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Search term: YGR188C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name BUB1
SGD link S000003420
Alternative ID YGR188C
Description Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p
Synonyms YGR188C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1166 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Mitotic checkpoint serine/threonine protein kinase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g20635 GI:15225393
Arabidopsis thaliana (Ath) At2g33560 GI:15226131
Arabidopsis thaliana (Ath) At5g05510 GI:15239147
Caenorhabditis elegans (Cel) CE06251_2 GI:17508581 Q21776
Caenorhabditis elegans (Cel) CE15187 GI:17510989
Drosophila melanogaster (Dme) 7296964 GI:19920746
Drosophila melanogaster (Dme) 7302202
(BubR1)		 GI:17137586 A1Z6I7
Homo sapiens (Hsa) Hs20149509 GI:20149509
Homo sapiens (Hsa) Hs4757878
(BUB1)		 GI:4757878 O43683
Saccharomyces cerevisiae (Sce) YGR188c
(S000003420)		 GI:6321627 P41695
Saccharomyces cerevisiae (Sce) YJL013c
(S000003550)		 GI:6322447 P47074
Schizosaccharomyces pombe (Spo) SPCC1322.12c GI:19075640 O94751
Arabidopsis thaliana (Ath) At2g20635 GI:15225393
Arabidopsis thaliana (Ath) At2g33560 GI:15226131
Arabidopsis thaliana (Ath) At5g05510 GI:15239147
Caenorhabditis elegans (Cel) CE06251_2 GI:17508581 Q21776
Caenorhabditis elegans (Cel) CE15187 GI:17510989
Drosophila melanogaster (Dme) 7296964 GI:19920746
Drosophila melanogaster (Dme) 7302202
(BubR1)		 GI:17137586 A1Z6I7
Homo sapiens (Hsa) Hs20149509 GI:20149509
Homo sapiens (Hsa) Hs4757878
(BUB1)		 GI:4757878 O43683
Saccharomyces cerevisiae (Sce) YGR188c
(S000003420)		 GI:6321627 P41695
Saccharomyces cerevisiae (Sce) YJL013c
(S000003550)		 GI:6322447 P47074
Schizosaccharomyces pombe (Spo) SPCC1322.12c GI:19075640 O94751


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000776 kinetochore C
IDA
AthAt2g33560
CelWBGene00000275
DmeBubR1
HsaBUB1
SceS000003420
TAS
DmeBubR1
GO:0000777 condensed chromosome kinetochore C
IDA
HsaBUB1
GO:0000778 condensed nuclear chromosome kinetochore C
IDA
SceS000003420
SpoSPCC1322.12c
GO:0000780 condensed nuclear chromosome, centromeric
region		 C
IDA
SceS000003420
GO:0000940 outer kinetochore of condensed
chromosome		 C
NAS
DmeBubR1
GO:0005575 cellular_component C
ND
AthAt5g05510
At2g20635
GO:0005634 nucleus C
IDA
SceS000003420
SpoSPCC1322.12c
GO:0005737 cytoplasm C
IDA
DmeBubR1
GO:0005816 spindle pole body C
TAS
HsaBUB1
GO:0005856 cytoskeleton C
RCA
SceS000003420
GO:0010369 chromocenter C
IDA
AthAt2g33560
GO:0015630 microtubule cytoskeleton C
RCA
SceS000003420
GO:0033597 mitotic checkpoint complex C
IDA
SceS000003550
IMP
SceS000003550
IPI
SceS000003550
GO:0044430 cytoskeletal part C
RCA
SceS000003420
GO:0003674 molecular_function F
ND
AthAt2g33560
At5g05510
SceS000003550
GO:0004672 protein kinase activity F
IDA
SceS000003420
NAS
DmeBubR1
TAS
HsaBUB1
GO:0004674 protein serine/threonine kinase
activity		 F
ISS
DmeBubR1
NAS
DmeBubR1
RCA
SceS000003420
TAS
SpoSPCC1322.12c
GO:0005515 protein binding F
IPI
HsaBUB1
SceS000003420
SpoSPCC1322.12c
GO:0000003 reproduction P
IMP
CelWBGene00000275
GO:0000278 mitotic cell cycle P
RCA
SceS000003420
GO:0000279 M phase P
RCA
SceS000003420
GO:0000910 cytokinesis P
IMP
CelWBGene00000275
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00000275
GO:0002119 nematode larval development P
IMP
CelWBGene00000275
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000003420
NAS
DmeBubR1
GO:0007052 mitotic spindle organization P
IMP
DmeBubR1
GO:0007063 regulation of sister chromatid
cohesion		 P
IDA
HsaBUB1
GO:0007093 mitotic cell cycle checkpoint P
TAS
HsaBUB1
GO:0007094 mitotic cell cycle spindle assembly
checkpoint		 P
IDA
AthAt2g33560
DmeBubR1
IGI
SceS000003550
IMP
DmeBubR1
SceS000003550
SpoSPCC1322.12c
ISS
DmeBubR1
TAS
DmeBubR1
HsaBUB1
SceS000003420
GO:0007096 regulation of exit from mitosis P
IGI
DmeBubR1
IMP
DmeBubR1
GO:0008150 biological_process P
ND
AthAt5g05510
GO:0008608 attachment of spindle microtubules to
kinetochore		 P
IGI
SpoSPCC1322.12c
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000275
GO:0031134 sister chromatid biorientation P
IMP
SceS000003420
GO:0031577 spindle checkpoint P
IMP
DmeBubR1
GO:0032837 distributive segregation P
IMP
SceS000003550
GO:0034501 protein localization to kinetochore P
IMP
SceS000003420
GO:0034613 cellular protein localization P
IGI
SpoSPCC1322.12c
GO:0035186 syncytial blastoderm mitotic cell
cycle		 P
IMP
DmeBubR1
GO:0040011 locomotion P
IMP
CelWBGene00000275
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00000275
GO:0051129 negative regulation of cellular component
organization		 P
RCA
SceS000003420
GO:0051177 meiotic sister chromatid cohesion P
IGI
SpoSPCC1322.12c
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000003420
GO:0051301 cell division P
IMP
CelWBGene00000275
GO:0051983 regulation of chromosome segregation P
IMP
HsaBUB1
GO:0070683 decatenation checkpoint P
IGI
SceS000003550
GO:0071173 spindle assembly checkpoint P
IDA
HsaBUB1
IMP
HsaBUB1

