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Search term: YGR019W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name UGA1
SGD link S000003251
Alternative ID YGR019W
Description Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization
Synonyms YGR019W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1405 -CDHYP-

KOGs classification KOGs description
METABOLISM 4-aminobutyrate aminotransferase

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE06092
(WBGene00001794)		 GI:17541228 Q21217
Drosophila melanogaster (Dme) 7293712 GI:7293712 Q9VW68
Homo sapiens (Hsa) Hs4501847 GI:4501847
Homo sapiens (Hsa) Hs17487486 GI:17487486
Saccharomyces cerevisiae (Sce) YGR019w
(S000003251)		 GI:6321456 P17649
Schizosaccharomyces pombe (Spo) SPAC19D5.07 GI:19115817 O13837


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
IC
SceS000003251
GO:0005739 mitochondrion C
ISS
SpoSPAC19D5.07
GO:0005829 cytosol C
IDA
SpoSPAC19D5.07
GO:0003867 4-aminobutyrate transaminase activity F
IDA
SpoSPAC19D5.07
IMP
SceS000003251
GO:0030170 pyridoxal phosphate binding F
IDA
SpoSPAC19D5.07
GO:0006536 glutamate metabolic process P
IDA
SpoSPAC19D5.07
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000003251
GO:0009450 gamma-aminobutyric acid catabolic
process		 P
IDA
SpoSPAC19D5.07
IMP
SceS000003251
GO:0019740 nitrogen utilization P
ISS
SpoSPAC19D5.07
TAS
SceS000003251

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
542

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ABAT GI:38679950
Pan troglodytes (Ptr) ABAT GI:114660900
Canis familiaris (Cfa) ABAT GI:73958963
Mus musculus (Mmu) Abat
(MGI:2443582)		 GI:37202121 P61922
Rattus norvegicus (Rno) Abat
(RGD:620948)		 GI:13591900
Gallus gallus (Gga) ABAT GI:118098116
Drosophila melanogaster (Dme) CG7433
(FBgn0036927)		 GI:24667139
Anopheles gambiae (Aga) AgaP_AGAP006966 GI:158286528
Caenorhabditis elegans (Cel) gta-1
(CE06092;
WBGene00001794)		 GI:17541228 Q21217
Schizosaccharomyces pombe (Spo) SPAC19D5.07 GI:19115817 O13837
Saccharomyces cerevisiae (Sce) UGA1
(S000003251)		 GI:6321456 P17649
Kluyveromyces lactis (Kla) KLLA0F20548g GI:50311943
Eremothecium gossypii (Ego) AGOS_AGL050C GI:45201046
Magnaporthe grisea (Mgr) MGG_01662 GI:39952039
Neurospora crassa (Ncr) NCU08998.1 GI:32421893


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
IC
SceS000003251
GO:0005739 mitochondrion C
IDA
HsaABAT
MmuMGI:2443582
ISO
MmuMGI:2443582
ISS
DmeFBgn0036927
HsaABAT
SpoSPAC19D5.07
GO:0005759 mitochondrial matrix C
ISS
DmeFBgn0036927
GO:0005829 cytosol C
IDA
SpoSPAC19D5.07
GO:0019717 synaptosome C
ISO
MmuMGI:2443582
GO:0032144 4-aminobutyrate transaminase complex C
IDA
HsaABAT
GO:0003867 4-aminobutyrate transaminase activity F
IDA
HsaABAT
SpoSPAC19D5.07
IMP
SceS000003251
ISO
MmuMGI:2443582
ISS
DmeFBgn0036927
GO:0005515 protein binding F
IPI
HsaABAT
GO:0030170 pyridoxal phosphate binding F
IDA
HsaABAT
SpoSPAC19D5.07
GO:0032145 succinate-semialdehyde dehydrogenase
binding		 F
ISS
HsaABAT
GO:0042803 protein homodimerization activity F
IPI
HsaABAT
GO:0001666 response to hypoxia P
ISO
MmuMGI:2443582
GO:0006520 cellular amino acid metabolic process P
ISS
DmeFBgn0036927
GO:0006536 glutamate metabolic process P
IDA
SpoSPAC19D5.07
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000003251
GO:0007610 behavior P
NAS
HsaABAT
GO:0007620 copulation P
ISO
MmuMGI:2443582
GO:0007626 locomotory behavior P
ISO
MmuMGI:2443582
GO:0009450 gamma-aminobutyric acid catabolic
process		 P
IDA
SpoSPAC19D5.07
IMP
SceS000003251
NAS
HsaABAT
GO:0010039 response to iron ion P
ISO
MmuMGI:2443582
GO:0019740 nitrogen utilization P
ISS
SpoSPAC19D5.07
TAS
SceS000003251
GO:0035094 response to nicotine P
ISO
MmuMGI:2443582
GO:0042135 neurotransmitter catabolic process P
NAS
HsaABAT
GO:0042220 response to cocaine P
ISO
MmuMGI:2443582
GO:0042493 response to drug P
ISO
MmuMGI:2443582
GO:0045471 response to ethanol P
ISO
MmuMGI:2443582
GO:0045776 negative regulation of blood pressure P
ISO
MmuMGI:2443582
GO:0048148 behavioral response to cocaine P
IMP
MmuMGI:2443582
ISS
HsaABAT

