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Search term: YGR162W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name TIF4631
SGD link S000003394
Alternative ID YGR162W
Description Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p
Synonyms YGR162W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0401 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g62410 GI:15220777
Arabidopsis thaliana (Ath) At2g24050 GI:15224087
Arabidopsis thaliana (Ath) At3g60240_1 GI:11358898
Arabidopsis thaliana (Ath) At4g30680 GI:15234815
Arabidopsis thaliana (Ath) At5g57870 GI:15242889
Caenorhabditis elegans (Cel) CE02277
(WBGene00002066)		 GI:17535211
Drosophila melanogaster (Dme) 7301059 GI:7301059
Drosophila melanogaster (Dme) 7302843
(FBgn0034181)		 GI:19922420 Q7K581
Drosophila melanogaster (Dme) 7303385 GI:7303385
Drosophila melanogaster (Dme) 7304373 GI:17864194
Homo sapiens (Hsa) Hs10092601
(EIF4G3)		 GI:10092601 O43432
Homo sapiens (Hsa) Hs17511255
(PAIP1)		 GI:17511255 Q9H074
Homo sapiens (Hsa) Hs4503539
(EIF4G2)		 GI:4503539 P78344
Homo sapiens (Hsa) Hs4826710 GI:4826710
Saccharomyces cerevisiae (Sce) YGL049c
(S000003017)		 GI:6321389 P39936
Saccharomyces cerevisiae (Sce) YGR162w
(S000003394)		 GI:6321601 P39935
Schizosaccharomyces pombe (Spo) SPAC17C9.03 GI:19115514 Q10475
Encephalitozoon cuniculi (Ecu) ECU04g1610 GI:19074240 Q8SVP8
Arabidopsis thaliana (Ath) At1g62410 GI:15220777
Arabidopsis thaliana (Ath) At2g24050 GI:15224087
Arabidopsis thaliana (Ath) At3g60240_1 GI:11358898
Arabidopsis thaliana (Ath) At4g30680 GI:15234815
Arabidopsis thaliana (Ath) At5g57870 GI:15242889
Caenorhabditis elegans (Cel) CE02277
(WBGene00002066)		 GI:17535211
Drosophila melanogaster (Dme) 7301059 GI:7301059
Drosophila melanogaster (Dme) 7302843
(FBgn0034181)		 GI:19922420 Q7K581
Drosophila melanogaster (Dme) 7303385 GI:7303385
Drosophila melanogaster (Dme) 7304373 GI:17864194
Homo sapiens (Hsa) Hs10092601
(EIF4G3)		 GI:10092601 O43432
Homo sapiens (Hsa) Hs17511255
(PAIP1)		 GI:17511255 Q9H074
Homo sapiens (Hsa) Hs4503539
(EIF4G2)		 GI:4503539 P78344
Homo sapiens (Hsa) Hs4826710 GI:4826710
Saccharomyces cerevisiae (Sce) YGL049c
(S000003017)		 GI:6321389 P39936
Saccharomyces cerevisiae (Sce) YGR162w
(S000003394)		 GI:6321601 P39935
Schizosaccharomyces pombe (Spo) SPAC17C9.03 GI:19115514 Q10475
Encephalitozoon cuniculi (Ecu) ECU04g1610 GI:19074240 Q8SVP8
Arabidopsis thaliana (Ath) At1g62410 GI:15220777
Arabidopsis thaliana (Ath) At2g24050 GI:15224087
Arabidopsis thaliana (Ath) At3g60240_1 GI:11358898
Arabidopsis thaliana (Ath) At4g30680 GI:15234815
Arabidopsis thaliana (Ath) At5g57870 GI:15242889
Caenorhabditis elegans (Cel) CE02277
(WBGene00002066)		 GI:17535211
Drosophila melanogaster (Dme) 7301059 GI:7301059
Drosophila melanogaster (Dme) 7302843
(FBgn0034181)		 GI:19922420 Q7K581
Drosophila melanogaster (Dme) 7303385 GI:7303385
Drosophila melanogaster (Dme) 7304373 GI:17864194
Homo sapiens (Hsa) Hs10092601
(EIF4G3)		 GI:10092601 O43432
Homo sapiens (Hsa) Hs17511255
