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Search term: YGR217W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name CCH1
SGD link S000003449
Alternative ID YGR217W
Description Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
Synonyms YGR217W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2301 ACDHYP-

KOGs classification KOGs description
METABOLISMCELLULAR PROCESSES AND SIGNALING Voltage-gated Ca2+ channels, alpha1 subunits

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g03560 GI:4206210
Caenorhabditis elegans (Cel) CE00960
(WBGene00008911)		 GI:17553074 Q19526
Caenorhabditis elegans (Cel) CE16846 GI:17538668
Caenorhabditis elegans (Cel) CE23561 GI:17552328
Caenorhabditis elegans (Cel) CE28820
(WBGene00001187)		 GI:17539612
Caenorhabditis elegans (Cel) CE29459
(WBGene00006742)		 GI:17570163
Caenorhabditis elegans (Cel) CE29574 GI:17538670
Caenorhabditis elegans (Cel) CE29575 GI:17538672
Drosophila melanogaster (Dme) 7291872 GI:7291872
Drosophila melanogaster (Dme) 7292723 GI:7292723
Drosophila melanogaster (Dme) 7292976 GI:7292976
Drosophila melanogaster (Dme) 7293235 GI:7293235
Drosophila melanogaster (Dme) 7298274 GI:19584591
Homo sapiens (Hsa) Hs10337597 GI:10337597
Homo sapiens (Hsa) Hs13386498 GI:13386498
Homo sapiens (Hsa) Hs13386500 GI:13386500
Homo sapiens (Hsa) Hs16876443 GI:16876443 Q96P56
Homo sapiens (Hsa) Hs17474438 GI:17474438
Homo sapiens (Hsa) Hs18581612 GI:18581612
Homo sapiens (Hsa) Hs19923117 GI:19923117
Homo sapiens (Hsa) Hs19923381 GI:19923381
Homo sapiens (Hsa) Hs20473855 GI:20473855
Homo sapiens (Hsa) Hs20536765 GI:20536765
Homo sapiens (Hsa) Hs20589958 GI:20589958
Homo sapiens (Hsa) Hs21914836 GI:12642270 P35498
Homo sapiens (Hsa) Hs22051246 GI:22051246
Homo sapiens (Hsa) Hs22061743_2 GI:22061743
Homo sapiens (Hsa) Hs4502523
(CACNA1B)		 GI:4502523 Q00975
Homo sapiens (Hsa) Hs4502527
(CACNA1D)		 GI:4502527 Q01668
Homo sapiens (Hsa) Hs4502529 GI:4502529
Homo sapiens (Hsa) Hs4506807 GI:4506807
Homo sapiens (Hsa) Hs4506809 GI:4506809
Homo sapiens (Hsa) Hs4506811 GI:4506811
Homo sapiens (Hsa) Hs4506813
(SCN9A)		 GI:4506813 Q8WWN4
Homo sapiens (Hsa) Hs4557401 GI:4557401
Homo sapiens (Hsa) Hs4885103 GI:4885103
Homo sapiens (Hsa) Hs5730033 GI:5730033
Homo sapiens (Hsa) Hs7657542 GI:7657542
Homo sapiens (Hsa) Hs7657544
(SCN8A)		 GI:7657544 Q9P2Q6
Saccharomyces cerevisiae (Sce) YGR217w
(S000003449)		 GI:6321656 P50077
Schizosaccharomyces pombe (Spo) SPAC6F6.01 GI:19114806 O14234


