGL048C
(S000003016)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000003016
SpoSPBC23G7.12c
GO:0005635 nuclear envelope C
IDA
SpoSPBC23G7.12c
GO:0005829 cytosol C
IDA
SpoSPBC23G7.12c
GO:0008540 proteasome regulatory particle, base
subcomplex		 C
IDA
SceS000003016
ISS
SpoSPBC23G7.12c
GO:0034515 proteasome storage granule C
IDA
SceS000003016
GO:0004175 endopeptidase activity F
ISS
SpoSPBC23G7.12c
GO:0005524 ATP binding F
ISS
SpoSPBC23G7.12c
GO:0010843 promoter binding F
IDA
SceS000003016
GO:0016887 ATPase activity F
ISS
SpoSPBC23G7.12c
TAS
SceS000003016
GO:0000278 mitotic cell cycle P
IC
SpoSPBC23G7.12c
GO:0006200 ATP catabolic process P
ISS
SpoSPBC23G7.12c
GO:0006508 proteolysis P
RCA
SceS000003016
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000003016
ISS
SpoSPBC23G7.12c
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPBC23G7.12c
GO:0032968 positive regulation of RNA elongation from RNA
polymerase II promoter		 P
IMP
SceS000003016
GO:0045899 positive regulation of RNA polymerase II
transcriptional preinitiation complex
assembly		 P
IGI
SceS000003016
IMP
SceS000003016
GO:0070682 proteasome regulatory particle
assembly		 P
IMP
SceS000003016

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