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Search term: YHR007C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ERG11
SGD link S000001049
Alternative ID YHR007C
Description Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
Synonyms YHR007C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0684 A--HYP-

KOGs classification KOGs description
METABOLISM Cytochrome P450

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g11680 GI:15221075
Arabidopsis thaliana (Ath) At2g17330 GI:15227817
Homo sapiens (Hsa) Hs13650621 GI:13650621
Homo sapiens (Hsa) Hs13699859
(PTGIS)		 GI:13699859 Q16647
Homo sapiens (Hsa) Hs13929429 GI:13929429
Homo sapiens (Hsa) Hs4503243
(CYP51A1)		 GI:4503243 Q16850
Homo sapiens (Hsa) Hs4503245 GI:4503245
Homo sapiens (Hsa) Hs4758104
(CYP7B1)		 GI:4758104 O75881
Homo sapiens (Hsa) Hs7706129 GI:7706129
Saccharomyces cerevisiae (Sce) YHR007c
(S000001049)		 GI:6321795 P10614
Schizosaccharomyces pombe (Spo) SPAC13A11.02c GI:19113902 Q09736
Arabidopsis thaliana (Ath) At1g11680 GI:15221075
Arabidopsis thaliana (Ath) At2g17330 GI:15227817
Homo sapiens (Hsa) Hs13650621 GI:13650621
Homo sapiens (Hsa) Hs13699859
(PTGIS)		 GI:13699859 Q16647
Homo sapiens (Hsa) Hs13929429 GI:13929429
Homo sapiens (Hsa) Hs4503243
(CYP51A1)		 GI:4503243 Q16850
Homo sapiens (Hsa) Hs4503245 GI:4503245
Homo sapiens (Hsa) Hs4758104
(CYP7B1)		 GI:4758104 O75881
Homo sapiens (Hsa) Hs7706129 GI:7706129
Saccharomyces cerevisiae (Sce) YHR007c
(S000001049)		 GI:6321795 P10614
Schizosaccharomyces pombe (Spo) SPAC13A11.02c GI:19113902 Q09736


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
AthAt1g11680
SceS000001049
SpoSPAC13A11.02c
GO:0005788 endoplasmic reticulum lumen C
EXP
HsaPTGIS
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaCYP51A1
CYP7B1
ISS
SpoSPAC13A11.02c
GO:0005886 plasma membrane C
IDA
AthAt1g11680
GO:0005515 protein binding F
IPI
SpoSPAC13A11.02c
GO:0008116 prostaglandin-I synthase activity F
EXP
HsaPTGIS
GO:0008396 oxysterol 7-alpha-hydroxylase activity F
EXP
HsaCYP7B1
GO:0008398 sterol 14-demethylase activity F
EXP
HsaCYP51A1
IDA
SceS000001049
ISS
SpoSPAC13A11.02c
TAS
AthAt1g11680
GO:0019825 oxygen binding F
ISS
AthAt1g11680
GO:0006066 alcohol metabolic process P
RCA
SceS000001049
GO:0006629 lipid metabolic process P
NAS
HsaPTGIS
GO:0006696 ergosterol biosynthetic process P
IEP
SpoSPAC13A11.02c
IMP
SceS000001049
GO:0009793 embryo development ending in seed
dormancy		 P
NAS
AthAt1g11680
GO:0016126 sterol biosynthetic process P
IMP
AthAt1g11680
TAS
AthAt1g11680
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001049
GO:0044255 cellular lipid metabolic process P
RCA
SceS000001049
GO:0070988 demethylation P
ISS
SpoSPAC13A11.02c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
55488

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) CYP51A1 GI:4503243 Q16850
Pan troglodytes (Ptr) CYP51A1 GI:114614422
Canis familiaris (Cfa) LOC475225 GI:57095976
Mus musculus (Mmu) Cyp51
(MGI:106040)		 GI:71061451 Q8K0C4
Rattus norvegicus (Rno) Cyp51
(RGD:2481)		 GI:6978751 41312
Gallus gallus (Gga) CYP51A1 GI:114326305
Schizosaccharomyces pombe (Spo) erg11
(SPAC13A11.02c)		 GI:19113902 Q09736
Saccharomyces cerevisiae (Sce) ERG11
(S000001049)		 GI:6321795 P10614
Kluyveromyces lactis (Kla) KLLA0E03553g GI:50308217
Eremothecium gossypii (Ego) AGOS_ADR162W GI:45188036
Magnaporthe grisea (Mgr) MGG_04628 GI:39945292
Arabidopsis thaliana (Ath) CYP51G1 GI:15221075
Oryza sativa (Osa) Os11g0525200 GI:115485695


