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Search term: YGR060W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ERG25
SGD link S000003292
Alternative ID YGR060W
Description C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
Synonyms YGR060W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0873 ACDHYP-

KOGs classification KOGs description
METABOLISM C-4 sterol methyl oxidase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g07420 GI:18390767
Arabidopsis thaliana (Ath) At2g29390 GI:15227079
Arabidopsis thaliana (Ath) At4g12110 GI:15234416
Arabidopsis thaliana (Ath) At4g22750_1 GI:7486880
Caenorhabditis elegans (Cel) CE03385
(WBGene00009902)		 GI:17534223 Q20611
Caenorhabditis elegans (Cel) CE03386
(WBGene00009903)		 GI:17534225 Q20612
Caenorhabditis elegans (Cel) CE04497
(WBGene00018036)		 GI:17567475 Q20027
Drosophila melanogaster (Dme) 7292879
(FBgn0030485)		 GI:18859821
Drosophila melanogaster (Dme) 7292910 GI:7292910 Q9VYA2
Homo sapiens (Hsa) Hs5803157
(SC4MOL)		 GI:5803157 Q15800
Homo sapiens (Hsa) Hs4502499
(CH25H)		 GI:4502499 O95992
Homo sapiens (Hsa) Hs14150217 GI:14150217
Saccharomyces cerevisiae (Sce) YGR060w
(S000003292)		 GI:6321497 P53045
Schizosaccharomyces pombe (Spo) SPAC630.08c GI:19113815 Q9UUH4
Arabidopsis thaliana (Ath) At1g07420 GI:18390767
Arabidopsis thaliana (Ath) At2g29390 GI:15227079
Arabidopsis thaliana (Ath) At4g12110 GI:15234416
Arabidopsis thaliana (Ath) At4g22750_1 GI:7486880
Caenorhabditis elegans (Cel) CE03385
(WBGene00009902)		 GI:17534223 Q20611
Caenorhabditis elegans (Cel) CE03386
(WBGene00009903)		 GI:17534225 Q20612
Caenorhabditis elegans (Cel) CE04497
(WBGene00018036)		 GI:17567475 Q20027
Drosophila melanogaster (Dme) 7292879
(FBgn0030485)		 GI:18859821
Drosophila melanogaster (Dme) 7292910 GI:7292910 Q9VYA2
Homo sapiens (Hsa) Hs5803157
(SC4MOL)		 GI:5803157 Q15800
Homo sapiens (Hsa) Hs4502499
(CH25H)		 GI:4502499 O95992
Homo sapiens (Hsa) Hs14150217 GI:14150217
Saccharomyces cerevisiae (Sce) YGR060w
(S000003292)		 GI:6321497 P53045
Schizosaccharomyces pombe (Spo) SPAC630.08c GI:19113815 Q9UUH4


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC630.08c
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaSC4MOL
IDA
SceS000003292
ISS
SpoSPAC630.08c
GO:0005829 cytosol C
EXP
HsaCH25H
GO:0005886 plasma membrane C
IDA
SceS000003292
TAS
HsaSC4MOL
GO:0009941 chloroplast envelope C
IDA
AthAt1g07420
GO:0016020 membrane C
TAS
AthAt4g12110
At2g29390
GO:0000254 C-4 methylsterol oxidase activity F
EXP
HsaSC4MOL
IDA
SceS000003292
IGI
AthAt2g29390
At1g07420
IMP
AthAt4g12110
ISS
AthAt4g12110
DmeFBgn0030485
SpoSPAC630.08c
GO:0003824 catalytic activity F
ISS
AthAt4g12110
GO:0005506 iron ion binding F
ISS
SpoSPAC630.08c
GO:0008395 steroid hydroxylase activity F
EXP
HsaCH25H
GO:0080064 4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl
oxidase activity		 F
NAS
AthAt4g12110
GO:0080065 4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase
activity		 F
IGI
AthAt1g07420
At2g29390
GO:0006066 alcohol metabolic process P
RCA
SceS000003292
GO:0006629 lipid metabolic process P
TAS
HsaCH25H
GO:0006631 fatty acid metabolic process P
TAS
HsaSC4MOL
GO:0006696 ergosterol biosynthetic process P
IDA
SceS000003292
ISS
SpoSPAC630.08c
GO:0008202 steroid metabolic process P
TAS
HsaSC4MOL
GO:0016126 sterol biosynthetic process P
IGI
AthAt2g29390
IMP
AthAt4g12110
GO:0044255 cellular lipid metabolic process P
RCA
SceS000003292