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39155

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) bub1
(SPCC1322.12c)		 GI:19075640 O94751
Saccharomyces cerevisiae (Sce) BUB1
(S000003420)		 GI:6321627 P41695
Kluyveromyces lactis (Kla) KLLA0F22605g GI:50312117
Eremothecium gossypii (Ego) AGOS_AGR315C GI:45201411
Magnaporthe grisea (Mgr) MGG_14329 GI:145616442
Neurospora crassa (Ncr) NCU10043.1 GI:32405098
Oryza sativa (Osa) Os07g0508500 GI:115472293


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000776 kinetochore C
IDA
SceS000003420
GO:0000778 condensed nuclear chromosome kinetochore C
IDA
SceS000003420
SpoSPCC1322.12c
GO:0000780 condensed nuclear chromosome, centromeric
region		 C
IDA
SceS000003420
GO:0005634 nucleus C
IDA
SceS000003420
SpoSPCC1322.12c
GO:0005856 cytoskeleton C
RCA
SceS000003420
GO:0015630 microtubule cytoskeleton C
RCA
SceS000003420
GO:0044430 cytoskeletal part C
RCA
SceS000003420
GO:0004672 protein kinase activity F
IDA
SceS000003420
GO:0004674 protein serine/threonine kinase
activity		 F
RCA
SceS000003420
TAS
SpoSPCC1322.12c
GO:0005515 protein binding F
IPI
SceS000003420
SpoSPCC1322.12c
GO:0000278 mitotic cell cycle P
RCA
SceS000003420
GO:0000279 M phase P
RCA
SceS000003420
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000003420
GO:0007094 mitotic cell cycle spindle assembly
checkpoint		 P
IMP
SpoSPCC1322.12c
TAS
SceS000003420
GO:0008608 attachment of spindle microtubules to
kinetochore		 P
IGI
SpoSPCC1322.12c
GO:0031134 sister chromatid biorientation P
IMP
SceS000003420
GO:0034501 protein localization to kinetochore P
IMP
SceS000003420
GO:0034613 cellular protein localization P
IGI
SpoSPCC1322.12c
GO:0051129 negative regulation of cellular component
organization		 P
RCA
SceS000003420
GO:0051177 meiotic sister chromatid cohesion P
IGI
SpoSPCC1322.12c
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000003420