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
AthCYP51G1
SceS000001049
SpoSPAC13A11.02c
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaCYP51A1
ISS
SpoSPAC13A11.02c
GO:0005792 microsome C
ISO
MmuMGI:106040
GO:0005886 plasma membrane C
IDA
AthCYP51G1
GO:0005515 protein binding F
IPI
SpoSPAC13A11.02c
GO:0008398 sterol 14-demethylase activity F
EXP
HsaCYP51A1
IDA
SceS000001049
ISO
MmuMGI:106040
ISS
SpoSPAC13A11.02c
TAS
AthCYP51G1
MmuMGI:106040
GO:0019825 oxygen binding F
ISS
AthCYP51G1
GO:0006066 alcohol metabolic process P
RCA
SceS000001049
GO:0006695 cholesterol biosynthetic process P
TAS
MmuMGI:106040
GO:0006696 ergosterol biosynthetic process P
IEP
SpoSPAC13A11.02c
IMP
SceS000001049
GO:0009793 embryo development ending in seed
dormancy		 P
NAS
AthCYP51G1
GO:0016126 sterol biosynthetic process P
IMP
AthCYP51G1
TAS
AthCYP51G1
GO:0033488 cholesterol biosynthetic process via
24,25-dihydrolanosterol		 P
ISO
MmuMGI:106040
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001049
GO:0044255 cellular lipid metabolic process P
RCA
SceS000001049
GO:0070988 demethylation P
ISS
SpoSPAC13A11.02c
TAS
MmuMGI:106040

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3735

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago1904 ADR162W
Arabidopsis thaliana (Ath) ath1222 At1g11680.1
Candida glabrata (Cgl) cgl1129 CAGL0E04334g
Cryptococcus neoformans (Cne) cne1853 181.m07816
Dictyostelium discoideum (Ddi) ddi6465 DDB0218166
Debaryomyces hansenii (Dha) dha4145 DEHA0E20383g
Takifugu rubripes (Fru) fru4306 SINFRUP00000135614
Gallus gallus (Gga) gga9698 ENSGALP00000015237
(CYP51A1)		 Q0KKP5
Homo sapiens (Hsa) hsa28947 ENSP00000003100
(CYP51A1)		 Q16850-1
Kluyveromyces lactis (Kla) kla3108 KLLA0E03553g
Mus musculus (Mmu) mmu19629 ENSMUSP00000001507
(MGI:106040)		 Q8K0C4
Neurospora crassa (Ncr) ncr2542 NCU02624.2
Oryza sativa (Osa) osa23461 3730.m00148
Oryza sativa (Osa) osa23476 3730.m00154
Oryza sativa (Osa) osa44001 5318.m00117
Oryza sativa (Osa) osa55800 6378.m00371
Oryza sativa (Osa) osa62616 6508.m00173
Oryza sativa (Osa) osa62627 6508.m00179
Oryza sativa (Osa) osa67903 7007.m00192
Rattus norvegicus (Rno) rno20754 ENSRNOP00000009985
(RGD:2481)		 Q64654
Saccharomyces cerevisiae (Sce) sce2752 YHR007C
(S000001049)
Schizosaccharomyces pombe (Spo) spo761 SPAC13A11.02c Q09736
Yarrowia lipolytica (Yli) yli950 YALI0B05126g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
AthAt1g11680
SceS000001049
SpoSPAC13A11.02c
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPAC13A11.02c
GO:0005792 microsome C
ISO
MmuMGI:106040
GO:0005886 plasma membrane C
IDA
AthAt1g11680
GO:0005515 protein binding F
IPI
SpoSPAC13A11.02c
GO:0008398 sterol 14-demethylase activity F
IDA
SceS000001049
ISO
MmuMGI:106040
ISS
SpoSPAC13A11.02c
TAS
AthAt1g11680
MmuMGI:106040
GO:0019825 oxygen binding F
ISS
AthAt1g11680
GO:0006066 alcohol metabolic process P
RCA
SceS000001049
GO:0006695 cholesterol biosynthetic process P
TAS
MmuMGI:106040
GO:0006696 ergosterol biosynthetic process P
IEP
SpoSPAC13A11.02c
IMP
SceS000001049
GO:0009793 embryo development ending in seed
dormancy		 P
NAS
AthAt1g11680
GO:0016126 sterol biosynthetic process P
IMP
AthAt1g11680
TAS
AthAt1g11680
GO:0033488 cholesterol biosynthetic process via
24,25-dihydrolanosterol		 P
ISO
MmuMGI:106040
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001049
GO:0044255 cellular lipid metabolic process P
RCA
SceS000001049
GO:0070988 demethylation P
ISS
SpoSPAC13A11.02c
TAS
MmuMGI:106040

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC13A11.02c
(Q09736)		 YHR007C
(S000001049)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000001049
SpoSPAC13A11.02c
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPAC13A11.02c
GO:0005515 protein binding F
IPI
SpoSPAC13A11.02c
GO:0008398 sterol 14-demethylase activity F
IDA
SceS000001049
ISS
SpoSPAC13A11.02c
GO:0006066 alcohol metabolic process P
RCA
SceS000001049
GO:0006696 ergosterol biosynthetic process P
IEP
SpoSPAC13A11.02c
IMP
SceS000001049
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001049
GO:0044255 cellular lipid metabolic process P
RCA
SceS000001049
GO:0070988 demethylation P
ISS
SpoSPAC13A11.02c

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GO info in one table:

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