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Search term: YGR006W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PRP18
SGD link S000003238
Alternative ID YGR006W
Description Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p
Synonyms YGR006W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2808 ACDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING U5 snRNP-associated RNA splicing factor

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g03140 GI:18379060
Arabidopsis thaliana (Ath) At1g54590 GI:15221867
Caenorhabditis elegans (Cel) CE20741 GI:17540108
Drosophila melanogaster (Dme) 7300471 GI:5733741
Homo sapiens (Hsa) Hs4506123
(PRPF18)		 GI:4506123 Q99633
Saccharomyces cerevisiae (Sce) YGR006w
(S000003238)		 GI:6321443
Schizosaccharomyces pombe (Spo) SPCC126.14 GI:19075957 O94406


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPCC126.14
GO:0005681 spliceosomal complex C
ISS
AthAt1g54590
At1g03140
SpoSPCC126.14
GO:0005682 U5 snRNP C
IDA
SceS000003238
GO:0046540 U4/U6 x U5 tri-snRNP complex C
IDA
SceS000003238
GO:0000386 second spliceosomal transesterification
activity		 F
IDA
SceS000003238
IGI
SceS000003238
GO:0003674 molecular_function F
ND
SpoSPCC126.14
GO:0000350 generation of catalytic spliceosome for second
transesterification step		 P
IDA
SceS000003238
GO:0000398 nuclear mRNA splicing, via spliceosome P
IMP
SceS000003238
ISS
SpoSPCC126.14
GO:0008380 RNA splicing P
ISS
AthAt1g03140
At1g54590
GO:0071048 nuclear retention of unspliced pre-mRNA at the
site of transcription		 P
IGI
SceS000003238
IMP
SceS000003238

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39071

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) PRP18
(S000003238)		 GI:41629693
Eremothecium gossypii (Ego) AGOS_AFR503W GI:45199021


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005682 U5 snRNP C
IDA
SceS000003238
GO:0046540 U4/U6 x U5 tri-snRNP complex C
IDA
SceS000003238
GO:0000386 second spliceosomal transesterification
activity		 F
IDA
SceS000003238
IGI
SceS000003238
GO:0000350 generation of catalytic spliceosome for second
transesterification step		 P
IDA
SceS000003238
GO:0000398 nuclear mRNA splicing, via spliceosome P
IMP
SceS000003238
GO:0071048 nuclear retention of unspliced pre-mRNA at the
site of transcription		 P
IGI
SceS000003238
IMP
SceS000003238

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2392

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4459 ENSANGP00000020655
Ashbya gossypii (Ago) ago3695 AFR503W
Arabidopsis thaliana (Ath) ath251 At1g03140.1
Caenorhabditis elegans (Cel) cel7888 F32B6.3
(CE35518;
WBGene00009320)
Candida glabrata (Cgl) cgl1605 CAGL0F08701g
Cryptococcus neoformans (Cne) cne1338 180.m00285
Dictyostelium discoideum (Ddi) ddi1513 DDB0167790
Debaryomyces hansenii (Dha) dha321 DEHA0A07238g
Drosophila melanogaster (Dme) dme13330 CG6011-PA
(FBgn0027784)
Danio rerio (Dre) dre8711 ENSDARP00000040688
Danio rerio (Dre) dre28567 ENSDARP00000042852
Takifugu rubripes (Fru) fru10411 SINFRUP00000136243
Takifugu rubripes (Fru) fru10409 SINFRUP00000166936
Takifugu rubripes (Fru) fru10410 SINFRUP00000167586
Gallus gallus (Gga) gga34 ENSGALP00000010775
(PRPF18)
Homo sapiens (Hsa) hsa3525 ENSP00000298452
Kluyveromyces lactis (Kla) kla2008 KLLA0C18172g
Mus musculus (Mmu) mmu14024 ENSMUSP00000041428
(MGI:1914479)		 Q8BM39-1
Neurospora crassa (Ncr) ncr151 NCU00158.2
Oryza sativa (Osa) osa18753 3216.m00156
Oryza sativa (Osa) osa18768 3216.m00169
Plasmodium falciparum (Pfa) pfa4689 PFI1115c
Rattus norvegicus (Rno) rno13636 ENSRNOP00000024872
(RGD:708550)		 Q9JKB8
Saccharomyces cerevisiae (Sce) sce2367 YGR006W
(S000003238)
Schizosaccharomyces pombe (Spo) spo2014 SPCC126.14 O94406
Yarrowia lipolytica (Yli) yli6008 YALI0F15807g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1914479
GO:0005634 nucleus C
IDA
SpoSPCC126.14
GO:0005681 spliceosomal complex C
ISS
AthAt1g03140
DmeFBgn0027784
SpoSPCC126.14
GO:0005682 U5 snRNP C
IDA
SceS000003238
GO:0046540 U4/U6 x U5 tri-snRNP complex C
IDA
SceS000003238
GO:0000386 second spliceosomal transesterification
activity		 F
IDA
SceS000003238
IGI
SceS000003238
GO:0003674 molecular_function F
ND
SpoSPCC126.14
GO:0008266 poly(U) RNA binding F
NAS
DmeFBgn0027784
GO:0019870 potassium channel inhibitor activity F
ISO
MmuMGI:1914479
GO:0000003 reproduction P
IMP
CelWBGene00009320
GO:0000350 generation of catalytic spliceosome for second
transesterification step		 P
IDA
SceS000003238
GO:0000398 nuclear mRNA splicing, via spliceosome P
IMP
SceS000003238
ISS
DmeFBgn0027784
SpoSPCC126.14
NAS
DmeFBgn0027784
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00009320
GO:0008150 biological_process P
ND
MmuMGI:1914479
GO:0008380 RNA splicing P
ISS
AthAt1g03140
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00009320
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00009320
GO:0071048 nuclear retention of unspliced pre-mRNA at the
site of transcription		 P
IGI
SceS000003238
IMP
SceS000003238

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC126.14
(O94406)		 YGR006W
(S000003238)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPCC126.14
GO:0005681 spliceosomal complex C
ISS
SpoSPCC126.14
GO:0005682 U5 snRNP C
IDA
SceS000003238
GO:0046540 U4/U6 x U5 tri-snRNP complex C
IDA
SceS000003238
GO:0000386 second spliceosomal transesterification
activity		 F
IDA
SceS000003238
IGI
SceS000003238
GO:0003674 molecular_function F
ND
SpoSPCC126.14
GO:0000350 generation of catalytic spliceosome for second
transesterification step		 P
IDA
SceS000003238
GO:0000398 nuclear mRNA splicing, via spliceosome P
IMP
SceS000003238
ISS
SpoSPCC126.14
GO:0071048 nuclear retention of unspliced pre-mRNA at the
site of transcription		 P
IGI
SceS000003238
IMP
SceS000003238

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s.khadayate@ucl.ac.uk