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Search term: YGR195W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SKI6
SGD link S000003427
Alternative ID YGR195W
Description Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
Synonyms YGR195W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1068 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Exosomal 3'-5' exoribonuclease complex, subunit Rrp41 and related exoribonucleases

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g61620 GI:15233167
Caenorhabditis elegans (Cel) CE20469
(WBGene00007201)
GI:17538326
Caenorhabditis elegans (Cel) CE26236_1 GI:17555548
Drosophila melanogaster (Dme) 7293727 GI:7293727
Drosophila melanogaster (Dme) 7298022 GI:7298022
Homo sapiens (Hsa) Hs9506689
(EXOSC4)
GI:9506689 Q9NPD3
Homo sapiens (Hsa) Hs20542749 GI:20542749
Homo sapiens (Hsa) Hs17402904
(EXOSC6)
GI:17402904 Q5RKV6
Saccharomyces cerevisiae (Sce) YGR158c
(S000003390)
GI:6321597 P48240
Saccharomyces cerevisiae (Sce) YGR195w
(S000003427)
GI:6321634 P46948
Schizosaccharomyces pombe (Spo) SPAC3G9.10c GI:19114994 O42872
Schizosaccharomyces pombe (Spo) SPBC211.08c GI:19113410 Q9P7R3
Encephalitozoon cuniculi (Ecu) ECU09g0830 GI:19173205
Arabidopsis thaliana (Ath) At3g61620 GI:15233167
Caenorhabditis elegans (Cel) CE20469
(WBGene00007201)
GI:17538326
Caenorhabditis elegans (Cel) CE26236_1 GI:17555548
Drosophila melanogaster (Dme) 7293727 GI:7293727
Drosophila melanogaster (Dme) 7298022 GI:7298022
Homo sapiens (Hsa) Hs9506689
(EXOSC4)
GI:9506689 Q9NPD3
Homo sapiens (Hsa) Hs20542749 GI:20542749
Homo sapiens (Hsa) Hs17402904
(EXOSC6)
GI:17402904 Q5RKV6
Saccharomyces cerevisiae (Sce) YGR158c
(S000003390)
GI:6321597 P48240
Saccharomyces cerevisiae (Sce) YGR195w
(S000003427)
GI:6321634 P46948
Schizosaccharomyces pombe (Spo) SPAC3G9.10c GI:19114994 O42872
Schizosaccharomyces pombe (Spo) SPBC211.08c GI:19113410 Q9P7R3
Encephalitozoon cuniculi (Ecu) ECU09g0830 GI:19173205


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000176 nuclear exosome (RNase complex) C
IDA
SceS000003427
S000003390
ISS
SpoSPAC3G9.10c
SPBC211.08c
GO:0000177 cytoplasmic exosome (RNase complex) C
IDA
SceS000003427
S000003390
ISS
SpoSPAC3G9.10c
SPBC211.08c
GO:0005575 cellular_component C
ND
AthAt3g61620
GO:0005634 nucleus C
IDA
SpoSPAC3G9.10c
SPBC211.08c
GO:0005730 nucleolus C
IDA
SceS000003390
NAS
HsaEXOSC4
GO:0005737 cytoplasm C
NAS
HsaEXOSC4
GO:0005816 spindle pole body C
IDA
SpoSPAC3G9.10c
GO:0005829 cytosol C
IDA
SpoSPAC3G9.10c
SPBC211.08c
GO:0000175 3'-5'-exoribonuclease activity F
ISS
AthAt3g61620
SpoSPAC3G9.10c
NAS
HsaEXOSC4
SpoSPBC211.08c
GO:0003674 molecular_function F
ND
SceS000003390
S000003427
GO:0003723 RNA binding F
ISS
AthAt3g61620
GO:0005515 protein binding F
IPI
HsaEXOSC4
GO:0000467 exonucleolytic trimming to generate mature 3'-end
of 5.8S rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P
IMP
SceS000003390
S000003427
GO:0002119 nematode larval development P
IMP
CelWBGene00007201
GO:0006364 rRNA processing P
ISS
SpoSPAC3G9.10c
SPBC211.08c
NAS
HsaEXOSC4
GO:0006396 RNA processing P
ISS
AthAt3g61620
GO:0006402 mRNA catabolic process P
ISS
SpoSPAC3G9.10c
SPBC211.08c
GO:0008406 gonad development P
IMP
CelWBGene00007201
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00007201
GO:0010171 body morphogenesis P
IMP
CelWBGene00007201
GO:0016075 rRNA catabolic process P
IMP
SceS000003427
GO:0034427 nuclear-transcribed mRNA catabolic process,
exonucleolytic, 3'-5'
P
IC
SceS000003390
IMP
SceS000003427
GO:0034473 U1 snRNA 3'-end processing P
IGI
SceS000003427
IMP
SceS000003427
GO:0034475 U4 snRNA 3'-end processing P
IGI
SceS000003427
IMP
SceS000003427
S000003390
GO:0034476 U5 snRNA 3'-end processing P
IGI
SceS000003427
IMP
SceS000003427
GO:0040007 growth P
IMP
CelWBGene00007201
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00007201
GO:0040018 positive regulation of multicellular organism
growth
P
IMP
CelWBGene00007201
GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5'
exonucleolytic nonsense-mediated
decay
P
IC
SceS000003390
IGI
SceS000003427
IMP
SceS000003427
GO:0070481 nuclear-transcribed mRNA catabolic process,
non-stop decay
P
IC
SceS000003390
S000003427
GO:0070651 nonfunctional rRNA decay P
IC
SceS000003427
S000003390
GO:0071028 nuclear mRNA surveillance P
IGI
SceS000003427
IMP
SceS000003427
S000003390
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic
process
P
IMP
SceS000003390
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic
process
P
IDA
SceS000003390
S000003427
GO:0071039 nuclear polyadenylation-dependent CUT catabolic
process
P
IMP
SceS000003390
S000003427
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic
process
P
IC
SceS000003390
S000003427
GO:0071044 histone mRNA catabolic process P
IMP
HsaEXOSC4
GO:0071051 polyadenylation-dependent snoRNA 3'-end
processing
P
IMP
SceS000003390
S000003427