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000325 plant-type vacuole C
IDA
AthAt4g03560
GO:0001518 voltage-gated sodium channel complex C
IC
HsaSCN8A
GO:0005773 vacuole C
IDA
AthAt4g03560
GO:0005774 vacuolar membrane C
IDA
AthAt4g03560
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC6F6.01
GO:0005886 plasma membrane C
EXP
HsaCACNA1B
IDA
AthAt4g03560
SceS000003449
TAS
AthAt4g03560
GO:0005887 integral to plasma membrane C
NAS
SpoSPAC6F6.01
GO:0005891 voltage-gated calcium channel complex C
IDA
HsaCACNA1D
GO:0033268 node of Ranvier C
ISS
HsaSCN8A
GO:0048787 presynaptic active zone membrane C
IDA
CelWBGene00006742
GO:0005245 voltage-gated calcium channel activity F
IDA
HsaCACNA1D
IGI
AthAt4g03560
ISS
AthAt4g03560
SceS000003449
GO:0005248 voltage-gated sodium channel activity F
NAS
HsaSCN8A
GO:0005262 calcium channel activity F
IDA
SceS000003449
IGI
AthAt4g03560
IMP
AthAt4g03560
SceS000003449
ISS
AthAt4g03560
SpoSPAC6F6.01
GO:0005515 protein binding F
IPI
HsaCACNA1B
GO:0008022 protein C-terminus binding F
IPI
HsaCACNA1B
GO:0015270 dihydropyridine-sensitive calcium channel
activity		 F
IDA
HsaCACNA1D
GO:0000003 reproduction P
IMP
CelWBGene00001187
GO:0001505 regulation of neurotransmitter
levels		 P
IMP
CelWBGene00006742
GO:0006810 transport P
TAS
HsaCACNA1B
GO:0006814 sodium ion transport P
NAS
HsaSCN8A
TAS
HsaSCN9A
GO:0006816 calcium ion transport P
IC
AthAt4g03560
IDA
HsaCACNA1D
SceS000003449
IMP
AthAt4g03560
SceS000003449
GO:0007268 synaptic transmission P
TAS
HsaCACNA1B
GO:0007399 nervous system development P
TAS
HsaSCN8A
GO:0007422 peripheral nervous system development P
ISS
HsaSCN8A
GO:0007626 locomotory behavior P
IMP
CelWBGene00006742
GO:0009408 response to heat P
IMP
CelWBGene00006742
GO:0009845 seed germination P
IMP
AthAt4g03560
GO:0010119 regulation of stomatal movement P
IMP
AthAt4g03560
GO:0010171 body morphogenesis P
IMP
CelWBGene00001187
GO:0018991 oviposition P
IMP
CelWBGene00001187
GO:0019722 calcium-mediated signaling P
IMP
AthAt4g03560
GO:0030421 defecation P
IMP
CelWBGene00006742
GO:0030512 negative regulation of transforming growth factor
beta receptor signaling pathway		 P
IGI
CelWBGene00006742
GO:0034609 spicule insertion P
IMP
CelWBGene00001187
GO:0040011 locomotion P
IMP
CelWBGene00006742
GO:0040015 negative regulation of multicellular organism
growth		 P
IMP
CelWBGene00001187
GO:0040017 positive regulation of locomotion P
IMP
CelWBGene00001187
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00001187
GO:0042552 myelination P
ISS
HsaSCN8A
GO:0042594 response to starvation P
IMP
CelWBGene00006742
GO:0043050 pharyngeal pumping P
IMP
CelWBGene00006742
GO:0043051 regulation of pharyngeal pumping P
IMP
CelWBGene00001187
GO:0050850 positive regulation of calcium-mediated
signaling		 P
IMP
SpoSPAC6F6.01
GO:0070588 calcium ion transmembrane transport P
IC
SpoSPAC6F6.01
GO:0080141 regulation of jasmonic acid biosynthetic
process		 P
IMP
AthAt4g03560

