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Search term: YGL231C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name EMC4
SGD link S000003200
Alternative ID YGL231C
Description Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis
Synonyms YGL231C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3318 ACDHYP-

KOGs classification KOGs description
POORLY CHARACTERIZED Predicted membrane protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g10780 GI:11358300
Caenorhabditis elegans (Cel) CE26347
(WBGene00022776)		 GI:17544614 Q9N4N3
Drosophila melanogaster (Dme) 7296588 GI:7296588
Homo sapiens (Hsa) Hs7705997
(TMEM85)		 GI:7705997 Q5J8M3
Saccharomyces cerevisiae (Sce) YGL231c
(S000003200)		 GI:6321206 P53073
Schizosaccharomyces pombe (Spo) SPCC1281.03c GI:19075667 O94520


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g10780
GO:0005783 endoplasmic reticulum C
IDA
SceS000003200
SpoSPCC1281.03c
ISS
SpoSPCC1281.03c
GO:0003674 molecular_function F
ND
AthAt5g10780
SceS000003200
SpoSPCC1281.03c
GO:0000003 reproduction P
IMP
CelWBGene00022776
GO:0002119 nematode larval development P
IMP
CelWBGene00022776
GO:0008150 biological_process P
ND
AthAt5g10780
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00022776
GO:0033554 cellular response to stress P
ISS
SpoSPCC1281.03c
GO:0034975 protein folding in endoplasmic
reticulum		 P
IGI
SceS000003200
ISS
SpoSPCC1281.03c
GO:0040007 growth P
IMP
CelWBGene00022776

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
31613

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) SPCC1281.03c GI:19075667 O94520
Saccharomyces cerevisiae (Sce) YGL231C
(S000003200)		 GI:6321206 P53073
Kluyveromyces lactis (Kla) KLLA0A01067g GI:50302225
Eremothecium gossypii (Ego) AGOS_AFR249W GI:45198767


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000003200
SpoSPCC1281.03c
ISS
SpoSPCC1281.03c
GO:0003674 molecular_function F
ND
SceS000003200
SpoSPCC1281.03c
GO:0033554 cellular response to stress P
ISS
SpoSPCC1281.03c
GO:0034975 protein folding in endoplasmic
reticulum		 P
IGI
SceS000003200
ISS
SpoSPCC1281.03c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3069

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga7523 ENSANGP00000016305
Ashbya gossypii (Ago) ago3441 AFR249W
Arabidopsis thaliana (Ath) ath23284 At5g10780.1
Caenorhabditis elegans (Cel) cel22044 ZK616.6
(CE26347;
WBGene00022776)
Candida glabrata (Cgl) cgl2411 CAGL0H07953g
Cryptococcus neoformans (Cne) cne1973 181.m07951
Debaryomyces hansenii (Dha) dha6489 DEHA0G17622g
Drosophila melanogaster (Dme) dme10764 CG11137-PA
(FBgn0037199)
Takifugu rubripes (Fru) fru4188 SINFRUP00000156833
Homo sapiens (Hsa) hsa10382 ENSP00000267750
(TMEM85)		 Q5J8M3-1
Kluyveromyces lactis (Kla) kla43 KLLA0A01067g
Mus musculus (Mmu) mmu15208 ENSMUSP00000028551
(MGI:1915282)		 Q9CZX9
Neurospora crassa (Ncr) ncr5078 NCU05231.2
Oryza sativa (Osa) osa21725 3659.m00171
Oryza sativa (Osa) osa21733 3659.m00269
Plasmodium falciparum (Pfa) pfa1786 PF14_0335
Rattus norvegicus (Rno) rno19405 ENSRNOP00000007612
(RGD:1310905)
Saccharomyces cerevisiae (Sce) sce2328 YGL231C
(S000003200)
Schizosaccharomyces pombe (Spo) spo2649 SPCC1281.03c O94520
Yarrowia lipolytica (Yli) yli343 YALI0A10274g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g10780
MmuMGI:1915282
GO:0005783 endoplasmic reticulum C
IDA
SceS000003200
SpoSPCC1281.03c
ISS
SpoSPCC1281.03c
GO:0003674 molecular_function F
ND
AthAt5g10780
MmuMGI:1915282
PfaPF14_0335
SceS000003200
SpoSPCC1281.03c
GO:0000003 reproduction P
IMP
CelWBGene00022776
GO:0002119 nematode larval development P
IMP
CelWBGene00022776
GO:0008150 biological_process P
ND
AthAt5g10780
MmuMGI:1915282
PfaPF14_0335
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00022776
GO:0033554 cellular response to stress P
ISS
SpoSPCC1281.03c
GO:0034975 protein folding in endoplasmic
reticulum		 P
IGI
SceS000003200
ISS
SpoSPCC1281.03c
GO:0040007 growth P
IMP
CelWBGene00022776

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC1281.03c
(O94520)		 YGL231C
(S000003200)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000003200
SpoSPCC1281.03c
ISS
SpoSPCC1281.03c
GO:0003674 molecular_function F
ND
SceS000003200
SpoSPCC1281.03c
GO:0033554 cellular response to stress P
ISS
SpoSPCC1281.03c
GO:0034975 protein folding in endoplasmic
reticulum		 P
IGI
SceS000003200
ISS
SpoSPCC1281.03c

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