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6017

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) EXOSC4 GI:9506689 Q9NPD3
Pan troglodytes (Ptr) EXOSC4 GI:114622153
Canis familiaris (Cfa) EXOSC4 GI:57095694
Mus musculus (Mmu) Exosc4
(MGI:1923576)
GI:29611663 Q542B0
Rattus norvegicus (Rno) Exosc4 GI:34866849
Drosophila melanogaster (Dme) Ski6
(FBgn0032487)
GI:24584046
Caenorhabditis elegans (Cel) exos-4.1
(CE20469;
WBGene00007201)
GI:71981632
Schizosaccharomyces pombe (Spo) ski6
(SPAC3G9.10c)
GI:19114994 O42872
Saccharomyces cerevisiae (Sce) SKI6
(S000003427)
GI:6321634 P46948
Kluyveromyces lactis (Kla) KLLA0D09625g GI:50307027
Eremothecium gossypii (Ego) AGOS_ACR035W GI:45185722
Magnaporthe grisea (Mgr) MGG_06785 GI:39977801
Neurospora crassa (Ncr) NCU00812.1 GI:32409023
Arabidopsis thaliana (Ath) RRP41 GI:186511299
Oryza sativa (Osa) Os09g0252000 GI:115478178
Plasmodium falciparum (Pfa) PF14_0256 GI:124808870


