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Search term: YGL125W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MET13
SGD link S000003093
Alternative ID YGL125W
Description Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
Synonyms YGL125W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0564 ACDHYP-

KOGs classification KOGs description
METABOLISM 5,10-methylenetetrahydrofolate reductase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g44160 GI:6093430
Arabidopsis thaliana (Ath) At3g59970 GI:15232215
Caenorhabditis elegans (Cel) CE02451 GI:17531547
Drosophila melanogaster (Dme) 7294732 GI:7294732
Homo sapiens (Hsa) Hs6631098 GI:6631098
Saccharomyces cerevisiae (Sce) YGL125w
(S000003093)		 GI:6321313
Saccharomyces cerevisiae (Sce) YPL023c
(S000005944)		 GI:6325234 P46151
Schizosaccharomyces pombe (Spo) SPAC343.10 GI:19114342 O74927
Schizosaccharomyces pombe (Spo) SPAC56F8.10 GI:19114136 Q10258
Arabidopsis thaliana (Ath) At2g44160 GI:6093430
Arabidopsis thaliana (Ath) At3g59970 GI:15232215
Caenorhabditis elegans (Cel) CE02451 GI:17531547
Drosophila melanogaster (Dme) 7294732 GI:7294732
Homo sapiens (Hsa) Hs6631098 GI:6631098
Saccharomyces cerevisiae (Sce) YGL125w
(S000003093)		 GI:6321313
Saccharomyces cerevisiae (Sce) YPL023c
(S000005944)		 GI:6325234 P46151
Schizosaccharomyces pombe (Spo) SPAC343.10 GI:19114342 O74927
Schizosaccharomyces pombe (Spo) SPAC56F8.10 GI:19114136 Q10258


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005944
GO:0005634 nucleus C
IDA
SpoSPAC56F8.10
GO:0005737 cytoplasm C
ISS
SpoSPAC343.10
GO:0005739 mitochondrion C
IDA
SceS000003093
ISS
SpoSPAC56F8.10
GO:0005829 cytosol C
IDA
SpoSPAC56F8.10
GO:0004489 methylenetetrahydrofolate reductase (NADPH)
activity		 F
IDA
SceS000005944
S000003093
SpoSPAC56F8.10
SPAC343.10
ISS
AthAt3g59970
At2g44160
SceS000003093
S000005944
GO:0006082 organic acid metabolic process P
RCA
SceS000003093
GO:0006414 translational elongation P
RCA
SceS000003093
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000003093
GO:0006555 methionine metabolic process P
IDA
SpoSPAC343.10
ISS
AthAt2g44160
At3g59970
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000003093
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000003093
GO:0008150 biological_process P
ND
SceS000005944
GO:0009086 methionine biosynthetic process P
IDA
SpoSPAC56F8.10
IMP
SceS000003093
ISS
SceS000003093

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4349

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) MTHFR GI:87240000
Pan troglodytes (Ptr) MTHFR GI:114553986
Canis familiaris (Cfa) MTHFR GI:73950791
Mus musculus (Mmu) Mthfr
(MGI:106639)		 GI:31543271 Q3UDB2
Rattus norvegicus (Rno) Mthfr
(RGD:619900)		 GI:109475762
Gallus gallus (Gga) MTHFR GI:118101220
Caenorhabditis elegans (Cel) C06A8.1
(CE30593;
WBGene00015512)		 GI:25147436
Schizosaccharomyces pombe (Spo) met5 GI:19114136
Saccharomyces cerevisiae (Sce) MET13
(S000003093)		 GI:27808705
Kluyveromyces lactis (Kla) KLLA0F09647g GI:50310991
Eremothecium gossypii (Ego) AGOS_AAR170W GI:45184995
Magnaporthe grisea (Mgr) MGG_01728 GI:145613335
Neurospora crassa (Ncr) NCU07690.1 GI:32415836
Arabidopsis thaliana (Ath) MTHFR2 GI:18406468
Arabidopsis thaliana (Ath) MTHFR1 GI:15232215
Oryza sativa (Osa) Os03g0815200 GI:115456165


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005625 soluble fraction C
ISO
MmuMGI:106639
GO:0005739 mitochondrion C
IDA
SceS000003093
GO:0005829 cytosol C
EXP
HsaMTHFR
GO:0004489 methylenetetrahydrofolate reductase (NADPH)
activity		 F
EXP
HsaMTHFR
IDA
SceS000003093
IMP
MmuMGI:106639
ISO
MmuMGI:106639
ISS
AthMTHFR2
MTHFR1
SceS000003093
GO:0005515 protein binding F
IPI
HsaMTHFR
GO:0050660 FAD binding F
ISO
MmuMGI:106639
GO:0050661 NADP or NADPH binding F
ISO
MmuMGI:106639
GO:0006082 organic acid metabolic process P
RCA
SceS000003093
GO:0006414 translational elongation P
RCA
SceS000003093
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000003093
GO:0006520 cellular amino acid metabolic process P
TAS
HsaMTHFR
GO:0006555 methionine metabolic process P
ISS
AthMTHFR1
MTHFR2
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000003093
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000003093
GO:0008015 blood circulation P
TAS
HsaMTHFR
GO:0009086 methionine biosynthetic process P
IMP
MmuMGI:106639
SceS000003093
ISS
SceS000003093
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00015512
GO:0046653 tetrahydrofolate metabolic process P
ISO
MmuMGI:106639