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1058

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga13899 ENSANGP00000001105
Anopheles gambiae (Aga) aga8149 ENSANGP00000008371
Anopheles gambiae (Aga) aga5706 ENSANGP00000026786
Anopheles gambiae (Aga) aga13900 ENSANGP00000028046
Ashbya gossypii (Ago) ago4626 AGR315C
Arabidopsis thaliana (Ath) ath8935 At2g20635.1
Arabidopsis thaliana (Ath) ath10390 At2g33560.1
Caenorhabditis elegans (Cel) cel13445 R06C7.8
(CE06251;
WBGene00000275)
Candida glabrata (Cgl) cgl1923 CAGL0G06930g
Candida glabrata (Cgl) cgl2905 CAGL0I08899g
Cryptococcus neoformans (Cne) cne4469 177.m03222
Dictyostelium discoideum (Ddi) ddi13630 DDB0231500
Debaryomyces hansenii (Dha) dha6711 DEHA0G22682g
Drosophila melanogaster (Dme) dme871 CG14030-PA
(FBgn0031696)
Drosophila melanogaster (Dme) dme3414 CG7838-PA
(FBgn0025458)
Danio rerio (Dre) dre23270 ENSDARP00000016966
Danio rerio (Dre) dre24323 ENSDARP00000025686
Takifugu rubripes (Fru) fru6383 SINFRUP00000165671
Gallus gallus (Gga) gga18690 ENSGALP00000007713
(BUB1B)		 Q5F3E7
Gallus gallus (Gga) gga14321 ENSGALP00000013385
(BUB1)		 Q5ZLQ8
Homo sapiens (Hsa) hsa10432 ENSP00000287598
(BUB1B)		 O60566-1
Homo sapiens (Hsa) hsa18423 ENSP00000302530
(BUB1)		 O43683
Kluyveromyces lactis (Kla) kla5090 KLLA0F22605g
Mus musculus (Mmu) mmu15466 ENSMUSP00000028858
(MGI:1100510)		 A2APR8
Mus musculus (Mmu) mmu15252 ENSMUSP00000037126
(MGI:1333889)		 A2ARS1
Neurospora crassa (Ncr) ncr9778 NCU10043.2
Oryza sativa (Osa) osa3584 2051.m00149
Oryza sativa (Osa) osa6466 2452.m00088
Oryza sativa (Osa) osa13501 2942.m00109
Oryza sativa (Osa) osa19051 3450.m00126
Oryza sativa (Osa) osa32371 4479.m00093
Oryza sativa (Osa) osa47523 5789.m00117
Rattus norvegicus (Rno) rno19448 ENSRNOP00000010406
(RGD:619791)		 O35822
Rattus norvegicus (Rno) rno19677 ENSRNOP00000042114
(RGD:1311707)
Rattus norvegicus (Rno) rno19678 ENSRNOP00000042645
Saccharomyces cerevisiae (Sce) sce2568 YGR188C
(S000003420)
Saccharomyces cerevisiae (Sce) sce3270 YJL013C
(S000003550)
Schizosaccharomyces pombe (Spo) spo1980 SPCC1322.12c O94751
Schizosaccharomyces pombe (Spo) spo2430 SPCC1795.01c O59767
Yarrowia lipolytica (Yli) yli1708 YALI0B23144g
Yarrowia lipolytica (Yli) yli1709 YALI0B23166g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000775 chromosome, centromeric region C
IDA
MmuMGI:1100510
GO:0000776 kinetochore C
IDA
AthAt2g33560
CelWBGene00000275
DmeFBgn0025458
MmuMGI:1333889
MGI:1100510
SceS000003420
IMP
MmuMGI:1333889
ISO
MmuMGI:1100510
MGI:1333889
TAS
DmeFBgn0025458
GO:0000778 condensed nuclear chromosome kinetochore C
IDA
SceS000003420
SpoSPCC1795.01c
SPCC1322.12c
GO:0000780 condensed nuclear chromosome, centromeric
region		 C
IDA
MmuMGI:1100510
SceS000003420
GO:0000940 outer kinetochore of condensed
chromosome		 C
IDA
MmuMGI:1333889
NAS
DmeFBgn0025458
GO:0005575 cellular_component C
ND
AthAt2g20635
GO:0005634 nucleus C
IDA
SceS000003420
SpoSPCC1322.12c
SPCC1795.01c
GO:0005737 cytoplasm C
IDA
DmeFBgn0025458
GO:0005829 cytosol C
IDA
SpoSPCC1795.01c
GO:0005856 cytoskeleton C
RCA
SceS000003420
GO:0010369 chromocenter C
IDA
AthAt2g33560
GO:0015630 microtubule cytoskeleton C
RCA
SceS000003420
GO:0033597 mitotic checkpoint complex C
IDA
SceS000003550
SpoSPCC1795.01c
IMP
SceS000003550
IPI
SceS000003550
GO:0044430 cytoskeletal part C
RCA
SceS000003420
GO:0003674 molecular_function F
ND
AthAt2g33560
SceS000003550
GO:0004672 protein kinase activity F
IDA
SceS000003420
NAS
DmeFBgn0025458
FBgn0031696
GO:0004674 protein serine/threonine kinase
activity		 F
ISS
DmeFBgn0031696
FBgn0025458
NAS
DmeFBgn0025458
RCA
SceS000003420
TAS
SpoSPCC1322.12c
GO:0005515 protein binding F
IPI
SceS000003420
SpoSPCC1322.12c
SPCC1795.01c
GO:0010997 anaphase-promoting complex binding F
IPI
SpoSPCC1795.01c
GO:0000003 reproduction P
IMP
CelWBGene00000275
GO:0000278 mitotic cell cycle P
RCA
SceS000003420
GO:0000279 M phase P
RCA
SceS000003420
GO:0000910 cytokinesis P
IMP
CelWBGene00000275
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00000275
GO:0002119 nematode larval development P
IMP
CelWBGene00000275
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000003420
NAS
DmeFBgn0031696
FBgn0025458
GO:0006915 apoptosis P
IMP
MmuMGI:1100510
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0025458
GO:0007091 mitotic metaphase/anaphase transition P
IGI
MmuMGI:1333889
GO:0007094 mitotic cell cycle spindle assembly
checkpoint		 P
IDA
AthAt2g33560
DmeFBgn0031696
FBgn0025458
IGI
SceS000003550
SpoSPCC1795.01c
IMP
DmeFBgn0025458
SceS000003550
SpoSPCC1322.12c
ISS
DmeFBgn0025458
TAS
DmeFBgn0025458
SceS000003420
GO:0007096 regulation of exit from mitosis P
IGI
DmeFBgn0025458
IMP
DmeFBgn0025458
GO:0008608 attachment of spindle microtubules to
kinetochore		 P
IGI
SpoSPCC1322.12c
GO:0009790 embryo development P
IDA
MmuMGI:1100510
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00000275
GO:0031134 sister chromatid biorientation P
IMP
SceS000003420
GO:0031577 spindle checkpoint P
IMP
DmeFBgn0025458
GO:0032837 distributive segregation P
IMP
SceS000003550
GO:0034501 protein localization to kinetochore P
IMP
SceS000003420
GO:0034613 cellular protein localization P
IGI
SpoSPCC1322.12c
GO:0035186 syncytial blastoderm mitotic cell
cycle		 P
IMP
DmeFBgn0025458
GO:0040011 locomotion P
IMP
CelWBGene00000275
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00000275
GO:0045841 negative regulation of mitotic metaphase/anaphase
transition		 P
IPI
SpoSPCC1795.01c
GO:0051129 negative regulation of cellular component
organization		 P
RCA
SceS000003420
GO:0051177 meiotic sister chromatid cohesion P
IGI
SpoSPCC1322.12c
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000003420
GO:0051301 cell division P
IMP
CelWBGene00000275
GO:0051444 negative regulation of ubiquitin-protein ligase
activity		 P
TAS
SpoSPCC1795.01c
GO:0060565 inhibition of mitotic anaphase-promoting complex
activity		 P
IPI
SpoSPCC1795.01c
GO:0070683 decatenation checkpoint P
IGI
SceS000003550
GO:0071173 spindle assembly checkpoint P
IDA
MmuMGI:1100510

