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Search term: YGR267C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name FOL2
SGD link S000003499
Alternative ID YGR267C
Description GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
Synonyms YGR267C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2698 ACDHYP-

KOGs classification KOGs description
METABOLISM GTP cyclohydrolase I

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g07270 GI:15231435
Caenorhabditis elegans (Cel) CE05795
(WBGene00000298)		 GI:17560486 Q19980
Drosophila melanogaster (Dme) 7291259 GI:9297102
Drosophila melanogaster (Dme) 7291261 GI:7291261
Homo sapiens (Hsa) Hs4503949
(GCH1)		 GI:4503949 P30793
Saccharomyces cerevisiae (Sce) YGR267c
(S000003499)		 GI:6321706 P51601
Schizosaccharomyces pombe (Spo) SPAC17A5.13 GI:19114393 O13774


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
HsaGCH1
SceS000003499
SpoSPAC17A5.13
GO:0005737 cytoplasm C
IDA
HsaGCH1
SceS000003499
ISS
SpoSPAC17A5.13
GO:0005829 cytosol C
IDA
HsaGCH1
SpoSPAC17A5.13
GO:0031410 cytoplasmic vesicle C
IDA
HsaGCH1
GO:0043234 protein complex C
IDA
HsaGCH1
GO:0003934 GTP cyclohydrolase I activity F
IDA
HsaGCH1
IMP
SceS000003499
ISS
AthAt3g07270
SpoSPAC17A5.13
GO:0005515 protein binding F
IPI
HsaGCH1
GO:0005525 GTP binding F
IDA
HsaGCH1
GO:0008270 zinc ion binding F
IDA
HsaGCH1
GO:0042803 protein homodimerization activity F
IPI
HsaGCH1
GO:0006082 organic acid metabolic process P
RCA
SceS000003499
GO:0006184 GTP catabolic process P
IDA
HsaGCH1
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000003499
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000003499
GO:0006729 tetrahydrobiopterin biosynthetic
process		 P
IDA
HsaGCH1
IMP
HsaGCH1
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000003499
GO:0006809 nitric oxide biosynthetic process P
NAS
HsaGCH1
GO:0008217 regulation of blood pressure P
IMP
HsaGCH1
GO:0009058 biosynthetic process P
ISS
AthAt3g07270
GO:0009396 folic acid and derivative biosynthetic
process		 P
IMP
SceS000003499
ISS
SpoSPAC17A5.13
GO:0032496 response to lipopolysaccharide P
IDA
HsaGCH1
GO:0034341 response to interferon-gamma P
IDA
HsaGCH1
GO:0034607 turning behavior involved in mating P
IMP
CelWBGene00000298
GO:0034612 response to tumor necrosis factor P
IDA
HsaGCH1
GO:0042416 dopamine biosynthetic process P
IDA
HsaGCH1
IMP
CelWBGene00000298
GO:0042417 dopamine metabolic process P
IMP
CelWBGene00000298
GO:0042438 melanin biosynthetic process P
IMP
CelWBGene00000298
GO:0042559 pteridine and derivative biosynthetic
process		 P
IDA
HsaGCH1
GO:0048265 response to pain P
ISS
HsaGCH1
GO:0050884 neuromuscular process controlling
posture		 P
IMP
HsaGCH1
GO:0051000 positive regulation of nitric-oxide synthase
activity		 P
IDA
HsaGCH1
IMP
HsaGCH1
GO:0051260 protein homooligomerization P
IDA
HsaGCH1
GO:0060179 male mating behavior P
IMP
CelWBGene00000298

