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Search term: YGR184C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name UBR1
SGD link S000003416
Alternative ID YGR184C
Description E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)
Synonyms YGR184C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1140 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING N-end rule pathway, recognition component UBR1

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g02300 GI:15241751
Caenorhabditis elegans (Cel) CE08535 GI:17505805
Drosophila melanogaster (Dme) 7293307 GI:7293307
Homo sapiens (Hsa) Hs18597977 GI:18597977
Homo sapiens (Hsa) Hs22057398 GI:22057398
Homo sapiens (Hsa) Hs20485571 GI:20485571
Homo sapiens (Hsa) Hs20555197 GI:20555197
Saccharomyces cerevisiae (Sce) YGR184c
(S000003416)		 GI:6321623 P19812
Saccharomyces cerevisiae (Sce) YLR024c
(S000004014)		 GI:6323052 Q07963
Schizosaccharomyces pombe (Spo) SPAC15A10.11 GI:19115210 O13731
Schizosaccharomyces pombe (Spo) SPBC19C7.02 GI:19112950 O60152
Arabidopsis thaliana (Ath) At5g02300 GI:15241751
Caenorhabditis elegans (Cel) CE08535 GI:17505805
Drosophila melanogaster (Dme) 7293307 GI:7293307
Homo sapiens (Hsa) Hs18597977 GI:18597977
Homo sapiens (Hsa) Hs22057398 GI:22057398
Homo sapiens (Hsa) Hs20485571 GI:20485571
Homo sapiens (Hsa) Hs20555197 GI:20555197
Saccharomyces cerevisiae (Sce) YGR184c
(S000003416)		 GI:6321623 P19812
Saccharomyces cerevisiae (Sce) YLR024c
(S000004014)		 GI:6323052 Q07963
Schizosaccharomyces pombe (Spo) SPAC15A10.11 GI:19115210 O13731
Schizosaccharomyces pombe (Spo) SPBC19C7.02 GI:19112950 O60152


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
NAS
SpoSPAC15A10.11
SPBC19C7.02
GO:0005737 cytoplasm C
IDA
SceS000004014
IGI
SceS000003416
IMP
SceS000003416
GO:0008540 proteasome regulatory particle, base
subcomplex		 C
IPI
SceS000003416
GO:0004842 ubiquitin-protein ligase activity F
IMP
SceS000003416
SpoSPBC19C7.02
IPI
SceS000003416
ISS
SpoSPAC15A10.11
TAS
SceS000004014
GO:0008270 zinc ion binding F
ISS
SpoSPBC19C7.02
SPAC15A10.11
GO:0000209 protein polyubiquitination P
IMP
SceS000003416
GO:0006513 protein monoubiquitination P
IDA
SceS000004014
GO:0010570 regulation of filamentous growth P
IMP
SpoSPBC19C7.02
GO:0016567 protein ubiquitination P
IMP
SpoSPBC19C7.02
ISS
SpoSPAC15A10.11
GO:0031144 proteasome localization P
IMP
SpoSPBC19C7.02
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
SpoSPBC19C7.02
GO:0071596 ubiquitin-dependent protein catabolic process via
the N-end rule pathway		 P
IMP
SceS000003416
GO:0071629 cytoplasm-associated proteasomal
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000003416
GO:0090089 regulation of dipeptide transport P
IMP
SceS000003416

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39153

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) UBR1
(S000003416)		 GI:6321623 P19812
Kluyveromyces lactis (Kla) UBR1_KLULA GI:50311487
Eremothecium gossypii (Ego) AGOS_AAL146W GI:45184678


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IGI
SceS000003416
IMP
SceS000003416
GO:0008540 proteasome regulatory particle, base
subcomplex		 C
IPI
SceS000003416
GO:0004842 ubiquitin-protein ligase activity F
IMP
SceS000003416
IPI
SceS000003416
GO:0000209 protein polyubiquitination P
IMP
SceS000003416
GO:0071596 ubiquitin-dependent protein catabolic process via
the N-end rule pathway		 P
IMP
SceS000003416
GO:0071629 cytoplasm-associated proteasomal
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000003416
GO:0090089 regulation of dipeptide transport P
IMP
SceS000003416

