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Search term: YGR175C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ERG1
SGD link S000003407
Alternative ID YGR175C
Description Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
Synonyms YGR175C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1298 A--HYP-

KOGs classification KOGs description
METABOLISM Squalene monooxygenase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g58440 GI:12321049
Arabidopsis thaliana (Ath) At2g22830 GI:15227757
Arabidopsis thaliana (Ath) At4g37760 GI:7488348
Arabidopsis thaliana (Ath) At5g24140 GI:15237900
Arabidopsis thaliana (Ath) At5g24150 GI:15237902
Arabidopsis thaliana (Ath) At5g24160 GI:15237903
Homo sapiens (Hsa) Hs4507197 GI:4507197
Saccharomyces cerevisiae (Sce) YGR175c
(S000003407)		 GI:6321614 P32476
Schizosaccharomyces pombe (Spo) SPBC713.12 GI:19112143 Q9C1W3


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SpoSPBC713.12
GO:0005737 cytoplasm C
IDA
SpoSPBC713.12
GO:0005783 endoplasmic reticulum C
IDA
SceS000003407
SpoSPBC713.12
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPBC713.12
GO:0005811 lipid particle C
IDA
SceS000003407
GO:0004506 squalene monooxygenase activity F
IDA
SceS000003407
IGI
AthAt1g58440
At4g37760
IMP
SceS000003407
ISS
AthAt5g24150
SpoSPBC713.12
GO:0008144 drug binding F
IMP
SceS000003407
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000003407
ISS
SpoSPBC713.12
GO:0009414 response to water deprivation P
IMP
AthAt1g58440
GO:0009611 response to wounding P
IEP
AthAt4g37760
GO:0009753 response to jasmonic acid stimulus P
IEP
AthAt4g37760
GO:0016126 sterol biosynthetic process P
IMP
AthAt1g58440
TAS
AthAt5g24150
At5g24140
At5g24160
At4g37760
At2g22830
At1g58440
GO:0019748 secondary metabolic process P
RCA
SceS000003407

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
2355

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SQLE GI:62865635
Pan troglodytes (Ptr) SQLE GI:114621629
Canis familiaris (Cfa) SQLE GI:73974450
Mus musculus (Mmu) Sqle
(MGI:109296)		 GI:6678127 P52019
Rattus norvegicus (Rno) Sqle
(RGD:3755)		 GI:8394354
Gallus gallus (Gga) SQLE GI:71896553
Schizosaccharomyces pombe (Spo) erg1
(SPBC713.12)		 GI:19112143 Q9C1W3
Saccharomyces cerevisiae (Sce) ERG1
(S000003407)		 GI:6321614 P32476
Kluyveromyces lactis (Kla) KLLA0F15224g GI:50311477
Eremothecium gossypii (Ego) AGOS_AAL141C GI:45184683
Magnaporthe grisea (Mgr) MGG_06139 GI:39975869
Neurospora crassa (Ncr) NCU08280.1 GI:32417016
Arabidopsis thaliana (Ath) XF1 GI:18406296
Oryza sativa (Osa) Os03g0231800 GI:115451725
Oryza sativa (Osa) Os03g0231700 GI:115451723


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SpoSPBC713.12
GO:0005575 cellular_component C
ND
AthXF1
GO:0005618 cell wall C
IDA
AthXF1
GO:0005737 cytoplasm C
IDA
SpoSPBC713.12
GO:0005783 endoplasmic reticulum C
IDA
SceS000003407
SpoSPBC713.12
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaSQLE
ISS
SpoSPBC713.12
GO:0005792 microsome C
ISO
MmuMGI:109296
NAS
HsaSQLE
GO:0005811 lipid particle C
IDA
SceS000003407
GO:0003674 molecular_function F
ND
AthXF1
GO:0004506 squalene monooxygenase activity F
EXP
HsaSQLE
IDA
SceS000003407
IGI
AthXF1
IMP
SceS000003407
ISO
MmuMGI:109296
ISS
SpoSPBC713.12
NAS
HsaSQLE
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl
compounds		 F
ISS
AthXF1
GO:0008047 enzyme activator activity F
IDA
AthXF1
GO:0008144 drug binding F
IMP
SceS000003407
GO:0016301 kinase activity F
ISS
AthXF1
GO:0016740 transferase activity F
ISS
AthXF1
GO:0031176 endo-1,4-beta-xylanase activity F
IDA
AthXF1
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000003407
ISS
SpoSPBC713.12
GO:0006725 cellular aromatic compound metabolic
process		 P
ISO
MmuMGI:109296
GO:0008150 biological_process P
ND
AthXF1
GO:0008203 cholesterol metabolic process P
ISO
MmuMGI:109296
GO:0009414 response to water deprivation P
IMP
AthXF1
GO:0010033 response to organic substance P
ISO
MmuMGI:109296
GO:0016126 sterol biosynthetic process P
IMP
AthXF1
NAS
HsaSQLE
TAS
AthXF1
GO:0019748 secondary metabolic process P
RCA
SceS000003407
GO:0043085 positive regulation of catalytic
activity		 P
IDA
AthXF1

