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Search term: YGR253C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PUP2
SGD link S000003485
Alternative ID YGR253C
Description Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
Synonyms YGR253C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0176 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING 20S proteasome, regulatory subunit alpha type PSMA5/PUP2

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g53850 GI:15220961
Arabidopsis thaliana (Ath) At3g14290 GI:15231824
Caenorhabditis elegans (Cel) CE09654
(WBGene00003926)		 GI:17508493 Q95008
Drosophila melanogaster (Dme) 7302800 GI:12643296
Homo sapiens (Hsa) Hs4506187 GI:4506187
Saccharomyces cerevisiae (Sce) YGR253c
(S000003485)		 GI:6321692 P32379
Schizosaccharomyces pombe (Spo) SPAC323.02c GI:19115284 Q9UT97
Encephalitozoon cuniculi (Ecu) ECU05g1400 GI:19173680 Q8SRU3
Arabidopsis thaliana (Ath) At1g53850 GI:15220961
Arabidopsis thaliana (Ath) At3g14290 GI:15231824
Caenorhabditis elegans (Cel) CE09654
(WBGene00003926)		 GI:17508493 Q95008
Drosophila melanogaster (Dme) 7302800 GI:12643296
Homo sapiens (Hsa) Hs4506187 GI:4506187
Saccharomyces cerevisiae (Sce) YGR253c
(S000003485)		 GI:6321692 P32379
Schizosaccharomyces pombe (Spo) SPAC323.02c GI:19115284 Q9UT97
Encephalitozoon cuniculi (Ecu) ECU05g1400 GI:19173680 Q8SRU3
Arabidopsis thaliana (Ath) At1g53850 GI:15220961
Arabidopsis thaliana (Ath) At3g14290 GI:15231824
Caenorhabditis elegans (Cel) CE09654
(WBGene00003926)		 GI:17508493 Q95008
Drosophila melanogaster (Dme) 7302800 GI:12643296
Homo sapiens (Hsa) Hs4506187 GI:4506187
Saccharomyces cerevisiae (Sce) YGR253c
(S000003485)		 GI:6321692 P32379
Schizosaccharomyces pombe (Spo) SPAC323.02c GI:19115284 Q9UT97
Encephalitozoon cuniculi (Ecu) ECU05g1400 GI:19173680 Q8SRU3


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SceS000003485
IDA
SpoSPAC323.02c
TAS
SpoSPAC323.02c
GO:0005739 mitochondrion C
IC
SceS000003485
GO:0005829 cytosol C
IDA
SpoSPAC323.02c
GO:0005839 proteasome core complex C
TAS
AthAt1g53850
At3g14290
GO:0005886 plasma membrane C
IDA
AthAt1g53850
GO:0019773 proteasome core complex, alpha-subunit
complex		 C
IDA
SceS000003485
ISS
SpoSPAC323.02c
GO:0022626 cytosolic ribosome C
IDA
AthAt3g14290
At1g53850
GO:0034515 proteasome storage granule C
IDA
SceS000003485
GO:0042175 nuclear membrane-endoplasmic reticulum
network		 C
IC
SceS000003485
GO:0003674 molecular_function F
ND
SceS000003485
GO:0004175 endopeptidase activity F
ISS
SpoSPAC323.02c
GO:0008233 peptidase activity F
ISS
AthAt3g14290
At1g53850
GO:0000003 reproduction P
IMP
CelWBGene00003926
GO:0000278 mitotic cell cycle P
IC
SpoSPAC323.02c
GO:0002119 nematode larval development P
IMP
CelWBGene00003926
GO:0006508 proteolysis P
RCA
SceS000003485
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
TAS
AthAt1g53850
At3g14290
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPAC323.02c
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003926
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003926
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000003485
GO:0040007 growth P
IMP
CelWBGene00003926
GO:0040011 locomotion P
IMP
CelWBGene00003926
GO:0040022 feminization of hermaphroditic
germ-line		 P
IMP
CelWBGene00003926
GO:0040025 vulval development P
IMP
CelWBGene00003926
GO:0040027 negative regulation of vulval development P
IMP
CelWBGene00003926
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000003485
NAS
SpoSPAC323.02c
GO:0046686 response to cadmium ion P
IEP
AthAt1g53850

