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Search term: YGL065C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ALG2
SGD link S000003033
Alternative ID YGL065C
Description Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
Synonyms YGL065C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0853 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Glycosyltransferase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g04920 GI:15220352
Arabidopsis thaliana (Ath) At1g19710 GI:15223628
Arabidopsis thaliana (Ath) At1g52420 GI:15218994
Arabidopsis thaliana (Ath) At1g73370 GI:15219457
Arabidopsis thaliana (Ath) At1g75420 GI:15222229
Arabidopsis thaliana (Ath) At1g78800 GI:15219195
Arabidopsis thaliana (Ath) At3g15940 GI:15233237
Arabidopsis thaliana (Ath) At3g43190 GI:11257953
Arabidopsis thaliana (Ath) At4g02280 GI:15235300
Arabidopsis thaliana (Ath) At4g10120 GI:15234950
Arabidopsis thaliana (Ath) At5g11110 GI:15238949
Arabidopsis thaliana (Ath) At5g20280 GI:15241313
Arabidopsis thaliana (Ath) At5g20830 GI:15242073
Arabidopsis thaliana (Ath) At5g37180 GI:15240133
Arabidopsis thaliana (Ath) At5g49190 GI:15239816
Caenorhabditis elegans (Cel) CE02609_1 GI:17533013
Caenorhabditis elegans (Cel) CE28488
(WBGene00020734)		 GI:17569999 Q22698
Drosophila melanogaster (Dme) 7292312 GI:7292312
Homo sapiens (Hsa) Hs14861836
(ALG2)		 GI:14861836 Q9H553
Saccharomyces cerevisiae (Sce) YGL065c
(S000003033)		 GI:6321373 P43636
Schizosaccharomyces pombe (Spo) SPBC32H8.14 GI:19112413
Arabidopsis thaliana (Ath) At1g04920 GI:15220352
Arabidopsis thaliana (Ath) At1g19710 GI:15223628
Arabidopsis thaliana (Ath) At1g52420 GI:15218994
Arabidopsis thaliana (Ath) At1g73370 GI:15219457
Arabidopsis thaliana (Ath) At1g75420 GI:15222229
Arabidopsis thaliana (Ath) At1g78800 GI:15219195
Arabidopsis thaliana (Ath) At3g15940 GI:15233237
Arabidopsis thaliana (Ath) At3g43190 GI:11257953
Arabidopsis thaliana (Ath) At4g02280 GI:15235300
Arabidopsis thaliana (Ath) At4g10120 GI:15234950
Arabidopsis thaliana (Ath) At5g11110 GI:15238949
Arabidopsis thaliana (Ath) At5g20280 GI:15241313
Arabidopsis thaliana (Ath) At5g20830 GI:15242073
Arabidopsis thaliana (Ath) At5g37180 GI:15240133
Arabidopsis thaliana (Ath) At5g49190 GI:15239816
Caenorhabditis elegans (Cel) CE02609_1 GI:17533013
Caenorhabditis elegans (Cel) CE28488
(WBGene00020734)		 GI:17569999 Q22698
Drosophila melanogaster (Dme) 7292312 GI:7292312
Homo sapiens (Hsa) Hs14861836
(ALG2)		 GI:14861836 Q9H553
Saccharomyces cerevisiae (Sce) YGL065c
(S000003033)		 GI:6321373 P43636
Schizosaccharomyces pombe (Spo) SPBC32H8.14 GI:19112413


