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Search term: YGR232W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name NAS6
SGD link S000003464
Alternative ID YGR232W
Description Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
Synonyms YGR232W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4412 A--HYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING 26S proteasome regulatory complex, subunit PSMD10

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g03430 GI:15227631
Homo sapiens (Hsa) Hs4506217
(PSMD10)		 GI:4506217 O75832
Homo sapiens (Hsa) Hs20478597 GI:20478597
Saccharomyces cerevisiae (Sce) YGR232w
(S000003464)		 GI:6321671 P50086
Schizosaccharomyces pombe (Spo) SPAC6C3.08 GI:19114634 Q10311


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
TAS
HsaPSMD10
GO:0005618 cell wall C
IDA
AthAt2g03430
GO:0005634 nucleus C
IDA
HsaPSMD10
SceS000003464
SpoSPAC6C3.08
GO:0005737 cytoplasm C
IDA
HsaPSMD10
GO:0005829 cytosol C
IDA
SceS000003464
SpoSPAC6C3.08
GO:0005838 proteasome regulatory particle C
IDA
SceS000003464
ISS
SpoSPAC6C3.08
TAS
HsaPSMD10
GO:0015629 actin cytoskeleton C
IDA
HsaPSMD10
GO:0045111 intermediate filament cytoskeleton C
IDA
HsaPSMD10
GO:0003674 molecular_function F
ND
SceS000003464
SpoSPAC6C3.08
GO:0005515 protein binding F
IPI
HsaPSMD10
ISS
AthAt2g03430
GO:0008134 transcription factor binding F
IPI
HsaPSMD10
GO:0006508 proteolysis P
IPI
SceS000003464
ISS
SceS000003464
RCA
SceS000003464
GO:0007253 cytoplasmic sequestering of NF-kappaB P
IDA
HsaPSMD10
GO:0008150 biological_process P
ND
AthAt2g03430
GO:0010553 negative regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IDA
HsaPSMD10
GO:0030307 positive regulation of cell growth P
IDA
HsaPSMD10
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMD10
GO:0031398 positive regulation of protein
ubiquitination		 P
IMP
HsaPSMD10
GO:0032088 negative regulation of NF-kappaB transcription
factor activity		 P
IDA
HsaPSMD10
GO:0032436 positive regulation of proteasomal
ubiquitin-dependent protein catabolic
process		 P
IDA
HsaPSMD10
TAS
HsaPSMD10
GO:0042176 regulation of protein catabolic
process		 P
RCA
SceS000003464
GO:0043066 negative regulation of apoptosis P
IDA
HsaPSMD10
IMP
HsaPSMD10
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
NAS
SpoSPAC6C3.08
GO:0043409 negative regulation of MAPKKK cascade P
IMP
HsaPSMD10
GO:0043518 negative regulation of DNA damage response, signal
transduction by p53 class mediator		 P
IDA
HsaPSMD10
GO:0045737 positive regulation of cyclin-dependent protein
kinase activity		 P
IDA
HsaPSMD10
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMD10
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMD10
GO:0070682 proteasome regulatory particle
assembly		 P
IGI
SceS000003464
IMP
HsaPSMD10
SceS000003464
GO:0090201 negative regulation of release of cytochrome c
from mitochondria		 P
IMP
HsaPSMD10

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
94517

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PSMD10 GI:4506217 O75832
Pan troglodytes (Ptr) PSMD10 GI:114689806
Canis familiaris (Cfa) PSMD10 GI:57112311
Mus musculus (Mmu) Psmd10
(MGI:1858898)		 GI:31980811 Q8R0G2
Gallus gallus (Gga) PSMD10 GI:118089655
Anopheles gambiae (Aga) AgaP_AGAP000809 GI:158289680
Schizosaccharomyces pombe (Spo) SPAC6C3.08 GI:19114634 Q10311
Saccharomyces cerevisiae (Sce) NAS6
(S000003464)		 GI:6321671 P50086
Kluyveromyces lactis (Kla) KLLA0E15796g GI:50309303
Eremothecium gossypii (Ego) AGOS_ADL142C GI:45187731
Magnaporthe grisea (Mgr) MGG_05617 GI:145615476
Neurospora crassa (Ncr) NCU02967.1 GI:32419423


