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Search term: YGR238C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name KEL2
SGD link S000003470
Alternative ID YGR238C
Description Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
Synonyms YGR238C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0379 ACDHYP-

KOGs classification KOGs description
POORLY CHARACTERIZED Kelch repeat-containing proteins

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g03445_1 GI:15218816
Arabidopsis thaliana (Ath) At1g08420_1 GI:15223207
Arabidopsis thaliana (Ath) At1g18610 GI:15221823
Arabidopsis thaliana (Ath) At1g51550 GI:18403574
Arabidopsis thaliana (Ath) At1g54040 GI:15221025
Arabidopsis thaliana (Ath) At1g74150 GI:15221158
Arabidopsis thaliana (Ath) At2g27210_1 GI:15225857
Arabidopsis thaliana (Ath) At2g36360 GI:15227641
Arabidopsis thaliana (Ath) At3g05420_2 GI:15229986
Arabidopsis thaliana (Ath) At3g07720 GI:18398038
Arabidopsis thaliana (Ath) At4g03080_1 GI:15236244
Arabidopsis thaliana (Ath) At4g04670_2 GI:18412640
Arabidopsis thaliana (Ath) At5g04420 GI:15237715
Arabidopsis thaliana (Ath) At5g18590 GI:15238883
Arabidopsis thaliana (Ath) At5g23410 GI:15237313
Arabidopsis thaliana (Ath) At5g27630_2 GI:15241009
Arabidopsis thaliana (Ath) At5g42730 GI:15239044
Arabidopsis thaliana (Ath) At5g48180 GI:8777408
Caenorhabditis elegans (Cel) CE26138 GI:17556084
Caenorhabditis elegans (Cel) CE28374 GI:17543980
Drosophila melanogaster (Dme) 7291384 GI:7291384
Drosophila melanogaster (Dme) 7302605 GI:17647937 A1ZB86
Homo sapiens (Hsa) Hs14744278 GI:14744278
Homo sapiens (Hsa) Hs17450863 GI:17450863
Homo sapiens (Hsa) Hs20543271 GI:20543271
Homo sapiens (Hsa) Hs22041644 GI:22041644
Homo sapiens (Hsa) Hs5032015 GI:5032015
Homo sapiens (Hsa) Hs7657301
(KLHDC2)		 GI:7657301 Q9Y2U9
Saccharomyces cerevisiae (Sce) YGR238c
(S000003470)		 GI:6321677 P50090
Saccharomyces cerevisiae (Sce) YHR158c
(S000001201)		 GI:6321952 P38853
Schizosaccharomyces pombe (Spo) SPAC6G10.02c_1 GI:19115011 O14248
Schizosaccharomyces pombe (Spo) SPBC21.05c GI:19113131 P15258
Schizosaccharomyces pombe (Spo) SPCC1223.06 GI:19075851 P87061
Arabidopsis thaliana (Ath) At1g03445_1 GI:15218816
Arabidopsis thaliana (Ath) At1g08420_1 GI:15223207
Arabidopsis thaliana (Ath) At1g18610 GI:15221823
Arabidopsis thaliana (Ath) At1g51550 GI:18403574
Arabidopsis thaliana (Ath) At1g54040 GI:15221025
Arabidopsis thaliana (Ath) At1g74150 GI:15221158
Arabidopsis thaliana (Ath) At2g27210_1 GI:15225857
Arabidopsis thaliana (Ath) At2g36360 GI:15227641
Arabidopsis thaliana (Ath) At3g05420_2 GI:15229986
Arabidopsis thaliana (Ath) At3g07720 GI:18398038
Arabidopsis thaliana (Ath) At4g03080_1 GI:15236244
Arabidopsis thaliana (Ath) At4g04670_2 GI:18412640
Arabidopsis thaliana (Ath) At5g04420 GI:15237715