(PAIP1)		 GI:17511255 Q9H074
Homo sapiens (Hsa) Hs4503539
(EIF4G2)		 GI:4503539 P78344
Homo sapiens (Hsa) Hs4826710 GI:4826710
Saccharomyces cerevisiae (Sce) YGL049c
(S000003017)		 GI:6321389 P39936
Saccharomyces cerevisiae (Sce) YGR162w
(S000003394)		 GI:6321601 P39935
Schizosaccharomyces pombe (Spo) SPAC17C9.03 GI:19115514 Q10475
Encephalitozoon cuniculi (Ecu) ECU04g1610 GI:19074240 Q8SVP8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
AthAt5g57870
GO:0005737 cytoplasm C
IDA
AthAt5g57870
GO:0005739 mitochondrion C
IDA
SceS000003394
GO:0005829 cytosol C
IDA
CelWBGene00002066
SpoSPAC17C9.03
GO:0005840 ribosome C
TAS
SceS000003017
S000003394
GO:0010494 stress granule C
IDA
SceS000003017
S000003394
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
IDA
CelWBGene00002066
HsaEIF4G2
IGI
SceS000003017
S000003394
IMP
SceS000003394
ISS
SceS000003017
S000003394
TAS
HsaEIF4G3
GO:0000339 RNA cap binding F
TAS
HsaEIF4G3
GO:0003723 RNA binding F
ISS
AthAt2g24050
At5g57870
RCA
SceS000003017
TAS
HsaPAIP1
GO:0003743 translation initiation factor activity F
IDA
HsaEIF4G2
ISS
AthAt3g60240
At4g30680
At5g57870
At1g62410
TAS
SceS000003017
S000003394
GO:0005198 structural molecule activity F
TAS
SpoSPAC17C9.03
GO:0005515 protein binding F
IPI
HsaEIF4G3
PAIP1
EIF4G2
SpoSPAC17C9.03
GO:0008135 translation factor activity, nucleic acid
binding		 F
IDA
HsaEIF4G2
TAS
HsaEIF4G3
GO:0008494 translation activator activity F
IDA
HsaPAIP1
GO:0000003 reproduction P
IMP
CelWBGene00002066
GO:0001964 startle response P
IMP
DmeFBgn0034181
GO:0002119 nematode larval development P
IMP
CelWBGene00002066
GO:0002121 inter-male aggressive behavior P
IMP
DmeFBgn0034181
GO:0006412 translation P
IMP
CelWBGene00002066
ISS
AthAt1g62410
At5g57870
At2g24050
GO:0006413 translational initiation P
ISS
AthAt5g57870
TAS
HsaPAIP1
SceS000003017
S000003394
SpoSPAC17C9.03
GO:0006414 translational elongation P
RCA
SceS000003017
GO:0006417 regulation of translation P
RCA
SceS000003394
GO:0006446 regulation of translational initiation P
IDA
HsaEIF4G2
TAS
HsaEIF4G3
GO:0007050 cell cycle arrest P
TAS
HsaEIF4G2
GO:0008150 biological_process P
ND
AthAt4g30680
GO:0008219 cell death P
TAS
HsaEIF4G2
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00002066
GO:0009408 response to heat P
IMP
CelWBGene00002066
GO:0009615 response to virus P
IMP
AthAt3g60240
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00002066
GO:0010171 body morphogenesis P
IMP
CelWBGene00002066
GO:0019915 lipid storage P
IMP
CelWBGene00002066
GO:0031987 locomotion involved in locomotory
behavior		 P
IMP
DmeFBgn0034181
GO:0034063 stress granule assembly P
IMP
SceS000003017
S000003394
GO:0040007 growth P
IMP
CelWBGene00002066
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00002066
GO:0042048 olfactory behavior P
IMP
DmeFBgn0034181
GO:0042273 ribosomal large subunit biogenesis P
IMP
SceS000003394
ISS
SpoSPAC17C9.03
GO:0048255 mRNA stabilization P
TAS
HsaPAIP1
GO:0048854 brain morphogenesis P
IMP
DmeFBgn0034181

