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Search term: YGL062W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PYC1
SGD link S000003030
Alternative ID YGL062W
Description Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
Synonyms YGL062W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0369 -CDHYP-

KOGs classification KOGs description
METABOLISM Pyruvate carboxylase

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE09072
(WBGene00004258)		 GI:17562816 O17732
Drosophila melanogaster (Dme) 7303838 GI:19921944 Q7KN97
Homo sapiens (Hsa) Hs4505627 GI:4505627
Saccharomyces cerevisiae (Sce) YBR218c
(S000000422)		 GI:6319695 P32327
Saccharomyces cerevisiae (Sce) YGL062w
(S000003030)		 GI:6321376 P11154
Schizosaccharomyces pombe (Spo) SPBC17G9.11c GI:19112692 Q9UUE1
Caenorhabditis elegans (Cel) CE09072
(WBGene00004258)		 GI:17562816 O17732
Drosophila melanogaster (Dme) 7303838 GI:19921944 Q7KN97
Homo sapiens (Hsa) Hs4505627 GI:4505627
Saccharomyces cerevisiae (Sce) YBR218c
(S000000422)		 GI:6319695 P32327
Saccharomyces cerevisiae (Sce) YGL062w
(S000003030)		 GI:6321376 P11154
Schizosaccharomyces pombe (Spo) SPBC17G9.11c GI:19112692 Q9UUE1
Caenorhabditis elegans (Cel) CE09072
(WBGene00004258)		 GI:17562816 O17732
Drosophila melanogaster (Dme) 7303838 GI:19921944 Q7KN97
Homo sapiens (Hsa) Hs4505627 GI:4505627
Saccharomyces cerevisiae (Sce) YBR218c
(S000000422)		 GI:6319695 P32327
Saccharomyces cerevisiae (Sce) YGL062w
(S000003030)		 GI:6321376 P11154
Schizosaccharomyces pombe (Spo) SPBC17G9.11c GI:19112692 Q9UUE1


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005829 cytosol C
IDA
SceS000000422
S000003030
SpoSPBC17G9.11c
GO:0004736 pyruvate carboxylase activity F
IDA
SceS000000422
S000003030
IMP
SceS000000422
S000003030
ISS
SpoSPBC17G9.11c
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPBC17G9.11c
GO:0006094 gluconeogenesis P
IMP
SceS000000422
S000003030
ISS
SpoSPBC17G9.11c
GO:0006740 NADPH regeneration P
TAS
SceS000003030
S000000422
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000003030
GO:0051098 regulation of binding P
RCA
SceS000003030

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5422

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PC GI:106049292
Canis familiaris (Cfa) PC GI:73982895
Mus musculus (Mmu) Pcx
(MGI:97520)		 GI:6679237 Q05920
Rattus norvegicus (Rno) Pc
(RGD:3262)		 GI:31543464 39094
Drosophila melanogaster (Dme) CG1516
(FBgn0027580)		 GI:24652218
Anopheles gambiae (Aga) AgaP_AGAP004742 GI:158297962
Caenorhabditis elegans (Cel) pyc-1
(CE09072;
WBGene00004258)		 GI:17562816 O17732
Schizosaccharomyces pombe (Spo) pyr1
(SPBC17G9.11c)		 GI:19112692 Q9UUE1
Saccharomyces cerevisiae (Sce) PYC2
(S000000422)		 GI:6319695 P32327
Saccharomyces cerevisiae (Sce) PYC1
(S000003030)		 GI:6321376 P11154
Kluyveromyces lactis (Kla) KLLA0C05764g GI:50304997
Eremothecium gossypii (Ego) AGOS_AAR162C GI:45184987
Magnaporthe grisea (Mgr) MGG_07756 GI:145604521
Neurospora crassa (Ncr) NCU02505.1 GI:32422521