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
132

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) GCH1 GI:4503949 P30793
Pan troglodytes (Ptr) GCH1 GI:114653131
Canis familiaris (Cfa) GCH1 GI:73963001
Mus musculus (Mmu) Gch1
(MGI:95675)		 GI:6679967 Q05915
Rattus norvegicus (Rno) Gch1 GI:13242245
Gallus gallus (Gga) GCH1 GI:45382575
Drosophila melanogaster (Dme) Pu
(FBgn0003162)		 GI:24656791
Anopheles gambiae (Aga) AgaP_AGAP006441 GI:158295842
Caenorhabditis elegans (Cel) cat-4
(CE05795;
WBGene00000298)		 GI:17560486 Q19980
Schizosaccharomyces pombe (Spo) SPAC17A5.13 GI:19114393 O13774
Saccharomyces cerevisiae (Sce) FOL2
(S000003499)		 GI:6321706 P51601
Kluyveromyces lactis (Kla) KLLA0A09735g GI:50302975
Eremothecium gossypii (Ego) AGOS_AGR335C GI:45201431
Magnaporthe grisea (Mgr) MGG_09458 GI:145602544
Neurospora crassa (Ncr) NCU07774.1 GI:32416004


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005625 soluble fraction C
ISO
MmuMGI:95675
GO:0005634 nucleus C
IDA
HsaGCH1
SceS000003499
SpoSPAC17A5.13
GO:0005737 cytoplasm C
IDA
DmeFBgn0003162
HsaGCH1
SceS000003499
ISS
SpoSPAC17A5.13
GO:0005829 cytosol C
IDA
HsaGCH1
SpoSPAC17A5.13
GO:0031410 cytoplasmic vesicle C
IDA
HsaGCH1
GO:0043234 protein complex C
IDA
HsaGCH1
ISO
MmuMGI:95675
GO:0003933 GTP cyclohydrolase activity F
IDA
DmeFBgn0003162
GO:0003934 GTP cyclohydrolase I activity F
IDA
DmeFBgn0003162
HsaGCH1
MmuMGI:95675
IMP
SceS000003499
ISO
MmuMGI:95675
ISS
DmeFBgn0003162
SpoSPAC17A5.13
NAS
DmeFBgn0003162
GO:0005509 calcium ion binding F
ISO
MmuMGI:95675
GO:0005515 protein binding F
IPI
HsaGCH1
GO:0005525 GTP binding F
IDA
HsaGCH1
ISO
MmuMGI:95675
GO:0008270 zinc ion binding F
IDA
HsaGCH1
ISO
MmuMGI:95675
GO:0030742 GTP-dependent protein binding F
ISO
MmuMGI:95675
GO:0042803 protein homodimerization activity F
IPI
HsaGCH1
GO:0050662 coenzyme binding F
ISO
MmuMGI:95675
GO:0006082 organic acid metabolic process P
RCA
SceS000003499
GO:0006184 GTP catabolic process P
IDA
HsaGCH1
GO:0006461 protein complex assembly P
ISO
MmuMGI:95675
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000003499
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000003499
GO:0006728 pteridine biosynthetic process P
IMP
DmeFBgn0003162
GO:0006729 tetrahydrobiopterin biosynthetic
process		 P
IC
MmuMGI:95675
IDA
HsaGCH1
IMP
HsaGCH1
NAS
DmeFBgn0003162
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000003499
GO:0006809 nitric oxide biosynthetic process P
NAS
HsaGCH1
GO:0008152 metabolic process P
IDA
MmuMGI:95675
GO:0008217 regulation of blood pressure P
IMP
HsaGCH1
MmuMGI:95675
GO:0008363 larval chitin-based cuticle development P
IMP
DmeFBgn0003162
GO:0009396 folic acid and derivative biosynthetic
process		 P
IMP
SceS000003499
ISS
SpoSPAC17A5.13
GO:0009880 embryonic pattern specification P
IMP
DmeFBgn0003162
GO:0014916 regulation of lung blood pressure P
IMP
MmuMGI:95675
GO:0032496 response to lipopolysaccharide P
IDA
HsaGCH1
GO:0034341 response to interferon-gamma P
IDA
HsaGCH1
GO:0034607 turning behavior involved in mating P
IMP
CelWBGene00000298
GO:0034612 response to tumor necrosis factor P
IDA
HsaGCH1
GO:0035185 preblastoderm mitotic cell cycle P
IMP
DmeFBgn0003162
GO:0042311 vasodilation P
ISO
MmuMGI:95675
GO:0042416 dopamine biosynthetic process P
IDA
HsaGCH1
IMP
CelWBGene00000298
GO:0042417 dopamine metabolic process P
IMP
CelWBGene00000298
GO:0042438 melanin biosynthetic process P
IMP
CelWBGene00000298
GO:0042559 pteridine and derivative biosynthetic
process		 P
IDA
HsaGCH1
GO:0045776 negative regulation of blood pressure P
ISO
MmuMGI:95675
GO:0048067 cuticle pigmentation P
IMP
DmeFBgn0003162
GO:0048072 compound eye pigmentation P
IMP
DmeFBgn0003162
GO:0048265 response to pain P
ISO
MmuMGI:95675
ISS
HsaGCH1
GO:0050884 neuromuscular process controlling
posture		 P
IMP
HsaGCH1
ISO
MmuMGI:95675
GO:0051000 positive regulation of nitric-oxide synthase
activity		 P
IDA
HsaGCH1
IMP
HsaGCH1
GO:0051066 dihydrobiopterin metabolic process P
ISO
MmuMGI:95675
GO:0051260 protein homooligomerization P
IDA
HsaGCH1
ISO
MmuMGI:95675
GO:0051291 protein heterooligomerization P
ISO
MmuMGI:95675
GO:0060179 male mating behavior P
IMP
CelWBGene00000298