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000176 nuclear exosome (RNase complex) C
IDA
SceS000003427
IPI
DmeFBgn0032487
ISS
DmeFBgn0032487
SpoSPAC3G9.10c
GO:0000177 cytoplasmic exosome (RNase complex) C
IDA
SceS000003427
ISS
DmeFBgn0032487
SpoSPAC3G9.10c
GO:0000178 exosome (RNase complex) C
ISS
PfaPF14_0256
GO:0005575 cellular_component C
ND
AthRRP41
MmuMGI:1923576
GO:0005634 nucleus C
IDA
SpoSPAC3G9.10c
GO:0005652 nuclear lamina C
IDA
DmeFBgn0032487
GO:0005700 polytene chromosome C
IDA
DmeFBgn0032487
GO:0005730 nucleolus C
NAS
HsaEXOSC4
GO:0005737 cytoplasm C
IDA
DmeFBgn0032487
NAS
HsaEXOSC4
GO:0005816 spindle pole body C
IDA
SpoSPAC3G9.10c
GO:0005829 cytosol C
IDA
SpoSPAC3G9.10c
GO:0000175 3'-5'-exoribonuclease activity F
ISS
AthRRP41
DmeFBgn0032487
SpoSPAC3G9.10c
NAS
HsaEXOSC4
GO:0003674 molecular_function F
ND
MmuMGI:1923576
SceS000003427
GO:0003723 RNA binding F
ISS
AthRRP41
GO:0005515 protein binding F
IPI
HsaEXOSC4
GO:0000467 exonucleolytic trimming to generate mature 3'-end
of 5.8S rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P
IMP
SceS000003427
GO:0002119 nematode larval development P
IMP
CelWBGene00007201
GO:0006364 rRNA processing P
ISS
PfaPF14_0256
SpoSPAC3G9.10c
NAS
HsaEXOSC4
GO:0006396 RNA processing P
ISS
AthRRP41
GO:0006402 mRNA catabolic process P
ISS
SpoSPAC3G9.10c
GO:0008150 biological_process P
ND
MmuMGI:1923576
GO:0008406 gonad development P
IMP
CelWBGene00007201
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00007201
GO:0010171 body morphogenesis P
IMP
CelWBGene00007201
GO:0016075 rRNA catabolic process P
IMP
SceS000003427
GO:0034427 nuclear-transcribed mRNA catabolic process,
exonucleolytic, 3'-5'
P
IMP
SceS000003427
GO:0034473 U1 snRNA 3'-end processing P
IGI
SceS000003427
IMP
SceS000003427
GO:0034475 U4 snRNA 3'-end processing P
IGI
SceS000003427
IMP
SceS000003427
GO:0034476 U5 snRNA 3'-end processing P
IGI
SceS000003427
IMP
SceS000003427
GO:0040007 growth P
IMP
CelWBGene00007201
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00007201
GO:0040018 positive regulation of multicellular organism
growth
P
IMP
CelWBGene00007201
GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5'
exonucleolytic nonsense-mediated
decay
P
IGI
SceS000003427
IMP
SceS000003427
GO:0070481 nuclear-transcribed mRNA catabolic process,
non-stop decay
P
IC
SceS000003427
GO:0070651 nonfunctional rRNA decay P
IC
SceS000003427
GO:0071028 nuclear mRNA surveillance P
IGI
SceS000003427
IMP
SceS000003427
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic
process
P
IDA
SceS000003427
GO:0071039 nuclear polyadenylation-dependent CUT catabolic
process
P
IMP
SceS000003427
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic
process
P
IC
SceS000003427
GO:0071044 histone mRNA catabolic process P
IMP
HsaEXOSC4
GO:0071051 polyadenylation-dependent snoRNA 3'-end
processing
P
IMP
SceS000003427

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2003

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga9263 ENSANGP00000009222
Anopheles gambiae (Aga) aga9269 ENSANGP00000017010
Ashbya gossypii (Ago) ago1083 ACR035W
Arabidopsis thaliana (Ath) ath17604 At3g61620.1
Caenorhabditis elegans (Cel) cel633 B0564.1a
(CE20469;
WBGene00007201)
Candida glabrata (Cgl) cgl2028 CAGL0G09317g
Cryptococcus neoformans (Cne) cne1058 163.m06611
Dictyostelium discoideum (Ddi) ddi10579 DDB0183823
Debaryomyces hansenii (Dha) dha6566 DEHA0G19371g
Drosophila melanogaster (Dme) dme2232 CG15481-PA
(FBgn0032487)
Danio rerio (Dre) dre25731 ENSDARP00000045255
(LOC558013)
Q05AI7
Encephalitozoon cuniculi (Ecu) ecu1356 19173205
Takifugu rubripes (Fru) fru7654 SINFRUP00000140794
Homo sapiens (Hsa) hsa30869 ENSP00000315476
(EXOSC4)
Q9NPD3
Kluyveromyces lactis (Kla) kla2490 KLLA0D09625g
Mus musculus (Mmu) mmu9177 ENSMUSP00000050940
(MGI:1923576)
Q921I9
Neurospora crassa (Ncr) ncr790 NCU00812.2
Oryza sativa (Osa) osa46119 5697.m00160
Oryza sativa (Osa) osa62151 6497.m00174
Plasmodium falciparum (Pfa) pfa1690 PF14_0256
Rattus norvegicus (Rno) rno27280 ENSRNOP00000016464
(RGD:1310986)
Saccharomyces cerevisiae (Sce) sce2575 YGR195W
(S000003427)
Schizosaccharomyces pombe (Spo) spo3995 SPAC3G9.10c O42872
Yarrowia lipolytica (Yli) yli2985 YALI0D06776g