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Search term: YGL173C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name KEM1
SGD link S000003141
Alternative ID YGL173C
Description Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
Synonyms YGL173C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2045 -CDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSINGCELLULAR PROCESSES AND SIGNALING 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand exchange and mRNA turnover

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE26838 GI:17537089
Drosophila melanogaster (Dme) 7293586 GI:7293586
Homo sapiens (Hsa) Hs22041601 GI:22041601
Saccharomyces cerevisiae (Sce) YGL173c
(S000003141)		 GI:6321265 P22147
Schizosaccharomyces pombe (Spo) SPAC17A5.14 GI:19114394 P40383


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000932 cytoplasmic mRNA processing body C
IDA
SceS000003141
IMP
SceS000003141
ISS
SpoSPAC17A5.14
GO:0005737 cytoplasm C
IDA
SpoSPAC17A5.14
TAS
SceS000003141
GO:0005829 cytosol C
IDA
SpoSPAC17A5.14
GO:0000287 magnesium ion binding F
IDA
SpoSPAC17A5.14
GO:0004534 5'-3' exoribonuclease activity F
TAS
SceS000003141
GO:0004536 deoxyribonuclease activity F
TAS
SceS000003141
GO:0004540 ribonuclease activity F
IDA
SpoSPAC17A5.14
GO:0045145 single-stranded DNA specific 5'-3'
exodeoxyribonuclease activity		 F
IDA
SpoSPAC17A5.14
GO:0051908 double-stranded DNA specific 5'-3'
exodeoxyribonuclease activity		 F
IDA
SpoSPAC17A5.14
GO:0000742 karyogamy involved in conjugation with cellular
fusion		 P
IGI
SceS000003141
IMP
SceS000003141
GO:0000956 nuclear-transcribed mRNA catabolic
process		 P
TAS
SceS000003141
GO:0006364 rRNA processing P
ISS
SpoSPAC17A5.14
TAS
SceS000003141
GO:0006402 mRNA catabolic process P
ISS
SpoSPAC17A5.14
GO:0007089 traversing start control point of mitotic cell
cycle		 P
IMP
SceS000003141
GO:0030447 filamentous growth P
IMP
SceS000003141
GO:0070651 nonfunctional rRNA decay P
IMP
SceS000003141

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5894

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) XRN1 GI:110624792
Pan troglodytes (Ptr) XRN1 GI:114589588
Canis familiaris (Cfa) XRN1 GI:73990324
Mus musculus (Mmu) Xrn1
(MGI:891964)		 GI:115495455 P97789
Rattus norvegicus (Rno) Xrn1 GI:109483825
Gallus gallus (Gga) XRN1 GI:118095039
Drosophila melanogaster (Dme) pcm
(FBgn0020261)		 GI:24643245
Anopheles gambiae (Aga) AgaP_AGAP004430 GI:158292164
Caenorhabditis elegans (Cel) xrn-1
(CE32750;
WBGene00012730)		 GI:32564611
Schizosaccharomyces pombe (Spo) exo2
(SPAC17A5.14)		 GI:19114394 P40383
Saccharomyces cerevisiae (Sce) KEM1
(S000003141)		 GI:6321265 P22147
Kluyveromyces lactis (Kla) KLLA0F22385g GI:50312097
Eremothecium gossypii (Ego) AGOS_ADL046C GI:45187827
Magnaporthe grisea (Mgr) MGG_12403 GI:145612697
Neurospora crassa (Ncr) NCU06678.1 GI:32412968


