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Search term: YGR258C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RAD2
SGD link S000003490
Alternative ID YGR258C
Description Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
Synonyms YGR258C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2520 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING 5'-3' exonuclease

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g28030 GI:15232891
Caenorhabditis elegans (Cel) CE01401
(WBGene00020442)		 GI:17555016 Q22418
Caenorhabditis elegans (Cel) CE11308
(WBGene00019004)		 GI:17507747 O44737
Drosophila melanogaster (Dme) 7297419 GI:17316370
Homo sapiens (Hsa) Hs4503601 GI:4503601
Saccharomyces cerevisiae (Sce) YER041w
(S000000843)		 GI:6320880 P40028
Saccharomyces cerevisiae (Sce) YGR258c
(S000003490)		 GI:6321697 P07276
Schizosaccharomyces pombe (Spo) SPBC3E7.08c GI:19112887 P28706
Encephalitozoon cuniculi (Ecu) ECU09g1620 GI:19173283


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000112 nucleotide-excision repair factor 3
complex		 C
IDA
SceS000003490
GO:0005634 nucleus C
IDA
SceS000000843
SpoSPBC3E7.08c
GO:0005737 cytoplasm C
IDA
SceS000000843
GO:0000014 single-stranded DNA specific endodeoxyribonuclease
activity		 F
IDA
SceS000003490
ISS
SceS000000843
GO:0004518 nuclease activity F
ISS
AthAt3g28030
GO:0004527 exonuclease activity F
RCA
SceS000003490
GO:0005515 protein binding F
IPI
AthAt3g28030
GO:0008409 5'-3' exonuclease activity F
RCA
SceS000003490
GO:0008821 crossover junction endodeoxyribonuclease
activity		 F
IDA
SceS000000843
IMP
SceS000000843
GO:0016888 endodeoxyribonuclease activity, producing
5'-phosphomonoesters		 F
RCA
SceS000003490
GO:0016893 endonuclease activity, active with either ribo- or
deoxyribonucleic acids and producing
5'-phosphomonoesters		 F
RCA
SceS000003490
GO:0017108 5'-flap endonuclease activity F
RCA
SceS000003490
GO:0048256 flap endonuclease activity F
RCA
SceS000003490
GO:0006281 DNA repair P
IGI
SceS000000843
ISS
AthAt3g28030
GO:0006289 nucleotide-excision repair P
IGI
SpoSPBC3E7.08c
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to
lesion		 P
IDA
SceS000003490
IMP
SceS000003490
TAS
SpoSPBC3E7.08c
GO:0006366 transcription from RNA polymerase II
promoter		 P
IGI
SceS000003490
GO:0006914 autophagy P
RCA
SceS000003490
GO:0006974 response to DNA damage stimulus P
IGI
SceS000000843
GO:0009408 response to heat P
IMP
AthAt3g28030
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019004
GO:0010213 non-photoreactive DNA repair P
IMP
AthAt3g28030
GO:0010224 response to UV-B P
IGI
AthAt3g28030

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
37265

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ERCC5 GI:51988900
Pan troglodytes (Ptr) ERCC5 GI:114650610
Canis familiaris (Cfa) ERCC5 GI:73989268
Mus musculus (Mmu) Ercc5
(MGI:103582)		 GI:6756023 B2RUC3
Rattus norvegicus (Rno) Ercc5 GI:109486023
Gallus gallus (Gga) ERCC5 GI:77736641
Drosophila melanogaster (Dme) Chrac-14
(FBgn0043002)		 GI:78706850
Anopheles gambiae (Aga) AgaP_AGAP008939 GI:158299596
Schizosaccharomyces pombe (Spo) rad13
(SPBC3E7.08c)		 GI:19112887 P28706
Saccharomyces cerevisiae (Sce) RAD2
(S000003490)		 GI:6321697 P07276
Kluyveromyces lactis (Kla) KLLA0A09427g GI:50302949
Eremothecium gossypii (Ego) AGOS_AFR133C GI:45198651
Magnaporthe grisea (Mgr) MGG_00155 GI:39975397
Neurospora crassa (Ncr) NCU07498.1 GI:32414609