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
21832

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) NALCN GI:24119274
Pan troglodytes (Ptr) NALCN GI:114650533
Canis familiaris (Cfa) NALCN GI:73989454
Mus musculus (Mmu) Nalcn
(MGI:2444306)		 GI:123173782 Q8BXR5
Rattus norvegicus (Rno) Nalcn GI:24025650
Gallus gallus (Gga) NALCN GI:118084673
Drosophila melanogaster (Dme) na
(FBgn0002917)		 GI:161077820
Anopheles gambiae (Aga) AgaP_AGAP003921 GI:158298175
Caenorhabditis elegans (Cel) nca-2
(CE38941;
WBGene00003558)		 GI:86562741
Caenorhabditis elegans (Cel) nca-1
(CE37194;
WBGene00003557)		 GI:71982830
Schizosaccharomyces pombe (Spo) SPAC6F6.01 GI:19114806 O14234
Saccharomyces cerevisiae (Sce) CCH1
(S000003449)		 GI:6321656 P50077
Kluyveromyces lactis (Kla) KLLA0E16126g GI:50309333
Eremothecium gossypii (Ego) AGOS_ACL143C GI:45185545
Magnaporthe grisea (Mgr) MGG_05643 GI:39941464
Neurospora crassa (Ncr) NCU02762.1 GI:32423047


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC6F6.01
GO:0005886 plasma membrane C
IDA
SceS000003449
GO:0005887 integral to plasma membrane C
NAS
SpoSPAC6F6.01
GO:0043025 neuronal cell body C
IDA
DmeFBgn0002917
GO:0043679 axon terminus C
IDA
DmeFBgn0002917
GO:0005216 ion channel activity F
IMP
DmeFBgn0002917
GO:0005245 voltage-gated calcium channel activity F
ISS
DmeFBgn0002917
SceS000003449
GO:0005261 cation channel activity F
IMP
DmeFBgn0002917
GO:0005262 calcium channel activity F
IDA
SceS000003449
IMP
SceS000003449
ISS
SpoSPAC6F6.01
GO:0006816 calcium ion transport P
IDA
SceS000003449
IMP
SceS000003449
GO:0007623 circadian rhythm P
IMP
DmeFBgn0002917
GO:0008344 adult locomotory behavior P
IMP
DmeFBgn0002917
GO:0032224 positive regulation of synaptic transmission,
cholinergic		 P
IGI
CelWBGene00003558
GO:0032230 positive regulation of synaptic transmission,
GABAergic		 P
IGI
CelWBGene00003558
GO:0040017 positive regulation of locomotion P
IGI
CelWBGene00003558
GO:0042752 regulation of circadian rhythm P
IMP
DmeFBgn0002917
GO:0048512 circadian behavior P
IDA
DmeFBgn0002917
GO:0050850 positive regulation of calcium-mediated
signaling		 P
IMP
SpoSPAC6F6.01
GO:0070588 calcium ion transmembrane transport P
IC
SpoSPAC6F6.01

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1618

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga6432 ENSANGP00000024607
Ashbya gossypii (Ago) ago906 ACL143C
Caenorhabditis elegans (Cel) cel1788 C11D2.6a
(CE37194;
WBGene00003557)
Caenorhabditis elegans (Cel) cel1789 C11D2.6b
(CE37195)
Caenorhabditis elegans (Cel) cel1790 C11D2.6c
(CE31301)
Caenorhabditis elegans (Cel) cel1791 C11D2.6d
(CE37196)
Caenorhabditis elegans (Cel) cel2866 C27F2.2
(CE38941;
WBGene00003558)
Candida glabrata (Cgl) cgl300 CAGL0B02211g
Cryptococcus neoformans (Cne) cne572 163.m06263
Debaryomyces hansenii (Dha) dha3010 DEHA0D15862g
Drosophila melanogaster (Dme) dme17818 CG1517-PB
(FBgn0002917)
Drosophila melanogaster (Dme) dme17819 CG1517-PC
(FBgn0002917)
Danio rerio (Dre) dre23686 ENSDARP00000027604
Danio rerio (Dre) dre20804 ENSDARP00000033924
Danio rerio (Dre) dre20803 ENSDARP00000048468
Takifugu rubripes (Fru) fru30074 SINFRUP00000134627
Takifugu rubripes (Fru) fru30076 SINFRUP00000134630
Takifugu rubripes (Fru) fru30077 SINFRUP00000170485
Takifugu rubripes (Fru) fru30078 SINFRUP00000172670
Takifugu rubripes (Fru) fru30075 SINFRUP00000175835
Gallus gallus (Gga) gga2758 ENSGALP00000027197
(NALCN)
Gallus gallus (Gga) gga2759 ENSGALP00000027198
Gallus gallus (Gga) gga2761 ENSGALP00000027200
Gallus gallus (Gga) gga2763 ENSGALP00000027202
Gallus gallus (Gga) gga2764 ENSGALP00000027203
Gallus gallus (Gga) gga2765 ENSGALP00000027204
Homo sapiens (Hsa) hsa8981 ENSP00000251127
(NALCN)		 Q8IZF0-1
Homo sapiens (Hsa) hsa8983 ENSP00000321227
Homo sapiens (Hsa) hsa8982 ENSP00000342900
Kluyveromyces lactis (Kla) kla3672 KLLA0E16126g
Mus musculus (Mmu) mmu8689 ENSMUSP00000000201
(MGI:2444306)		 Q8BXR5-1
Mus musculus (Mmu) mmu8690 ENSMUSP00000072105
(MGI:2444306)		 Q8BXR5-2
Neurospora crassa (Ncr) ncr2674 NCU02762.2
Rattus norvegicus (Rno) rno11900 ENSRNOP00000006286
Rattus norvegicus (Rno) rno11899 ENSRNOP00000006624
(RGD:628710)		 Q6Q760
Saccharomyces cerevisiae (Sce) sce2598 YGR217W
(S000003449)
Schizosaccharomyces pombe (Spo) spo4410 SPAC6F6.01 O14234
Yarrowia lipolytica (Yli) yli4494 YALI0E15334g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC6F6.01
GO:0005886 plasma membrane C
IDA
SceS000003449
GO:0005887 integral to plasma membrane C
NAS
SpoSPAC6F6.01
GO:0043025 neuronal cell body C
IDA
DmeFBgn0002917
GO:0043679 axon terminus C
IDA
DmeFBgn0002917
GO:0005216 ion channel activity F
IMP
DmeFBgn0002917
GO:0005245 voltage-gated calcium channel activity F
ISS
DmeFBgn0002917
SceS000003449
GO:0005261 cation channel activity F
IMP
DmeFBgn0002917
GO:0005262 calcium channel activity F
IDA
SceS000003449
IMP
SceS000003449
ISS
SpoSPAC6F6.01
GO:0006816 calcium ion transport P
IDA
SceS000003449
IMP
SceS000003449
GO:0007623 circadian rhythm P
IMP
DmeFBgn0002917
GO:0008344 adult locomotory behavior P
IMP
DmeFBgn0002917
GO:0032224 positive regulation of synaptic transmission,
cholinergic		 P
IGI
CelWBGene00003558
GO:0032230 positive regulation of synaptic transmission,
GABAergic		 P
IGI
CelWBGene00003558
GO:0040017 positive regulation of locomotion P
IGI
CelWBGene00003558
GO:0042752 regulation of circadian rhythm P
IMP
DmeFBgn0002917
GO:0048512 circadian behavior P
IDA
DmeFBgn0002917
GO:0050850 positive regulation of calcium-mediated
signaling		 P
IMP
SpoSPAC6F6.01
GO:0070588 calcium ion transmembrane transport P
IC
SpoSPAC6F6.01

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC6F6.01
(O14234)		 YGR217W
(S000003449)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC6F6.01
GO:0005886 plasma membrane C
IDA
SceS000003449
GO:0005887 integral to plasma membrane C
NAS
SpoSPAC6F6.01
GO:0005245 voltage-gated calcium channel activity F
ISS
SceS000003449
GO:0005262 calcium channel activity F
IDA
SceS000003449
IMP
SceS000003449
ISS
SpoSPAC6F6.01
GO:0006816 calcium ion transport P
IDA
SceS000003449
IMP
SceS000003449
GO:0050850 positive regulation of calcium-mediated
signaling		 P
IMP
SpoSPAC6F6.01
GO:0070588 calcium ion transmembrane transport P
IC
SpoSPAC6F6.01

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s.khadayate@ucl.ac.uk