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000932 cytoplasmic mRNA processing body C
IDA
DmeFBgn0020261
SceS000003141
IMP
SceS000003141
ISS
SpoSPAC17A5.14
GO:0005737 cytoplasm C
IDA
MmuMGI:891964
SpoSPAC17A5.14
NAS
DmeFBgn0020261
TAS
SceS000003141
GO:0005829 cytosol C
IDA
SpoSPAC17A5.14
GO:0000287 magnesium ion binding F
IDA
SpoSPAC17A5.14
GO:0004534 5'-3' exoribonuclease activity F
IDA
DmeFBgn0020261
ISS
DmeFBgn0020261
TAS
MmuMGI:891964
SceS000003141
GO:0004536 deoxyribonuclease activity F
TAS
SceS000003141
GO:0004540 ribonuclease activity F
IDA
SpoSPAC17A5.14
GO:0005515 protein binding F
IPI
HsaXRN1
GO:0045145 single-stranded DNA specific 5'-3'
exodeoxyribonuclease activity		 F
IDA
SpoSPAC17A5.14
GO:0051908 double-stranded DNA specific 5'-3'
exodeoxyribonuclease activity		 F
IDA
SpoSPAC17A5.14
GO:0000184 nuclear-transcribed mRNA catabolic process,
nonsense-mediated decay		 P
IMP
DmeFBgn0020261
GO:0000723 telomere maintenance P
NAS
MmuMGI:891964
GO:0000742 karyogamy involved in conjugation with cellular
fusion		 P
IGI
SceS000003141
IMP
SceS000003141
GO:0000956 nuclear-transcribed mRNA catabolic
process		 P
TAS
SceS000003141
GO:0002119 nematode larval development P
IMP
CelWBGene00012730
GO:0006364 rRNA processing P
ISS
SpoSPAC17A5.14
TAS
SceS000003141
GO:0006396 RNA processing P
TAS
MmuMGI:891964
GO:0006401 RNA catabolic process P
NAS
DmeFBgn0020261
GO:0006402 mRNA catabolic process P
ISS
SpoSPAC17A5.14
GO:0007089 traversing start control point of mitotic cell
cycle		 P
IMP
SceS000003141
GO:0007126 meiosis P
NAS
MmuMGI:891964
GO:0007283 spermatogenesis P
IMP
DmeFBgn0020261
GO:0007369 gastrulation P
NAS
DmeFBgn0020261
GO:0007391 dorsal closure P
IMP
DmeFBgn0020261
GO:0007476 imaginal disc-derived wing morphogenesis P
IMP
DmeFBgn0020261
GO:0007569 cell aging P
NAS
MmuMGI:891964
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012730
GO:0016246 RNA interference P
IMP
CelWBGene00012730
DmeFBgn0020261
GO:0030447 filamentous growth P
IMP
SceS000003141
GO:0034428 nuclear-transcribed mRNA catabolic process,
exonucleolytic, 5'-3'		 P
IMP
DmeFBgn0020261
GO:0040007 growth P
IMP
CelWBGene00012730
GO:0042060 wound healing P
IMP
DmeFBgn0020261
GO:0046529 imaginal disc fusion, thorax closure P
IMP
DmeFBgn0020261
GO:0070651 nonfunctional rRNA decay P
IMP
SceS000003141
GO:0071044 histone mRNA catabolic process P
IMP
HsaXRN1

