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Search term: YGL253W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HXK2
SGD link S000003222
Alternative ID YGL253W
Description Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
Synonyms YGL253W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1369 ACDHYPE

KOGs classification KOGs description
METABOLISM Hexokinase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g47840 GI:15220989
Arabidopsis thaliana (Ath) At1g47860_3 GI:15220992
Arabidopsis thaliana (Ath) At1g50460 GI:15222973
Arabidopsis thaliana (Ath) At2g19860 GI:15224857
Arabidopsis thaliana (Ath) At3g20040 GI:15231023
Arabidopsis thaliana (Ath) At4g29130 GI:15233457
Arabidopsis thaliana (Ath) At4g37840 GI:15235722
Caenorhabditis elegans (Cel) CE05628
(WBGene00008780)		 GI:17506621
Caenorhabditis elegans (Cel) CE18823
(WBGene00010416)		 GI:17507937 Q9XU15
Caenorhabditis elegans (Cel) CE25610
(WBGene00022306)		 GI:17544236 Q9N4A5
Drosophila melanogaster (Dme) 7291070
(FBgn0001186)		 GI:18079297 Q9GNH8
Drosophila melanogaster (Dme) 7301467 GI:7301467
Drosophila melanogaster (Dme) 7303093
(FBgn0001187)		 GI:17864242
Homo sapiens (Hsa) Hs4504391 GI:4504391
Homo sapiens (Hsa) Hs4504395 GI:4504395
Homo sapiens (Hsa) Hs15967159 GI:15967159 P35557
Homo sapiens (Hsa) Hs13376711 GI:13376711
Homo sapiens (Hsa) Hs15553127
(HK2)		 GI:15553127 Q7Z7Q6
Homo sapiens (Hsa) Hs15967161 GI:15967161 P35557
Homo sapiens (Hsa) Hs15991827 GI:15991827 P78542
Homo sapiens (Hsa) Hs15991829 GI:15991829 P78542
Homo sapiens (Hsa) Hs15991833 GI:15991833
Homo sapiens (Hsa) Hs4503951
(GCK)		 GI:4503951 P35557
Saccharomyces cerevisiae (Sce) YCL040w
(S000000545)		 GI:6319809 P17709
Saccharomyces cerevisiae (Sce) YDR516c
(S000002924)		 GI:6320724 Q04409
Saccharomyces cerevisiae (Sce) YFR053c
(S000001949)		 GI:14318578 P04806
Saccharomyces cerevisiae (Sce) YGL253w
(S000003222)		 GI:6321184 P04807
Saccharomyces cerevisiae (Sce) YLR446w GI:6323479 Q06204
Schizosaccharomyces pombe (Spo) SPAC24H6.04 GI:19113860 Q09756
Schizosaccharomyces pombe (Spo) SPAC4F8.07c GI:19114777 P50521
Encephalitozoon cuniculi (Ecu) ECU11g1540 GI:19074954 Q8SU17