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3202

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago46 AAL141C
Arabidopsis thaliana (Ath) ath5103 At1g58440.1
Arabidopsis thaliana (Ath) ath9182 At2g22830.1
Arabidopsis thaliana (Ath) ath21960 At4g37760.1
Candida glabrata (Cgl) cgl912 CAGL0D05940g
Cryptococcus neoformans (Cne) cne456 163.m06373
Dictyostelium discoideum (Ddi) ddi11133 DDB0192021
Debaryomyces hansenii (Dha) dha6377 DEHA0G15202g
Danio rerio (Dre) dre16043 ENSDARP00000009394
Danio rerio (Dre) dre16044 ENSDARP00000013012
Danio rerio (Dre) dre29249 ENSDARP00000019550
Danio rerio (Dre) dre29250 ENSDARP00000022492
Danio rerio (Dre) dre29248 ENSDARP00000032932
Danio rerio (Dre) dre16042 ENSDARP00000044118
Takifugu rubripes (Fru) fru16052 SINFRUP00000131959
Gallus gallus (Gga) gga11593 ENSGALP00000026293
(SQLE)		 Q5ZKQ4
Gallus gallus (Gga) gga11594 ENSGALP00000026294
Homo sapiens (Hsa) hsa30713 ENSP00000265896
(SQLE)		 Q14534
Kluyveromyces lactis (Kla) kla4763 KLLA0F15224g
Mus musculus (Mmu) mmu9021 ENSMUSP00000022977
(MGI:109296)		 P52019
Neurospora crassa (Ncr) ncr8069 NCU08280.2
Oryza sativa (Osa) osa69836 6973.m00151
Oryza sativa (Osa) osa69837 6973.m00152
Oryza sativa (Osa) osa69851 6973.m00189
Rattus norvegicus (Rno) rno27116 ENSRNOP00000012883
(RGD:3755)		 P52020
Saccharomyces cerevisiae (Sce) sce2555 YGR175C
(S000003407)
Schizosaccharomyces pombe (Spo) spo2609 SPBC713.12 Q9C1W3
Yarrowia lipolytica (Yli) yli4510 YALI0E15730g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SpoSPBC713.12
GO:0005737 cytoplasm C
IDA
SpoSPBC713.12
GO:0005783 endoplasmic reticulum C
IDA
SceS000003407
SpoSPBC713.12
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPBC713.12
GO:0005792 microsome C
ISO
MmuMGI:109296
GO:0005811 lipid particle C
IDA
SceS000003407
GO:0004506 squalene monooxygenase activity F
IDA
SceS000003407
IGI
AthAt1g58440
At4g37760
IMP
SceS000003407
ISO
MmuMGI:109296
ISS
SpoSPBC713.12
GO:0008144 drug binding F
IMP
SceS000003407
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000003407
ISS
SpoSPBC713.12
GO:0006725 cellular aromatic compound metabolic
process		 P
ISO
MmuMGI:109296
GO:0008203 cholesterol metabolic process P
ISO
MmuMGI:109296
GO:0009414 response to water deprivation P
IMP
AthAt1g58440
GO:0009611 response to wounding P
IEP
AthAt4g37760
GO:0009753 response to jasmonic acid stimulus P
IEP
AthAt4g37760
GO:0010033 response to organic substance P
ISO
MmuMGI:109296
GO:0016126 sterol biosynthetic process P
IMP
AthAt1g58440
TAS
AthAt4g37760
At2g22830
At1g58440
GO:0019748 secondary metabolic process P
RCA
SceS000003407

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC713.12
(Q9C1W3)		 YGR175C
(S000003407)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SpoSPBC713.12
GO:0005737 cytoplasm C
IDA
SpoSPBC713.12
GO:0005783 endoplasmic reticulum C
IDA
SceS000003407
SpoSPBC713.12
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPBC713.12
GO:0005811 lipid particle C
IDA
SceS000003407
GO:0004506 squalene monooxygenase activity F
IDA
SceS000003407
IMP
SceS000003407
ISS
SpoSPBC713.12
GO:0008144 drug binding F
IMP
SceS000003407
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000003407
ISS
SpoSPBC713.12
GO:0019748 secondary metabolic process P
RCA
SceS000003407

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GO info in one table:

s.khadayate@ucl.ac.uk