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005625 soluble fraction C
ISO
MmuMGI:97520
GO:0005739 mitochondrion C
IDA
HsaPC
MmuMGI:97520
ISO
MmuMGI:97520
GO:0005743 mitochondrial inner membrane C
IDA
MmuMGI:97520
GO:0005759 mitochondrial matrix C
EXP
HsaPC
ISS
DmeFBgn0027580
GO:0005811 lipid particle C
IDA
DmeFBgn0027580
GO:0005829 cytosol C
IDA
SceS000000422
S000003030
SpoSPBC17G9.11c
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0027580
GO:0004736 pyruvate carboxylase activity F
EXP
HsaPC
IDA
SceS000000422
S000003030
IMP
SceS000000422
S000003030
ISO
MmuMGI:97520
ISS
DmeFBgn0027580
SpoSPBC17G9.11c
GO:0005524 ATP binding F
ISO
MmuMGI:97520
GO:0009374 biotin binding F
ISO
MmuMGI:97520
GO:0031406 carboxylic acid binding F
ISO
MmuMGI:97520
GO:0006090 pyruvate metabolic process P
ISO
MmuMGI:97520
ISS
DmeFBgn0027580
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPBC17G9.11c
GO:0006094 gluconeogenesis P
IMP
SceS000000422
S000003030
ISO
MmuMGI:97520
ISS
SpoSPBC17G9.11c
GO:0006107 oxaloacetate metabolic process P
ISO
MmuMGI:97520
GO:0006740 NADPH regeneration P
TAS
SceS000003030
S000000422
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000003030
GO:0051098 regulation of binding P
RCA
SceS000003030

