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Search term: YGL220W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name FRA2
SGD link S000003188
Alternative ID YGL220W
Description Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
Synonyms YGL220W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3348 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING BolA (bacterial stress-induced morphogen)-related protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g09830 GI:18416103
Caenorhabditis elegans (Cel) CE16400_1 GI:17555048
Caenorhabditis elegans (Cel) CE25173 GI:17510781
Drosophila melanogaster (Dme) 7303423 GI:7303423
Homo sapiens (Hsa) Hs22069812 GI:12001972 B4DHK7
Saccharomyces cerevisiae (Sce) YAL046c
(S000000044)		 GI:6319270 P39724
Saccharomyces cerevisiae (Sce) YGL220w
(S000003188)		 GI:6321218 P53082
Schizosaccharomyces pombe (Spo) SPAC8C9.11 GI:19115194 O14280
Schizosaccharomyces pombe (Spo) SPCC4B3.11c GI:19075579 Q9USK1


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g09830
SceS000000044
SpoSPAC8C9.11
GO:0005634 nucleus C
IDA
SceS000003188
GO:0005737 cytoplasm C
IDA
SceS000003188
GO:0005739 mitochondrion C
IDA
SpoSPCC4B3.11c
GO:0005829 cytosol C
IDA
SceS000003188
GO:0003674 molecular_function F
ND
SceS000003188
S000000044
SpoSPAC8C9.11
SPCC4B3.11c
GO:0030528 transcription regulator activity F
ISS
AthAt5g09830
GO:0008150 biological_process P
ND
AthAt5g09830
SceS000000044
SpoSPAC8C9.11
SPCC4B3.11c
GO:0034396 negative regulation of transcription from RNA
polymerase II promoter in response to
iron		 P
IMP
SceS000003188

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
38988

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) AIM15 GI:6321218 P53082
Kluyveromyces lactis (Kla) KLLA0A01551g GI:50302267
Eremothecium gossypii (Ego) AGOS_AGR232C GI:45201328


GO terms for Homologene results:

None found.

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2736

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago4543 AGR232C
Arabidopsis thaliana (Ath) ath23179 At5g09830.1
Caenorhabditis elegans (Cel) cel15358 T12D8.10
(CE37144;
WBGene00023450)
Candida glabrata (Cgl) cgl2824 CAGL0I06985g
Cryptococcus neoformans (Cne) cne4313 177.m03069
Dictyostelium discoideum (Ddi) ddi8229 DDB0188689
Debaryomyces hansenii (Dha) dha2241 DEHA0C18304g
Drosophila melanogaster (Dme) dme4742 CG33009-PB
Takifugu rubripes (Fru) fru17864 SINFRUP00000140914
Homo sapiens (Hsa) hsa11989 ENSP00000306752
(BOLA2)
Homo sapiens (Hsa) hsa11940 ENSP00000331127
(BOLA2)
Kluyveromyces lactis (Kla) kla64 KLLA0A01551g
Mus musculus (Mmu) mmu25093 ENSMUSP00000058825
(MGI:1913412)		 Q8BGS2-1
Neurospora crassa (Ncr) ncr5934 NCU06107.2
Oryza sativa (Osa) osa41913 5139.m00164
Plasmodium falciparum (Pfa) pfa3607 PFE0790c
Rattus norvegicus (Rno) rno28652 ENSRNOP00000020553
(RGD:1563585)
Rattus norvegicus (Rno) rno2988 ENSRNOP00000026267
(RGD:1565363)
Saccharomyces cerevisiae (Sce) sce2316 YGL220W
(S000003188)
Schizosaccharomyces pombe (Spo) spo4559 SPAC8C9.11 O14280
Yarrowia lipolytica (Yli) yli3563 YALI0D20504g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g09830
MmuMGI:1913412
SpoSPAC8C9.11
GO:0005634 nucleus C
IDA
SceS000003188
GO:0005737 cytoplasm C
IDA
SceS000003188
GO:0005829 cytosol C
IDA
SceS000003188
GO:0003674 molecular_function F
ND
MmuMGI:1913412
SceS000003188
SpoSPAC8C9.11
GO:0030528 transcription regulator activity F
ISS
AthAt5g09830
GO:0008150 biological_process P
ND
AthAt5g09830
MmuMGI:1913412
SpoSPAC8C9.11
GO:0034396 negative regulation of transcription from RNA
polymerase II promoter in response to
iron		 P
IMP
SceS000003188

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC8C9.11
(O14280)		 YGL220W
(S000003188)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SpoSPAC8C9.11
GO:0005634 nucleus C
IDA
SceS000003188
GO:0005737 cytoplasm C
IDA
SceS000003188
GO:0005829 cytosol C
IDA
SceS000003188
GO:0003674 molecular_function F
ND
SceS000003188
SpoSPAC8C9.11
GO:0008150 biological_process P
ND
SpoSPAC8C9.11
GO:0034396 negative regulation of transcription from RNA
polymerase II promoter in response to
iron		 P
IMP
SceS000003188

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s.khadayate@ucl.ac.uk