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_586

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga14751 ENSANGP00000008105
Ashbya gossypii (Ago) ago41 AAL146W
Arabidopsis thaliana (Ath) ath22376 At5g02310.1
Caenorhabditis elegans (Cel) cel3205 C32E8.11
(CE40441;
WBGene00016326)
Candida glabrata (Cgl) cgl2472 CAGL0H09350g
Cryptococcus neoformans (Cne) cne3173 167.m05858
Dictyostelium discoideum (Ddi) ddi10798 DDB0184244
Dictyostelium discoideum (Ddi) ddi6366 DDB0185543
Dictyostelium discoideum (Ddi) ddi7358 DDB0219346
Debaryomyces hansenii (Dha) dha6583 DEHA0G19745g
Debaryomyces hansenii (Dha) dha6584 DEHA0G19767g
Drosophila melanogaster (Dme) dme18284 CG9086-PA
(FBgn0030809)
Danio rerio (Dre) dre23164 ENSDARP00000005939
Danio rerio (Dre) dre3846 ENSDARP00000019478
Danio rerio (Dre) dre3845 ENSDARP00000039023
Danio rerio (Dre) dre3849 ENSDARP00000043549
Takifugu rubripes (Fru) fru9220 SINFRUP00000132192
Takifugu rubripes (Fru) fru15157 SINFRUP00000140022
Takifugu rubripes (Fru) fru15158 SINFRUP00000140023
Takifugu rubripes (Fru) fru15161 SINFRUP00000140024
Takifugu rubripes (Fru) fru15160 SINFRUP00000140027
Takifugu rubripes (Fru) fru9221 SINFRUP00000174093
Takifugu rubripes (Fru) fru15162 SINFRUP00000175636
Takifugu rubripes (Fru) fru15159 SINFRUP00000175865
Gallus gallus (Gga) gga19287 ENSGALP00000015032
Gallus gallus (Gga) gga19285 ENSGALP00000015034
(UBR1)
Gallus gallus (Gga) gga19286 ENSGALP00000015035
Gallus gallus (Gga) gga14710 ENSGALP00000016089
Gallus gallus (Gga) gga14711 ENSGALP00000016090
Gallus gallus (Gga) gga14712 ENSGALP00000016091
Gallus gallus (Gga) gga14708 ENSGALP00000016092
(UBR2)
Gallus gallus (Gga) gga14709 ENSGALP00000016093
(UBR2)
Homo sapiens (Hsa) hsa27146 ENSP00000229488
Homo sapiens (Hsa) hsa10526 ENSP00000290650
(UBR1)		 Q8IWV7-1
Kluyveromyces lactis (Kla) kla4768 KLLA0F15334g
Mus musculus (Mmu) mmu11825 ENSMUSP00000024772
Mus musculus (Mmu) mmu15337 ENSMUSP00000028728
(MGI:1277977)		 A2AQ54
Mus musculus (Mmu) mmu11826 ENSMUSP00000075230
(MGI:1861099)		 Q6WKZ8-1
Neurospora crassa (Ncr) ncr3134 NCU03234.2
Oryza sativa (Osa) osa8779 2684.m00176
Oryza sativa (Osa) osa10817 2784.m00143
Oryza sativa (Osa) osa10842 2784.m00196
Rattus norvegicus (Rno) rno19531 ENSRNOP00000015086
(RGD:1562326)
Rattus norvegicus (Rno) rno29638 ENSRNOP00000021158
(GI:363188)
Rattus norvegicus (Rno) rno29639 ENSRNOP00000021540
Saccharomyces cerevisiae (Sce) sce2564 YGR184C
(S000003416)
Schizosaccharomyces pombe (Spo) spo2500 SPAC15A10.11 O13731
Schizosaccharomyces pombe (Spo) spo4956 SPBC19C7.02 O60152
Yarrowia lipolytica (Yli) yli896 YALI0B03718g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
IGI
MmuMGI:1277977
MGI:1861099
ISS
DmeFBgn0030809
GO:0000502 proteasome complex C
IGI
MmuMGI:1277977
GO:0005634 nucleus C
NAS
SpoSPAC15A10.11
SPBC19C7.02
GO:0005737 cytoplasm C
IGI
SceS000003416
IMP
SceS000003416
GO:0008540 proteasome regulatory particle, base
subcomplex		 C
IPI
SceS000003416
GO:0004842 ubiquitin-protein ligase activity F
IDA
AthAt5g02310
MmuMGI:1861099
MGI:1277977
IGI
MmuMGI:1277977
MGI:1861099
IMP
SceS000003416
SpoSPBC19C7.02
IPI
SceS000003416
ISS
DmeFBgn0030809
SpoSPAC15A10.11
GO:0005515 protein binding F
IPI
MmuMGI:1277977
MGI:1861099
GO:0008270 zinc ion binding F
ISS
SpoSPBC19C7.02
SPAC15A10.11
GO:0000209 protein polyubiquitination P
IMP
SceS000003416
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IDA
AthAt5g02310
MmuMGI:1277977
MGI:1861099
IMP
MmuMGI:1277977
GO:0007141 male meiosis I P
IMP
MmuMGI:1861099
GO:0007283 spermatogenesis P
IMP
MmuMGI:1861099
GO:0009737 response to abscisic acid stimulus P
IMP
AthAt5g02310
GO:0010029 regulation of seed germination P
IMP
AthAt5g02310
GO:0010570 regulation of filamentous growth P
IMP
SpoSPBC19C7.02
GO:0016567 protein ubiquitination P
IDA
MmuMGI:1277977
MGI:1861099
IGI
MmuMGI:1861099
MGI:1277977
IMP
SpoSPBC19C7.02
ISS
DmeFBgn0030809
SpoSPAC15A10.11
GO:0031144 proteasome localization P
IMP
SpoSPBC19C7.02
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
SpoSPBC19C7.02
GO:0050994 regulation of lipid catabolic process P
IMP
AthAt5g02310
GO:0071596 ubiquitin-dependent protein catabolic process via
the N-end rule pathway		 P
IMP
SceS000003416
GO:0071629 cytoplasm-associated proteasomal
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000003416
GO:0090089 regulation of dipeptide transport P
IMP
SceS000003416