Arabidopsis thaliana (Ath) At5g18590 GI:15238883
Arabidopsis thaliana (Ath) At5g23410 GI:15237313
Arabidopsis thaliana (Ath) At5g27630_2 GI:15241009
Arabidopsis thaliana (Ath) At5g42730 GI:15239044
Arabidopsis thaliana (Ath) At5g48180 GI:8777408
Caenorhabditis elegans (Cel) CE26138 GI:17556084
Caenorhabditis elegans (Cel) CE28374 GI:17543980
Drosophila melanogaster (Dme) 7291384 GI:7291384
Drosophila melanogaster (Dme) 7302605 GI:17647937 A1ZB86
Homo sapiens (Hsa) Hs14744278 GI:14744278
Homo sapiens (Hsa) Hs17450863 GI:17450863
Homo sapiens (Hsa) Hs20543271 GI:20543271
Homo sapiens (Hsa) Hs22041644 GI:22041644
Homo sapiens (Hsa) Hs5032015 GI:5032015
Homo sapiens (Hsa) Hs7657301
(KLHDC2)		 GI:7657301 Q9Y2U9
Saccharomyces cerevisiae (Sce) YGR238c
(S000003470)		 GI:6321677 P50090
Saccharomyces cerevisiae (Sce) YHR158c
(S000001201)		 GI:6321952 P38853
Schizosaccharomyces pombe (Spo) SPAC6G10.02c_1 GI:19115011 O14248
Schizosaccharomyces pombe (Spo) SPBC21.05c GI:19113131 P15258
Schizosaccharomyces pombe (Spo) SPCC1223.06 GI:19075851 P87061
Arabidopsis thaliana (Ath) At1g03445_1 GI:15218816
Arabidopsis thaliana (Ath) At1g08420_1 GI:15223207
Arabidopsis thaliana (Ath) At1g18610 GI:15221823
Arabidopsis thaliana (Ath) At1g51550 GI:18403574
Arabidopsis thaliana (Ath) At1g54040 GI:15221025
Arabidopsis thaliana (Ath) At1g74150 GI:15221158
Arabidopsis thaliana (Ath) At2g27210_1 GI:15225857
Arabidopsis thaliana (Ath) At2g36360 GI:15227641
Arabidopsis thaliana (Ath) At3g05420_2 GI:15229986
Arabidopsis thaliana (Ath) At3g07720 GI:18398038
Arabidopsis thaliana (Ath) At4g03080_1 GI:15236244
Arabidopsis thaliana (Ath) At4g04670_2 GI:18412640
Arabidopsis thaliana (Ath) At5g04420 GI:15237715
Arabidopsis thaliana (Ath) At5g18590 GI:15238883
Arabidopsis thaliana (Ath) At5g23410 GI:15237313
Arabidopsis thaliana (Ath) At5g27630_2 GI:15241009
Arabidopsis thaliana (Ath) At5g42730 GI:15239044
Arabidopsis thaliana (Ath) At5g48180 GI:8777408
Caenorhabditis elegans (Cel) CE26138 GI:17556084
Caenorhabditis elegans (Cel) CE28374 GI:17543980
Drosophila melanogaster (Dme) 7291384 GI:7291384
Drosophila melanogaster (Dme) 7302605 GI:17647937 A1ZB86
Homo sapiens (Hsa) Hs14744278 GI:14744278
Homo sapiens (Hsa) Hs17450863 GI:17450863
Homo sapiens (Hsa) Hs20543271 GI:20543271
Homo sapiens (Hsa) Hs22041644 GI:22041644
Homo sapiens (Hsa) Hs5032015 GI:5032015
Homo sapiens (Hsa) Hs7657301
(KLHDC2)		 GI:7657301 Q9Y2U9
Saccharomyces cerevisiae (Sce) YGR238c
(S000003470)		 GI:6321677 P50090
Saccharomyces cerevisiae (Sce) YHR158c
(S000001201)		 GI:6321952 P38853
Schizosaccharomyces pombe (Spo) SPAC6G10.02c_1 GI:19115011 O14248
Schizosaccharomyces pombe (Spo) SPBC21.05c GI:19113131 P15258
Schizosaccharomyces pombe (Spo) SPCC1223.06 GI:19075851 P87061