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3113

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga2424 ENSANGP00000021720
Ashbya gossypii (Ago) ago4261 AGL050C
Caenorhabditis elegans (Cel) cel11858 K04D7.3
(CE06092;
WBGene00001794)
Candida glabrata (Cgl) cgl836 CAGL0D04026g
Cryptococcus neoformans (Cne) cne642 163.m06111
Cryptococcus neoformans (Cne) cne3030 167.m03334
Dictyostelium discoideum (Ddi) ddi11543 DDB0231448
Debaryomyces hansenii (Dha) dha2208 DEHA0C17556g
Debaryomyces hansenii (Dha) dha4835 DEHA0F10219g
Drosophila melanogaster (Dme) dme10321 CG7433-PA
(FBgn0036927)
Drosophila melanogaster (Dme) dme10320 CG7433-PB
(FBgn0036927)
Danio rerio (Dre) dre17375 ENSDARP00000016806
(abat)		 Q7ZVS4
Takifugu rubripes (Fru) fru23881 SINFRUP00000150989
Gallus gallus (Gga) gga6759 ENSGALP00000011853
(ABAT)
Gallus gallus (Gga) gga6760 ENSGALP00000011854
Homo sapiens (Hsa) hsa11632 ENSP00000268251
(ABAT)		 B7Z1V4
Kluyveromyces lactis (Kla) kla5003 KLLA0F20548g
Mus musculus (Mmu) mmu9860 ENSMUSP00000063548
(MGI:2443582)		 P61922-1
Neurospora crassa (Ncr) ncr8769 NCU08998.2
Rattus norvegicus (Rno) rno4435 ENSRNOP00000003633
(RGD:620948)		 P50554
Saccharomyces cerevisiae (Sce) sce2380 YGR019W
(S000003251)
Schizosaccharomyces pombe (Spo) spo791 SPAC19D5.07 O13837
Yarrowia lipolytica (Yli) yli4614 YALI0E18238g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
IC
SceS000003251
GO:0005739 mitochondrion C
IDA
MmuMGI:2443582
ISO
MmuMGI:2443582
ISS
DmeFBgn0036927
SpoSPAC19D5.07
GO:0005759 mitochondrial matrix C
ISS
DmeFBgn0036927
GO:0005829 cytosol C
IDA
SpoSPAC19D5.07
GO:0019717 synaptosome C
ISO
MmuMGI:2443582
GO:0003867 4-aminobutyrate transaminase activity F
IDA
SpoSPAC19D5.07
IMP
SceS000003251
ISO
MmuMGI:2443582
ISS
DmeFBgn0036927
GO:0030170 pyridoxal phosphate binding F
IDA
SpoSPAC19D5.07
GO:0001666 response to hypoxia P
ISO
MmuMGI:2443582
GO:0006520 cellular amino acid metabolic process P
ISS
DmeFBgn0036927
GO:0006536 glutamate metabolic process P
IDA
SpoSPAC19D5.07
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000003251
GO:0007620 copulation P
ISO
MmuMGI:2443582
GO:0007626 locomotory behavior P
ISO
MmuMGI:2443582
GO:0009450 gamma-aminobutyric acid catabolic
process		 P
IDA
SpoSPAC19D5.07
IMP
SceS000003251
GO:0010039 response to iron ion P
ISO
MmuMGI:2443582
GO:0019740 nitrogen utilization P
ISS
SpoSPAC19D5.07
TAS
SceS000003251
GO:0035094 response to nicotine P
ISO
MmuMGI:2443582
GO:0042220 response to cocaine P
ISO
MmuMGI:2443582
GO:0042493 response to drug P
ISO
MmuMGI:2443582
GO:0045471 response to ethanol P
ISO
MmuMGI:2443582
GO:0045776 negative regulation of blood pressure P
ISO
MmuMGI:2443582
GO:0048148 behavioral response to cocaine P
IMP
MmuMGI:2443582

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC19D5.07
(O13837)		 YGR019W
(S000003251)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
IC
SceS000003251
GO:0005739 mitochondrion C
ISS
SpoSPAC19D5.07
GO:0005829 cytosol C
IDA
SpoSPAC19D5.07
GO:0003867 4-aminobutyrate transaminase activity F
IDA
SpoSPAC19D5.07
IMP
SceS000003251
GO:0030170 pyridoxal phosphate binding F
IDA
SpoSPAC19D5.07
GO:0006536 glutamate metabolic process P
IDA
SpoSPAC19D5.07
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000003251
GO:0009450 gamma-aminobutyric acid catabolic
process		 P
IDA
SpoSPAC19D5.07
IMP
SceS000003251
GO:0019740 nitrogen utilization P
ISS
SpoSPAC19D5.07
TAS
SceS000003251

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s.khadayate@ucl.ac.uk