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
28096

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) tif471
(SPAC17C9.03)		 GI:19115514 Q10475
Saccharomyces cerevisiae (Sce) TIF4632
(S000003017)		 GI:6321389 P39936
Saccharomyces cerevisiae (Sce) TIF4631
(S000003394)		 GI:6321601 P39935
Kluyveromyces lactis (Kla) KLLA0A04730g GI:50302543
Eremothecium gossypii (Ego) AGOS_AGL044C GI:45201052
Magnaporthe grisea (Mgr) MGG_06396 GI:145608756
Neurospora crassa (Ncr) NCU07868.1 GI:32416192


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000003394
GO:0005829 cytosol C
IDA
SpoSPAC17C9.03
GO:0005840 ribosome C
TAS
SceS000003017
S000003394
GO:0010494 stress granule C
IDA
SceS000003017
S000003394
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
IGI
SceS000003017
S000003394
IMP
SceS000003394
ISS
SceS000003017
S000003394
GO:0003723 RNA binding F
RCA
SceS000003017
GO:0003743 translation initiation factor activity F
TAS
SceS000003017
S000003394
GO:0005198 structural molecule activity F
TAS
SpoSPAC17C9.03
GO:0005515 protein binding F
IPI
SpoSPAC17C9.03
GO:0006413 translational initiation P
TAS
SceS000003017
S000003394
SpoSPAC17C9.03
GO:0006414 translational elongation P
RCA
SceS000003017
GO:0006417 regulation of translation P
RCA
SceS000003394
GO:0034063 stress granule assembly P
IMP
SceS000003017
S000003394
GO:0042273 ribosomal large subunit biogenesis P
IMP
SceS000003394
ISS
SpoSPAC17C9.03

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_492

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4699 ENSANGP00000021865
Ashbya gossypii (Ago) ago4267 AGL044C
Arabidopsis thaliana (Ath) ath17450 At3g60240.1
Caenorhabditis elegans (Cel) cel12987 M110.4a
(CE02277;
WBGene00002066)
Caenorhabditis elegans (Cel) cel12988 M110.4b
(CE35745)
Candida glabrata (Cgl) cgl925 CAGL0D06314g
Candida glabrata (Cgl) cgl1085 CAGL0E03289g
Cryptococcus neoformans (Cne) cne2123 181.m08133
Cryptococcus neoformans (Cne) cne2136 181.m08148
Dictyostelium discoideum (Ddi) ddi3181 DDB0217646
Debaryomyces hansenii (Dha) dha1902 DEHA0C10626g
Drosophila melanogaster (Dme) dme14083 CG10192-PA
(FBgn0039122)
Drosophila melanogaster (Dme) dme15603 CG10811-PA
(FBgn0023213)
Danio rerio (Dre) dre15439 ENSDARP00000002101
Danio rerio (Dre) dre15438 ENSDARP00000016244
(LOC568761)
Danio rerio (Dre) dre15484 ENSDARP00000021459
(LOC568761)
Danio rerio (Dre) dre26896 ENSDARP00000022083
Danio rerio (Dre) dre26897 ENSDARP00000025865
(LOC572435)
Danio rerio (Dre) dre15436 ENSDARP00000042107
Danio rerio (Dre) dre15437 ENSDARP00000048969
(LOC568761)
Encephalitozoon cuniculi (Ecu) ecu878 19074240
Takifugu rubripes (Fru) fru20542 SINFRUP00000137165
Takifugu rubripes (Fru) fru20543 SINFRUP00000137166
Takifugu rubripes (Fru) fru20545 SINFRUP00000137167
Takifugu rubripes (Fru) fru6604 SINFRUP00000140176
Takifugu rubripes (Fru) fru6605 SINFRUP00000140179
Takifugu rubripes (Fru) fru6844 SINFRUP00000161192
Takifugu rubripes (Fru) fru6606 SINFRUP00000168081
Takifugu rubripes (Fru) fru20544 SINFRUP00000168370
Gallus gallus (Gga) gga23604 ENSGALP00000013861
Gallus gallus (Gga) gga23602 ENSGALP00000013862
Gallus gallus (Gga) gga23603 ENSGALP00000013863
Gallus gallus (Gga) gga25695 ENSGALP00000016374
Gallus gallus (Gga) gga25696 ENSGALP00000016375
(EIF4G3)
Gallus gallus (Gga) gga25697 ENSGALP00000016376
Homo sapiens (Hsa) hsa475 ENSP00000264211
(EIF4G3)		 O43432-1
Homo sapiens (Hsa) hsa23552 ENSP00000316879
(EIF4G1)		 Q04637-1
Homo sapiens (Hsa) hsa23550 ENSP00000317600
(EIF4G1)
Homo sapiens (Hsa) hsa23553 ENSP00000323737
(EIF4G1)		 Q04637-1
Homo sapiens (Hsa) hsa23551 ENSP00000338020
(EIF4G1)
Kluyveromyces lactis (Kla) kla204 KLLA0A04730g
Mus musculus (Mmu) mmu19176 ENSMUSP00000030543
Mus musculus (Mmu) mmu10090 ENSMUSP00000047678
(MGI:2384784)		 Q6NZJ6-1
Mus musculus (Mmu) mmu31196 ENSMUSP00000072638
Neurospora crassa (Ncr) ncr7664 NCU07868.2