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1427

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga6972 ENSANGP00000003801
Anopheles gambiae (Aga) aga6971 ENSANGP00000025858
Ashbya gossypii (Ago) ago1695 ADL046C
Arabidopsis thaliana (Ath) ath26049 At5g42540.1
Caenorhabditis elegans (Cel) cel18610 Y39G8C.1
(CE32750;
WBGene00012730)
Candida glabrata (Cgl) cgl4334 CAGL0L05874g
Cryptococcus neoformans (Cne) cne3170 167.m03507
Dictyostelium discoideum (Ddi) ddi2408 DDB0169529
Debaryomyces hansenii (Dha) dha2103 DEHA0C15224g
Drosophila melanogaster (Dme) dme18618 CG3291-PA
(FBgn0020261)
Danio rerio (Dre) dre10928 ENSDARP00000020544
Danio rerio (Dre) dre10929 ENSDARP00000042195
Takifugu rubripes (Fru) fru3011 SINFRUP00000133891
Takifugu rubripes (Fru) fru3010 SINFRUP00000173046
Gallus gallus (Gga) gga23142 ENSGALP00000004257
(XRN1)
Gallus gallus (Gga) gga23143 ENSGALP00000004258
Gallus gallus (Gga) gga23144 ENSGALP00000004259
Gallus gallus (Gga) gga23141 ENSGALP00000004260
Homo sapiens (Hsa) hsa23251 ENSP00000264951
(XRN1)		 Q8IZH2-1
Kluyveromyces lactis (Kla) kla5080 KLLA0F22385g
Mus musculus (Mmu) mmu28093 ENSMUSP00000034981
(MGI:891964)		 P97789-1
Neurospora crassa (Ncr) ncr6494 NCU06678.2
Plasmodium falciparum (Pfa) pfa1024 PF11_0074
Rattus norvegicus (Rno) rno29101 ENSRNOP00000014481
(RGD:1309713)
Saccharomyces cerevisiae (Sce) sce2268 YGL173C
(S000003141)
Schizosaccharomyces pombe (Spo) spo3347 SPAC17A5.14 P40383
Yarrowia lipolytica (Yli) yli2647 YALI0C23144g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000932 cytoplasmic mRNA processing body C
IDA
DmeFBgn0020261
SceS000003141
IMP
SceS000003141
ISS
SpoSPAC17A5.14
GO:0005634 nucleus C
IDA
AthAt5g42540
GO:0005737 cytoplasm C
IDA
MmuMGI:891964
SpoSPAC17A5.14
NAS
DmeFBgn0020261
TAS
SceS000003141
GO:0005829 cytosol C
IDA
SpoSPAC17A5.14
GO:0020011 apicoplast C
RCA
PfaPF11_0074
GO:0000287 magnesium ion binding F
IDA
SpoSPAC17A5.14
GO:0003676 nucleic acid binding F
ISS
AthAt5g42540
GO:0004534 5'-3' exoribonuclease activity F
IDA
DmeFBgn0020261
IGI
AthAt5g42540
ISS
DmeFBgn0020261
TAS
MmuMGI:891964
SceS000003141
GO:0004536 deoxyribonuclease activity F
TAS
SceS000003141
GO:0004540 ribonuclease activity F
IDA
SpoSPAC17A5.14
GO:0008409 5'-3' exonuclease activity F
ISS
AthAt5g42540
GO:0045145 single-stranded DNA specific 5'-3'
exodeoxyribonuclease activity		 F
IDA
SpoSPAC17A5.14
GO:0051908 double-stranded DNA specific 5'-3'
exodeoxyribonuclease activity		 F
IDA
SpoSPAC17A5.14
GO:0000184 nuclear-transcribed mRNA catabolic process,
nonsense-mediated decay		 P
IMP
DmeFBgn0020261
GO:0000723 telomere maintenance P
NAS
MmuMGI:891964
GO:0000742 karyogamy involved in conjugation with cellular
fusion		 P
IGI
SceS000003141
IMP
SceS000003141
GO:0000956 nuclear-transcribed mRNA catabolic
process		 P
TAS
SceS000003141
GO:0002119 nematode larval development P
IMP
CelWBGene00012730
GO:0006364 rRNA processing P
ISS
SpoSPAC17A5.14
TAS
SceS000003141
GO:0006396 RNA processing P
TAS
MmuMGI:891964
GO:0006401 RNA catabolic process P
NAS
DmeFBgn0020261
GO:0006402 mRNA catabolic process P
ISS
SpoSPAC17A5.14
GO:0007089 traversing start control point of mitotic cell
cycle		 P
IMP
SceS000003141
GO:0007126 meiosis P
NAS
MmuMGI:891964
GO:0007283 spermatogenesis P
IMP
DmeFBgn0020261
GO:0007369 gastrulation P
NAS
DmeFBgn0020261
GO:0007391 dorsal closure P
IMP
DmeFBgn0020261
GO:0007476 imaginal disc-derived wing morphogenesis P
IMP
DmeFBgn0020261
GO:0007569 cell aging P
NAS
MmuMGI:891964
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012730
GO:0010587 miRNA catabolic process P
IMP
AthAt5g42540
GO:0016246 RNA interference P
IMP
CelWBGene00012730
DmeFBgn0020261
GO:0030447 filamentous growth P
IMP
SceS000003141
GO:0034428 nuclear-transcribed mRNA catabolic process,
exonucleolytic, 5'-3'		 P
IMP
DmeFBgn0020261
GO:0040007 growth P
IMP
CelWBGene00012730
GO:0042060 wound healing P
IMP
DmeFBgn0020261
GO:0046529 imaginal disc fusion, thorax closure P
IMP
DmeFBgn0020261
GO:0070651 nonfunctional rRNA decay P
IMP
SceS000003141

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC17A5.14
(P40383)		 YGL173C
(S000003141)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000932 cytoplasmic mRNA processing body C
IDA
SceS000003141
IMP
SceS000003141
ISS
SpoSPAC17A5.14
GO:0005737 cytoplasm C
IDA
SpoSPAC17A5.14
TAS
SceS000003141
GO:0005829 cytosol C
IDA
SpoSPAC17A5.14
GO:0000287 magnesium ion binding F
IDA
SpoSPAC17A5.14
GO:0004534 5'-3' exoribonuclease activity F
TAS
SceS000003141
GO:0004536 deoxyribonuclease activity F
TAS
SceS000003141
GO:0004540 ribonuclease activity F
IDA
SpoSPAC17A5.14
GO:0045145 single-stranded DNA specific 5'-3'
exodeoxyribonuclease activity		 F
IDA
SpoSPAC17A5.14
GO:0051908 double-stranded DNA specific 5'-3'
exodeoxyribonuclease activity		 F
IDA
SpoSPAC17A5.14
GO:0000742 karyogamy involved in conjugation with cellular
fusion		 P
IGI
SceS000003141
IMP
SceS000003141
GO:0000956 nuclear-transcribed mRNA catabolic
process		 P
TAS
SceS000003141
GO:0006364 rRNA processing P
ISS
SpoSPAC17A5.14
TAS
SceS000003141
GO:0006402 mRNA catabolic process P
ISS
SpoSPAC17A5.14
GO:0007089 traversing start control point of mitotic cell
cycle		 P
IMP
SceS000003141
GO:0030447 filamentous growth P
IMP
SceS000003141
GO:0070651 nonfunctional rRNA decay P
IMP
SceS000003141

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