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC1322.12c
(O94751)		 YGR188C
(S000003420)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000776 kinetochore C
IDA
SceS000003420
GO:0000778 condensed nuclear chromosome kinetochore C
IDA
SceS000003420
SpoSPCC1322.12c
GO:0000780 condensed nuclear chromosome, centromeric
region		 C
IDA
SceS000003420
GO:0005634 nucleus C
IDA
SceS000003420
SpoSPCC1322.12c
GO:0005856 cytoskeleton C
RCA
SceS000003420
GO:0015630 microtubule cytoskeleton C
RCA
SceS000003420
GO:0044430 cytoskeletal part C
RCA
SceS000003420
GO:0004672 protein kinase activity F
IDA
SceS000003420
GO:0004674 protein serine/threonine kinase
activity		 F
RCA
SceS000003420
TAS
SpoSPCC1322.12c
GO:0005515 protein binding F
IPI
SceS000003420
SpoSPCC1322.12c
GO:0000278 mitotic cell cycle P
RCA
SceS000003420
GO:0000279 M phase P
RCA
SceS000003420
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000003420
GO:0007094 mitotic cell cycle spindle assembly
checkpoint		 P
IMP
SpoSPCC1322.12c
TAS
SceS000003420
GO:0008608 attachment of spindle microtubules to
kinetochore		 P
IGI
SpoSPCC1322.12c
GO:0031134 sister chromatid biorientation P
IMP
SceS000003420
GO:0034501 protein localization to kinetochore P
IMP
SceS000003420
GO:0034613 cellular protein localization P
IGI
SpoSPCC1322.12c
GO:0051129 negative regulation of cellular component
organization		 P
RCA
SceS000003420
GO:0051177 meiotic sister chromatid cohesion P
IGI
SpoSPCC1322.12c
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000003420

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Query species:

Include wild-cards:   

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GO info in one table:

s.khadayate@ucl.ac.uk