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
2084

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PSMA5 GI:23110942
Canis familiaris (Cfa) PSMA5 GI:73959335
Mus musculus (Mmu) Psma5
(MGI:1347009)		 GI:7106387 Q3TUI9
Rattus norvegicus (Rno) Psma5
(RGD:61848)		 GI:8394072
Gallus gallus (Gga) PSMA5 GI:71897167
Drosophila melanogaster (Dme) ProsMA5
(FBgn0016697)		 GI:24654391
Anopheles gambiae (Aga) AgaP_AGAP008816 GI:31211921
Caenorhabditis elegans (Cel) pas-5
(CE09654;
WBGene00003926)		 GI:17508493 Q95008
Schizosaccharomyces pombe (Spo) SPAC323.02c GI:19115284 Q9UT97
Saccharomyces cerevisiae (Sce) PUP2
(S000003485)		 GI:6321692 P32379
Kluyveromyces lactis (Kla) KLLA0A05093g GI:50302577
Eremothecium gossypii (Ego) AGOS_AER296W GI:45190899
Magnaporthe grisea (Mgr) MGG_07130 GI:145612449
Neurospora crassa (Ncr) NCU05295.1 GI:32408341
Arabidopsis thaliana (Ath) PAE2 GI:15231824
Arabidopsis thaliana (Ath) PAE1 GI:145325425
Oryza sativa (Osa) Os11g0615700 GI:115486269
Plasmodium falciparum (Pfa) PF07_0112 GI:124512076


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
NAS
DmeFBgn0016697
TAS
HsaPSMA5
GO:0005575 cellular_component C
ND
MmuMGI:1347009
GO:0005634 nucleus C
IC
SceS000003485
IDA
SpoSPAC323.02c
TAS
SpoSPAC323.02c
GO:0005739 mitochondrion C
IC
SceS000003485
GO:0005829 cytosol C
IDA
SpoSPAC323.02c
GO:0005839 proteasome core complex C
NAS
DmeFBgn0016697
TAS
AthPAE1
PAE2
GO:0005886 plasma membrane C
IDA
AthPAE1
GO:0019773 proteasome core complex, alpha-subunit
complex		 C
IDA
SceS000003485
ISS
PfaPF07_0112
SpoSPAC323.02c
GO:0022626 cytosolic ribosome C
IDA
AthPAE2
PAE1
GO:0034515 proteasome storage granule C
IDA
SceS000003485
GO:0042175 nuclear membrane-endoplasmic reticulum
network		 C
IC
SceS000003485
GO:0003674 molecular_function F
ND
MmuMGI:1347009
SceS000003485
GO:0004175 endopeptidase activity F
ISS
SpoSPAC323.02c
NAS
DmeFBgn0016697
GO:0005515 protein binding F
IPI
HsaPSMA5
GO:0008233 peptidase activity F
ISS
AthPAE2
PAE1
GO:0000003 reproduction P
IMP
CelWBGene00003926
GO:0000278 mitotic cell cycle P
IC
SpoSPAC323.02c
GO:0002119 nematode larval development P
IMP
CelWBGene00003926
GO:0006508 proteolysis P
RCA
SceS000003485
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
NAS
DmeFBgn0016697
TAS
AthPAE1
PAE2
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPAC323.02c
GO:0008150 biological_process P
ND
MmuMGI:1347009
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003926
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003926
GO:0009987 cellular process P
IMP
DmeFBgn0016697
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000003485
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMA5
GO:0040007 growth P
IMP
CelWBGene00003926
GO:0040011 locomotion P
IMP
CelWBGene00003926
GO:0040022 feminization of hermaphroditic
germ-line		 P
IMP
CelWBGene00003926
GO:0040025 vulval development P
IMP
CelWBGene00003926
GO:0040027 negative regulation of vulval development P
IMP
CelWBGene00003926
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000003485
NAS
SpoSPAC323.02c
GO:0046686 response to cadmium ion P
IEP
AthPAE1
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMA5
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMA5