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
90891

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SC4MOL GI:5803157 Q15800
Pan troglodytes (Ptr) SC4MOL GI:114596709
Canis familiaris (Cfa) SC4MOL GI:57096891
Mus musculus (Mmu) Sc4mol
(MGI:1913484)		 GI:13384836 Q9CRA4
Rattus norvegicus (Rno) Sc4mol
(RGD:620281)		 GI:18266684
Gallus gallus (Gga) SC4MOL GI:57530155
Schizosaccharomyces pombe (Spo) erg25
(SPAC630.08c)		 GI:19113815 Q9UUH4
Saccharomyces cerevisiae (Sce) ERG25
(S000003292)		 GI:6321497 P53045
Kluyveromyces lactis (Kla) KLLA0B08085g GI:50303885
Eremothecium gossypii (Ego) AGOS_AFR572W GI:45199090
Magnaporthe grisea (Mgr) MGG_06133 GI:39975881
Neurospora crassa (Ncr) NCU06402.1 GI:32411553
Arabidopsis thaliana (Ath) SMO2-1 GI:18390767
Arabidopsis thaliana (Ath) SMO2-2 GI:18402028
Oryza sativa (Osa) Os07g0101500 GI:115470159
Oryza sativa (Osa) Os11g0707600 GI:115486827


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1913484
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC630.08c
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaSC4MOL
IDA
SceS000003292
ISS
SpoSPAC630.08c
GO:0005886 plasma membrane C
IDA
SceS000003292
TAS
HsaSC4MOL
GO:0009941 chloroplast envelope C
IDA
AthSMO2-1
GO:0016020 membrane C
TAS
AthSMO2-2
GO:0000254 C-4 methylsterol oxidase activity F
EXP
HsaSC4MOL
IDA
SceS000003292
IGI
AthSMO2-1
SMO2-2
ISS
SpoSPAC630.08c
GO:0003674 molecular_function F
ND
MmuMGI:1913484
GO:0005506 iron ion binding F
ISS
SpoSPAC630.08c
GO:0080065 4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase
activity		 F
IGI
AthSMO2-1
SMO2-2
GO:0006066 alcohol metabolic process P
RCA
SceS000003292
GO:0006631 fatty acid metabolic process P
TAS
HsaSC4MOL
GO:0006696 ergosterol biosynthetic process P
IDA
SceS000003292
ISS
SpoSPAC630.08c
GO:0008150 biological_process P
ND
MmuMGI:1913484
GO:0008202 steroid metabolic process P
TAS
HsaSC4MOL
GO:0016126 sterol biosynthetic process P
IGI
AthSMO2-2
GO:0044255 cellular lipid metabolic process P
RCA
SceS000003292