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000000545
GO:0005575 cellular_component C
ND
SceYLR446w
GO:0005634 nucleus C
IDA
AthAt4g29130
SceS000003222
SpoSPAC4F8.07c
SPAC24H6.04
GO:0005737 cytoplasm C
IDA
SceS000002924
S000001949
GO:0005739 mitochondrion C
IDA
AthAt4g29130
At1g50460
At2g19860
At4g37840
At3g20040
SceS000001949
S000003222
TAS
AthAt4g29130
At2g19860
GO:0005773 vacuole C
IDA
AthAt4g29130
GO:0005829 cytosol C
IDA
SceS000000545
S000001949
S000003222
SpoSPAC4F8.07c
SPAC24H6.04
GO:0005886 plasma membrane C
IDA
AthAt4g29130
GO:0009507 chloroplast C
IDA
AthAt1g47840
GO:0009536 plastid C
IDA
AthAt1g50460
At4g29130
At2g19860
GO:0016020 membrane C
IDA
AthAt4g29130
GO:0003674 molecular_function F
ND
SceS000002924
YLR446w
GO:0004340 glucokinase activity F
IDA
AthAt4g29130
At2g19860
At1g47840
SceS000000545
SpoSPAC24H6.04
SPAC4F8.07c
IMP
SceS000000545
GO:0004396 hexokinase activity F
IDA
AthAt4g29130
DmeFBgn0001186
FBgn0001187
SceS000001949
S000003222
SpoSPAC24H6.04
IGI
SpoSPAC24H6.04
IMP
AthAt2g19860
DmeFBgn0001186
SceS000001949
S000003222
ISS
AthAt1g47840
At4g37840
At4g29130
At2g19860
At1g50460
At3g20040
DmeFBgn0001187
NAS
DmeFBgn0001187
GO:0005524 ATP binding F
ISS
AthAt1g47840
At1g50460
At2g19860
At4g29130
At4g37840
At3g20040
SpoSPAC24H6.04
GO:0008270 zinc ion binding F
IDA
AthAt4g29130
GO:0008865 fructokinase activity F
IDA
AthAt1g47840
At2g19860
At4g29130
SpoSPAC4F8.07c
SPAC24H6.04
GO:0016301 kinase activity F
RCA
SceS000002924
GO:0016773 phosphotransferase activity, alcohol group as
acceptor		 F
RCA
SceS000002924
GO:0019158 mannokinase activity F
IDA
SpoSPAC4F8.07c
SPAC24H6.04
GO:0001302 replicative cell aging P
IMP
SceS000003222
GO:0006000 fructose metabolic process P
IMP
SceS000001949
S000003222
GO:0006002 fructose 6-phosphate metabolic
process		 P
IDA
SpoSPAC4F8.07c
SPAC24H6.04
GO:0006006 glucose metabolic process P
IMP
SceS000000545
S000001949
S000003222
GO:0006013 mannose metabolic process P
IDA
SceS000000545
S000001949
S000003222
SpoSPAC4F8.07c
SPAC24H6.04
GO:0006066 alcohol metabolic process P
RCA
SceS000000545
S000001949
GO:0006096 glycolysis P
IC
SpoSPAC24H6.04
IDA
SceS000000545
S000001949
S000003222
IMP
SceS000003222
GO:0006112 energy reserve metabolic process P
RCA
SceS000002924
S000001949
GO:0006970 response to osmotic stress P
IEP
AthAt1g50460
At4g37840
GO:0006974 response to DNA damage stimulus P
IEP
AthAt4g37840
GO:0006979 response to oxidative stress P
IEP
AthAt4g37840
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000000545
S000001949
GO:0008150 biological_process P
ND
SceYLR446w
GO:0008361 regulation of cell size P
IMP
SceS000003222
GO:0009051 pentose-phosphate shunt, oxidative
branch		 P
TAS
SpoSPAC24H6.04
GO:0009266 response to temperature stimulus P
RCA
SceS000000545
GO:0009408 response to heat P
IEP
AthAt4g37840
GO:0009409 response to cold P
IEP
AthAt1g50460
At4g37840
GO:0009414 response to water deprivation P
IEP
AthAt4g37840
GO:0009651 response to salt stress P
IEP
AthAt4g37840
At1g50460
GO:0009747 hexokinase-dependent signaling P
IMP
AthAt2g19860
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00008780
GO:0010182 sugar mediated signaling pathway P
IMP
AthAt2g19860
TAS
AthAt4g29130
GO:0010224 response to UV-B P
IEP
AthAt4g37840
GO:0010255 glucose mediated signaling pathway P
IMP
AthAt4g29130
GO:0012501 programmed cell death P
IMP
AthAt4g29130
At2g19860
GO:0019320 hexose catabolic process P
IDA
AthAt4g29130
GO:0030437 ascospore formation P
IMP
SceS000002924
GO:0032445 fructose import P
IGI
SceS000001949
S000003222
GO:0044262 cellular carbohydrate metabolic
process		 P
RCA
SceS000000545
S000001949
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter		 P
IMP
SceS000002924
GO:0046015 regulation of transcription by
glucose		 P
IDA
SceS000003222
GO:0046323 glucose import P
IGI
SceS000000545
S000001949
S000003222
GO:0046835 carbohydrate phosphorylation P
IDA
SpoSPAC4F8.07c
SPAC24H6.04
GO:0051049 regulation of transport P
RCA
SceS000000545
GO:0051156 glucose 6-phosphate metabolic process P
IDA
SpoSPAC24H6.04
SPAC4F8.07c
GO:0060361 flight P
IMP
DmeFBgn0001186

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
100530

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) HK1 GI:188497754
Pan troglodytes (Ptr) HK1 GI:114630829
Canis familiaris (Cfa) HK1 GI:73953342
Mus musculus (Mmu) Hk1
(MGI:96103)		 GI:6754206 B4YB29
Gallus gallus (Gga) HK1 GI:45383904
Drosophila melanogaster (Dme) Hex-t2
(FBgn0042710)		 GI:45551986
Schizosaccharomyces pombe (Spo) hxk1
(SPAC24H6.04)		 GI:19113860 Q09756
Saccharomyces cerevisiae (Sce) HXK1
(S000001949)		 GI:14318578 P04806
Saccharomyces cerevisiae (Sce) HXK2
(S000003222)		 GI:6321184 P04807
Kluyveromyces lactis (Kla) HXK_KLULA GI:50307177
Eremothecium gossypii (Ego) AGOS_AFR279C GI:45198797
Magnaporthe grisea (Mgr) MGG_09289 GI:39958811
Neurospora crassa (Ncr) NCU02542.1 GI:32422595
Arabidopsis thaliana (Ath) HXK2 GI:15224857
Arabidopsis thaliana (Ath) HXK1 GI:15233457
Oryza sativa (Osa) Os05g0522500 GI:115464965
Oryza sativa (Osa) Os01g0742500 GI:115439869