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt1g78800
At1g75420
At5g20830
At1g04920
GO:0005618 cell wall C
IDA
AthAt1g73370
At5g37180
GO:0005624 membrane fraction C
IDA
HsaALG2
GO:0005634 nucleus C
IDA
HsaALG2
GO:0005737 cytoplasm C
IDA
HsaALG2
GO:0005773 vacuole C
IDA
AthAt3g43190
GO:0005783 endoplasmic reticulum C
IC
SceS000003033
TAS
SceS000003033
GO:0005794 Golgi apparatus C
IDA
AthAt1g19710
GO:0005829 cytosol C
IDA
AthAt5g49190
GO:0005886 plasma membrane C
IDA
AthAt4g10120
At3g43190
At5g11110
At5g20280
GO:0009505 plant-type cell wall C
IDA
AthAt5g49190
GO:0016020 membrane C
IDA
AthAt3g43190
At5g49190
GO:0048471 perinuclear region of cytoplasm C
IDA
HsaALG2
GO:0000033 alpha-1,3-mannosyltransferase activity F
IDA
HsaALG2
GO:0004378 glycolipid 3-alpha-mannosyltransferase
activity		 F
IDA
SceS000003033
GO:0005515 protein binding F
IPI
HsaALG2
GO:0008194 UDP-glycosyltransferase activity F
ISS
AthAt1g73370
At5g20830
At3g43190
At4g02280
At5g49190
At5g37180
GO:0016157 sucrose synthase activity F
IDA
AthAt4g02280
At1g73370
At3g43190
At5g20830
At5g37180
IGI
AthAt5g20830
At3g43190
IMP
AthAt5g49190
ISS
AthAt5g20830
At1g73370
At3g43190
At4g02280
At5g37180
At5g49190
GO:0016757 transferase activity, transferring glycosyl
groups		 F
ISS
AthAt1g04920
At3g15940
At5g20280
At1g75420
At1g52420
At4g10120
At4g02280
At1g78800
At1g19710
At3g43190
At5g49190
GO:0033164 glycolipid 6-alpha-mannosyltransferase
activity		 F
IDA
SceS000003033
GO:0043495 protein anchor F
IMP
HsaALG2
GO:0046524 sucrose-phosphate synthase activity F
IDA
AthAt5g20280
RCA
AthAt4g10120
At5g11110
At5g20280
At1g04920
GO:0046982 protein heterodimerization activity F
IPI
HsaALG2
GO:0047485 protein N-terminus binding F
IPI
HsaALG2
GO:0048306 calcium-dependent protein binding F
IMP
HsaALG2
IPI
HsaALG2
GO:0001666 response to hypoxia P
IEP
AthAt5g49190
GO:0005982 starch metabolic process P
IMP
AthAt4g02280
At5g49190
GO:0005985 sucrose metabolic process P
IMP
AthAt4g02280
At5g49190
GO:0005986 sucrose biosynthetic process P
ISS
AthAt5g20830
At4g02280
At1g73370
At3g43190
At5g37180
At5g49190
GO:0006414 translational elongation P
RCA
SceS000003033
GO:0006488 dolichol-linked oligosaccharide biosynthetic
process		 P
IGI
HsaALG2
GO:0006490 oligosaccharide-lipid intermediate
assembly		 P
IDA
SceS000003033
GO:0006970 response to osmotic stress P
IEP
AthAt5g20830
GO:0009409 response to cold P
IEP
AthAt5g20830
GO:0009413 response to flooding P
IEP
AthAt5g20830
GO:0010431 seed maturation P
IMP
AthAt4g02280
At5g49190
GO:0033577 protein amino acid glycosylation in endoplasmic
reticulum		 P
IGI
HsaALG2
GO:0046686 response to cadmium ion P
IEP
AthAt5g20830
GO:0051592 response to calcium ion P
IDA
HsaALG2

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5930

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ALG2 GI:14861836 Q9H553
Pan troglodytes (Ptr) ALG2 GI:114625824
Canis familiaris (Cfa) ALG2 GI:73971882
Mus musculus (Mmu) Alg2
(MGI:1914731)		 GI:31560366 Q8BMZ4
Rattus norvegicus (Rno) Alg2
(RGD:1309940)		 GI:62648970
Drosophila melanogaster (Dme) CG1291
(FBgn0035401)		 GI:21357469
Anopheles gambiae (Aga) AgaP_AGAP001232 GI:58396476
Caenorhabditis elegans (Cel) F09E5.2
(CE32364;
WBGene00017282)		 GI:32564184
Schizosaccharomyces pombe (Spo) alg2
(SPBC11B10.01)		 GI:63054730 Q96WW6
Saccharomyces cerevisiae (Sce) ALG2
(S000003033)		 GI:6321373 P43636
Kluyveromyces lactis (Kla) KLLA0B02420g GI:50303395
Eremothecium gossypii (Ego) AGOS_AFL098W GI:45198423
Magnaporthe grisea (Mgr) MGG_02384 GI:145606336
Neurospora crassa (Ncr) NCU03503.1 GI:32404296
Arabidopsis thaliana (Ath) AT1G78800 GI:22330726
Oryza sativa (Osa) Os04g0589600 GI:115460198


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt1g78800
MmuMGI:1914731
GO:0005624 membrane fraction C
IDA
HsaALG2
GO:0005634 nucleus C
IDA
HsaALG2
GO:0005737 cytoplasm C
IDA
HsaALG2
GO:0005783 endoplasmic reticulum C
IC
SceS000003033
ISS
SpoSPBC11B10.01
TAS
SceS000003033
GO:0005811 lipid particle C
IDA
DmeFBgn0035401
GO:0048471 perinuclear region of cytoplasm C
IDA
HsaALG2
GO:0000033 alpha-1,3-mannosyltransferase activity F
IDA
HsaALG2
GO:0003674 molecular_function F
ND
MmuMGI:1914731
GO:0004376 glycolipid mannosyltransferase
activity		 F
ISS
DmeFBgn0035401
GO:0004378 glycolipid 3-alpha-mannosyltransferase
activity		 F
IDA
SceS000003033
ISS
SpoSPBC11B10.01
GO:0005515 protein binding F
IPI
HsaALG2
GO:0016757 transferase activity, transferring glycosyl
groups		 F
ISS
AthAt1g78800
GO:0033164 glycolipid 6-alpha-mannosyltransferase
activity		 F
IDA
SceS000003033
ISS
SpoSPBC11B10.01
GO:0043495 protein anchor F
IMP
HsaALG2
GO:0046982 protein heterodimerization activity F
IPI
HsaALG2
GO:0047485 protein N-terminus binding F
IPI
HsaALG2
GO:0048306 calcium-dependent protein binding F
IMP
HsaALG2
IPI
HsaALG2
GO:0002119 nematode larval development P
IMP
CelWBGene00017282
GO:0006414 translational elongation P
RCA
SceS000003033
GO:0006488 dolichol-linked oligosaccharide biosynthetic
process		 P
IGI
HsaALG2
GO:0006490 oligosaccharide-lipid intermediate
assembly		 P
IDA
SceS000003033
ISS
SpoSPBC11B10.01
GO:0008150 biological_process P
ND
MmuMGI:1914731
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00017282
GO:0033577 protein amino acid glycosylation in endoplasmic
reticulum		 P
IGI
HsaALG2
GO:0040007 growth P
IMP
CelWBGene00017282
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00017282
GO:0040015 negative regulation of multicellular organism
growth		 P
IMP
CelWBGene00017282
GO:0043413 macromolecule glycosylation P
IC
SpoSPBC11B10.01
GO:0051592 response to calcium ion P
IDA
HsaALG2