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1229

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga14655 ENSANGP00000019886
Anopheles gambiae (Aga) aga14654 ENSANGP00000023718
Ashbya gossypii (Ago) ago3764 AFR572W
Arabidopsis thaliana (Ath) ath720 At1g07420.1
Arabidopsis thaliana (Ath) ath721 At1g07420.2
Arabidopsis thaliana (Ath) ath9906 At2g29390.1
Arabidopsis thaliana (Ath) ath9907 At2g29390.2
Arabidopsis thaliana (Ath) ath9908 At2g29390.3
Caenorhabditis elegans (Cel) cel9727 F49E12.10
(CE03386;
WBGene00009903)
Caenorhabditis elegans (Cel) cel9736 F49E12.9
(CE03385;
WBGene00009902)
Candida glabrata (Cgl) cgl3715 CAGL0K04477g
Cryptococcus neoformans (Cne) cne5369 179.m00221
Dictyostelium discoideum (Ddi) ddi1022 DDB0190553
Dictyostelium discoideum (Ddi) ddi1875 DDB0216700
Debaryomyces hansenii (Dha) dha565 DEHA0A12661g
Debaryomyces hansenii (Dha) dha5835 DEHA0G03124g
Drosophila melanogaster (Dme) dme17732 CG11162-PA
(FBgn0030509)
Drosophila melanogaster (Dme) dme17704 CG1998-PA
(FBgn0030485)
Danio rerio (Dre) dre448 ENSDARP00000008728
Danio rerio (Dre) dre25992 ENSDARP00000035841
(zgc:55420)		 Q803P4
Takifugu rubripes (Fru) fru31565 SINFRUP00000134844
Takifugu rubripes (Fru) fru17618 SINFRUP00000160382
Gallus gallus (Gga) gga5864 ENSGALP00000006317
(C5orf4)
Gallus gallus (Gga) gga17256 ENSGALP00000015550
(SC4MOL)		 Q5ZLL6
Homo sapiens (Hsa) hsa24823 ENSP00000261507
(SC4MOL)		 Q15800
Homo sapiens (Hsa) hsa26049 ENSP00000320604
(C5orf4)		 Q96IV6
Kluyveromyces lactis (Kla) kla888 KLLA0B08085g
Mus musculus (Mmu) mmu26020 ENSMUSP00000034015
(MGI:1913484)		 Q9CRA4
Mus musculus (Mmu) mmu3711 ENSMUSP00000040965
Neurospora crassa (Ncr) ncr6221 NCU06402.2
Oryza sativa (Osa) osa42207 5276.m00129
Rattus norvegicus (Rno) rno5030 ENSRNOP00000033145
(GI:686661)
Rattus norvegicus (Rno) rno12328 ENSRNOP00000043782
(RGD:620281)		 O35532
Saccharomyces cerevisiae (Sce) sce2427 YGR060W
(S000003292)
Schizosaccharomyces pombe (Spo) spo4677 SPAC630.08c Q9UUH4
Yarrowia lipolytica (Yli) yli5817 YALI0F11297g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1913484
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC630.08c
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000003292
ISS
SpoSPAC630.08c
GO:0005886 plasma membrane C
IDA
SceS000003292
GO:0009941 chloroplast envelope C
IDA
AthAt1g07420
GO:0016020 membrane C
TAS
AthAt2g29390
GO:0000254 C-4 methylsterol oxidase activity F
IDA
SceS000003292
IGI
AthAt2g29390
At1g07420
ISS
DmeFBgn0030509
FBgn0030485
SpoSPAC630.08c
GO:0003674 molecular_function F
ND
MmuMGI:1913484
GO:0005506 iron ion binding F
ISS
SpoSPAC630.08c
GO:0080065 4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase
activity		 F
IGI
AthAt1g07420
At2g29390
GO:0006066 alcohol metabolic process P
RCA
SceS000003292
GO:0006696 ergosterol biosynthetic process P
IDA
SceS000003292
ISS
SpoSPAC630.08c
GO:0008150 biological_process P
ND
MmuMGI:1913484
GO:0016126 sterol biosynthetic process P
IGI
AthAt2g29390
GO:0044255 cellular lipid metabolic process P
RCA
SceS000003292

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC630.08c
(Q9UUH4)		 YGR060W
(S000003292)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC630.08c
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000003292
ISS
SpoSPAC630.08c
GO:0005886 plasma membrane C
IDA
SceS000003292
GO:0000254 C-4 methylsterol oxidase activity F
IDA
SceS000003292
ISS
SpoSPAC630.08c
GO:0005506 iron ion binding F
ISS
SpoSPAC630.08c
GO:0006066 alcohol metabolic process P
RCA
SceS000003292
GO:0006696 ergosterol biosynthetic process P
IDA
SceS000003292
ISS
SpoSPAC630.08c
GO:0044255 cellular lipid metabolic process P
RCA
SceS000003292

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Search for gene by ID or name:

Query species:

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GO info in one table:

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