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt2g36360
At1g74150
At1g18610
At4g04670
At5g23410
At5g48180
GO:0005634 nucleus C
IDA
AthAt1g03445
At5g04420
At3g07720
At3g05420
At1g54040
GO:0005737 cytoplasm C
IDA
AthAt3g07720
SceS000001201
SpoSPAC6G10.02c
ISS
SpoSPBC21.05c
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC21.05c
GO:0005829 cytosol C
IDA
AthAt5g04420
At3g05420
At2g27210
At5g27630
At5g18590
GO:0005875 microtubule associated complex C
TAS
SpoSPCC1223.06
GO:0005886 plasma membrane C
IDA
AthAt1g08420
At2g27210
At4g03080
GO:0005934 cellular bud tip C
IDA
SceS000003470
S000001201
GO:0005935 cellular bud neck C
IDA
SceS000003470
S000001201
GO:0015630 microtubule cytoskeleton C
IDA
SpoSPCC1223.06
GO:0031500 Tea1 cell-end complex C
IDA
SpoSPCC1223.06
GO:0032153 cell division site C
IDA
SpoSPCC1223.06
SPAC6G10.02c
GO:0043332 mating projection tip C
IDA
SceS000003470
S000001201
GO:0051285 cell cortex of cell tip C
IDA
SpoSPCC1223.06
SPAC6G10.02c
GO:0051286 cell tip C
IDA
SpoSPCC1223.06
GO:0000062 acyl-CoA binding F
IDA
AthAt3g05420
At5g27630
ISS
AthAt3g05420
At5g27630
GO:0003674 molecular_function F
ND
AthAt2g36360
At5g04420
At1g74150
At1g18610
At3g07720
At5g18590
At5g23410
At5g48180
SceS000003470
S000001201
SpoSPAC6G10.02c
GO:0004722 protein serine/threonine phosphatase
activity		 F
IDA
AthAt1g03445
ISS
AthAt2g27210
At1g08420
At1g03445
At4g03080
GO:0004842 ubiquitin-protein ligase activity F
ISS
AthAt1g51550
GO:0005515 protein binding F
IPI
AthAt4g03080
At1g03445
HsaKLHDC2
SpoSPCC1223.06
GO:0030234 enzyme regulator activity F
IDA
AthAt1g54040
GO:0030695 GTPase regulator activity F
NAS
SpoSPBC21.05c
GO:0042802 identical protein binding F
IPI
SpoSPCC1223.06
GO:0000003 reproduction P
RCA
SceS000001201
GO:0000747 conjugation with cellular fusion P
IGI
SceS000003470
IMP
SpoSPBC21.05c
GO:0000755 cytogamy P
IGI
SceS000001201
IMP
SceS000001201
IPI
SceS000001201
GO:0000902 cell morphogenesis P
TAS
SceS000001201
GO:0000918 selection of site for barrier septum
formation		 P
IMP
SpoSPAC6G10.02c
GO:0001100 negative regulation of exit from
mitosis		 P
IMP
SceS000003470
S000001201
IPI
SceS000003470
S000001201
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
TAS
AthAt1g51550
GO:0006869 lipid transport P
IDA
AthAt3g05420
At5g27630
GO:0007163 establishment or maintenance of cell
polarity		 P
IMP
SpoSPCC1223.06
SPAC6G10.02c
GO:0008150 biological_process P
ND
AthAt2g27210
At2g36360
At1g08420
At1g18610
At1g74150
At5g04420
At5g23410
At5g18590
GO:0008360 regulation of cell shape P
IMP
SceS000001201
GO:0009742 brassinosteroid mediated signaling
pathway		 P
IGI
AthAt1g03445
GO:0009753 response to jasmonic acid stimulus P
IMP
AthAt1g54040
TAS
AthAt1g54040
GO:0009966 regulation of signal transduction P
RCA
SceS000001201
GO:0010043 response to zinc ion P
IEP
AthAt3g07720
GO:0010150 leaf senescence P
IMP
AthAt1g54040
GO:0010570 regulation of filamentous growth P
IMP
SpoSPCC1223.06
SPBC21.05c
GO:0010811 positive regulation of cell-substrate
adhesion		 P
IMP
SpoSPBC21.05c
GO:0019762 glucosinolate catabolic process P
IDA
AthAt1g54040
At5g48180
GO:0019953 sexual reproduction P
RCA
SceS000001201
GO:0031591 wybutosine biosynthetic process P
ISS
AthAt4g04670
GO:0032005 regulation of conjugation with cellular fusion by
signal transduction		 P
IGI
SpoSPBC21.05c
GO:0032465 regulation of cytokinesis P
IGI
SpoSPCC1223.06
GO:0032489 regulation of Cdc42 protein signal
transduction		 P
NAS
SpoSPBC21.05c
GO:0032880 regulation of protein localization P
IDA
AthAt1g03445
GO:0034613 cellular protein localization P
IGI
SpoSPCC1223.06
GO:0042742 defense response to bacterium P
IMP
AthAt1g54040
GO:0045026 plasma membrane fusion P
TAS
SceS000001201
GO:0051301 cell division P
RCA
SceS000001201
GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape		 P
IMP
SpoSPCC1223.06
SPAC6G10.02c
GO:0080028 nitrile biosynthetic process P
IDA
AthAt5g48180