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC15A10.11
(O13731)		 YGR184C
(S000003416)
SPBC19C7.02
(O60152)		 YGR184C
(S000003416)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
NAS
SpoSPAC15A10.11
SPBC19C7.02
GO:0005737 cytoplasm C
IGI
SceS000003416
IMP
SceS000003416
GO:0008540 proteasome regulatory particle, base
subcomplex		 C
IPI
SceS000003416
GO:0004842 ubiquitin-protein ligase activity F
IMP
SceS000003416
SpoSPBC19C7.02
IPI
SceS000003416
ISS
SpoSPAC15A10.11
GO:0008270 zinc ion binding F
ISS
SpoSPBC19C7.02
SPAC15A10.11
GO:0000209 protein polyubiquitination P
IMP
SceS000003416
GO:0010570 regulation of filamentous growth P
IMP
SpoSPBC19C7.02
GO:0016567 protein ubiquitination P
IMP
SpoSPBC19C7.02
ISS
SpoSPAC15A10.11
GO:0031144 proteasome localization P
IMP
SpoSPBC19C7.02
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IMP
SpoSPBC19C7.02
GO:0071596 ubiquitin-dependent protein catabolic process via
the N-end rule pathway		 P
IMP
SceS000003416
GO:0071629 cytoplasm-associated proteasomal
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000003416
GO:0090089 regulation of dipeptide transport P
IMP
SceS000003416

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GO info in one table:

s.khadayate@ucl.ac.uk