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
TAS
HsaPSMD10
GO:0005575 cellular_component C
ND
MmuMGI:1858898
GO:0005634 nucleus C
IDA
HsaPSMD10
SceS000003464
SpoSPAC6C3.08
GO:0005737 cytoplasm C
IDA
HsaPSMD10
GO:0005829 cytosol C
IDA
SceS000003464
SpoSPAC6C3.08
GO:0005838 proteasome regulatory particle C
IDA
SceS000003464
ISS
SpoSPAC6C3.08
TAS
HsaPSMD10
GO:0015629 actin cytoskeleton C
IDA
HsaPSMD10
GO:0045111 intermediate filament cytoskeleton C
IDA
HsaPSMD10
GO:0003674 molecular_function F
ND
MmuMGI:1858898
SceS000003464
SpoSPAC6C3.08
GO:0005515 protein binding F
IPI
HsaPSMD10
GO:0008134 transcription factor binding F
IPI
HsaPSMD10
GO:0006508 proteolysis P
IPI
SceS000003464
ISS
SceS000003464
RCA
SceS000003464
GO:0007253 cytoplasmic sequestering of NF-kappaB P
IDA
HsaPSMD10
GO:0008150 biological_process P
ND
MmuMGI:1858898
GO:0010553 negative regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IDA
HsaPSMD10
GO:0030307 positive regulation of cell growth P
IDA
HsaPSMD10
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMD10
GO:0031398 positive regulation of protein
ubiquitination		 P
IMP
HsaPSMD10
GO:0032088 negative regulation of NF-kappaB transcription
factor activity		 P
IDA
HsaPSMD10
GO:0032436 positive regulation of proteasomal
ubiquitin-dependent protein catabolic
process		 P
IDA
HsaPSMD10
TAS
HsaPSMD10
GO:0042176 regulation of protein catabolic
process		 P
RCA
SceS000003464
GO:0043066 negative regulation of apoptosis P
IDA
HsaPSMD10
IMP
HsaPSMD10
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
NAS
SpoSPAC6C3.08
GO:0043409 negative regulation of MAPKKK cascade P
IMP
HsaPSMD10
GO:0043518 negative regulation of DNA damage response, signal
transduction by p53 class mediator		 P
IDA
HsaPSMD10
GO:0045737 positive regulation of cyclin-dependent protein
kinase activity		 P
IDA
HsaPSMD10
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMD10
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMD10
GO:0070682 proteasome regulatory particle
assembly		 P
IGI
SceS000003464
IMP
HsaPSMD10
SceS000003464
GO:0090201 negative regulation of release of cytochrome c
from mitochondria		 P
IMP
HsaPSMD10

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_4326

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago1599 ADL142C
Arabidopsis thaliana (Ath) ath7750 At2g03430.1
Caenorhabditis elegans (Cel) cel8707 F40G9.1
(CE19848;
WBGene00018239)
Candida glabrata (Cgl) cgl4367 CAGL0L06600g
Cryptococcus neoformans (Cne) cne3605 176.m02339
Dictyostelium discoideum (Ddi) ddi8862 DDB0188298
Debaryomyces hansenii (Dha) dha2025 DEHA0C13497g
Danio rerio (Dre) dre5361 ENSDARP00000010745
(psmd10)		 Q4VBW1
Takifugu rubripes (Fru) fru10606 SINFRUP00000135059
Gallus gallus (Gga) gga17094 ENSGALP00000013470
(PSMD10)
Homo sapiens (Hsa) hsa33217 ENSP00000217958
(PSMD10)		 O75832
Homo sapiens (Hsa) hsa33218 ENSP00000345963
(PSMD10)		 B1AJY7
Kluyveromyces lactis (Kla) kla3657 KLLA0E15796g
Mus musculus (Mmu) mmu29641 ENSMUSP00000033805
(MGI:1858898)		 Q8R0G2
Neurospora crassa (Ncr) ncr2872 NCU02967.2
Oryza sativa (Osa) osa442 755.m00671
Saccharomyces cerevisiae (Sce) sce2613 YGR232W
(S000003464)
Schizosaccharomyces pombe (Spo) spo3613 SPAC6C3.08 Q10311
Yarrowia lipolytica (Yli) yli1775 YALI0C01221g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1858898
GO:0005618 cell wall C
IDA
AthAt2g03430
GO:0005634 nucleus C
IDA
SceS000003464
SpoSPAC6C3.08
GO:0005829 cytosol C
IDA
SceS000003464
SpoSPAC6C3.08
GO:0005838 proteasome regulatory particle C
IDA
SceS000003464
ISS
SpoSPAC6C3.08
GO:0003674 molecular_function F
ND
MmuMGI:1858898
SceS000003464
SpoSPAC6C3.08
GO:0005515 protein binding F
ISS
AthAt2g03430
GO:0002119 nematode larval development P
IMP
CelWBGene00018239
GO:0006508 proteolysis P
IPI
SceS000003464
ISS
SceS000003464
RCA
SceS000003464
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00018239
GO:0008150 biological_process P
ND
AthAt2g03430
MmuMGI:1858898
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00018239
GO:0040007 growth P
IMP
CelWBGene00018239
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00018239
GO:0040011 locomotion P
IMP
CelWBGene00018239
GO:0042176 regulation of protein catabolic
process		 P
RCA
SceS000003464
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
NAS
SpoSPAC6C3.08
GO:0070682 proteasome regulatory particle
assembly		 P
IGI
SceS000003464
IMP
SceS000003464

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC6C3.08
(Q10311)		 YGR232W
(S000003464)