Oryza sativa (Osa) osa33164 4507.m00181
Rattus norvegicus (Rno) rno7585 ENSRNOP00000002371
Rattus norvegicus (Rno) rno15839 ENSRNOP00000014986
Rattus norvegicus (Rno) rno7582 ENSRNOP00000040698
(RGD:1306144)
Rattus norvegicus (Rno) rno24203 ENSRNOP00000043593
(RGD:1311370)
Rattus norvegicus (Rno) rno7586 ENSRNOP00000046015
Rattus norvegicus (Rno) rno7587 ENSRNOP00000047319
Rattus norvegicus (Rno) rno24204 ENSRNOP00000049512
(RGD:1311370)
Rattus norvegicus (Rno) rno7588 ENSRNOP00000049629
(RGD:1306144)
Rattus norvegicus (Rno) rno7584 ENSRNOP00000050436
Saccharomyces cerevisiae (Sce) sce2142 YGL049C
(S000003017)
Saccharomyces cerevisiae (Sce) sce2540 YGR162W
(S000003394)
Schizosaccharomyces pombe (Spo) spo3032 SPAC17C9.03 Q10475
Yarrowia lipolytica (Yli) yli1909 YALI0C04620g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
MmuMGI:2384784
GO:0005739 mitochondrion C
IDA
SceS000003394
GO:0005829 cytosol C
IDA
CelWBGene00002066
SpoSPAC17C9.03
ISS
DmeFBgn0023213
GO:0005840 ribosome C
TAS
SceS000003017
S000003394
GO:0010494 stress granule C
IDA
SceS000003017
S000003394
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
IDA
CelWBGene00002066
IGI
SceS000003017
S000003394
IMP
SceS000003394
ISO
MmuMGI:2384784
ISS
DmeFBgn0023213
SceS000003017
S000003394
GO:0000340 RNA 7-methylguanosine cap binding F
IDA
DmeFBgn0023213
GO:0003723 RNA binding F
RCA
SceS000003017
GO:0003743 translation initiation factor activity F
ISS
AthAt3g60240
DmeFBgn0023213
TAS
SceS000003017
S000003394
GO:0005198 structural molecule activity F
TAS
SpoSPAC17C9.03
GO:0005515 protein binding F
IPI
SpoSPAC17C9.03
GO:0008190 eukaryotic initiation factor 4E
binding		 F
ISO
MmuMGI:2384784
GO:0000003 reproduction P
IMP
CelWBGene00002066
GO:0000022 mitotic spindle elongation P
IMP
DmeFBgn0023213
GO:0000082 G1/S transition of mitotic cell
cycle		 P
IMP
DmeFBgn0023213
GO:0002119 nematode larval development P
IMP
CelWBGene00002066
GO:0006412 translation P
IMP
CelWBGene00002066
GO:0006413 translational initiation P
ISS
DmeFBgn0023213
TAS
SceS000003017
S000003394
SpoSPAC17C9.03
GO:0006414 translational elongation P
RCA
SceS000003017
GO:0006417 regulation of translation P
RCA
SceS000003394
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0023213
GO:0008150 biological_process P
ND
MmuMGI:2384784
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00002066
GO:0009408 response to heat P
IMP
CelWBGene00002066
GO:0009615 response to virus P
IMP
AthAt3g60240
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00002066
GO:0010171 body morphogenesis P
IMP
CelWBGene00002066
GO:0019915 lipid storage P
IMP
CelWBGene00002066
GO:0034063 stress granule assembly P
IMP
SceS000003017
S000003394
GO:0040007 growth P
IMP
CelWBGene00002066
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00002066
GO:0042273 ribosomal large subunit biogenesis P
IMP
SceS000003394
ISS
SpoSPAC17C9.03

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC17C9.03
(Q10475)		 YGR162W
(S000003394)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000003394
GO:0005829 cytosol C
IDA
SpoSPAC17C9.03
GO:0005840 ribosome C
TAS
SceS000003394
GO:0010494 stress granule C
IDA
SceS000003394
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
IGI
SceS000003394
IMP
SceS000003394
ISS
SceS000003394
GO:0003743 translation initiation factor activity F
TAS
SceS000003394
GO:0005198 structural molecule activity F
TAS
SpoSPAC17C9.03
GO:0005515 protein binding F
IPI
SpoSPAC17C9.03
GO:0006413 translational initiation P
TAS
SceS000003394
SpoSPAC17C9.03
GO:0006417 regulation of translation P
RCA
SceS000003394
GO:0034063 stress granule assembly P
IMP
SceS000003394
GO:0042273 ribosomal large subunit biogenesis P
IMP
SceS000003394
ISS
SpoSPAC17C9.03

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GO info in one table:

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