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1132

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga1890 ENSANGP00000013527
Ashbya gossypii (Ago) ago4646 AGR335C
Arabidopsis thaliana (Ath) ath12814 At3g07270.1
Arabidopsis thaliana (Ath) ath12815 At3g07270.2
Caenorhabditis elegans (Cel) cel7937 F32G8.6
(CE05795;
WBGene00000298)
Candida glabrata (Cgl) cgl1596 CAGL0F08503g
Cryptococcus neoformans (Cne) cne5012 186.m03931
Dictyostelium discoideum (Ddi) ddi12859 DDB0191399
Debaryomyces hansenii (Dha) dha6664 DEHA0G21593g
Drosophila melanogaster (Dme) dme6298 CG9441-PA
(FBgn0003162)
Drosophila melanogaster (Dme) dme6297 CG9441-PB
(FBgn0003162)
Drosophila melanogaster (Dme) dme6299 CG9441-PC
(FBgn0003162)
Danio rerio (Dre) dre25446 ENSDARP00000008311
(gch)		 Q6IQV5
Danio rerio (Dre) dre435 ENSDARP00000009012
Escherichia coli (Eco) eco2085 16130091
Takifugu rubripes (Fru) fru16820 SINFRUP00000141488
Takifugu rubripes (Fru) fru25159 SINFRUP00000163260
Gallus gallus (Gga) gga20014 ENSGALP00000019895
(GCH1)		 P50141
Homo sapiens (Hsa) hsa9561 ENSP00000254299
Homo sapiens (Hsa) hsa9562 ENSP00000352686
Kluyveromyces lactis (Kla) kla422 KLLA0A09735g
Mus musculus (Mmu) mmu8005 ENSMUSP00000049098
Neurospora crassa (Ncr) ncr7570 NCU07774.2
Oryza sativa (Osa) osa81208 8213.m00156
Plasmodium falciparum (Pfa) pfa5014 PFL1155w
Rattus norvegicus (Rno) rno11162 ENSRNOP00000014821
(RGD:61992)		 P22288
Saccharomyces cerevisiae (Sce) sce2649 YGR267C
(S000003499)
Schizosaccharomyces pombe (Spo) spo1186 SPAC17A5.13 O13774
Yarrowia lipolytica (Yli) yli345 YALI0A10310g