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000112 nucleotide-excision repair factor 3
complex		 C
IDA
SceS000003490
GO:0005575 cellular_component C
ND
MmuMGI:103582
GO:0005634 nucleus C
IDA
HsaERCC5
SpoSPBC3E7.08c
GO:0005654 nucleoplasm C
EXP
HsaERCC5
GO:0005675 holo TFIIH complex C
IDA
HsaERCC5
GO:0008623 chromatin accessibility complex C
IDA
DmeFBgn0043002
NAS
DmeFBgn0043002
GO:0016591 DNA-directed RNA polymerase II,
holoenzyme		 C
IDA
HsaERCC5
GO:0000014 single-stranded DNA specific endodeoxyribonuclease
activity		 F
IDA
SceS000003490
GO:0000405 bubble DNA binding F
IDA
HsaERCC5
GO:0003674 molecular_function F
ND
MmuMGI:103582
GO:0003690 double-stranded DNA binding F
IDA
HsaERCC5
GO:0003697 single-stranded DNA binding F
IDA
HsaERCC5
GO:0004519 endonuclease activity F
EXP
HsaERCC5
GO:0004520 endodeoxyribonuclease activity F
IDA
HsaERCC5
GO:0004527 exonuclease activity F
RCA
SceS000003490
GO:0005515 protein binding F
IPI
DmeFBgn0043002
HsaERCC5
GO:0008409 5'-3' exonuclease activity F
RCA
SceS000003490
GO:0016888 endodeoxyribonuclease activity, producing
5'-phosphomonoesters		 F
RCA
SceS000003490
GO:0016893 endonuclease activity, active with either ribo- or
deoxyribonucleic acids and producing
5'-phosphomonoesters		 F
RCA
SceS000003490
GO:0017108 5'-flap endonuclease activity F
RCA
SceS000003490
GO:0042803 protein homodimerization activity F
IPI
HsaERCC5
GO:0046982 protein heterodimerization activity F
IPI
DmeFBgn0043002
GO:0047485 protein N-terminus binding F
IPI
HsaERCC5
GO:0048256 flap endonuclease activity F
RCA
SceS000003490
GO:0000718 nucleotide-excision repair, DNA damage
removal		 P
EXP
HsaERCC5
GO:0006281 DNA repair P
IMP
MmuMGI:103582
GO:0006283 transcription-coupled nucleotide-excision
repair		 P
IMP
HsaERCC5
GO:0006289 nucleotide-excision repair P
IGI
SpoSPBC3E7.08c
IMP
MmuMGI:103582
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to
lesion		 P
IDA
HsaERCC5
SceS000003490
IMP
HsaERCC5
SceS000003490
TAS
SpoSPBC3E7.08c
GO:0006366 transcription from RNA polymerase II
promoter		 P
IGI
SceS000003490
GO:0006914 autophagy P
RCA
SceS000003490
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0043002
GO:0008340 determination of adult lifespan P
IMP
MmuMGI:103582
GO:0009411 response to UV P
IDA
HsaERCC5
IMP
HsaERCC5
MmuMGI:103582
GO:0009650 UV protection P
IDA
MmuMGI:103582
IGI
HsaERCC5
IMP
MmuMGI:103582
ISO
MmuMGI:103582
GO:0010225 response to UV-C P
IMP
HsaERCC5
GO:0035264 multicellular organism growth P
IMP
MmuMGI:103582
GO:0042766 nucleosome mobilization P
IDA
DmeFBgn0043002
GO:0043066 negative regulation of apoptosis P
IMP
HsaERCC5