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2074

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga10861 ENSANGP00000019329
Ashbya gossypii (Ago) ago2798 AER296W
Arabidopsis thaliana (Ath) ath4687 At1g53850.1
Arabidopsis thaliana (Ath) ath13626 At3g14290.1
Caenorhabditis elegans (Cel) cel7273 F25H2.9
(CE09654;
WBGene00003926)
Candida glabrata (Cgl) cgl2629 CAGL0I02442g
Dictyostelium discoideum (Ddi) ddi821 DDB0216562
Debaryomyces hansenii (Dha) dha6804 DEHA0G24882g
Drosophila melanogaster (Dme) dme5623 CG10938-PA
(FBgn0016697)
Drosophila melanogaster (Dme) dme5624 CG10938-PB
(FBgn0016697)
Danio rerio (Dre) dre2949 ENSDARP00000009133
(psma5)		 Q6TGV6
Encephalitozoon cuniculi (Ecu) ecu1242 19173680
Takifugu rubripes (Fru) fru10836 SINFRUP00000128581
Gallus gallus (Gga) gga24325 ENSGALP00000000088
(PSMA5)
Homo sapiens (Hsa) hsa1633 ENSP00000271308
(PSMA5)		 P28066
Kluyveromyces lactis (Kla) kla221 KLLA0A05093g
Mus musculus (Mmu) mmu17392 ENSMUSP00000080583
Mus musculus (Mmu) mmu31253 ENSMUSP00000080761
Neurospora crassa (Ncr) ncr5140 NCU05295.2
Oryza sativa (Osa) osa71375 6998.m00176
Plasmodium falciparum (Pfa) pfa2442 PF07_0112
Rattus norvegicus (Rno) rno16848 ENSRNOP00000026928
(RGD:61848)		 P34064
Saccharomyces cerevisiae (Sce) sce2635 YGR253C
(S000003485)
Schizosaccharomyces pombe (Spo) spo2105 SPAC323.02c Q9UT97
Yarrowia lipolytica (Yli) yli3976 YALI0E02794g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
NAS
DmeFBgn0016697
GO:0005634 nucleus C
IC
SceS000003485
IDA
SpoSPAC323.02c
TAS
SpoSPAC323.02c
GO:0005739 mitochondrion C
IC
SceS000003485
GO:0005829 cytosol C
IDA
SpoSPAC323.02c
GO:0005839 proteasome core complex C
NAS
DmeFBgn0016697
TAS
AthAt1g53850
At3g14290
GO:0005886 plasma membrane C
IDA
AthAt1g53850
GO:0019773 proteasome core complex, alpha-subunit
complex		 C
IDA
SceS000003485
ISS
PfaPF07_0112
SpoSPAC323.02c
GO:0022626 cytosolic ribosome C
IDA
AthAt3g14290
At1g53850
GO:0034515 proteasome storage granule C
IDA
SceS000003485
GO:0042175 nuclear membrane-endoplasmic reticulum
network		 C
IC
SceS000003485
GO:0003674 molecular_function F
ND
SceS000003485
GO:0004175 endopeptidase activity F
ISS
SpoSPAC323.02c
NAS
DmeFBgn0016697
GO:0008233 peptidase activity F
ISS
AthAt3g14290
At1g53850
GO:0000003 reproduction P
IMP
CelWBGene00003926
GO:0000278 mitotic cell cycle P
IC
SpoSPAC323.02c
GO:0002119 nematode larval development P
IMP
CelWBGene00003926
GO:0006508 proteolysis P
RCA
SceS000003485
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
NAS
DmeFBgn0016697
TAS
AthAt1g53850
At3g14290
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPAC323.02c
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003926
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003926
GO:0009987 cellular process P
IMP
DmeFBgn0016697
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000003485
GO:0040007 growth P
IMP
CelWBGene00003926
GO:0040011 locomotion P
IMP
CelWBGene00003926
GO:0040022 feminization of hermaphroditic
germ-line		 P
IMP
CelWBGene00003926
GO:0040025 vulval development P
IMP
CelWBGene00003926
GO:0040027 negative regulation of vulval development P
IMP
CelWBGene00003926
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000003485
NAS
SpoSPAC323.02c
GO:0046686 response to cadmium ion P
IEP
AthAt1g53850

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC323.02c
(Q9UT97)		 YGR253C
(S000003485)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SceS000003485
IDA
SpoSPAC323.02c
TAS
SpoSPAC323.02c
GO:0005739 mitochondrion C
IC
SceS000003485
GO:0005829 cytosol C
IDA
SpoSPAC323.02c
GO:0019773 proteasome core complex, alpha-subunit
complex		 C
IDA
SceS000003485
ISS
SpoSPAC323.02c
GO:0034515 proteasome storage granule C
IDA
SceS000003485
GO:0042175 nuclear membrane-endoplasmic reticulum
network		 C
IC
SceS000003485
GO:0003674 molecular_function F
ND
SceS000003485
GO:0004175 endopeptidase activity F
ISS
SpoSPAC323.02c
GO:0000278 mitotic cell cycle P
IC
SpoSPAC323.02c
GO:0006508 proteolysis P
RCA
SceS000003485
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPAC323.02c
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000003485
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000003485
NAS
SpoSPAC323.02c

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