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2780

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3307 ENSANGP00000013950
Ashbya gossypii (Ago) ago3097 AFL098W
Arabidopsis thaliana (Ath) ath7232 At1g78800.1
Caenorhabditis elegans (Cel) cel5791 F09E5.2
(CE32364;
WBGene00017282)
Candida glabrata (Cgl) cgl4905 CAGL0M05731g
Cryptococcus neoformans (Cne) cne707 163.m03806
Dictyostelium discoideum (Ddi) ddi11624 DDB0231364
Debaryomyces hansenii (Dha) dha1639 DEHA0C04752g
Drosophila melanogaster (Dme) dme7706 CG1291-PA
(FBgn0035401)
Danio rerio (Dre) dre28570 ENSDARP00000042583
Takifugu rubripes (Fru) fru12503 SINFRUP00000157154
Gallus gallus (Gga) gga10821 ENSGALP00000022055
Homo sapiens (Hsa) hsa31631 ENSP00000238477
Homo sapiens (Hsa) hsa31630 ENSP00000326609
(ALG2)		 Q9H553-2
Kluyveromyces lactis (Kla) kla637 KLLA0B02420g
Mus musculus (Mmu) mmu18114 ENSMUSP00000043580
(MGI:1914731)		 Q9DBE8
Neurospora crassa (Ncr) ncr3395 NCU03503.2
Oryza sativa (Osa) osa82313 8183.m00160
Rattus norvegicus (Rno) rno23109 ENSRNOP00000008913
(RGD:1309940)		 Q3B8P6
Saccharomyces cerevisiae (Sce) sce2159 YGL065C
(S000003033)
Schizosaccharomyces pombe (Spo) spo354 SPBC11B10.01 Q96WW6
Yarrowia lipolytica (Yli) yli5182 YALI0E31797g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt1g78800
MmuMGI:1914731
GO:0005783 endoplasmic reticulum C
IC
SceS000003033
ISS
SpoSPBC11B10.01
TAS
SceS000003033
GO:0005811 lipid particle C
IDA
DmeFBgn0035401
GO:0003674 molecular_function F
ND
MmuMGI:1914731
GO:0004376 glycolipid mannosyltransferase
activity		 F
ISS
DmeFBgn0035401
GO:0004378 glycolipid 3-alpha-mannosyltransferase
activity		 F
IDA
SceS000003033
ISS
SpoSPBC11B10.01
GO:0016757 transferase activity, transferring glycosyl
groups		 F
ISS
AthAt1g78800
GO:0033164 glycolipid 6-alpha-mannosyltransferase
activity		 F
IDA
SceS000003033
ISS
SpoSPBC11B10.01
GO:0002119 nematode larval development P
IMP
CelWBGene00017282
GO:0006414 translational elongation P
RCA
SceS000003033
GO:0006490 oligosaccharide-lipid intermediate
assembly		 P
IDA
SceS000003033
ISS
SpoSPBC11B10.01
GO:0008150 biological_process P
ND
MmuMGI:1914731
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00017282
GO:0040007 growth P
IMP
CelWBGene00017282
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00017282
GO:0040015 negative regulation of multicellular organism
growth		 P
IMP
CelWBGene00017282
GO:0043413 macromolecule glycosylation P
IC
SpoSPBC11B10.01

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC11B10.01
(Q96WW6)		 YGL065C
(S000003033)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IC
SceS000003033
ISS
SpoSPBC11B10.01
TAS
SceS000003033
GO:0004378 glycolipid 3-alpha-mannosyltransferase
activity		 F
IDA
SceS000003033
ISS
SpoSPBC11B10.01
GO:0033164 glycolipid 6-alpha-mannosyltransferase
activity		 F
IDA
SceS000003033
ISS
SpoSPBC11B10.01
GO:0006414 translational elongation P
RCA
SceS000003033
GO:0006490 oligosaccharide-lipid intermediate
assembly		 P
IDA
SceS000003033
ISS
SpoSPBC11B10.01
GO:0043413 macromolecule glycosylation P
IC
SpoSPBC11B10.01

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