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1473

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga11023 ENSANGP00000021368
Anopheles gambiae (Aga) aga11024 ENSANGP00000029505
Ashbya gossypii (Ago) ago3325 AFR133C
Arabidopsis thaliana (Ath) ath15158 At3g28030.1
Caenorhabditis elegans (Cel) cel10715 F57B10.6
(CE11308;
WBGene00019004)
Candida glabrata (Cgl) cgl1589 CAGL0F08327g
Cryptococcus neoformans (Cne) cne2083 181.m08070
Dictyostelium discoideum (Ddi) ddi11002 DDB0215138
Debaryomyces hansenii (Dha) dha6716 DEHA0G22792g
Drosophila melanogaster (Dme) dme1469 CG32956-PB
Drosophila melanogaster (Dme) dme1472 CG32956-PC
Drosophila melanogaster (Dme) dme1471 CG32956-PD
Danio rerio (Dre) dre25785 ENSDARP00000033024
(zgc:110827)		 Q58EB6
Encephalitozoon cuniculi (Ecu) ecu1434 19173283
Takifugu rubripes (Fru) fru3637 SINFRUP00000133111
Gallus gallus (Gga) gga2747 ENSGALP00000027186
(ERCC5)		 Q4AEJ2
Homo sapiens (Hsa) hsa8995 ENSP00000347978
(ERCC5)		 P28715-1
Kluyveromyces lactis (Kla) kla409 KLLA0A09427g
Mus musculus (Mmu) mmu281 ENSMUSP00000027214
(MGI:103582)		 B2RUC3
Mus musculus (Mmu) mmu282 ENSMUSP00000068268
(MGI:103582)		 Q8CAG2
Neurospora crassa (Ncr) ncr7299 NCU07498.2
Oryza sativa (Osa) osa4984 2343.m00139
Oryza sativa (Osa) osa36962 4852.m00123
Oryza sativa (Osa) osa50244 5904.m00120
Plasmodium falciparum (Pfa) pfa6 PFB0265c
Rattus norvegicus (Rno) rno29966 ENSRNOP00000014836
(RGD:1586176)
Saccharomyces cerevisiae (Sce) sce2640 YGR258C
(S000003490)
Schizosaccharomyces pombe (Spo) spo4564 SPBC3E7.08c P28706
Yarrowia lipolytica (Yli) yli3553 YALI0D20240g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000112 nucleotide-excision repair factor 3
complex		 C
IDA
SceS000003490
GO:0005575 cellular_component C
ND
MmuMGI:103582
PfaPFB0265c
GO:0005634 nucleus C
IDA
SpoSPBC3E7.08c
GO:0000014 single-stranded DNA specific endodeoxyribonuclease
activity		 F
IDA
SceS000003490
GO:0003674 molecular_function F
ND
MmuMGI:103582
GO:0003684 damaged DNA binding F
ISS
PfaPFB0265c
GO:0004518 nuclease activity F
ISS
AthAt3g28030
GO:0004519 endonuclease activity F
ISS
PfaPFB0265c
GO:0004527 exonuclease activity F
RCA
SceS000003490
GO:0005515 protein binding F
IPI
AthAt3g28030
GO:0008409 5'-3' exonuclease activity F
RCA
SceS000003490
GO:0016888 endodeoxyribonuclease activity, producing
5'-phosphomonoesters		 F
RCA
SceS000003490
GO:0016893 endonuclease activity, active with either ribo- or
deoxyribonucleic acids and producing
5'-phosphomonoesters		 F
RCA
SceS000003490
GO:0017108 5'-flap endonuclease activity F
RCA
SceS000003490
GO:0048256 flap endonuclease activity F
RCA
SceS000003490
GO:0006281 DNA repair P
IMP
MmuMGI:103582
ISS
AthAt3g28030
GO:0006289 nucleotide-excision repair P
IGI
SpoSPBC3E7.08c
IMP
MmuMGI:103582
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to
lesion		 P
IDA
SceS000003490
IMP
SceS000003490
TAS
SpoSPBC3E7.08c
GO:0006366 transcription from RNA polymerase II
promoter		 P
IGI
SceS000003490
GO:0006914 autophagy P
RCA
SceS000003490
GO:0008340 determination of adult lifespan P
IMP
MmuMGI:103582
GO:0009408 response to heat P
IMP
AthAt3g28030
GO:0009411 response to UV P
IMP
MmuMGI:103582
GO:0009650 UV protection P
IDA
MmuMGI:103582
IMP
MmuMGI:103582
ISO
MmuMGI:103582
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019004
GO:0010213 non-photoreactive DNA repair P
IMP
AthAt3g28030
GO:0010224 response to UV-B P
IGI
AthAt3g28030
GO:0035264 multicellular organism growth P
IMP
MmuMGI:103582

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC3E7.08c
(P28706)		 YGR258C
(S000003490)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000112 nucleotide-excision repair factor 3
complex		 C
IDA
SceS000003490
GO:0005634 nucleus C
IDA
SpoSPBC3E7.08c
GO:0000014 single-stranded DNA specific endodeoxyribonuclease
activity		 F
IDA
SceS000003490
GO:0004527 exonuclease activity F
RCA
SceS000003490
GO:0008409 5'-3' exonuclease activity F
RCA
SceS000003490
GO:0016888 endodeoxyribonuclease activity, producing
5'-phosphomonoesters		 F
RCA
SceS000003490
GO:0016893 endonuclease activity, active with either ribo- or
deoxyribonucleic acids and producing
5'-phosphomonoesters		 F
RCA
SceS000003490
GO:0017108 5'-flap endonuclease activity F
RCA
SceS000003490
GO:0048256 flap endonuclease activity F
RCA
SceS000003490
GO:0006289 nucleotide-excision repair P
IGI
SpoSPBC3E7.08c
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to
lesion		 P
IDA
SceS000003490
IMP
SceS000003490
TAS
SpoSPBC3E7.08c
GO:0006366 transcription from RNA polymerase II
promoter		 P
IGI
SceS000003490
GO:0006914 autophagy P
RCA
SceS000003490

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