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
48772

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) RABEPK GI:33695109
Pan troglodytes (Ptr) RABEPK GI:114626700
Canis familiaris (Cfa) LOC609581 GI:73968215
Mus musculus (Mmu) Rabepk
(MGI:2139530)		 GI:31559945 Q3U6R8
Rattus norvegicus (Rno) Rabepk
(RGD:1310612)		 GI:67846008
Gallus gallus (Gga) RABEPK GI:118099486
Saccharomyces cerevisiae (Sce) KEL2
(S000003470)		 GI:6321677 P50090
Kluyveromyces lactis (Kla) KLLA0E15598g GI:50309287


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005886 plasma membrane C
IDA
HsaRABEPK
GO:0005934 cellular bud tip C
IDA
SceS000003470
GO:0005935 cellular bud neck C
IDA
SceS000003470
GO:0043231 intracellular membrane-bounded
organelle		 C
IDA
HsaRABEPK
GO:0043332 mating projection tip C
IDA
SceS000003470
GO:0003674 molecular_function F
ND
SceS000003470
GO:0000747 conjugation with cellular fusion P
IGI
SceS000003470
GO:0001100 negative regulation of exit from
mitosis		 P
IMP
SceS000003470
IPI
SceS000003470
GO:0006898 receptor-mediated endocytosis P
TAS
HsaRABEPK
GO:0006904 vesicle docking involved in exocytosis P
TAS
HsaRABEPK