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_208

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga74 ENSANGP00000003518
Anopheles gambiae (Aga) aga73 ENSANGP00000023222
Ashbya gossypii (Ago) ago350 AAR162C
Arabidopsis thaliana (Ath) ath25307 At5g35360.1
Caenorhabditis elegans (Cel) cel5068 D2023.2
(CE09072;
WBGene00004258)
Caenorhabditis elegans (Cel) cel7490 F27D9.5
(CE04451;
WBGene00017864)
Candida glabrata (Cgl) cgl1528 CAGL0F06941g
Candida glabrata (Cgl) cgl3813 CAGL0K06787g
Cryptococcus neoformans (Cne) cne1326 180.m00273
Dictyostelium discoideum (Ddi) ddi11948 DDB0230063
Debaryomyces hansenii (Dha) dha1882 DEHA0C10208g
Drosophila melanogaster (Dme) dme4161 CG1516-PA
(FBgn0027580)
Drosophila melanogaster (Dme) dme4164 CG1516-PB
(FBgn0027580)
Drosophila melanogaster (Dme) dme4162 CG1516-PD
(FBgn0027580)
Drosophila melanogaster (Dme) dme4159 CG1516-PE
(FBgn0027580)
Drosophila melanogaster (Dme) dme4166 CG1516-PG
(FBgn0027580)
Drosophila melanogaster (Dme) dme4160 CG1516-PI
(FBgn0027580)
Drosophila melanogaster (Dme) dme4163 CG1516-PJ
(FBgn0027580)
Drosophila melanogaster (Dme) dme4165 CG1516-PK
(FBgn0027580)
Drosophila melanogaster (Dme) dme4167 CG1516-PL
(FBgn0027580)
Danio rerio (Dre) dre22010 ENSDARP00000001575
Danio rerio (Dre) dre13803 ENSDARP00000005230
Danio rerio (Dre) dre788 ENSDARP00000020266
Danio rerio (Dre) dre22002 ENSDARP00000045088
(LOC572793)		 Q58EN6
Escherichia coli (Eco) eco3146 16131144
Takifugu rubripes (Fru) fru29549 SINFRUP00000146882
Takifugu rubripes (Fru) fru8231 SINFRUP00000146903
Takifugu rubripes (Fru) fru13599 SINFRUP00000158890
Takifugu rubripes (Fru) fru13601 SINFRUP00000170739
Takifugu rubripes (Fru) fru13600 SINFRUP00000173073
Takifugu rubripes (Fru) fru8232 SINFRUP00000177264
Gallus gallus (Gga) gga2769 ENSGALP00000027208
(PCCA)
Gallus gallus (Gga) gga2770 ENSGALP00000027209
(PCCA)
Homo sapiens (Hsa) hsa8977 ENSP00000308554
Homo sapiens (Hsa) hsa6051 ENSP00000336709
Homo sapiens (Hsa) hsa6050 ENSP00000338125
Homo sapiens (Hsa) hsa6049 ENSP00000347900
(PC)		 B4DN00
Kluyveromyces lactis (Kla) kla1455 KLLA0C05764g
Mus musculus (Mmu) mmu8685 ENSMUSP00000038763
(MGI:97499)		 Q91ZA3
Mus musculus (Mmu) mmu13086 ENSMUSP00000063825
(MGI:97520)		 Q05920
Mus musculus (Mmu) mmu13087 ENSMUSP00000075877
Neurospora crassa (Ncr) ncr2426 NCU02505.2
Rattus norvegicus (Rno) rno11895 ENSRNOP00000019144
(RGD:3264)		 P14882
Rattus norvegicus (Rno) rno3454 ENSRNOP00000026316
(RGD:3262)		 P52873
Saccharomyces cerevisiae (Sce) sce490 YBR218C
(S000000422)
Saccharomyces cerevisiae (Sce) sce2155 YGL062W
(S000003030)
Schizosaccharomyces pombe (Spo) spo2669 SPBC17G9.11c Q9UUE1
Yarrowia lipolytica (Yli) yli2692 YALI0C24101g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005625 soluble fraction C
ISO
MmuMGI:97520
GO:0005739 mitochondrion C
IDA
MmuMGI:97520
MGI:97499
ISO
MmuMGI:97520
GO:0005743 mitochondrial inner membrane C
IDA
MmuMGI:97520
GO:0005759 mitochondrial matrix C
ISS
DmeFBgn0027580
GO:0005811 lipid particle C
IDA
DmeFBgn0027580
GO:0005829 cytosol C
IDA
SceS000000422
S000003030
SpoSPBC17G9.11c
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0027580
GO:0009507 chloroplast C
IDA
AthAt5g35360
ISS
AthAt5g35360
GO:0009570 chloroplast stroma C
IDA
AthAt5g35360
GO:0009941 chloroplast envelope C
IDA
AthAt5g35360
GO:0003989 acetyl-CoA carboxylase activity F
IDA
AthAt5g35360
GO:0004075 biotin carboxylase activity F
IDA
AthAt5g35360
GO:0004658 propionyl-CoA carboxylase activity F
IMP
MmuMGI:97499
GO:0004736 pyruvate carboxylase activity F
IDA
SceS000000422
S000003030
IMP
SceS000000422
S000003030
ISO
MmuMGI:97520
ISS
DmeFBgn0027580
SpoSPBC17G9.11c
GO:0005524 ATP binding F
ISO
MmuMGI:97520
GO:0009374 biotin binding F
ISO
MmuMGI:97520
GO:0031406 carboxylic acid binding F
ISO
MmuMGI:97520
GO:0006090 pyruvate metabolic process P
ISO
MmuMGI:97520
ISS
DmeFBgn0027580
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPBC17G9.11c
GO:0006094 gluconeogenesis P
IMP
SceS000000422
S000003030
ISO
MmuMGI:97520
ISS
SpoSPBC17G9.11c
GO:0006107 oxaloacetate metabolic process P
ISO
MmuMGI:97520
GO:0006633 fatty acid biosynthetic process P
IDA
AthAt5g35360
GO:0006740 NADPH regeneration P
TAS
SceS000003030
S000000422
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000003030
GO:0008152 metabolic process P
IMP
MmuMGI:97499
GO:0051098 regulation of binding P
RCA
SceS000003030

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC17G9.11c
(Q9UUE1)		 YGL062W
(S000003030)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005829 cytosol C
IDA
SceS000003030
SpoSPBC17G9.11c
GO:0004736 pyruvate carboxylase activity F
IDA
SceS000003030
IMP
SceS000003030
ISS
SpoSPBC17G9.11c
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPBC17G9.11c
GO:0006094 gluconeogenesis P
IMP
SceS000003030
ISS
SpoSPBC17G9.11c
GO:0006740 NADPH regeneration P
TAS
SceS000003030
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000003030
GO:0051098 regulation of binding P
RCA
SceS000003030

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Search for gene by ID or name:

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Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk