Bahler Lab

Search term: YGR092W

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name DBF2

SGD link S000003324

Alternative ID YGR092W

Description Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis

Synonyms YGR092W

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG0605 ACDHYP-

KOGs classification KOGs description

POORLY CHARACTERIZED NDR and related serine/threonine kinases

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000131 incipient cellular bud site C
IDA
Sce S000005105

GO:0005575 cellular_component C
ND
Ath At2g19400
At1g30640
At4g33080

GO:0005628 prospore membrane C
IDA
Spo SPCC417.06c

GO:0005634 nucleus C
IDA
Ath At4g14350
Hsa STK38
Sce S000001861
S000005105
Spo SPAC821.12
SPCC417.06c

GO:0005730 nucleolus C
IDA
Spo SPCC417.06c

GO:0005737 cytoplasm C
IDA
Ath At4g14350
Hsa STK38
Sce S000001861
S000005105
S000006315

GO:0005816 spindle pole body C
IDA
Sce S000003324
Spo SPAC24B11.11c
SPAC24B11.11c
SPCC417.06c

GO:0005829 cytosol C
IDA
Ath At1g03920
At3g23310
At4g14350
At5g09890
Spo SPAC24B11.11c
SPBC725.06c
SPCC1450.11c
SPAC821.12
SPCC417.06c

GO:0005886 plasma membrane C
IDA
Ath At3g23310
At4g14350
At1g03920

GO:0005933 cellular bud C
IDA
Sce S000005105

GO:0005934 cellular bud tip C
IDA
Sce S000005105

GO:0005935 cellular bud neck C
IDA
Sce S000005105
S000003324

GO:0005938 cell cortex C
IDA
Sce S000005105

GO:0009524 phragmoplast C
IDA
Ath At4g14350

GO:0031097 medial cortex C
IDA
Spo SPAC24B11.11c

GO:0034973 Sid2-Mob1 complex C
IPI
Spo SPAC24B11.11c

GO:0043332 mating projection tip C
IDA
Sce S000005105

GO:0051285 cell cortex of cell tip C
IDA
Spo SPAC821.12

GO:0070688 MLL5-L complex C
IDA
Hsa STK38

GO:0000287 magnesium ion binding F
IDA
Hsa STK38

GO:0004672 protein kinase activity F
IDA
Sce S000001861
ISS
Ath At1g30640
At4g14350

GO:0004674 protein serine/threonine kinase
activity F
IDA
Hsa STK38
Sce S000003324
S000005105
S000006315
ISS
Sce S000001861
Spo SPBC725.06c
SPCC417.06c
TAS
Spo SPAC821.12
SPAC24B11.11c
SPCC1450.11c
SPBC725.06c
SPCC417.06c

GO:0005515 protein binding F
IPI
Hsa STK38
Spo SPAC821.12
SPAC24B11.11c

GO:0005524 ATP binding F
IDA
Hsa STK38
ISS
Ath At4g14350
Spo SPAC24B11.11c
SPBC725.06c
SPCC417.06c

GO:0016301 kinase activity F
ISS
Ath At2g19400
At4g14350
At3g23310
At1g30640
At1g03920
At2g20470
At4g33080
At5g09890

GO:0031435 mitogen-activated protein kinase kinase kinase
binding F
IPI
Hsa STK38

GO:0000003 reproduction P
RCA
Sce S000005105
S000003324

GO:0000078 cell shape checkpoint P
NAS
Spo SPAC821.12

GO:0000280 nuclear division P
IMP
Sce S000003324

GO:0000749 response to pheromone involved in conjugation with
cellular fusion P
IDA
Sce S000005105

GO:0000753 cell morphogenesis involved in conjugation with
cellular fusion P
IDA
Sce S000005105

GO:0001324 age-dependent response to oxidative stress
involved in chronological cell
aging P
IMP
Sce S000001861

GO:0006464 protein modification process P
IDA
Hsa STK38

GO:0006468 protein amino acid phosphorylation P
IC
Spo SPAC821.12
SPCC1450.11c
IDA
Hsa STK38
Sce S000003324
S000006315
S000001861
S000005105
IMP
Sce S000003324
ISS
Ath At4g14350
Spo SPBC725.06c
SPAC24B11.11c
SPCC417.06c

GO:0006793 phosphorus metabolic process P
RCA
Sce S000003324

GO:0006950 response to stress P
IMP
Sce S000001861

GO:0006970 response to osmotic stress P
IMP
Spo SPAC821.12

GO:0007035 vacuolar acidification P
IMP
Sce S000003324

GO:0007039 vacuolar protein catabolic process P
RCA
Sce S000001861

GO:0007047 cellular cell wall organization P
RCA
Sce S000005105

GO:0007049 cell cycle P
IEP
Sce S000006315
IGI
Sce S000006315

GO:0007096 regulation of exit from mitosis P
IMP
Sce S000005105

GO:0007118 budding cell apical bud growth P
IGI
Sce S000005105
IMP
Sce S000005105

GO:0007163 establishment or maintenance of cell
polarity P
IGI
Spo SPAC821.12
IMP
Sce S000005105
Spo SPAC821.12

GO:0007165 signal transduction P
IGI
Spo SPCC417.06c
NAS
Spo SPBC725.06c
SPCC1450.11c

GO:0007243 intracellular protein kinase cascade P
IDA
Hsa STK38

GO:0007346 regulation of mitotic cell cycle P
IGI
Spo SPAC821.12
SPCC1450.11c

GO:0008360 regulation of cell shape P
IGI
Spo SPAC821.12

GO:0009415 response to water P
RCA
Sce S000001861

GO:0009826 unidimensional cell growth P
IGI
Spo SPAC821.12

GO:0009966 regulation of signal transduction P
RCA
Sce S000001861

GO:0010590 regulation of cytokinetic cell
separation P
IGI
Spo SPAC821.12

GO:0030950 establishment or maintenance of actin cytoskeleton
polarity P
IMP
Sce S000005105
TAS
Spo SPAC821.12

GO:0031028 septation initiation signaling P
IMP
Spo SPAC24B11.11c

GO:0031321 ascospore-type prospore formation P
IGI
Spo SPCC417.06c

GO:0031383 regulation of mating projection
assembly P
IMP
Sce S000005105

GO:0032120 ascospore-type prospore membrane
assembly P
IMP
Spo SPCC417.06c

GO:0032465 regulation of cytokinesis P
IMP
Spo SPAC24B11.11c

GO:0032878 regulation of establishment or maintenance of cell
polarity P
IGI
Spo SPAC821.12

GO:0032889 regulation of vacuole fusion, non-autophagic P
IMP
Spo SPCC417.06c

GO:0034504 protein localization in nucleus P
IMP
Sce S000005105

GO:0040020 regulation of meiosis P
IMP
Sce S000001861

GO:0043407 negative regulation of MAP kinase
activity P
IDA
Hsa STK38

GO:0045132 meiotic chromosome segregation P
IMP
Spo SPCC417.06c

GO:0050790 regulation of catalytic activity P
RCA
Sce S000003324

GO:0051049 regulation of transport P
RCA
Sce S000005105

GO:0051098 regulation of binding P
RCA
Sce S000001861

GO:0051301 cell division P
RCA
Sce S000005105
S000003324

GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape P
IMP
Spo SPCC1450.11c

GO:0061167 maintenance of endoplasmic reticulum location
involved in endoplasmic reticulum polarization at
cell division site P
IMP
Spo SPAC24B11.11c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

56357

Species Gene ID NCBI link UniProt link

Schizosaccharomyces pombe (Spo) sid2
(SPAC24B11.11c) GI:19113760 Q09898

Saccharomyces cerevisiae (Sce) DBF2
(S000003324) GI:6321529 P22204

Saccharomyces cerevisiae (Sce) DBF20
(S000006315) GI:6325368 P32328

Kluyveromyces lactis (Kla) KLLA0D14905g GI:50307483

Eremothecium gossypii (Ego) AGOS_ADR033W GI:45187906

Magnaporthe grisea (Mgr) MGG_02757 GI:39970581

Neurospora crassa (Ncr) NCU09071.1 GI:32422039

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005737 cytoplasm C
IDA
Sce S000006315

GO:0005816 spindle pole body C
IDA
Sce S000003324
Spo SPAC24B11.11c
SPAC24B11.11c

GO:0005829 cytosol C
IDA
Spo SPAC24B11.11c

GO:0005935 cellular bud neck C
IDA
Sce S000003324

GO:0031097 medial cortex C
IDA
Spo SPAC24B11.11c

GO:0034973 Sid2-Mob1 complex C
IPI
Spo SPAC24B11.11c

GO:0004674 protein serine/threonine kinase
activity F
IDA
Sce S000003324
S000006315
TAS
Spo SPAC24B11.11c

GO:0005515 protein binding F
IPI
Spo SPAC24B11.11c

GO:0005524 ATP binding F
ISS
Spo SPAC24B11.11c

GO:0000003 reproduction P
RCA
Sce S000003324

GO:0000280 nuclear division P
IMP
Sce S000003324

GO:0006468 protein amino acid phosphorylation P
IDA
Sce S000003324
S000006315
IMP
Sce S000003324
ISS
Spo SPAC24B11.11c

GO:0006793 phosphorus metabolic process P
RCA
Sce S000003324

GO:0007035 vacuolar acidification P
IMP
Sce S000003324

GO:0007049 cell cycle P
IEP
Sce S000006315
IGI
Sce S000006315

GO:0031028 septation initiation signaling P
IMP
Spo SPAC24B11.11c

GO:0032465 regulation of cytokinesis P
IMP
Spo SPAC24B11.11c

GO:0050790 regulation of catalytic activity P
RCA
Sce S000003324

GO:0051301 cell division P
RCA
Sce S000003324

GO:0061167 maintenance of endoplasmic reticulum location
involved in endoplasmic reticulum polarization at
cell division site P
IMP
Spo SPAC24B11.11c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_7868

Species OrthoMCL
sequence Model organism
protein page UniProt link

Ashbya gossypii (Ago) ago1774 ADR033W

Candida glabrata (Cgl) cgl384 CAGL0B04147g

Candida glabrata (Cgl) cgl1756 CAGL0G03047g

Cryptococcus neoformans (Cne) cne3154 167.m03491

Dictyostelium discoideum (Ddi) ddi13346 DDB0219984

Dictyostelium discoideum (Ddi) ddi13035 DDB0229453

Dictyostelium discoideum (Ddi) ddi12532 DDB0231558

Debaryomyces hansenii (Dha) dha1810 DEHA0C08635g

Kluyveromyces lactis (Kla) kla2720 KLLA0D14905g

Neurospora crassa (Ncr) ncr8840 NCU09071.2

Saccharomyces cerevisiae (Sce) sce2460 YGR092W
(S000003324)

Saccharomyces cerevisiae (Sce) sce6567 YPR111W
(S000006315)

Schizosaccharomyces pombe (Spo) spo4071 SPAC24B11.11c Q09898

Yarrowia lipolytica (Yli) yli1326 YALI0B14201g

GO terms for OrthoMCL results:

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPAC24B11.11c
(Q09898) YGR092W
(S000003324)

SPCC417.06c
(O94487) YGR092W
(S000003324)

GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005628 prospore membrane C
IDA
Spo SPCC417.06c

GO:0005634 nucleus C
IDA
Spo SPCC417.06c

GO:0005730 nucleolus C
IDA
Spo SPCC417.06c

GO:0005816 spindle pole body C
IDA
Sce S000003324
Spo SPAC24B11.11c
SPAC24B11.11c
SPCC417.06c

GO:0005829 cytosol C
IDA
Spo SPAC24B11.11c
SPCC417.06c

GO:0005935 cellular bud neck C
IDA
Sce S000003324

GO:0031097 medial cortex C
IDA
Spo SPAC24B11.11c

GO:0034973 Sid2-Mob1 complex C
IPI
Spo SPAC24B11.11c

GO:0004674 protein serine/threonine kinase
activity F
IDA
Sce S000003324
ISS
Spo SPCC417.06c
TAS
Spo SPAC24B11.11c
SPCC417.06c

GO:0005515 protein binding F
IPI
Spo SPAC24B11.11c

GO:0005524 ATP binding F
ISS
Spo SPAC24B11.11c
SPCC417.06c

GO:0000003 reproduction P
RCA
Sce S000003324

GO:0000280 nuclear division P
IMP
Sce S000003324

GO:0006468 protein amino acid phosphorylation P
IDA
Sce S000003324
IMP
Sce S000003324
ISS
Spo SPAC24B11.11c
SPCC417.06c

GO:0006793 phosphorus metabolic process P
RCA
Sce S000003324

GO:0007035 vacuolar acidification P
IMP
Sce S000003324

GO:0007165 signal transduction P
IGI
Spo SPCC417.06c

GO:0031028 septation initiation signaling P
IMP
Spo SPAC24B11.11c

GO:0031321 ascospore-type prospore formation P
IGI
Spo SPCC417.06c

GO:0032120 ascospore-type prospore membrane
assembly P
IMP
Spo SPCC417.06c

GO:0032465 regulation of cytokinesis P
IMP
Spo SPAC24B11.11c

GO:0032889 regulation of vacuole fusion, non-autophagic P
IMP
Spo SPCC417.06c

GO:0045132 meiotic chromosome segregation P
IMP
Spo SPCC417.06c

GO:0050790 regulation of catalytic activity P
RCA
Sce S000003324

GO:0051301 cell division P
RCA
Sce S000003324

GO:0061167 maintenance of endoplasmic reticulum location
involved in endoplasmic reticulum polarization at
cell division site P
IMP
Spo SPAC24B11.11c

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0605	ACDHYP-

KOGs classification	KOGs description
POORLY CHARACTERIZED	NDR and related serine/threonine kinases

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At1g03920	GI:15219591
Arabidopsis thaliana (Ath)	At1g30640	GI:15221465
Arabidopsis thaliana (Ath)	At2g19400	GI:7446410
Arabidopsis thaliana (Ath)	At2g20470	GI:15225358
Arabidopsis thaliana (Ath)	At3g23310	GI:15229422
Arabidopsis thaliana (Ath)	At4g14350	GI:15236484
Arabidopsis thaliana (Ath)	At4g33080	GI:15234064
Arabidopsis thaliana (Ath)	At5g09890	GI:9758967
Caenorhabditis elegans (Cel)	CE28760	GI:17569431
Drosophila melanogaster (Dme)	7293735	GI:7293735
Homo sapiens (Hsa)	Hs6005814 (STK38)	GI:6005814	Q9UPD3
Homo sapiens (Hsa)	Hs18579683	GI:18579683
Saccharomyces cerevisiae (Sce)	YFL033c (S000001861)	GI:14318486	P43565
Saccharomyces cerevisiae (Sce)	YGR092w (S000003324)	GI:6321529	P22204
Saccharomyces cerevisiae (Sce)	YNL161w (S000005105)	GI:6324168	P53894
Saccharomyces cerevisiae (Sce)	YPR111w (S000006315)	GI:6325368	P32328
Schizosaccharomyces pombe (Spo)	SPAC24B11.11c	GI:19113760	Q09898
Schizosaccharomyces pombe (Spo)	SPAC821.12	GI:19114077	O13310
Schizosaccharomyces pombe (Spo)	SPBC725.06c	GI:19112278	O94324
Schizosaccharomyces pombe (Spo)	SPCC1450.11c	GI:19075810	P38938
Schizosaccharomyces pombe (Spo)	SPCC417.06c	GI:19075783	O94487
Arabidopsis thaliana (Ath)	At1g03920	GI:15219591
Arabidopsis thaliana (Ath)	At1g30640	GI:15221465
Arabidopsis thaliana (Ath)	At2g19400	GI:7446410
Arabidopsis thaliana (Ath)	At2g20470	GI:15225358
Arabidopsis thaliana (Ath)	At3g23310	GI:15229422
Arabidopsis thaliana (Ath)	At4g14350	GI:15236484
Arabidopsis thaliana (Ath)	At4g33080	GI:15234064
Arabidopsis thaliana (Ath)	At5g09890	GI:9758967
Caenorhabditis elegans (Cel)	CE28760	GI:17569431
Drosophila melanogaster (Dme)	7293735	GI:7293735
Homo sapiens (Hsa)	Hs6005814 (STK38)	GI:6005814	Q9UPD3
Homo sapiens (Hsa)	Hs18579683	GI:18579683
Saccharomyces cerevisiae (Sce)	YFL033c (S000001861)	GI:14318486	P43565
Saccharomyces cerevisiae (Sce)	YGR092w (S000003324)	GI:6321529	P22204
Saccharomyces cerevisiae (Sce)	YNL161w (S000005105)	GI:6324168	P53894
Saccharomyces cerevisiae (Sce)	YPR111w (S000006315)	GI:6325368	P32328
Schizosaccharomyces pombe (Spo)	SPAC24B11.11c	GI:19113760	Q09898
Schizosaccharomyces pombe (Spo)	SPAC821.12	GI:19114077	O13310
Schizosaccharomyces pombe (Spo)	SPBC725.06c	GI:19112278	O94324
Schizosaccharomyces pombe (Spo)	SPCC1450.11c	GI:19075810	P38938
Schizosaccharomyces pombe (Spo)	SPCC417.06c	GI:19075783	O94487

Species	Gene ID	NCBI link	UniProt link
Schizosaccharomyces pombe (Spo)	sid2 (SPAC24B11.11c)	GI:19113760	Q09898
Saccharomyces cerevisiae (Sce)	DBF2 (S000003324)	GI:6321529	P22204
Saccharomyces cerevisiae (Sce)	DBF20 (S000006315)	GI:6325368	P32328
Kluyveromyces lactis (Kla)	KLLA0D14905g	GI:50307483
Eremothecium gossypii (Ego)	AGOS_ADR033W	GI:45187906
Magnaporthe grisea (Mgr)	MGG_02757	GI:39970581
Neurospora crassa (Ncr)	NCU09071.1	GI:32422039

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Ashbya gossypii (Ago)	ago1774	ADR033W
Candida glabrata (Cgl)	cgl384	CAGL0B04147g
Candida glabrata (Cgl)	cgl1756	CAGL0G03047g
Cryptococcus neoformans (Cne)	cne3154	167.m03491
Dictyostelium discoideum (Ddi)	ddi13346	DDB0219984
Dictyostelium discoideum (Ddi)	ddi13035	DDB0229453
Dictyostelium discoideum (Ddi)	ddi12532	DDB0231558
Debaryomyces hansenii (Dha)	dha1810	DEHA0C08635g
Kluyveromyces lactis (Kla)	kla2720	KLLA0D14905g
Neurospora crassa (Ncr)	ncr8840	NCU09071.2
Saccharomyces cerevisiae (Sce)	sce2460	YGR092W (S000003324)
Saccharomyces cerevisiae (Sce)	sce6567	YPR111W (S000006315)
Schizosaccharomyces pombe (Spo)	spo4071	SPAC24B11.11c	Q09898
Yarrowia lipolytica (Yli)	yli1326	YALI0B14201g

S. pombe systematic ID	S. cerevisiae systematic ID
SPAC24B11.11c (Q09898)	YGR092W (S000003324)
SPCC417.06c (O94487)	YGR092W (S000003324)