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1318

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga2874 ENSANGP00000027924
Ashbya gossypii (Ago) ago358 AAR170W
Arabidopsis thaliana (Ath) ath11626 At2g44160.1
Arabidopsis thaliana (Ath) ath17420 At3g59970.1
Arabidopsis thaliana (Ath) ath17421 At3g59970.2
Arabidopsis thaliana (Ath) ath17422 At3g59970.3
Caenorhabditis elegans (Cel) cel1236 C06A8.1a
(CE30593;
WBGene00015512)
Caenorhabditis elegans (Cel) cel1237 C06A8.1b
(CE31291)
Candida glabrata (Cgl) cgl1532 CAGL0F07029g
Cryptococcus neoformans (Cne) cne2444 181.m08479
Dictyostelium discoideum (Ddi) ddi12340 DDB0230137
Debaryomyces hansenii (Dha) dha5767 DEHA0G01551g
Drosophila melanogaster (Dme) dme9049 CG7560-PA
(FBgn0036157)
Danio rerio (Dre) dre23046 ENSDARP00000025265
Danio rerio (Dre) dre23045 ENSDARP00000027986
Escherichia coli (Eco) eco3798 16131779
Gallus gallus (Gga) gga12616 ENSGALP00000007326
Gallus gallus (Gga) gga12612 ENSGALP00000007327
Gallus gallus (Gga) gga12613 ENSGALP00000007328
Gallus gallus (Gga) gga12617 ENSGALP00000007329
Gallus gallus (Gga) gga12614 ENSGALP00000007330
(MTHFR)
Gallus gallus (Gga) gga12618 ENSGALP00000007331
Gallus gallus (Gga) gga12615 ENSGALP00000007332
Homo sapiens (Hsa) hsa284 ENSP00000315965
Kluyveromyces lactis (Kla) kla4518 KLLA0F09647g
Mus musculus (Mmu) mmu19422 ENSMUSP00000065753
Mus musculus (Mmu) mmu19421 ENSMUSP00000069774
(MGI:106639)		 A2A7F7
Neurospora crassa (Ncr) ncr7487 NCU07690.2
Oryza sativa (Osa) osa59603 6357.m00191
Oryza sativa (Osa) osa63769 6744.m00050
Oryza sativa (Osa) osa86300 8348.m00029
Oryza sativa (Osa) osa84989 8369.m00170
Rattus norvegicus (Rno) rno24405 ENSRNOP00000011384
(RGD:1309952)		 Q62984
Saccharomyces cerevisiae (Sce) sce2220 YGL125W
(S000003093)
Schizosaccharomyces pombe (Spo) spo3045 SPAC56F8.10 Q10258
Yarrowia lipolytica (Yli) yli765 YALI0B00572g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005625 soluble fraction C
ISO
MmuMGI:106639
GO:0005634 nucleus C
IDA
SpoSPAC56F8.10
GO:0005739 mitochondrion C
IDA
SceS000003093
ISS
SpoSPAC56F8.10
GO:0005829 cytosol C
IDA
SpoSPAC56F8.10
GO:0004489 methylenetetrahydrofolate reductase (NADPH)
activity		 F
IDA
SceS000003093
SpoSPAC56F8.10
IMP
MmuMGI:106639
ISO
MmuMGI:106639
ISS
AthAt3g59970
At2g44160
DmeFBgn0036157
SceS000003093
GO:0050660 FAD binding F
ISO
MmuMGI:106639
GO:0050661 NADP or NADPH binding F
ISO
MmuMGI:106639
GO:0006082 organic acid metabolic process P
RCA
SceS000003093
GO:0006414 translational elongation P
RCA
SceS000003093
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000003093
GO:0006555 methionine metabolic process P
ISS
AthAt2g44160
At3g59970
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000003093
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000003093
GO:0009086 methionine biosynthetic process P
IDA
SpoSPAC56F8.10
IMP
MmuMGI:106639
SceS000003093
ISS
SceS000003093
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00015512
GO:0046653 tetrahydrofolate metabolic process P
ISO
MmuMGI:106639

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC56F8.10
(Q10258)		 YGL125W
(S000003093)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC56F8.10
GO:0005739 mitochondrion C
IDA
SceS000003093
ISS
SpoSPAC56F8.10
GO:0005829 cytosol C
IDA
SpoSPAC56F8.10
GO:0004489 methylenetetrahydrofolate reductase (NADPH)
activity		 F
IDA
SceS000003093
SpoSPAC56F8.10
ISS
SceS000003093
GO:0006082 organic acid metabolic process P
RCA
SceS000003093
GO:0006414 translational elongation P
RCA
SceS000003093
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000003093
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000003093
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000003093
GO:0009086 methionine biosynthetic process P
IDA
SpoSPAC56F8.10
IMP
SceS000003093
ISS
SceS000003093

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Query species:

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GO info in one table:

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