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3537

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago1592 ADL149W
Arabidopsis thaliana (Ath) ath25037 At5g27630.1
Candida glabrata (Cgl) cgl2613 CAGL0I02090g
Cryptococcus neoformans (Cne) cne606 163.m04722
Dictyostelium discoideum (Ddi) ddi3559 DDB0168644
Dictyostelium discoideum (Ddi) ddi5227 DDB0204718
Dictyostelium discoideum (Ddi) ddi11484 DDB0220505
Debaryomyces hansenii (Dha) dha604 DEHA0A13519g
Danio rerio (Dre) dre18210 ENSDARP00000027462
Takifugu rubripes (Fru) fru28598 SINFRUP00000127088
Takifugu rubripes (Fru) fru28599 SINFRUP00000170975
Gallus gallus (Gga) gga7789 ENSGALP00000001477
(RABEPK)		 Q5ZJ37
Homo sapiens (Hsa) hsa31902 ENSP00000259460
(RABEPK)		 Q7Z6M1-2
Homo sapiens (Hsa) hsa27165 ENSP00000331562
(KLHDC3)		 Q8N7S8
Homo sapiens (Hsa) hsa31901 ENSP00000335186
Kluyveromyces lactis (Kla) kla3649 KLLA0E15598g
Mus musculus (Mmu) mmu14486 ENSMUSP00000037746
(MGI:2139530)		 Q8VCH5
Neurospora crassa (Ncr) ncr603 NCU00622.2
Rattus norvegicus (Rno) rno18462 ENSRNOP00000025194
(RGD:1310612)		 Q4V8F4
Rattus norvegicus (Rno) rno18463 ENSRNOP00000030929
Saccharomyces cerevisiae (Sce) sce2619 YGR238C
(S000003470)
Saccharomyces cerevisiae (Sce) sce2929 YHR158C
(S000001201)
Schizosaccharomyces pombe (Spo) spo4165 SPCC1223.06 P87061
Yarrowia lipolytica (Yli) yli3617 YALI0D21725g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000001201
GO:0005829 cytosol C
IDA
AthAt5g27630
GO:0005875 microtubule associated complex C
TAS
SpoSPCC1223.06
GO:0005934 cellular bud tip C
IDA
SceS000003470
S000001201
GO:0005935 cellular bud neck C
IDA
SceS000003470
S000001201
GO:0015630 microtubule cytoskeleton C
IDA
SpoSPCC1223.06
GO:0031500 Tea1 cell-end complex C
IDA
SpoSPCC1223.06
GO:0032153 cell division site C
IDA
SpoSPCC1223.06
GO:0043332 mating projection tip C
IDA
SceS000003470
S000001201
GO:0051285 cell cortex of cell tip C
IDA
SpoSPCC1223.06
GO:0051286 cell tip C
IDA
SpoSPCC1223.06
GO:0000062 acyl-CoA binding F
IDA
AthAt5g27630
ISS
AthAt5g27630
GO:0003674 molecular_function F
ND
SceS000003470
S000001201
GO:0005515 protein binding F
IPI
SpoSPCC1223.06
GO:0042802 identical protein binding F
IPI
SpoSPCC1223.06
GO:0000003 reproduction P
RCA
SceS000001201
GO:0000747 conjugation with cellular fusion P
IGI
SceS000003470
GO:0000755 cytogamy P
IGI
SceS000001201
IMP
SceS000001201
IPI
SceS000001201
GO:0000902 cell morphogenesis P
TAS
SceS000001201
GO:0001100 negative regulation of exit from
mitosis		 P
IMP
SceS000003470
S000001201
IPI
SceS000003470
S000001201
GO:0006869 lipid transport P
IDA
AthAt5g27630
GO:0007163 establishment or maintenance of cell
polarity		 P
IMP
SpoSPCC1223.06
GO:0008360 regulation of cell shape P
IMP
SceS000001201
GO:0009966 regulation of signal transduction P
RCA
SceS000001201
GO:0010570 regulation of filamentous growth P
IMP
SpoSPCC1223.06
GO:0019953 sexual reproduction P
RCA
SceS000001201
GO:0032465 regulation of cytokinesis P
IGI
SpoSPCC1223.06
GO:0034613 cellular protein localization P
IGI
SpoSPCC1223.06
GO:0045026 plasma membrane fusion P
TAS
SceS000001201
GO:0051301 cell division P
RCA
SceS000001201
GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape		 P
IMP
SpoSPCC1223.06

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC6G10.02c
(O14248)		 YGR238C
(S000003470)
SPCC1223.06
(P87061)		 YGR238C
(S000003470)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SpoSPAC6G10.02c
GO:0005875 microtubule associated complex C
TAS
SpoSPCC1223.06
GO:0005934 cellular bud tip C
IDA
SceS000003470
GO:0005935 cellular bud neck C
IDA
SceS000003470
GO:0015630 microtubule cytoskeleton C
IDA
SpoSPCC1223.06
GO:0031500 Tea1 cell-end complex C
IDA
SpoSPCC1223.06
GO:0032153 cell division site C
IDA
SpoSPCC1223.06
SPAC6G10.02c
GO:0043332 mating projection tip C
IDA
SceS000003470
GO:0051285 cell cortex of cell tip C
IDA
SpoSPCC1223.06
SPAC6G10.02c
GO:0051286 cell tip C
IDA
SpoSPCC1223.06
GO:0003674 molecular_function F
ND
SceS000003470
SpoSPAC6G10.02c
GO:0005515 protein binding F
IPI
SpoSPCC1223.06
GO:0042802 identical protein binding F
IPI
SpoSPCC1223.06
GO:0000747 conjugation with cellular fusion P
IGI
SceS000003470
GO:0000918 selection of site for barrier septum
formation		 P
IMP
SpoSPAC6G10.02c
GO:0001100 negative regulation of exit from
mitosis		 P
IMP
SceS000003470
IPI
SceS000003470
GO:0007163 establishment or maintenance of cell
polarity		 P
IMP
SpoSPCC1223.06
SPAC6G10.02c
GO:0010570 regulation of filamentous growth P
IMP
SpoSPCC1223.06
GO:0032465 regulation of cytokinesis P
IGI
SpoSPCC1223.06
GO:0034613 cellular protein localization P
IGI
SpoSPCC1223.06
GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape		 P
IMP
SpoSPCC1223.06
SPAC6G10.02c

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